Phytochemical Profiling, Bioactivity, and Insecticidal Effectiveness of L. Leaf Extracts Against sp.

Plant botanical extracts are recognized for being a source of biologically active phytochemicals that potentially have diverse applications. The phytochemical composition, potential cytotoxicity, and insecticidal effectiveness of three leaf extracts from the folkloric medicinal plant L. (Calophyllaceae) were investigated.

Ethnic enclaves, neighborhood socioeconomic status, and obesity among Hispanic women in Chicago: a latent profile analysis approach.

Purpose: The prevalence of obesity, a crucial risk factor for breast cancer, is markedly higher among Hispanic women. The interaction between ethnic enclaves and neighborhood socioeconomic status (SES) as a determinant of this disparity warrants further research. We aimed to identify neighborhood profiles based on ethnic enclaves and socioeconomic status to evaluate the association with obesity among Hispanic women in the metropolitan Chicago region.

Dengue severity by serotype and immune status in 19 years of pediatric clinical studies in Nicaragua.

Background: Dengue virus, a major global health threat, consists of four serotypes (DENV1-4) that cause a range of clinical manifestations from mild to severe and potentially fatal disease.

Methods: This study, based on 19 years of data from the Pediatric Dengue Cohort Study and Pediatric Dengue Hospital-based Study in Managua, Nicaragua, investigates the relationship of serotype and immune status with dengue severity. Dengue cases were confirmed by molecular, serological, and/or virological methods, and study participants 6 months to 17 years old were followed during their hospital stay or as ambulatory patients.

Evidence for targeting autonomic dysfunction in systemic sclerosis: A scoping review.

Autonomic dysfunction is a common and early complication among patients with systemic sclerosis, suggesting that it may play a role in the pathogenesis of the disease and be a potential target for therapeutic interventions. Although the true prevalence of autonomic dysfunction among patients with systemic sclerosis is still unclear, it is estimated that as many as 80% of patients may be affected. Autonomic dysfunction may lead to widespread multi-organ dysfunction through its effects on the cardiovascular system, gastrointestinal tract, urinary tract, sweat and salivary glands, and pupils.

Quality Analysis of Online Resources for Patients Undergoing Coronary Artery Bypass Grafting.

Background: Online resources are becoming the primary educational resource for patients. Quality and reliability of websites about coronary artery bypass graft (CABG) procedures are unknown.

Methods: We queried 4 search engines (Google, Bing, Yahoo!, and Dogpile) for the terms , , , and .

Solutions to expand microbiome sciences in the Caribbean Region: an insider's perspective.

The Caribbean harbors diverse genetic resources, yet microbiome research in the region remains poorly characterized. Addressing infrastructure and training challenges through collaborations and capacity building is vital. This article reflects on the obstacles facing microbiome research in the region and proposes solutions to ensure equitable participation in the global microbial research ecosystem.

A genomics learning framework for undergraduates.

Genomics is an increasingly important part of biology research. However, educating undergraduates in genomics is not yet a standard part of life sciences curricula. We believe this is, in part, due to a lack of standard concepts for the teaching of genomics.

History of Health at Cayo Santiago-An Investigation of Environmental and Genetic Influences on the Skeletal Remains of the Introduced Rhesus Macaque (Macaca mulatta) Colony.

The Cayo Santiago rhesus macaque colony is a renowned primate population that has experienced significant natural and anthropogenic ecological variation in their 85-year history. Demographic and familial information is also tracked and collated for the majority of monkeys. Thus, the health history of rhesus macaques at Cayo Santiago should reflect the impacts of both environmental and genetic factors.

Real World Testing of a Clinical Strategy to Start Early Peritoneal Dialysis for High-Risk Newborns Following Cardiac Surgery.

Background: The beneficial impact of peritoneal dialysis (PD) catheter placement following cardiopulmonary bypass in young infants has been demonstrated. But the indications to start early peritoneal dialysis are not agreed upon.

Methods: This retrospective single center study was conducted to evaluate the performance of a clinical strategy for early PD start.

Impact of Perceived Discrimination and Pandemic Attitudes on Cancer Screening Behaviors Among Asian American Women: A Sequential Explanatory Mixed-Methods Study.

Purpose: The aim of this study was to assess how pandemic-related health concerns and discrimination affected cancer screenings among Asian American women (AAW).

Methods: A two-phase explanatory mixed-methods study was conducted. In phase 1, a survey was distributed among AAW eligible for lung, breast, or colorectal cancer screening to assess delays during the pandemic, concerns about contracting coronavirus disease 2019 (COVID-19), barriers to care, and experiences of discrimination.

Phlorotannin-Rich Seaweed Extract Inhibits Influenza Infection.

Seaweed-derived compounds are a renewable resource utilised in the manufacturing and food industry. This study focuses on an enriched seaweed extract (ESE) isolated from The ESE was screened for antiviral activity by plaque reduction assays against influenza A/Puerto Rico/8/1934 H1N1 (PR8), A/X-31 H3N2 (X31) and A/England/195/2009 H1N1 (Eng195), resulting in the complete inhibition of infection. Time of addition assays and FACS analysis were used to help determine the modes of action.

The Growing Phenomenon of 'Frozen' Virus Genome Sequences and Their Likely Origin in Research Facility Escapes.

'Frozen' virus genome sequences are sampled from outbreaks and have unusually low sequence divergence when compared to genome sequences from historical strains. A growing number of 'frozen' virus genome sequences are being reported as virus genome sequencing becomes more common. Examples of 'frozen' sequences include the 1977 H1N1 'Russian' flu; Venezuelan Equine Encephalitis Virus from Venezuela and Colombia in 1995; E71 sequences from a Hand, Foot and Mouth outbreak in 2007-2009 in China; and a polio strain isolated in 2014 from Anhui, China.

