2,491 results match your criteria: "Pulmonary Alveolar Proteinosis"
Tanaffos
January 2024
Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Disease (NRITLD), Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Background: Recently, genetic mutations in surfactant protein C (SFTPC) have been linked to diffuse parenchymal lung diseases (DPLD). The present study investigated mutations among Iranian patients with DPLD for the first time.
Materials And Methods: In this study, we examined 28 patients diagnosed with DPLD.
Cureus
November 2024
Department of Pulmonology, Centre Hospitalier Universitaire (CHU) Mohammed VI, Arrazi Hospital, Faculté de Médecine et de Pharmacie de Marrakech, Laboratoire de Recherche Morpho Sciences, Université Cadi Ayyad (FMPM, Labo LRMS, UCA), Marrakech, MAR.
Autoimmune pulmonary alveolar proteinosis (PAP) is a rare lung condition characterized by the accumulation of surfactant proteins within the alveoli, leading to respiratory distress. We describe a 49-year-old female homemaker with a history of passive smoking and exposure to wood smoke and pigeon droppings. She presented with a dry cough and progressive dyspnea, experiencing significant deterioration in her condition over one year.
View Article and Find Full Text PDFEur Respir J
December 2024
Division of Pulmonary and Critical Care Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA.
ERJ Open Res
November 2024
Pneumologie, Hôpital Pontchaillou, CHU Rennes, Rennes, France.
Background: Autoimmune pulmonary alveolar proteinosis (aPAP) is a rare disease that may progress towards pulmonary fibrosis. Data about fibrosis prevalence and risk factors are lacking.
Methods: In this retrospective multicentre nationwide cohort, we included patients newly diagnosed with aPAP between 2008 and 2018 in France and Belgium.
Heliyon
November 2024
Department of Respiratory and Critical Care Medicine, Chongqing Prevention and Treatment Center for Occupational Diseases, No.301, Nancheng Avenue, Nanan District, Chongqing, 400060, PR China.
J Clin Immunol
December 2024
Department of Blood and Marrow Transplantation, Bai Jerbai Wadia Hospital for Children, Mumbai, India, 400012.
Respir Investig
November 2024
Second Division, Department of Internal Medicine, Hamamatsu University School of Medicine, 1-2-1 Handayama, Chuo-ku, Hamamatsu City, Shizuoka, 431-2111, Japan.
Front Immunol
November 2024
Department of Clinical Immunology, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark.
Introduction: Cytokine autoantibodies (c-aAb) have been associated with pulmonary diseases, including severe novel coronavirus disease 2019 (COVID-19) and pulmonary alveolar proteinosis. This study aimed to determine c-aAb association with community-acquired pneumonia (CAP) etiology (SARS-CoV-2, influenza, or bacteria) and c-aAb associations with CAP-related clinical outcomes and pulmonary comorbidities.
Methods: In a cohort of 665 patients hospitalized with CAP, c-aAb targeting interferon α (IFNα), IFNβ, IFNγ, interleukin-1α (IL-1α), IL-6, IL-10, and granulocyte-macrophage colony-stimulating factor (GM-CSF) were measured in plasma samples.
AANA J
December 2024
Clinical Assistant Professor, Department of Nurse Anesthesia Education, University of Kansas Medical Center, Kansas City, Kansas.
Pulmonary alveolar proteinosis (PAP) is a rare pulmonary disorder characterized by the accumulation of surfactant/lipoprotein material in the alveoli and subsequent hypoxemic respiratory failure. Whole lung lavage (WLL), a procedure used to physically remove the lipoprotein material from the alveoli, is the first-line treatment for this disease process. Anesthesia providers may infrequently encounter the management of the WLL procedure due to the rarity of the underlying disease process.
View Article and Find Full Text PDFSaudi J Anaesth
October 2024
Department of Anesthesia, Sultan Qaboos University Hospital, Muscat, Oman.
This case report delves into pediatric lung isolation challenges and innovations in managing patients with pulmonary alveolar proteinosis undergoing whole lung lavage. The central focus is on a 5-year-old girl who initially encountered intraoperative complications, including bilateral pneumothorax and pulmonary edema. However, a subsequent attempt employing a Foley's catheter for lung isolation proved successful, with the patient displaying marked postoperative improvements.
