A Multi-Functional Cascade Nanoreactor for Remodeling Tumor Microenvironment to Realize Mitochondria Dysfunction via ROS/Zn Ions Overload.

Combining chemo/photodynamic therapy (CDT/PDT) to generate highly harmful reactive oxygen species and cause mitochondria dysfunction is considered a potential strategy to improve the efficiency of anticancer treatment. However, within tumor, the relatively deficient concentration of HO, hypoxic microenvironment, and overexpressed reduced glutathione (GSH) seriously suppress the efficacy of dynamic therapy. Herein, a multi-functional cascade nanoreactor, bovine serum albumin modified ZnO@CeO-ICG, is reported for remodeling tumor microenvironment (TME) to boost dynamic therapy and realize mitochondria dysfunction via reactive oxygen species (ROS) storm/Zn ions overload.

The effectiveness and safety of posaconazole enteric-coated tablet versus oral suspension in invasive fungal infections.

Posaconazole enteric-coated tablet and oral suspension are two oral drugs in the treatment of invasive fungal infections (IFIs). This study compared the effectiveness and safety between posaconazole enteric-coated tablet and oral suspension, and provided a real world basis for the clinical practice. A retrospective cohort study was performed on IFIs patients treated with posaconazole enteric-coated tablet or oral suspension.

Cellular mechanisms of combining innate immunity activation with PD-1/PD-L1 blockade in treatment of colorectal cancer.

PD-1/PD-L1 blockade therapies have displayed extraordinary clinical efficacy for melanoma, renal, bladder and lung cancer; however, only a minority of colorectal cancer (CRC) patients benefit from these treatments. The efficacy of PD-1/PD-L1 blockade in CRC is limited by the complexities of tumor microenvironment. PD-1/PD-L1 blockade immunotherapy is based on T cell-centered view of tumor immunity.

Bone features reinforce differential diagnosis between tuberculous spondylitis and brucellosis spondylitis.

Background: Tuberculous spondylitis (TS) and brucellar spondylitis (BS) both cause major long-term morbidity and disability. Though Spondylodiscitis is sensitive to magnetic resonance images, some are difficult to differentiate. This study aims to identify specific bone changes on computed tomography (CT) images, further to differentiate TS from BS.

Regulation of nerve cells and therapeutic potential in central nervous system injury using microglia-derived exosomes.

The intercellular communication within the central nervous system (CNS) is of great importance for in maintaining brain function, homeostasis, and CNS regulation. When the equilibrium of CNS is disrupted or injured, microglia are immediately activated and respond to CNS injury. Microglia-derived exosomes are capable of participating in intercellular communication within the CNS by transporting various bioactive substances, including nucleic acids, proteins, lipids, amino acids, and metabolites.

A PRKN-independent mechanism regulating cardiac mitochondrial quality control.

PRKN-dependent mitophagy plays a crucial role in maintaining mitochondrial health. Yet, PRKN-deficient mice do not exhibit mitochondrial and cardiac phenotypes at baseline, suggesting the existence of other mitochondrial ubiquitin (Ub) ligases. Here, we discuss our recent work identifying RNF7/RBX2 as a novel mitochondrial Ub ligase.

: Expression Patterns, Clinical Correlates and New Target of Papillary Thyroid Carcinoma.

Despite the generally favorable prognosis of PTC (Papillary Thyroid Carcinoma), it can still exhibit aggressive behavior and lead to patient mortality. (interaction protein for cytohesin exchange factors 1) has emerged as a critical player in cell signaling related to proliferation and migration in cancer progression. Our research aimed to determine whether is a key gene in PTC, elucidate its possible molecular mechanisms and ultimately search for new targets.

ANXA4 restricts HBV replication by inhibiting autophagic degradation of MCM2 in chronic hepatitis B.

Background: Hepatitis B virus (HBV) is an enveloped DNA virus that causes chronic hepatitis B (CHB) infection. Annexin, a Ca-activated protein, is widely expressed in various organs and tissues and has potential utility in disease diagnosis and treatment. However, the relationship between the annexin family and CHB remains unclear.

Enhancement of oral bioavailability of celastrol by chitosan microencapsulated porous starch carriers.

Celastrol demonstrates significant potential in immunomodulatory applications; however, its low oral bioavailability presents a substantial obstacle to its clinical translation. Here, we combined porous starch with chitosan to develop an efficacious microencapsulation system aimed at enhancing the oral absorption of celastrol. Microcapsule carrier for celastrol was formulated Through the utilization of chitosan-coated porous starch particle technology and Subsequent evaluations of the morphology and release kinetics of microcapsules.

The metabolic role of lactate dehydrogenase in the growth of diffuse large B cell lymphoma.

Lactate dehydrogenase (LDHA) activation induces tumorigenesis by activating tumor proliferation, growth, invasion, and metastasis. Whether LDHA mediates tumor metabolism that upon diffuse large B-cell lymphoma (DLBCL) occur remains unknown. Here, we investigated how LDHA adopt tumor metabolism after activation to regulate DLBCL-inducible.

Development and Validation of Machine Learning Models for Identifying Prediabetes and Diabetes in Normoglycemia.