Inheritance and Resistance Mechanisms of Field-Evolved Resistance to Pyrethroids in a Fall Armyworm ( J.E. Smith) (Lepidoptera: Noctuidae) Strain from Puerto Rico.

This study examines resistance inheritance to the pyrethroid insecticides esfenvalerate and deltamethrin in a Puerto Rican strain of fall armyworm (FAW), , a major global pest of corn. The resistant strain (PPR) showed significantly higher resistance compared to a susceptible strain (SUS), with a 62-fold X-linked and 15-fold autosomal-linked resistance ratio (RR) for esfenvalerate and deltamethrin, respectively. Resistance was incompletely dominant for both insecticides.

Understanding Mental Health Impact of COVID-19 on Puerto Rican Youth: Influence of Parental Stress.

The COVID-19 pandemic disrupted all areas of society. The socioemotional effects of isolation, financial instability, and educational and employment uncertainty are anticipated to have a ripple effect on the mental health of parents and children, which has not yet been studied in the Puerto Rican context. To examine the impact of COVID-19 on Puerto Rican families, we used a cross-sectional, correlational research design that studied the following: (a) Adverse experiences (AE) related to the COVID-19 pandemic reported by parents; (b) Parental stress; (c) Parental psychopathology: (d) The mental health of their children.

Diagnostic Accuracy of a Blood-Based Biomarker Panel for Colorectal Cancer Detection: A Pilot Study.

Colorectal cancer (CRC) is a leading cause of death worldwide. Despite its preventability through screening, compliance still needs to improve due to the invasiveness of current tools. There is a growing demand for validated molecular biomarker panels for minimally invasive blood-based CRC screening.

Geographic Variation in Signal Preferences in the Tropical Katydid .

In communication systems, the signal and preference for the signal have to match, limiting phenotypic variation. Yet, communication systems evolve, but the mechanisms of how phenotypic variation can come into existence while not disrupting the match are poorly understood. Geographic variation in communication can provide insights into the diversification of these systems.

Bathymetry estimation for coastal regions using self-attention.

Bathymetric mapping of the coastal area is essential for coastal development and management. However, conventional bathymetric measurement in coastal areas is resource-expensive and under many constraints. Various research have been conducted to improve the efficiency or effectiveness of bathymetric estimations.

Building a growing genomic repository for maternal and fetal health through the PING Consortium.

Background: Prenatally transmitted viruses can cause severe damage to the developing brain. There is unexplained variability in prenatal brain injury and postnatal neurodevelopmental outcomes, suggesting disease modifiers. Of note, prenatal Zika infection can cause a spectrum of neurodevelopmental disorders, including congenital Zika syndrome.

Relationship between physical activity and biomarkers of pathology and neuroinflammation in preclinical autosomal-dominant Alzheimer's disease.

Objective: Physical activity (PA) has been linked to reduced Alzheimer's disease (AD) risk. However, less is known about its effects in the AD preclinical stage. We aimed to investigate whether greater PA was associated with lower plasma biomarkers of AD pathology, neural injury, reactive astrocytes, and better cognition in individuals with autosomal-dominant AD due to the presenilin-1 E280A mutation who are virtually guaranteed to develop dementia.

Alternate definitions of adverse pathology to predict a very high risk of metastasis in men with intermediate- and low-risk prostate cancer.

Background: Adverse pathology (AP) is often used as an intermediate end point for long-term outcomes in men with prostate cancer (PCa) who are active surveillance candidates. The association between a commonly used AP definition and long-term outcomes was tested, which identified definitions more strongly linked to a high risk of metastasis.

Methods: Data were reviewed from the Shared Equal Access Regional Cancer Hospital cohort of men undergoing radical prostatectomy (RP) from 1988 to 2020 at nine Veterans Affairs hospitals.

Surveys of genotypes in breeding stations and commercial rice fields in Arkansas, Louisiana, and Puerto Rico from 2017 to 2019.

Major resistance (R) gene mediated resistance to rice blast fungus Magnaporthe oryzae is often overcome by the fungus due to the occurrences of new races with altered corresponding avirulence (AVR) genes. In this study, blast diseased rice tissue samples were collected from breeding stations and commercial rice fields in Arkansas, Louisiana, and Puerto Rico during 2017-2019 to determine the efficacy of major R genes, Pi-ta, Pik, Pizt, Pi9, and Pi33. A total of 185 blast isolates were isolated from the diseased tissue samples to examine the existence of AVR genes AVR-Pita1, AVR-Pib, AVR-Pik, AVR-Pizt, AVR-Pi9 and ACE1.

Assessing the 10/66 Dementia Classification Algorithm for International Comparative Analyses with the U.S.

Cross-national comparisons of dementia prevalence are essential for identifying unique determinants and cultural-specific risk factors, but methodological differences in dementia classification across countries hinder global comparisons. This study maps the 10/66 algorithm for dementia classification, widely used and validated in low- and middle-income countries (LMICs), to the U.S.

Transcriptomic Profiles in Nasal Epithelium and Asthma Endotypes in Youth.

Importance: T helper 2 (T2) cells and T helper 17 (T17) cells are CD4+ T cell subtypes involved in asthma. Characterizing asthma endotypes based on these cell types in diverse groups is important for developing effective therapies for youths with asthma.

Objective: To identify asthma endotypes in school-aged youths aged 6 to 20 years by examining the distribution and characteristics of transcriptomic profiles in nasal epithelium.