Worldwide Innovative Network (WIN) Consortium in Personalized Cancer Medicine: Bringing next-generation precision oncology to patients.

The human genome project ushered in a genomic medicine era that was largely unimaginable three decades ago. Discoveries of druggable cancer drivers enabled biomarker-driven gene- and immune-targeted therapy and transformed cancer treatment. Minimizing treatment not expected to benefit, and toxicity-including financial and time-are important goals of modern oncology.

Association between polymorphism and proton pump inhibitors adverse drug reactions: a narrative review.

Proton pump inhibitors (PPIs) are widely prescribed medications for the management of acid-related disorders, due to their effectiveness and favorable pharmacokinetics. However, the occurrence and severity of adverse drug reactions (ADRs) in patients using PPIs, particularly in relation to their association with polymorphisms, are of great concern. This association has largely been investigated through observational studies, which have shown conflicting or weak findings.

How Artificial Intelligence Can Revolutionize Evidence-Based Health Care: A Critical Commentary.

Evidence-based medicine (EBM) enhances clinical decision-making but faces implementation challenges, particularly in dentistry, where patient-specific complexities limit its effectiveness. This article examines EBM through the lens of Aristotelian logic, exploring its use of deductive and inductive reasoning and its limitations in addressing real-world variability. We then discuss how artificial intelligence (AI) can enhance EBM by synthesizing data, automating evidence appraisal, and generating personalized treatment insights.

Enhancing fetal ultrasound image quality and anatomical plane recognition in low-resource settings using super-resolution models.

Super-resolution (SR) techniques present a suitable solution to increase the image resolution acquired using an ultrasound device characterized by a low image resolution. This can be particularly beneficial in low-resource imaging settings. This work surveys advanced SR techniques applied to enhance the resolution and quality of fetal ultrasound images, focusing Dual back-projection based internal learning (DBPISR) technique, which utilizes internal learning for blind super-resolution, as opposed to blind super-resolution generative adversarial network (BSRGAN), real-world enhanced super-resolution generative adversarial network (Real-ESRGAN), swin transformer for image restoration (SwinIR) and SwinIR-Large.

The expanding global genomics landscape: Converging priorities from national genomics programs.

The global landscape of health genomics is expanding rapidly, with an increasing number of national and international initiatives, many of which are targeted toward accelerating the clinical implementation of genomic technologies and services in the context of local health systems. This includes a range of entities with different levels of maturity, funding sources, and strategies that focus on research and clinical priorities to varying degrees. While there is no "one-size-fits-all" approach, analysis of national genomics programs helps to identify common priority areas, barriers, and enablers.

Nurses' knowledge and attitudes about children maltreatment in Jordan: A cross-sectional study.

Objectives: To examine nurses' knowledge and attitudes, and the factors influencing them regarding managing child maltreatment in Jordan's acute and primary care settings.

Methods: This is a descriptive cross-sectional study. Nurses (n = 523, 84 % female) caring for children in Jordan's acute and primary healthcare settings completed the Child Abuse Report Intention Scale.

The Efficacy and Safety of Intravenous Prostaglandin E1 in the Management of Retinal Artery Occlusion: A Systematic Review.

Purpose: To evaluate the efficacy and safety of prostaglandin E1 (PGE1) for the management of central/branch retinal artery occlusion (CRAO/BRAO).

Methods: Our protocol was registered prospectively on PROSPERO (CRD42024522961). We searched 4 electronic databases [PubMed, Scopus, Web of Science, and Google Scholar] to retrieve all studies reported using PGE1 for patients with CRAO/BRAO.

From Cow's Milk to Cheese, Yogurt, and Labneh: Evaluating aflatoxin M fate in Traditional Lebanese Dairy Processing and the Efficacy of Regulations through a Risk Assessment Approach.

Aflatoxin M (AFM1) is a potent mycotoxin that can contaminate milk and dairy products. It is a metabolite of aflatoxin B (AFB1), which is produced by certain fungi that infect crops. In Lebanon, traditional dairy production-including various cheeses, yogurt, and Labneh-is widely practiced.

The influence of circadian rhythm disruption during Ramadan on metabolic responses to physical activity: a pilot study.

Background: Circadian rhythms and sleep patterns are important regulators of metabolic health. During Ramadan intermittent fasting (RIF), the sleep-wake cycles are often disrupted, which can affect physical activity (PA) and related metabolic responses. Limited knowledge is available on how sleep disruption influences PA in the general population during RIF.

Hepatitis B Antigenaemia, Nephrotic Syndrome and Pulmonary Embolism A Series of Unfortunate Events: A Case Report.

Hepatitis B is a major health concern. It primarily affects the liver, but it can also cause systemic complications like antigenaemia and nephrotic syndrome. Nephrotic syndrome causes proteinuria, hypoalbuminaemia, oedema, hyperlipidaemia and hypercoagulability.

Clinical Outcomes of Immediate Versus Staged Revascularization of Nonculprit Arteries in Patients With Acute Coronary Syndrome: A Systematic Review and Meta-Analysis.

Background: Recent guidelines for acute coronary syndrome (ACS) with multivessel coronary artery disease (MVD) recommend revascularization of non-culprit lesions following primary percutaneous coronary intervention (PCI). However, the optimal timing for this procedure-whether immediate or staged-remains uncertain.