View Article and Find Full Text PDFViruses
October 2024
Department of Medicine, National Jewish Health, Denver, CO 80206, USA.
Rhinovirus C (RV-C) infection can trigger asthma exacerbations in children and adults, and RV-C-induced wheezing illnesses in preschool children correlate with the development of childhood asthma. Surfactant protein A (SP-A) plays a critical role in regulating pulmonary innate immunity by binding to numerous respiratory pathogens. Mature SP-A consists of multiple isoforms that form the hetero-oligomers of SP-A1 and SP-A2, organized in 18-mers.
View Article and Find Full Text PDFCurr Opin Pulm Med
January 2025
Division of Respiratory and Critical Care Medicine, National University Hospital, Singapore.
Clin Case Rep
November 2024
Department of Pathology, Bir Hospital National Academy of Medical Sciences Kathmandu Nepal.
Eur Respir Rev
October 2024
Service de Radiologie, Hopital Bichat, APHP, Université Paris Cité, Paris, France.
Respir Res
November 2024
Division of Pioneering Advanced Therapeutics, Niigata University Medical and Dental Hospital, 1-754 Asahimachi-dori, Niigata, 951-8520, Japan.
Background: Repeated inhalation of granulocyte-macrophage colony-stimulating factor (GM-CSF) was recently approved in Japan as a treatment for autoimmune pulmonary alveolar proteinosis. However, the detailed physiological and pathological effects of repeated inhalation in the long term, especially at increasing doses, remain unclear.
Methods: In this chronic safety study, we administered 24 cynomolgus monkeys (Macaca fascicularis) aged 2-3 years with aerosolized sargramostim (a yeast-derived recombinant human GM-CSF [rhGM-CSF]) biweekly for 26 weeks across four dosing groups (0, 5, 100, and 500 µg/kg/day).
Curr Opin Pulm Med
January 2025
Department of Anesthesiology, University of Maryland School of Medicine, Baltimore, Maryland, USA.
Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi
October 2024
School of Public Health, North China University of Science and Technology, Hebei Key Laboratory of Occupational Health and Safety for Coal Industry, Tangshan 063210, China.
World J Clin Cases
October 2024
Department of Pediatrics, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok 10700, Thailand.
Respir Investig
November 2024
Department of Pathology, NHO Kinki Chuo Chest Medical Center, 1180 Nagasone-cho, Kita-ku, Sakai City, Osaka, 591-8555, Japan.
Background: Approximately 20% of patients with pulmonary alveolar proteinosis (PAP) present with pulmonary fibrosis on high-resolution computed tomography (HRCT). Although transbronchial lung cryobiopsy (TBLC) has recently been used to diagnose fibrotic interstitial lung disease, no studies have investigated whether TBLC is useful for the histopathological detection of pulmonary fibrosis coexisting with PAP. Therefore, the present study aimed to investigate the utility of TBLC for evaluating pulmonary fibrosis in patients with PAP.
View Article and Find Full Text PDFRadiol Case Rep
December 2024
Department of Clinical Oncology, Nagasaki University Graduate School of Biomedical Sciences, Sakamoto, Nagasaki 852-8501, Japan.
Transplant Cell Ther
September 2024
Division of Pulmonary, Critical Care and Sleep Medicine, Lenox Hill Hospital, Northwell Health, New York, New York. Electronic address:
Arch Pathol Lab Med
October 2024
The Department of Pathology, University of Sherbrooke Health Centre, Sherbrooke, Québec, Canada (Chevrier).
Context.—: The diagnosis of pulmonary alveolar proteinosis (PAP) relies on a limited set of stains, namely hematoxylin-eosin and periodic acid-Schiff-diastase (PAS-D), demonstrating abundant alveolar material representing mostly surfactant. As cells harboring surfactant also express Napsin-A (pneumocytes and macrophages), we hypothesized that it would also be expressed within alveoli in PAP.
View Article and Find Full Text PDFBr J Hosp Med (Lond)
September 2024
North West Lung Centre, Wythenshawe Hospital, Manchester University NHS Foundation Trust, Manchester, UK.
Leuk Lymphoma
September 2024
Division of Hematology, Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan.