Leukemia's Wake-Up Call - A Case Report of a Patient's Journey.

A 26-year-old male complained of fever, right neck swelling, anorexia, and weight loss for 4 months. The patient noticed a right swelling in the root of the neck that progressed from 1 × 1 cm to 5 × 6 cm. We reported a Kikuchi-like acute lymphoblastic leukemia (ALL) case.

Bubbles in the Heart: A Case Series of Three Varying Presentations of Hepatopulmonary Syndrome.

Hepatopulmonary syndrome (HPS) is described as an arterial oxygenation deficit caused by intrapulmonary vascular dilatations in the presence of chronic liver disease. This case series highlighted three HPS cases that were brought to the emergency unit of the institution. This helps clinicians evaluate and treat hepatopulmonary syndrome and emphasizes the involvement of interprofessional teamwork.

A Rare Case of Lupus Nephritis with Predominant Gastrointestinal Manifestation: A Case Study.

Lupus nephritis (LN) is one of the most dreaded complications of systemic lupus erythematosus (SLE). Gastrointestinal involvement is relatively uncommon and usually manifests as moderate and nonspecific indications. The present case report draws attention to the unusual presentation of SLE as LN with predominant gastrointestinal manifestations.

Evaluation of the Anticandidal Effect of Medicinal Plant Extracts to Drug Resistant Isolates from Type Two Diabetic patients with Stage Three Periodontitis.

Objectives: To assess the anticandidal efficacy of nine medicinal plants to drug resistant isolates from diabetic patients with chronic periodontitis. A comparison was done with chlorhexidine gluconate.

Methods: Isolates from the periodontal pockets of 121 diabetics with severe periodontitis was obtained.

Domestic Chicken Eggshell-Derived Bone Substitute: Synthesis, Characterization and Cell Viability.

Background: Hydroxyapatite (HA) is a material with excellent bioactivity and chemical similarity to bone. It can be extracted from natural sources or fabricated synthetic sources.

Objective: To synthesize HA from domestic chicken eggshells and to characterize it using Fourier transform infrared (FTIR), X-ray powder diffraction (XRD), scanning electron microscopy (SEM), energy-dispersive X-ray spectroscopy, and cell viability.

Phytonanoparticles as novel drug carriers for enhanced osteogenesis and osseointegration.

Phytonanoparticles have emerged as a promising class of biomaterials for enhancing bone regeneration and osseointegration, offering unique advantages in biocompatibility, multifunctionality, and sustainability. This comprehensive review explores the synthesis, characterization, and applications of phytonanoparticles in bone tissue engineering. The green synthesis approach, utilizing plant extracts as reducing and stabilizing agents, yields nanoparticles with intrinsic bioactive properties that can synergistically promote osteogenesis.

Effect of surface-engineered AuNPs on gene expression, bacterial interaction, protein denaturation, and toxicology assay: an and model.

We investigated the and uses of pamoic acid functionalized gold nanoparticles (PA@AuNPs), with a focus on determining their safety and potential toxicity in living beings. To test this theory, the bacterial interaction of PA@AuNPs was studied using , , and cultures, as well as the inhibition of the bovine serum albumin (BSA) protein. The real-time polymerase chain reaction (RT-PCR) is used to measure the expression of target genes.

Myasthenia Gravis as a Paraneoplastic Manifestation of Renal Cell Carcinoma: More Than a Coincidence?

Background: Myasthenia gravis is an autoimmune neuromuscular disease primarily caused by autoantibodies against nicotinic acetylcholine receptors (AChRs) at the neuromuscular junction. However, extrathymic malignancies need to be considered in the elderly population.

Purpose: Although thymic malignancy is the most common tumour association, several extrathymic malignancies complicated with myasthenia gravis have been reported.

Salivary advanced glycated end products, their receptors, and aMMP-8 in periodontitis patients with varying glycemic levels: A cross-sectional study.

Background: Advanced glycation end products (AGE) and their receptors (RAGE) have been implicated in developing periodontal complications in diabetic patients. This study aimed to identify salivary AGE, RAGE, soluble RAGE (sRAGE), and active-matrix metalloproteinase-8 (aMMP-8) levels at varying glycemic levels in periodontitis patients.

Methods: Ninety-eight participants were categorized into uncontrolled DM-PD group (n = 27)-periodontitis patients with uncontrolled Type 2 diabetes mellitus (T2DM) (glycated hemoglobin [HbA1c] ≥7%); controlled DM-PD group (n = 33)-periodontitis patients with controlled T2DM (HbA1c 5.

Diabetic Retinopathy and Periodontitis: Implications from a Systematic Review and Meta-Analysis.

Background: Diabetes mellitus, a chronic metabolic disorder affecting millions worldwide, is associated with microvascular complications, including diabetic retinopathy (DR) and periodontitis. Understanding their interrelationship is crucial for comprehensive patient care.

Objective: This systematic review and meta-analysis aim to investigate the association between DR and periodontitis in patients with Type 1 and Type 2 diabetes.

Leflunomide-Induced Drug Reaction With Eosinophilia and Systemic Symptoms: A Diagnostic Dilemma.

Drug reaction with eosinophilia and systemic symptoms (DRESS) syndrome is a severe idiosyncratic drug reaction. This commonly manifests with fever, lymphadenopathy, and a maculopapular rash. It can be fatal if early diagnosis and removal of the offending agent do not occur.

Photodynamic therapy: An emerging therapeutic modality in dentistry.

