138 results match your criteria: "Pyropoikilocytosis Hereditary"
Br J Haematol
November 2024
Centre for Haematology, St Mary's Hospital Campus of Imperial College Faculty of Medicine, St Mary's Hospital, London, UK.
Fetal Pediatr Pathol
May 2024
Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, TN, USA.
The available literature on intrauterine transfusion focuses largely on its application in fetal alloimmunization rather than hereditary red cell disorders, with limited illustration of its associated histopathologic findings. We present the histologic findings in a placenta associated with preterm delivery of an infant with autosomal mutation following multiple intrauterine transfusions, including appropriate villous maturation, subchorionic organizing hematomas, hemosiderin-laden macrophages, and dysmorphic fetal erythrocytes within villous capillaries. Intrauterine transfusion is associated with placental histologic findings that reflect procedural changes without significant disruption of placental membranes or villous maturation.
View Article and Find Full Text PDFTransfusion
January 2024
Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
Introduction: Hereditary pyropoikilocytosis (HPP) is a heterogeneous inherited disorder of red blood cell (RBC) membrane and cytoskeletal proteins that leads to hemolytic anemia. HPP is characterized by marked poikilocytosis, microspherocytes, RBC fragmentation, and elliptocytes on peripheral blood smear. Mutations in SPTA1 can cause HPP due to a quantitative defect in α-spectrin and can lead to profound fetal anemia and nonimmune hydrops fetalis, which can be managed with intrauterine transfusion.
View Article and Find Full Text PDFAnn Hematol
February 2024
Thalassemia and Hematology Center, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand.
Red blood cell (RBC) membrane disorders represent a significant category of hereditary hemolytic anemia; however, information from Southeast Asia is limited. We established a national registry aiming to characterize RBC membrane disorders and their molecular features in Thailand. A total of 100 patients (99 kindreds) diagnosed with RBC membrane disorders between 2011 and 2020 from seven university hospitals were enrolled.
View Article and Find Full Text PDFInt J Lab Hematol
April 2024
Pediatrics Hematology-Oncology, Department of Pediatrics, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand.
Blood Cells Mol Dis
November 2023
Department of Pediatrics, Hematology-Oncology Unit, Ain Shams University, Faculty of Medicine, Cairo, Egypt; Ibn Sina National College, Jeddah, KSA.
Ann Hematol
September 2023
Department of Pathology, Blood Bank and Laboratory Medicine, King Hamad University Hospital, Manama, Kingdom of Bahrain.
Hereditary elliptocytosis (HE) and pyropoikilocytosis (HPP) are considered a group of hemolytic anemias (HE/HPP) due to inherited abnormalities of erythrocyte membrane proteins with a worldwide distribution. Most cases are associated with molecular abnormalities linked to spectrin, band 4.1, and ankyrin.
View Article and Find Full Text PDFEur J Haematol
June 2023
Department of Pathology, University of Utah Health and ARUP Laboratories, Salt Lake City, Utah, USA.
Hematol Rep
October 2022
Servicio de Hematología, Hospital Clínico Universitario Virgen de la Arrixaca, 30120 Murcia, Spain.
Hereditary pyropoikilocytosis (HPP) is characterised by severe hemolytic anemia due to membrane instability. We report the case of a 13-day-old boy with neonatal jaundice and severe hemolytic anemia. A peripheral smear examination showed severe anisopoikylocytosis.
View Article and Find Full Text PDFGene
November 2022
Department of Haematogenetics, ICMR-National Institute of Immunohematology, 13(th) Floor, NMS Building, King Edward Memorial (K.E.M.) Hospital Campus, Parel, Mumbai 400012, India. Electronic address:
Hereditary Elliptocytosis (HE) and Hereditary Pyropoikilocytosis (HPP) are clinically and genetically heterogeneous red cell membranopathies that result from the defects in the horizontal linkage between RBC (red blood cell) membrane and cytoskeletal proteins affecting its mechanical stability and deformability thereby reducing its lifespan. The principal defect in HE and HPP is due to dysfunction or deficiency of RBC cytoskeletal proteins namely, α-spectrin (SPTA1), β-spectrin (SPTB) and protein 4.1R (EPB41R).
View Article and Find Full Text PDFAm J Hematol
October 2022
Department of Hematology/Oncology, Walter Reed National Military Medical Center, Bethesda, Maryland, USA.
Ann Hematol
March 2022
Hematology Department, Hospital Universitari de La Santa Creu i Sant Pau, Barcelona, Spain.
Red blood cell (RBC) morphology is, in general, the key diagnostic feature for hereditary spherocytosis (HS) and hereditary elliptocytosis (HE). However, in hereditary pyropoikilocytosis (HPP), the severe clinical form of HE, the morphological diagnosis is difficult due to the presence of a RBC morphological picture characterized by a mixture of elliptocytes, spherocytes, tear-drop cells, and fragmented cells. This difficulty increases in new-borns and/or patients requiring frequent transfusions, making impossible the prediction of the disease course or its severity.
View Article and Find Full Text PDFAm J Hematol
April 2022
Centre for Haematology, St Mary's Hospital Campus of Imperial College Faculty of Medicine, St Mary's Hospital, London, UK.
Pediatr Blood Cancer
October 2021
Department of Hematology, Post Graduate Institute of Medical Education and Research, Chandigarh, India.
Am J Hematol
May 2021
Hematology, University of Utah & Huntsman Cancer Center, Salt Lake City, Utah.
The measurement of band 3 (AE1, SLC4A1, CD233) content of red cells by eosin-5- maleimide (EMA) staining is swiftly replacing conventional osmotic fragility (OF) test as a tool for laboratory confirmation of hereditary spherocytosis across the globe. Our group has systematically evaluated the EMA test as a method to screen for a variety of anemias in the last 10 years, and compared these results to those obtained with the osmotic gradient ektacytometry (osmoscans) which we have used over three decades. Our overall experience allowed us to characterize the distinctive patterns with the two tests in several congenital erythrocyte membrane disorders, such as hereditary spherocytosis (HS), hereditary elliptocytosis (HE), Southeast Asian Ovalocytosis (SAO), hereditary pyropoikilocytosis (HPP) variants, erythrocyte volume disorders, various red cell enzymopathies, and hemoglobinopathies.
View Article and Find Full Text PDFBlood Cells Mol Dis
November 2020
Division of Neonatology, Department of Pediatrics, University of Utah Health, Salt Lake City, UT, United States of America; Division of Hematology/Oncology, Department of Pediatrics, University of Utah Health, Salt Lake City, UT, United States of America.
Ann Biol Clin (Paris)
June 2020
Service d'hématologie biologique, CHU de Rouen, Rouen, France.
J Pediatr Hematol Oncol
March 2021
Department of Pediatrics and Neonatology, Nagoya City University Graduate School of Medical Sciences, Nagoya.
Hereditary pyropoikilocytosis is a subtype of hereditary elliptocytosis because of biallelic mutations of SPTA1, SPTB, and EPB41. The authors present a proband with neonatal jaundice and hemolytic anemia, with poikilocytosis in the blood film. Targeted next-generation sequencing identified Q267del trans to the αLELY allele in SPTA1.
View Article and Find Full Text PDFIndian J Pediatr
January 2020
Department of Hematology, Post Graduate Institute of Medical Education and Research, Chandigarh, 160012, India.
Hemolytic anemias are a group of disorders with varied clinical and molecular heterogeneity. They are characterized by decreased levels of circulating erythrocytes in blood. The pathognomic finding is a reduced red cell life span with severe anemia or, compensated hemolysis accompanied by reticulocytosis.
View Article and Find Full Text PDFBr J Haematol
October 2019
Department of Molecular Medicine and Medical Biotechnologies, Federico II" University of Naples, Naples, Italy.
Hematol Transfus Cell Ther
April 2019
Academia de Ciência e Tecnologia (AC&T), São José do Rio Preto, SP, Brazil.
J Clin Invest
April 2019
Department of Pediatrics.
Pediatr Blood Cancer
February 2019
Cancer and Blood Diseases Institute, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio.
The broad phenotypic variability among individuals with sickle cell disease (SCD) suggests the presence of modifying factors. We identified two unrelated SCD patients with unusually severe clinical and laboratory phenotype that were found to carry the hereditary elliptocytosis-associated alpha-spectrin mutation c.460_462dupTTG (p.
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