Application of a definitive screening design for the synthesis of a charge-transfer complex of sparfloxacin with tetracyanoethylene: spectroscopic, thermodynamic, kinetics, and DFT computational studies.

Herein, a spectrochemical approach was adopted to study the charge-transfer (CT) complexation of sparfloxacin (SFX) with tetracyanoethylene (TCNE). In this study, a three-level design of experiments (DOE) involving a definitive screening design (DSD) was implemented. This is the first effort to operate this new category of design to determine a pharmaceutical compound in its pure form and in formulations.