Methods: A comprehensive search using PubMed (MEDLINE), Cochrane Central, and Google Scholar was conducted to identify studies comparing clinical outcomes between immediate and staged revascularization approaches in patients with MVD undergoing PCI.

Recommendations for management of infants and young children with achondroplasia: Does clinical practice align?

Background: Achondroplasia is one of the most prevalent forms of skeletal dysplasia. Lifelong follow-up by an experienced multidisciplinary team is required, particularly during the first 2 years. In 2021, international consensus recommendations and guiding principles were published by two groups.

A retrospective comparative analysis of anterior cervical discectomy and fusion using stand-alone titanium cage versus cage and plate fixation in two-level cervical disc herniation.

Background: This study aims to compare the outcomes of two-level anterior cervical discectomy and fusion (ACDF) procedures using stand-alone cages versus cage and plate fixation in patients diagnosed with cervical disc herniation (CDH).

Materials And Methods: This retrospective analysis included 60 patients who underwent two-level ACDF procedures. Patients were divided into two groups: one treated with stand-alone cages and the other with cage and plate fixation.

Prevalence of non-communicable disease and the associated factors among healthcare workers in Qatar.

Background: Non-communicable diseases (NCDs) significantly impact global health and contribute to economic burdens and premature deaths, with healthcare workers (HCWs) being at high risk. This study aims to assess the prevalence and associated factors of NCDs among newly hired HCWs at Hamad Medical Corporation (HMC) in Qatar.

Methods: This retrospective cross-sectional study analyzed 3097 electronic medical records of newly hired HCWs at HMC during 2021 and 2022.

Evaluating the environmental effects of bitcoin mining on energy and water use in the context of energy transition.

This study investigates the impact of Bitcoin's energy and water consumption on environmental sustainability, focusing on the load capacity factor (LCF) and the roles of energy transition green technology in major cryptocurrency-producing nations. Utilizing the method of moments quantile regression (MMQR) approach, the findings reveal a negative impact of mining energy consumption on environmental sustainability, particularly in the lower quantiles, with a stronger negative effect in the higher quantiles. Energy transition plays a critical role in moderating this impact, though the shift towards cleaner energy sources has not been sufficient to mitigate the adverse environmental effects.

Harnessing Smartphone Sensors for Enhanced Road Safety: A Comprehensive Dataset and Review.

Severe collisions can result from aggressive driving and poor road conditions, emphasizing the need for effective monitoring to ensure safety. Smartphones, with their array of built-in sensors, offer a practical and affordable solution for road-sensing. However, the lack of reliable, standardized datasets has hindered progress in assessing road conditions and driving patterns.

Inherited endurance: deciphering genetic associations of transgenerational and intergenerational heat stress memory in barley.

Barley (Hordeum vulgare L.), a cornerstone of global cereal crops, is increasingly vulnerable to concurrent heat stress, a critical abiotic factor that is intensified by climate change. This study employed genome-wide association studies (GWAS) to investigate "stress memory," a phenomenon where prior stress exposure enhances a plant's response to subsequent stress events.

Prevalence of homologous recombination deficiency among women with newly diagnosed ovarian, primary peritoneal, and/or fallopian tube cancer: the international HALO study.

Objective: The HALO study (NCT04991051) determined the prevalence of homologous recombination deficiency and its associated factors in patients with high-grade serous/endometrioid ovarian, primary peritoneal, and/or fallopian tube cancers across Asia, the Middle East, and Russia.

Methods: This multinational, cross-sectional, real-world study enrolled adult women with newly diagnosed stage III or IV high-grade serous/endometrioid ovarian, primary peritoneal, and/or fallopian tube cancers. Formalin-fixed paraffin-embedded tumor blocks were collected within 120 days of enrollment.

Novel small-sized ePTFE valves for neonatal RVOT reconstruction: an in-vitro investigation.

Small-sized right ventricle to pulmonary artery conduits are hindered by calcification, degeneration, or infective endocarditis and face limited availability. Valved conduits of expanded polytetrafluoroethylene leaflets offer a promising path toward enhanced longevity and performance. This in-vitro study introduces innovative expanded polytetrafluoroethylene valve designs for small-sized conduits.

Awake Prone Positioning in Adults With COVID-19: An Individual Participant Data Meta-Analysis.

Importance: The impact of awake prone positioning (APP) on clinical outcomes in patients with COVID-19 and acute hypoxemic respiratory failure (AHRF) remains uncertain.

Objective: To assess the association of APP with improved clinical outcomes among patients with COVID-19 and AHRF, and to identify potential effect modifiers.

Data Sources: PubMed, Embase, the Cochrane Library, and ClinicalTrials.

The utility of brain biomarkers in predicting survival and neurological outcomes in pediatric patients after cardiac arrest: A systematic review and meta-analysis.

Background: Cardiac arrest in children is associated with high morbidity and mortality, primarily due to neurological injury. Biomarkers linked to brain injury, released into circulation from compromised elements of the neurovascular unit, act as significant prognostic indicators in patients suffering from hypoxic-ischemic brain injury (HIBI) subsequent to the restoration of spontaneous circulation (ROSC) after pediatric cardiac arrest. The aim of this systematic review and meta-analysis is to evaluate the prognostic utility of brain injury biomarkers in predicting neurological outcomes and survival in patients following cardiac arrest in the pediatric population.