Mode-of-action of the natural herbicide radulanin A as an inhibitor of photosystem II.

Background: Radulanin A is a natural 2,5-dihydrobenzoxepin synthesized by several liverworts of the Radula genus. Breakthroughs in the total synthesis of radulanin A paved the way for the discovery of its phytotoxic activity. Nevertheless, its mode-of-action (MoA) has remained unknown so far and thus was investigated, in Arabidopsis thaliana.

Systematic Review and Meta-Analysis on Burnout Owing to Perfectionism in Elite Athletes Based on the Multidimensional Perfectionism Scale (MPS) and Athlete Burnout Questionnaire (ABQ).

Previous studies have shown that burnout negatively affects athletes' mental health. To further explore this subject, we conducted a systematic review and meta-analysis by combining data from previous studies. This study followed the PRISMA guidelines for systematic and reliable research and completed data extraction using 10 databases and 8 keywords in December 2021.

Structural insights into the action mechanisms of artificial electron acceptors in photosystem II.

Photosystem II (PSII) utilizes light energy to split water, and the electrons extracted from water are transferred to Q, a plastoquinone molecule bound to the D1 subunit of PSII. Many artificial electron acceptors (AEAs) with molecular structures similar to that of plastoquinone can accept electrons from PSII. However, the molecular mechanism by which AEAs act on PSII is unclear.

CryoEM PSII structure reveals adaptation mechanisms to environmental stress in .

Performing photosynthesis in the desert is a challenging task since it requires a fast adaptation to extreme illumination and temperature changes. To understand adaptive mechanisms, we purified Photosystem II (PSII) from , a green alga from the desert soil surface, and identified structural elements that might enable the photosystem functioning under harsh conditions. The 2.

Action of the fungal compound citrinin, a bioherbicide candidate, on photosystem II.

Background: Bioherbicides are becoming more attractive as safe weed control tools towards sustainable agriculture. Natural products constitute an important source chemicals and chemical leads for discovery and development of novel pesticide target sites. Citrinin is a bioactive compound produced by fungi of the genera Penicillium and Aspergillus.

Mechanism of Asparagine-Mediated Proton Transfer in Photosynthetic Reaction Centers.

In photosynthetic reaction centers from purple bacteria (PbRCs), light-induced charge separation leads to the reduction of the terminal electron acceptor quinone, Q. The reduction of Q to Q is followed by protonation via Asp-L213 and Ser-L223 in PbRC from . However, Asp-L213 is replaced with nontitratable Asn-L222 and Asn-L213 in PbRCs from and , respectively.

Altered Allocation of Vertical Attention in Individuals With Autism Spectrum Disorder.

Background: Typical adults most frequently orient their attention to other people's eyes, whereas individuals with autism spectrum disorder (ASD) orient their attention to other people's mouths. Typical adults also reveal visuospatial biases on tasks such as vertical and horizontal line bisections. Therefore, the difference in face viewing might be related to a more general group difference in the allocation of vertical attention.

Validation of the Parental Understanding and Misperceptions about BAby's Sleep Questionnaire using auto-videosomnography.

Background: Previous studies have suggested that parental cognitions about child's sleep may be an important factor underlying pediatric sleep problems. The current study aimed to (a) develop an assessment tool measuring parental understanding and misperceptions about baby's sleep (PUMBA-Q); (b) validate the questionnaire using self-report and objective sleep measures.

Methods: There were 1,420 English-speaking caregivers (68.

Identification of a Ubiquinone-Ubiquinol Quinhydrone Complex in Bacterial Photosynthetic Membranes and Isolated Reaction Centers by Time-Resolved Infrared Spectroscopy.

Ubiquinone redox chemistry is of fundamental importance in biochemistry, notably in bioenergetics. The bi-electronic reduction of ubiquinone to ubiquinol has been widely studied, including by Fourier transform infrared (FTIR) difference spectroscopy, in several systems. In this paper, we have recorded static and time-resolved FTIR difference spectra reflecting light-induced ubiquinone reduction to ubiquinol in bacterial photosynthetic membranes and in detergent-isolated photosynthetic bacterial reaction centers.

The Next Frontier in Sarcoma: Molecular Pathways and Associated Targeted Therapies.

Soft tissue sarcomas (STS) are a rare, complex, heterogeneous group of mesenchymal neoplasms with over 150 different histological subtypes. Treatments for this malignancy have been especially challenging due to the heterogeneity of the disease and the modest efficacy of conventional chemotherapy. The next frontier lies in discerning the molecular pathways in which these mesenchymal neoplasms arise, metastasize, and develop drug-resistance, thereby helping guide new therapeutic targets for the treatment of STS.

Relationship between photosystem activity and ultraweak luminescence excitation in Cerasus humilis leaves under salt stress.

Cerasus humilis (Bge.) Sok (C. humilis) is a wild fruit tree endemic to China.

Neoantigen-targeted CD8 T cell responses with PD-1 blockade therapy.