Photodynamic Therapy (PDT) is a rapidly evolving, non-invasive treatment modality with considerable promise in dental pharmacotherapeutics. This review article comprehensively examines PDT, beginning with its principles and then delving into its diverse applications in dentistry, including periodontal disease, endodontics, oral cancer, dental implants, and dental caries. Each area presents the latest research and discusses the potential benefits and challenges.

The Effectiveness of Curcumin Nanoparticle-Coated Titanium Surfaces in Osteogenesis: A Systematic Review.

(1) Background: This systematic review critically appraises and synthesizes evidence from in vitro studies investigating the effects of curcumin nanoparticles on titanium surface modification, focusing on cell adhesion, proliferation, osteogenic differentiation, and mineralization. (2) Methods: A comprehensive electronic search was conducted in PubMed, Cochrane Central Register of Controlled Trials, and Google Scholar databases, yielding six in vitro studies that met the inclusion criteria. The search strategy and study selection process followed PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guidelines.

Oral health status and dental treatment needs in children with autism spectrum disorder.

Objective: To evaluate oral health care practices, health status, and dental treatment needs in children with Autism Spectrum Disorder (ASD).

Methods: This cross-sectional study included 96 children diagnosed with ASD per the DSM-V criteria and 96 typically developing healthy children. The WHO form assessed oral health status and dental treatment needs.

A Cross-Sectional Study of Clinical Spectrum and Outcome of Pure Midbrain Strokes.

Background: Pure mesencephalic infarcts are uncommon, the main clinical manifestations being oculomotor signs and ataxia.

Objectives: Primary objective was to determine the incidence of pure midbrain strokes. We also evaluated the clinical spectrum, syndromes, arterial territories involved, risk factors, and outcome at 3 months.

"Visualization matters" - stereoscopic visualization of 3D graphic neuroanatomic models through AnaVu enhances basic recall and radiologic anatomy learning when compared with monoscopy.

Background: The authors had previously developed AnaVu, a low-resource 3D visualization tool for stereoscopic/monoscopic projection of 3D models generated from pre-segmented MRI neuroimaging data. However, its utility in neuroanatomical education compared to conventional methods (specifically whether the stereoscopic or monoscopic mode is more effective) is still unclear.

Methods: A three-limb randomized controlled trial was designed.

Prevalence of Cognitive Defects Among Senior Inmates of Old-Age Homes in a District of South Kerala.

Background Cognitive decline, including mild cognitive impairment and major neurocognitive disorder, is a growing concern among aging populations. The prevalence of these disorders is especially relevant in regions experiencing a surge in elderly care infrastructure, such as Kerala, India. Within the context of sociocultural shifts and a rising elderly population, old-age homes are increasingly becoming the focal point of care and support for cognitive health.

Fish scale-derived hydroxyapatite for alveolar ridge preservation.

Alveolar ridge resorption following tooth extraction poses significant challenges for future dental restorations. This study investigated the efficacy of fish scale-derived hydroxyapatite (FSHA) as a socket preservation graft material to maintain alveolar bone volume and architecture. FSHA was extracted from *Labeo rohita* fish scales and characterized using Fourier transform infrared (FTIR) analysis.

Association between metabolic syndrome and salivary MMP-8, myeloperoxidase in periodontitis.

Objective: This study investigated the effect of metabolic syndrome (MetS) on periodontal clinical parameters and salivary biomarkers' matrix metalloproteinase-8 (MMP-8) and myeloperoxidase (MPO) in patients with periodontitis.

Methods: A total of 120 participants aged 25-55 were categorized into three groups: MetS with periodontitis (n = 40); systemically healthy with periodontitis (n = 40); and systemically and periodontally healthy controls (n = 40). Data collected included systemic parameters like waist circumference (WC), blood pressure (BP), high- and low-density lipoproteins, triglycerides (TG), fasting blood sugar (FBS), and glycated hemoglobin (HbA1c).

Isolation, Culture, and Characterization of Dental Pulp Stem Cells from Human Deciduous and Permanent Teeth.

In the realm of regenerative medicine and therapeutic applications, stem cell research is rapidly gaining traction. Dental pulp stem cells (DPSCs), which are present in both deciduous and permanent teeth, have emerged as a vital stem cell source due to their accessibility, adaptability, and innate differentiation capabilities. DPSCs offer a readily available and abundant reservoir of mesenchymal stem cells, showcasing impressive versatility and potential, particularly for regenerative purposes.

Catheter ablation versus medical therapy in atrial fibrillation: an umbrella review of meta-analyses of randomized clinical trials.

This umbrella review synthesizes data from 17 meta-analyses investigating the comparative outcomes of catheter ablation (CA) and medical treatment (MT) for atrial fibrillation (AF). Outcomes assessed were mortality, risk of hospitalization, AF recurrence, cardiovascular events, pulmonary vein stenosis, major bleeding, and changes in left ventricular ejection fraction (LVEF) and MLHFQ score. The findings indicate that CA significantly reduces overall mortality and cardiovascular hospitalization with high strength of evidence.

Chitosan bioactive glass scaffolds for in vivo subcutaneous implantation, toxicity assessment, and diabetic wound healing upon animal model.

This study aims to develop chitosan-bioactive glass (BG) scaffolds for diabetic wound healing, toxicity valuation, and subcutaneous implantation in animals for biocompatibility assessment. The scaffolds were prepared by lyophilization technique. In specific BG without sodium (Na), composited with chitosan for better biological activities.