In vivo pharmacokinetic study of carmustine in rats after giving single-dose of carmustine API solution, flexible liposomes, in situ nasal gel, optimized flexible liposomes embedded in situ nasal gel, and marketed formulation.

Background: Carmustine is used in the treatment of glioblastoma (GBM). GBM is a well-known life-threatening type of cancerous tumor. GBM covers 60.

Linker Encouraged Solid State Synthesis of MOF Derived Z-Scheme NiCoO/NiO/C toward Efficient Removal of Organic and Inorganic Pollutants from Water.

Here, we represent a solid-state route for the construction of MOF derived multifunctional Z-scheme NiCoO/NiO/C applied for the photocatalytic removal of methylene blue (dye) and tetracycline (drug) and the reduction of Cr(VI) (heavy metal). The developed solid-state method yielded a highly effective NiCoO/NiO/C catalyst by mechanically grinding independently produced Ni and Co-MOFs and subsequently pyrolyzing them. The use of different linkers in the Ni MOF (H-BTC linker) and Co-MOF (2-methylimidazole linker) proved to be effective in constructing the NiCoO/NiO/C composite, ensuring a nonaggregated distribution on a carbon framework.

Metal-free approach for imidazole synthesis one-pot -α-C(sp)- bond functionalization of benzylamines.

A metal-free one-pot method is established for the synthesis of tetrasubstituted imidazoles from the reaction of arylmethylamines and 1,2-dicarbonyls/benzoin. The -α-C(sp)- bond functionalization of arylmethylamines using a catalytic amount of AcOH afforded polysubstituted imidazoles under aerobic conditions in significant yields of up to 95%.

Antiangiogenic potential of phytochemicals from Clerodendrum inerme (L.) Gaertn investigated through in silico and quantum computational methods.

Suppressing vascular endothelial growth factor (VEGF), its receptor (VEGFR2), and the VEGF/VEGFR2 signaling cascade system to inhibit angiogenesis has emerged as a possible cancer therapeutic target. The present work was designed to discover and evaluate bioactive phytochemicals from the Clerodendrum inerme (L.) Gaertn plant for their anti-angiogenic potential.

Facile construction of multifunctional xNiCoO/BiVO heterojunction with accelerated charge transfer for efficient photocatalytic treatment of Cr (VI), MB and TC under visible light.

The release of industrial effluents, comprising of organic dyes, antibiotics, and heavy metals poses substantial environmental and ecological threats. Among the different approaches, the utilization of heterogeneous photocatalysis based on semiconducting metal oxides is of paramount important to removal of organic ( MB dye and TC antibiotic) and inorganic pollutants ( Cr (VI) ) in wastewater. In this work, a new approach for creating type-II heterojunction photocatalysts named xNiCoO/BiVO or BNC is suggested.

Bismuth ferrite based acetone gas sensor: evaluation of graphene oxide loading.

We report a BiFeO/graphene oxide (BFO/GO) perovskite, synthesized using a CTAB-functionalized glycine combustion route, as a potential material for acetone gas sensing applications. The physicochemical properties of the developed perovskite were analysed using XRD, FE-SEM, TEM, HRTEM, EDAX and XPS. The gas sensing performance was analysed for various test gases, including ethanol, acetone, propanol, ammonia, nitric acid, hydrogen sulphide and trimethylamine at a concentration of 500 ppm.

Evaluation of Structural, Magnetic, and Electromagnetic Properties of Co-Substituted NiCuZn Ferrites.

We report citrate gel-assisted autocombusted spinel-type Co-substituted NiCuZn ferrites and their electromagnetic properties. Several complementary techniques were used to investigate the influence of Co on structural and electromagnetic properties of NiCoCuZnFeO with = 0.00-0.

One-Pot Sol-Gel Synthesis of Highly Insulative Hybrid P(AAm-CO-AAc)-Silica Aerogels with Improved Mechanical and Thermal Properties.

Silica aerogels and their derivatives have outstanding thermal properties with exceptional values in the thermal insulation industry. However, their brittle nature restricts their large-scale commercialization. Thus, enhancing their mechanical strength without affecting their thermal insulating properties is essential.

Land degradation vulnerability mapping in a west coast river basin of India using analytical hierarchy process combined machine learning models.

