Frieden's Group-V Aplasia Cutis Congenita with in utero Scarring in a Dichorionic Twin: A Case Report and Comprehensive Literature Review.

Introduction: Aplasia cutis congenita (ACC) is a rare congenital disorder characterized by the localized absence of skin at birth, primarily affecting the scalp but also affecting the trunk and limbs. Nine different presentations have been reported. Group V-ACC (G-V ACC) is a rare type associated with fetus papyraceus.

Perforated anterior tenia coli-type appendicitis in a case of vermiform appendix duplex in a toddler: a case report.

Duplication of the vermiform appendix is a rare anomaly observed in patients undergoing appendectomy. A 27-month-old male toddler presented with a 9-day history of abdominal pain, vomiting, and diarrhea, progressing to an acute abdomen with signs of severe peritonitis. Intraoperative findings revealed a periappendicular infiltrate from a perforated vermiform appendix of the tenia coli type.

Qatar's genetic counseling landscape: Current insights and future prospects.

Genetic counseling is a dynamic and rapidly growing field. In Qatar, the significance of genetic counseling is underscored by the distinctive demographic characteristics of the population, including elevated rates of consanguinity and larger family sizes, contributing to the increased incidence of many genetic conditions. This emphasizes the crucial role of genetic counseling in addressing the specific needs of the community.

The Prevalence of Potentially Inappropriate Medications Among Patients With Diabetic Nephropathy: A Cross-Sectional Study Conducted at a Tertiary Care Hospital.

Background Diabetic nephropathy is a serious complication of diabetes that significantly increases the risk of chronic kidney disease (CKD) and end-stage renal disease (ESRD). A critical concern in managing patients with diabetic nephropathy is the prevalence of potentially inappropriate medications (PIMs), which can exacerbate kidney dysfunction and lead to adverse health outcomes. PIMs are defined as medications whose risks outweigh their benefits, particularly when safer alternatives are available.

Modern-Day Management of the Dysglycemic Continuum: An Expert Viewpoint from the Arabian Gulf.

Prediabetes is the first stage of a continuum that extends through the diagnosis of clinical type 2 diabetes towards long-standing diabetes with multiple comorbidities. The diagnosis of prediabetes provides an opportunity to interrupt the diabetes continuum at an early stage to ensure long-term optimization of clinical outcomes. All people with prediabetes should receive intervention to improve their lifestyles (quality of diet and level of physical activity), as this has been proven beyond doubt to reduce substantially the risk of conversion to diabetes.

The Association Between Intensive Care Unit Nurses' Perception of Nursing Professional Autonomy and Nursing Professionalism: A Descriptive Correlational Design.

Introduction: The evolving landscape of healthcare in Jordan presents unique challenges and opportunities for nursing professionals. With a focus on critical care nurses, understanding the dynamics of professional autonomy and professionalism within this context is crucial for advancing nursing practice and improving patient care.

Objectives: This study aimed to investigate the relationships between perceived nursing professional autonomy and professionalism among critical care nurses in Jordan.

Smartphone use and personality: Their effects on sleep quality across groups using mediation analysis.

Purpose: The rapid rise in smartphone use has led to declining sleep quality. Excessive internet use has been linked to negative impacts on physical and mental health, and individual personality traits (PT) may contribute to internet addiction and mitigate its harmful effects. This study aims to: (1) examine whether PT mediate the relationship between smartphone use and sleep quality, and (2) investigate whether the relationship between smartphone use and sleep quality varies across different gender and age groups.

Associations between bone mineral density and WOMAC scores in healthy individuals: Insights from the Qatar Biobank.

Background: Bone mineral density (BMD) is an indicator of bone health that predicts future bone fractures. The Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) is used to assess the severity of symptoms related to pain, stiffness, and function in diseased hip and knee joints. Here we assessed whether BMD measured at specific sites predicts WOMAC scores in healthy individuals whilst controlling for sociodemographic variables.

Global climate change and its impact on the distribution and efficacy of Bacillus thuringiensis as a biopesticide.

This study is the first modeling exercise to assess the impacts of climate change on the current and future global distribution of Bacillus thuringiensis (Bt). Bt is a common Gram-positive, rod-shaped bacterium widely distributed in various environments, including soil and water. It is widely recognized as a source of effective and safe agricultural biopesticides for pest management in various climatic regions globally.

Tolerability and efficacy of botulinum toxin injection in the treatment of bromhidrosis: a systematic review and meta-analysis of clinical trials.

This review evaluates the risks and benefits of botulinum toxin (BTX) therapy for treating bromhidrosis. A search was conducted across six databases, including clinical trials comparing BTX therapy with BTX-free controls. The analyzed outcomes included pooled adverse events (AEs), treatment success, ≥ 50% overall improvement, and recurrence rates.

Novel Digital Anomalies, Hippocampal Atrophy, and Mutations Expand the Genotypic and Phenotypic Spectra of CNKSR2 in the Houge Type of X-Linked Syndromic Intellectual Development Disorder (MRXSHG).

The Houge type of X-linked syndromic intellectual developmental disorder (MRXSHG) encompasses a spectrum of neurodevelopmental disorders characterized by intellectual disability (ID), language/speech delay, attention issues, and epilepsy. These conditions arise from hemizygous or heterozygous deletions, along with point mutations, affecting CNKSR2, a gene located at Xp22.12.

Microbial and proteomic signatures of type 2 diabetes in an Arab population.

