Oxidored-nitro domain-containing protein 1 expression is associated with the progression of hepatocellular carcinoma.

Hepatocarcinogenesis is a stepwise process during which multiple genes are altered. Understanding the molecular mechanisms that induce hepatocarcinogenesis may improve the screening, prevention and treatment of patients with hepatocellular carcinoma (HCC). In recent years, the oxidored-nitro domain-containing protein 1 (NOR1) gene has been identified to have an important role in the development of HCC experiments.

Analysis of the sex ratio of reported gonorrhoea incidence in Shenzhen, China.

Objective: To assess the clinical process of gonorrhoea diagnosis and report in China, and to determine the difference of sex ratio between reported incidence based on reporting data and true diagnosis rate based on reference tests of gonorrhoea.

Setting: A total of 26 dermatology and sexually transmitted disease (STD) departments, 34 obstetrics-gynaecology clinics and 28 urology outpatient clinics selected from 34 hospitals of Shenzhen regarded as our study sites.

Participants: A total of 2754 participants were recruited in this study, and 2534 participants completed the questionnaire survey and provided genital tract secretion specimens.

[Survey of hospital infection management staff in the Inner Mongolia Autonomous Region].

Objective: To study the status of hospital infection management staff of the Inner Mongolia Autonomous Region.

Methods: The respondents completed the unified questionnaire. The person entered into the computer after checking, using EXCEL software for analysis.

Prevalence survey of nosocomial infections in the Inner Mongolia Autonomous Region of China [2012-2014].

Background: To investigate the prevalence of nosocomial infections, the distribution of nosocomial infection sites, the use of antibiotic and the situation of detected nosocomial infection pathogens in the Inner Mongolia Autonomous Region of China from 2012 to 2014, to grasp the current conditions of regional nosocomial infections in timely, for the development of infection prevention and control measures to provide a basis for effective hospital.

Methods: A survey of the prevalence of nosocomial infections was conducted in target hospitals using the combination of a bedside survey and medical record review.

Results: In total, 101,907 inpatients were surveyed from 2012 to 2014.

Safety and Efficacy of Dexmedetomidine as a Sedative Agent for Performing Awake Intubation: A Meta-analysis.

To compare the efficacy and safety of dexmedetomidine with other alternative sedative agents used for performing awake intubation. We conducted a meta-analysis of randomized controlled trials (RCTs) that compared the effects of dexmedetomidine with other alternative sedative agents used during awake intubation. The biomedical databases PubMed, Science Direct, and the Cochrane Library were searched for relevant RCTs with no restriction on the language of publication.

MicroRNA-433 inhibits cell proliferation in hepatocellular carcinoma by targeting p21 activated kinase (PAK4).

Hepatocellular carcinoma (HCC) is one of the most common cancers worldwide. P21-activated kinase 4 (PAK4) has been identified as an oncogenic protein in a variety of cancers. However, the contribution and regulation of PAK4 in HCC remain poorly understood.

[Primary risk factors of hepatitis E virus infection:a meta-analysis].

Objective: To analyze the main risk factors of hepatitis E virus infection.

Methods: Literatures published in China and abroad about the risk factors on the transmission of HEV were searched. HEV, risk factors, epidemiology and case-control were used as keywords to retrieve papers in Chinese literature databases including CNKI, Wanfang and SinoMed databases.

[Meta-analysis of risk factors for childhood cerebral palsy during pregnancy].

Objective: To investigate major risk factors for childhood cerebral palsy (CP) during pregnancy and to provide evidence for the prevention of CP.

Methods: Using the search terms of "cerebral palsy", "pregnancy", "risk factor", and "case-control", a search was performed to collect case-control studies on the risk factors for childhood CP from 1998 to 2011. The obtained data were subjected to metaanalysis using fixed effects model and DersimonionLaird random effects model to quantitatively evaluate risk factors for childhood CP during pregnancy.

[Survival analysis of patients with pneumoconiosis from 1956 to 2010 in Changsha].

Objective: To investigate the survival rate and life expectancy of patients with pneumoconiosis and influence factors in Changsha from 1956 to 2010.

Methods: A total of 3685 patients with pneumoconiosis were diagnosed and reported from 1956 to 2010 in Changsha. The fatality rate and life expectancy were analyzed by life table and the cause of death was analyzed by Kaplan-Meier method and Cox regression model.

The study of the combination detection of HPV-DNA and p16INK4a in cervical lesions.

The objective of this study is to detect the infection of human papillomavirus (HPV) and the expression of p16(INK4a) in cervical lesions and to investigate the interaction between hrHPV and p16(INK4a) for cervical lesions and its diagnostic efficiency. hrHPV-DNA was detected by the hybrid capture II (HC-II) system. Immunochemical method was used to detect the expression of p16(INK4a), and histopathologic test was performed to identify cervical lesions.

[Time trends and age-related characteristics of cardio-cerebrovascular deaths in Hunan].

Objective: To investigate the time trends and age-related characteristics of mortality and disease burden for cardiocerebrovascular diseases (CVD) in Hunan, China during three periods (1973-1975, 1990-1992 and 2004-2005).

Methods: The cardiocerebrovascular death data of Hunan residents were collected by three national retrospective sample surveys of death. Cause-specific mortality, proportion, years of potential life lost (YPLL) and associated indicators were identified in the population of Hunan in above mentioned three periods.

An analysis on the combination expression of HPV L1 capsid protein and p16INK4a in cervical lesions.

Human papillomavirus (HPV) infection in cervix is the most important reason for cervical cancer, but only 2% cervical HPV infection will develop into cervical cancer. So how to identify patients at risk of progressive cervical lesions from those infected with HPV to avoid over treatment is a big issue in clinic. The aims of this study were to detect the expression of HPV L1 capsid protein and p16(INK4a) in cervical lesions and to investigate the combination expression of HPV L1 capsid protein and p16(INK4a) in cervical lesions and its diagnostic efficiency in clinic.

[Simple screening table for primary osteoporosis in senior people].

Objective: To develop a simple screening table for primary osteoporosis (POP) in senior men and women.

Methods: Questionnaires were designed to obtain the risk factors associated with osteoporosis and bone mineral density (BMD), which were measured in 146 community residents over 60. The multiple stepwise regression was used to find out the risk factors and establish the screening index.

Analysis of the dose-response relationship between high-risk human papillomavirus viral load and cervical lesions.

The aims of this study were to explore the dose-response relationship between high-risk human papillomavirus (hrHPV) load and cervical lesions; the relationship between hrHPV viral load and the severity of cervical lesions; and the clinical application of the hybrid capture II (HC-II) system in the secondary prevention of cervical cancer. HrHPV viral load was detected by the HC-II system and cervical lesions were diagnosed from biopsied tissue. Curve estimation and Mantel trend analysis were used to explore the dose-response relationship between hrHPV viral load and cervical lesions.

[A case-control study on the risk factors for inguinal hernia in children].

Objective: Inguinal hernia is a common birth defect in children, but there is limited information about the risk factors for this disorder. The study aimed to explore the risk factors for the development of this disorder in children.

Methods: A frequency matching case-control study based on hospital group data was performed.

[Study on index of osteoporosis with height-shortening value for self-examination in middle-aged and elderly population].

Objective: To probe into the application value of the height shortening value as the self-examination index of the middle-aged and aged group's osteoporosis or reduced bone mineral density in communities.

Methods: Four communities were selected by cluster sampling at random in Changsha city to be the objects of study, among which women were 45 years old or older and men were 60 years old. Difference and the percentage proportion of the height shortening between the height of the research objects which was measured at their youth and the height measured at this study, were calculated.