Assessment and modelling of land degradation are crucial for the management of natural resources and sustainable development. The current study aims to evaluate land degradation by integrating various parameters derived from remote sensing and legacy data with analytical hierarchy process (AHP) combined machine learning models for the Mandovi river basin of western India. Various land degradation conditioning factors comprising of topographical, vegetation, pedological, and climatic variables were considered.

Reconnoitering imidazopyridazines as anticancer agents based on virtual modelling approach: quantitative structure activity relationship, molecular docking and molecular dynamics.

Cancer is an unimpeded growth of cells leading to metathesis of cancer and eventually spread throughout the body. PIM kinases are the members of the serine threonine kinase playing role in cancer progression, differentiation and proliferation. Till date there is no single drug targeting PIM-1 kinase in the market, that has made itself a target in limelight for the discover of new anticancer agents.

Potential arsenic-chromium-lead Co-contamination in the hilly terrain of Arunachal Pradesh, north-eastern India: Genesis and health perspective.

In the recent times, multi-metal co-contamination in the groundwater of various parts of the globe has emerged as a challenging environmental health problems. While arsenic (As) has been reported with high fluoride and at times with uranium; and Cr & Pb are also found in aquifers under high anthropogenic impacts. The present work probably for the first time traces the As-Cr-Pb co-contamination in the pristine aquifers of a hilly terrain that are under relatively less stress from the anthropogenic activities.

In Vitro Anticancer Screening, Molecular Docking and Antimicrobial Studies of Triazole-Based Nickel(II) Metal Complexes.

Herein we describe the synthesis of a series of nickel(II) complexes (C1-C3) with Schiff bases (HL1-HL3) derived from 4-amino-5-mercapto-3-methyl-1,2,4-triazole and ortho/meta/para-nitrobenzaldehyde having composition [Ni(L)(HO)]. The obtained ligands and their complexes were characterized using physico-chemical techniques viz., elemental analysis, magnetic moment study, spectral (electronic, FT-IR, 1H-NMR) and thermal analysis.

Analytical optimization of liquid-liquid extractive spectrophotometric assessment protocol for tetravalent platinum: Analysis of environmental samples and cisplatin.

An easy and reliable method is optimized for extractive spectrophotometric assessment of platinum(IV) with 4-(4'-nitrobenzylideneimino)-3-methyl-5-mercapto-1,2,4-triazole as an extractant. The basis of this method is the formation of red platinum(IV) complex with the above reagent in acetate buffer medium (pH 5.0) and extraction in chloroform.

Syntheses, Molecular Docking and Biological Evaluation of 2-(2- hydrazinyl)thiazoles as Potential Antioxidant, Anti-Inflammatory and Significant Anticancer Agents.

Background: Recently, researchers have worked on the development of new methods for the synthesis of bioactive heterocycles using polyethylene glycol as a green solvent. In this context, we report the synthesized 2-(2-hydrazinyl) thiazoles for their in vitro antioxidant, in vitro anti-inflammatory and in vitro anti-cancer activities.

Objective: The objective of the study was to develop novel antioxidant, anti-inflammatory and anti-cancer drugs.

Betelvine (Piper betle L.): A comprehensive insight into its ethnopharmacology, phytochemistry, and pharmacological, biomedical and therapeutic attributes.

Piper betle L. (synonym: Piper betel Blanco), or betel vine, an economically and medicinally important cash crop, belongs to the family Piperaceae, often known as the green gold. The plant can be found all over the world and is cultivatedprimarily in South East Asian countries for its beautiful glossy heart-shaped leaves, which are chewed or consumed as betelquidand widely used in Chinese and Indian folk medicine, as carminative, stimulant,astringent, against parasitic worms, conjunctivitis, rheumatism, wound, etc.

Simple practical method for synthesis of trisubstituted imidazoles: an efficient copper catalyzed multicomponent reaction.

A rapid practical process has been developed for synthesis of 2,4,5-trisubstituted-imidazoles in excellent yields up to 95% from readily available starting materials. In this CuI catalyzed synthesis, trisubstituted imidazoles were afforded in short reaction times, wherein the substrate scope is well explored with benzoin as well as benzil reacting with different aldehydes in the presence of ammonium acetate as the nitrogen source.

A Novel Method for the Syntheses of Imidazo-Thiadiazoles as Potential Antioxidants and Anti-Inflammatory Agents.

Background: A literature survey revealed that many imidazo-thiadiazole molecules were used as key intermediates for the development of novel drugs. The synthesized imidazo-thiadiazole derivatives were tested for their in vitro antioxidant and anti-inflammatory properties. The purpose of this research paper is to provide readers with information regarding diseases caused by free radicals.

Graphene-tethered 5-fluorouracil-loaded ZnO nanocomposites for pH-responsive enhanced efficacy in drug delivery on MCF-7 cells.

Graphene-tethered ZnO nanocomposites with rod shapes and oval-shaped 5-fluorouracil-loaded graphene-supported ZnO nanohybrids were synthesized using one pot wet chemical bottom up coprecipitation method. The presence of hexagonal nanophase of ZnO lattice with surface-tethered graphene sheets were confirmed using XRD pattern and supportive UV-Vis and FTIR spectrum. XRD data of these nanocomposites were matched with TEM images which proved the hexagonal ZnO core maintained even after surface tailoring with graphene and drug loading.

Identification of novel leads as potent inhibitors of HDAC3 using ligand-based pharmacophore modeling and MD simulation.

In the landscape of epigenetic regulation, histone deacetylase 3 (HDAC3) has emerged as a prominent therapeutic target for the design and development of candidate drugs against various types of cancers and other human disorders. Herein, we have performed ligand-based pharmacophore modeling, virtual screening, molecular docking, and MD simulations to design potent and selective inhibitors against HDAC3. The predicted best pharmacophore model 'Hypo 1' showed excellent correlation (R = 0.

Dioscin: A review on pharmacological properties and therapeutic values.

Dioscin has gained immense popularity as a natural, bioactive steroid saponin, which offers numerous medical benefits. The growing global incidence of disease-associated morbidity and mortality continues to compromise human health, facilitating an increasingly urgent need for nontoxic, noninvasive, and efficient treatment alternatives. Natural compounds can contribute vastly to this field.

Design and optimization of sensitive analytical spectrophotometric method for micro determination of copper(II) from e-waste by using of novel chromogenic extractant.

In this article, a novel spectrophotometric reagent 1-(pyrimidine)-4, 4, 6-trimethyl-1,4-dihydropyrimidine-2-thiol [PTPT] has been synthesized for liquid-liquid extraction and spectrophotometric determination of copper(II). The as-synthesized ligand has been selectively forms stable complex with copper(II) in basic medium (pH 9.0), in presence of mild pyridine the extraction and color stability has found to be synergistically enhanced.

Co Substituted Spinel MgCuZn Ferrimagnetic Oxide: A Highly Versatile Electromagnetic Material via a Facile Molten Salt Route.

We report on the electromagnetic properties of Co substituted spinel MgCuZn ferrites developed via a facile molten salt synthesis (MSS) route. The choice of synthesis route in combination with cobalt substitution led to strong electromagnetic properties such as high saturation magnetization (i.e.

Identification and characterization of novel RdRp and Nsp15 inhibitors for SARS-COV2 using computational approach.

The World Health Organization has declared COVID-19 as a global health emergency. COVID-19 is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and highlights an urgent need for therapeutics. Here, we have employed a series of computer-aided drug repurposing campaign to discover inhibitors of RNA dependent RNA polymerase (RdRp) and Nsp15/EndoU.

Synthesis, characterization and properties of novel polyamides derived from 4 4' bis(4-carboxy methylene) biphenyl and various diamines.

Novel aromatic aliphatic diacid monomer, 4 4' bis(4-carboxy methylene) biphenyl was synthesized via friedel craft acylation with acetic anhydride followed by willgerodot reaction and used in the preparation of polyamides by direct polycondensation using the Yamazaki phosphorylation reaction with commercial aromatic diamines. These polyamides were obtained in good yield with moderate-to-high-molecular-weight build up as evidenced by inherent viscosities in the range of 0.52-0.

Doxorubicin-Conjugated Innovative 16-mer DNA Aptamer-Based Annexin A1 Targeted Anti-Cancer Drug Delivery.

Aptamers are small, functional single-stranded DNA or RNA oligonucleotides that bind to their targets with high affinity and specificity. Experimentally, aptamers are selected by the systematic evolution of ligands by exponential enrichment (SELEX) method. Here, we have used rational drug designing and bioinformatics methods to design the aptamers, which involves three different steps.