Background: The rising prevalence of Type 2 diabetes mellitus (T2D) in the Qatari population presents a significant public health challenge, highlighting the need for innovative approaches to early detection and management. While most efforts are centered on using blood samples for biomarker discovery, the use of saliva remains underexplored.

Methods: Using noninvasive saliva samples from 2974 Qatari subjects, we analyzed the microbial communities from diabetic, pre-diabetic, and non-diabetic participants based on their HbA1C levels.

Disruption of gamete fusion alters the sperm-egg ratio at gamete interaction.

Background: The mechanisms enabling sperm to locate unfertilized eggs within the fallopian tubes remain a subject of debate in reproductive biology. Previous studies using polytocous mammals observed a 1:1 sperm-egg ratio within the ampulla at the time of fertilization. From these observations, it is hypothesized that this mechanism could be linked to sperm-egg fusion, such that unfertilized eggs may attract sperm until fusion occurs, whereupon the attraction ceases.

Developing entrustable professional activities for undergraduate operative dentistry clerkship.

Objective: In many dental schools worldwide, theoretical knowledge is prioritized over comprehensive training in essential clinical procedures. This leads to graduates with insufficient hands-on experience who are not fully "ready to practice", thereby failing to meet the demands of the job market and community needs. This study aimed to address this critical gap by developing and validating a set of core Entrustable Professional Activities (EPAs) specifically for operative dentistry clerkships to enhance the practical competencies and readiness of dental graduates for effective and independent practice.

ECCDN-Net: A deep learning-based technique for efficient organic and recyclable waste classification.

Efficient waste management is essential to minimizing environmental harm as well as encouraging sustainable progress. The escalating volume and sophistication of waste present significant challenges, prompting innovative methods for effective waste categorization and management. Deep learning models have become highly intriguing tools for automating trash categorization activities, providing effective ways to optimize processes for handling waste.

Automated detection of posterior urethral valves in voiding cystourethrography images: A novel AI-Based pipeline for enhanced diagnosis and classification.

Introduction: Posterior Urethral Valves (PUV) are rare congenital anomalies of the male urinary tract that can lead to urethral obstruction and increased risk of kidney disease. Traditional diagnosis relies on subjective interpretation of imaging techniques. This study aimed to automate and increase accuracy of PUV detection in voiding cystourethrography (VCUG) images using an AI-based pipeline.

Development and validation of the renal dosing questionnaire (RDQ-13) for pharmacists.

Pharmacists, as an integral part of the healthcare team, can play a crucial role in preventing drug-related problems in patients with chronic kidney disease that arise due to inappropriate doses. This study aimed to develop and validate a new tool, the renal dosing questionnaire (RDQ-13), for pharmacists working across hospital, community, and retail pharmacy settings. A cross-sectional study was conducted from January to March 2023 among pharmacists working in different settings.

An in-depth examination of the fuzzy fractional cancer tumor model and its numerical solution by implicit finite difference method.

The cancer tumor model serves a s a crucial instrument for understanding the behavior of different cancer tumors. Researchers have employed fractional differential equations to describe these models. In the context of time fractional cancer tumor models, there's a need to introduce fuzzy quantities instead of crisp quantities to accommodate the inherent uncertainty and imprecision in this model, giving rise to a formulation known as fuzzy time fractional cancer tumor models.

Severe Hyperkalemia in a Child with Vomiting and Diarrhea.

Case Presentation: A 13-month-old child with past medical history of congenital adrenal insufficiency presented to the emergency department with vomiting and diarrhea. Initially the child was noticed to have bradycardia with normal blood pressure. An electrocardiogram (ECG) showed tall T waves, broad QRS complex, and widened PR interval suggestive of severe hyperkalemia.

Trends of hip arthroscopy in Italy show an increase over the years: A nationwide study from 2001 to 2016.

Purpose: Hip arthroscopy has gained popularity among orthopaedic procedures over the last decade. The present study aims to evaluate the trends of hip arthroscopy procedures in Italy analysing data recorded by the Italian Ministry of Health, reporting demographics, length of hospitalisation (LOS), diagnosis and the economic impact of the procedure.

Methods: The National Hospital Discharge records reported by the Italian Ministry of Health were used, analysing the data regarding hip arthroscopy procedures performed in Italy between 2001 and 2016.

Clinical attachment loss may serve as a more precise, suitable, and pragmatic grading instrument for periodontitis: A clinical and radiographic validation study.

Objective: The present study was aimed at assessing the sensitivity and accuracy of using clinical attachment loss (CAL) as a substitute tool for grading periodontitis, instead of the interdental bone loss (BL) percentage derived from two-dimensional radiographs.

Methods: One hundred patients diagnosed with periodontitis were included in the study. Periodontitis was graded according to the American Academy of Periodontology (AAP) 2017 classification.

Reporting Clinical Outcomes in Hand Surgery Randomized Controlled Trials: A Systematic Review Using Wide-Awake Local Anesthesia No Tourniquet Studies as a Model.

Purpose: The purpose of this study was to comprehensively evaluate clinical outcome reporting in hand surgery randomized controlled trials (RCTs), using wide-awake local anesthesia no tourniquet (WALANT) studies as a model.

Methods: This International Prospective Register of Systematic Reviews-registered systematic review (CRD42023461653) adheres to preferred reporting items for systematic reviews and meta-analysis guidelines, focusing on RCTs evaluating WALANT in hand and upper limb surgery. A systematic search across five databases was conducted to include all eligible articles from inception until search date (April 1, 2023).