Neoantigens are peptides derived from non-synonymous mutations presented by human leukocyte antigens (HLAs), which are recognized by antitumour T cells. The large HLA allele diversity and limiting clinical samples have restricted the study of the landscape of neoantigen-targeted T cell responses in patients over their treatment course. Here we applied recently developed technologies to capture neoantigen-specific T cells from blood and tumours from patients with metastatic melanoma with or without response to anti-programmed death receptor 1 (PD-1) immunotherapy.

One-stop patient-specific myocardial blood flow quantification technique based on allometric scaling law.

Establishing a patient-specific and non-invasive technique to derive blood flow as well as coronary structural information from one single cardiac CT imaging modality. 336 patients with chest pain or ST segment depression on electrocardiogram were retrospectively enrolled. All patients underwent adenosine-stressed dynamic CT myocardial perfusion imaging (CT-MPI) and coronary computed tomography angiography (CCTA) in sequence.

The relationship between child maltreatment and social anxiety: A meta-analysis.

Background: Globally, child maltreatment has become a serious problem, affecting individuals' physical and mental health. This meta-analysis aimed to explore the association between child maltreatment and social anxiety.

Methods: MEDLINE, PsycINFO, EMBASE, Scopus, and Web of Science were searched for articles published by October 2021.

Biomechanical Assessment of Red Blood Cells in Pulsatile Blood Flows.

As rheological properties are substantially influenced by red blood cells (RBCs) and plasma, the separation of their individual contributions in blood is essential. The estimation of multiple rheological factors is a critical issue for effective early detection of diseases. In this study, three rheological properties (i.

Equivalent chemical substitution in double-double perovskite-type ALaLiTeO:Mn (A = Ba, Sr, Ca) phosphors enabling wide range crystal field strength regulation and efficient far-red emission.

Mn-activated phosphors have shown wide prospective applications in phosphor-converted white light-emitting diodes (pc-WLEDs) and pc-LEDs used in illumination and indoor plant cultivation, respectively. Recently, double perovskites AB'B''O with a tunable crystal structure and versatile octahedral sites have been extensively studied as good host matrixes for Mn-emitters to realize tunable far-red emissions. Herein, a series of double-double perovskite-type ALaLiTeO:Mn (A = Ba, BaSr, Sr, SrCa, Ca) phosphors were synthesized and structurally characterized, and the correlations between their structure and luminescence were also studied systematically.

SAUNA Q - Array: The realization of a new concept in radioxenon detection.

We introduce a new concept in radioxenon detection - the radioxenon Array, defined as a system where air sampling and activity measurement is performed at multiple locations, using measurement units that are less sensitive, but on the other hand less costly, and easier to install and operate, compared to current state-of-the-art radioxenon systems. The inter-unit distance in the Array is typically hundreds of kilometres. Using synthetic nuclear explosions together with a parametrized measurement system model, we argue that, when such measurement units are combined into an Array, the aggregated verification performance (detection, location, and characterization) can be high.

Effects of Mycotoxin Fumagillin, Mevastatin, Radicicol, and Wortmannin on Photosynthesis of .

Mycotoxins are one of the most important sources for the discovery of new pesticides and drugs because of their chemical structural diversity and fascinating bioactivity as well as unique novel targets. Here, the effects of four mycotoxins, fumagillin, mevastatin, radicicol, and wortmannin, on photosynthesis were investigated to identify their precise sites of action on the photosynthetic apparatus of . Our results showed that these four mycotoxins have multiple targets, acting mainly on photosystem II (PSII).

, a new species of Aristolochiaceae from northern Vietnam and two new combinations in .

Luu, Q.B.Nguyen & H.

Comparison of photosynthetic responses between haptophyte and diatom under phosphorus limitation.

The diatom and the haptophyte often form blooms in the coastal waters of the South China Sea. commonly dominates in nutrient enrichment coastal waters, whereas . starts flourishing after the diatom blooms when phosphorus (P) is limited.

Cyclic electron flow around photosystem II in silico: How it works and functions in vivo.

To date, cyclic electron flow around PSI (PSI-CEF) has been considered the primary (if not the only) mechanism accepted to adjust the ratio of linear vs cyclic electron flow that is essential to adjust the ratio of ATP/NADPH production needed for CO carboxylation. Here we provide a kinetic model showing that cyclic electron flow within PSII (PSII-CEF) is essential to account for the accelerating rate of decay in flash-induced oscillations of O yield as the PQ pool progressively reduces to PQH. Previously, PSII-CEF was modeled by backward transitions using empirical Markov models like Joliot-Kok (J-K) type.

Pilot Study of the Effects of Paced Breathing on Measures of Convergent and Divergent Thinking.

Background: The ability of the autonomic nervous system's stress response to impair aspects of cognitive flexibility is known. However, the ability to modulate the sympathetic response and improve these cognitive impairments via nonpharmacological intervention, such as paced breathing (PB), requires further investigation.

Objective: To better elucidate the effects of PB on cognition.

Development of rapid and precise approach for quantification of bacterial taxa correlated with soil health.

The structure and dynamic of soil bacterial community play a crucial role in soil health and plant productivity. However, there is a gap in studying the un-/or reclaimed soil bacteriome and its impact on future plant performance. The 16S metagenomic analysis is expensive and utilize sophisticated pipelines, making it unfavorable for researchers.