Background: Prediabetes and diabetes are both abnormal states of glucose metabolism (AGM) that can lead to severe complications. Early detection of AGM is crucial for timely intervention and treatment. However, fasting blood glucose (FBG) as a mass population screening method may fail to identify some individuals who are actually AGM but with normoglycemia.

Association between intake of whole grain and periodontitis among adults in the United States: a population-based study.

The objective was to examine the association between the intakes of whole grains, refined grains, and whole/refined ratio with periodontitis. Data from 7,753 adults participating in NHANES 2009-2014 were used. The intakes of whole grains, refined grains, and whole/refined ratio were collected and calculated.

Muscle Weakness in an Adult With 22q11.2 Deletion Syndrome.

This case report provides the first evidence that coenzyme Q10 may improve muscle weakness in patients with 22q11.2DS. The patient's genetic copy number deletion mutation region mainly contains COMT, PRODH functional genes related with mitochondria dynamics.

Metabolic disorders, inter-organ crosstalk, and inflammation in the progression of metabolic dysfunction-associated steatotic liver disease.

Metabolic dysfunction-associated steatotic liver disease (MASLD) represents a global health concern, affecting over 30 % of adults. It is a principal driver in the development of cirrhosis and hepatocellular carcinoma. The complex pathogenesis of MASLD involves an excessive accumulation of lipids, subsequently disrupting lipid metabolism and prompting inflammation within the liver.

Brief Report: Ivonescimab Combined With Etoposide Plus Carboplatin as First-Line Treatment for Extensive-Stage SCLC: Results of a Phase 1b Clinical Trial.

Introduction: Ivonescimab is a humanized IgG1 bispecific anti-programmed cell death protein 1/vascular endothelial growth factor antibody. This study aimed to evaluate the safety and tolerance of ivonescimab combined with etoposide and carboplatin as first-line treatment in patients with extensive-stage SCLC and to explore the primary efficacy of this regimen.

Methods: Eligible patients received intravenous ivonescimab 3 mg/kg, 10 mg/kg, or 20 mg/kg every 3 weeks combined with etoposide and carboplatin for up to four cycles, followed by ivonescimab as maintenance.

Using hyperspectral imaging to predict the occurrence of delayed graft function.

Delayed Graft Function (DGF) is a prevalent complication in kidney transplantation (KT) that significantly affects allograft function and patient prognosis. Early and precise identification of DGF is crucial for improving post-transplant outcomes. In this study, we present KGnet, a predictive model leveraging hyperspectral imaging (HSI) to assess delayed graft function status.

Functions of Langerhans cells in diisononyl phthalate-aggravated allergic contact dermatitis.

Diisononyl phthalate (DINP), a widely-used plasticizer, is associated with the development of allergic diseases including allergic contact dermatitis (ACD). Langerhans cells (LCs) are reported to be involved in the sensitization phase of ACD. However, the effect of skin DINP exposure on ACD in C57BL/6 mice and the functions of LCs remain unclear.

A modified separator based on ternary mixed-oxide for stable lithium metal batteries.

Li metal batteries (LMBs) are among the most promising options for next-generation secondary batteries under the rapidly growing demand for high-energy-density electrochemical energy storage. However, the implementation of LMBs are hindered by major obstacles such as dentritic Li deposition and low cycling Coulombic efficiency. A practical functional separator is developed in this study, which consists of a Lewis acidic mixed oxide of ZrO-SiO-AlO as a functional coating with anion anchoring ability to modulate ion transport in the vicinity of the Li metal anode, delivering a high Li transference number of 0.

ZC3HAV1 facilitates STING activation and enhances inflammation.

Stimulator of interferon genes (STING) is vital in the cytosolic DNA-sensing process and critical for initiating the innate immune response, which has important functions in host defense and contributes to the pathogenesis of inflammatory diseases. Zinc finger CCCH-type antiviral protein 1 (ZC3HAV1) specifically binds the CpG dinucleotides in the viral RNAs of multiple viruses and promotes their degradation. ZAPS (ZC3HAV1 short isoform) is a potent stimulator of retinoid acid-inducible gene I (RIG-I) signaling during the antiviral response.

Unleashing AdipoRon's Potential: A Fresh Approach to Tackle Infections in Bronchiectasis via Sphingosine Metabolism Modulation.

Purpose: Bronchiectasis patients are prone to infection due to decreased level of sphingosine in airway. Adiponectin receptor agonist AdipoRon activates the intrinsic ceramidase activity of adiponectin receptor 1 (AdipoR1) and positively regulates sphingosine metabolism. This study aimed to investigate the potential therapeutic benefit of AdipoRon against infection.

Fisher discriminant analysis of multimodal ultrasound in diagnosis of cervical metastatic lymph nodes in papillary thyroid cancer.

Background/aims: The purpose of this study was to develop a diagnostic model utilizing multimodal ultrasound parameters to aid in the detection of cervical lymph node metastasis in papillary thyroid cancer (PTC) patients.

Methods: The study included 84 suspicious lymph nodes from 69 PTC patients, all of whom underwent fine needle aspiration with pathological results. Data from conventional grayscale ultrasound, shear wave elastography (SWE), and superb microvascular imaging were analyzed.