[The study of the protection function of the sphingosine kinase 1 in the nerve cell damage caused by acrylamide].

To study the protective effect and effect of SphK1 overexpression on the injury of nerve cells induced by acrylamide. ACR with 99% purity was prepared into 1.25 mmol/L and 2.

Mapping Progressive Gray Matter Alterations in Early Childhood Autistic Brain.

Autism spectrum disorder is an early-onset neurodevelopmental condition. This study aimed to investigate the progressive structural alterations in the autistic brain during early childhood. Structural magnetic resonance imaging scans were examined in a cross-sectional sample of 67 autistic children and 63 demographically matched typically developing (TD) children, aged 2-7 years.

Biases of Happy Faces in Face Classification Processing of Depression in Chinese Patients.

We explored the face classification processing mechanism in depressed patients, especially the biases of happy faces in face classification processing of depression. Thirty patients with the first episode of depression at the First Affiliated Hospital of Harbin Medical University were selected as the depression group, while healthy people matched for age, gender, and educational level were assigned to the control group. The Hamilton Depression Scale and Hamilton Anxiety Scale were used to select the subjects; then, we used the forced face classification paradigm to collect behavioral (response time and accuracy) and event-related potential (ERP) data of the subjects.

Increased EEG coherence in long-distance and short-distance connectivity in children with autism spectrum disorders.

Introduction: Autism spectrum disorder (ASD) is a complex and prevalent neurodevelopmental disorder characterized by deficits in social communication and social interaction as well as repetitive behaviors. Alterations in function connectivity are widely recognized in recent electroencephalogram (EEG) studies. However, most studies have not reached consistent conclusions, which could be due to the developmental nature and the heterogeneity of ASD.

[Several considerations on the establishment of a new public health and preventive medicine system in national level].

Based on the new mission of public health set in the Healthy China strategy and the insufficient response to COVID-19, this article pointed out the problems of the current public health and preventive medicine system from the macro-system level, meso-organization level, and micro-individual level, including insufficient strategic planning, resource input, institutional coordination, talent training and team building. It was creatively proposed that a disease prevention and control bureau should be set up outside the health commission to implement the vertical management at four levels, from national level to province-level, including autonomous region, municipality directly under the central government, city-level and district/county-level. The disease prevention and control bureau should consist of a strategic research institute, a center for disease prevention and control (CDC), a human resources training base, and a scientific research institute, which could perform their own duties and rely on each other.

Copy number variation of ubiquitin- specific proteases genes in blood leukocytes and colorectal cancer.

Ubiquitin-specific proteases (USPs) play important roles in the regulation of many cancer-related biological processes. USPs copy number variation (CNVs) may affect the risk and prognosis of colorectal cancer (CRC). We detected CNVs of USPs genes in 468 matched CRC patients and controls, estimated the associations between the USPs genes CNVs and CRC risk and prognosis and their interactions with environmental factors on CRC risk.

[Spicy food intake increases the risk of overweight and obesity].

Objective: To explore the relationship between spicy food intake and overweight or obesity in the population, and provide theoretical basis for dietary prevention of obesity.

Methods: The data of this study was collected from the cross-sectional population of China Kadoorie Biobank(CKB) in Harbin from 2004 to 2008. A cluster random sampling method was used to select 57 555 subjects aged 30-79(23 254 males and 34 301 females).

Aberrant functional connectivity of neural circuits associated with social and sensorimotor deficits in young children with autism spectrum disorder.

Autism spectrum disorder (ASD) is a neurodevelopmental disorder characterized by atypical functional integration of brain regions. The vast majority of neuroimaging studies of ASD have focused on older children, adolescents, and adults with the disorder. Very little work has explored whole-brain functional connectivity of young children with ASD.

Fisher discriminant analysis for classification of autism spectrum disorders based on folate-related metabolism markers.

Autism spectrum disorders (ASDs) are neurodevelopmental disorders with an increasing prevalence but lack reliable biomarkers for early diagnosis. The present study investigated 13 serological metabolites and 2 genetic variants related to folate metabolism in a total of 89 ASD cases and 89 matched controls. Fisher discriminant analysis was used to establish the classification model to recognize ASD cases and controls.

Dynamic functional connectivity analysis reveals decreased variability of the default-mode network in developing autistic brain.

Accumulating neuroimaging evidence suggests that abnormal functional connectivity of the default mode network (DMN) contributes to the social-cognitive deficits of autism spectrum disorder (ASD). Although most previous studies relied on conventional functional connectivity methods, which assume that connectivity patterns remain constant over time, understanding the temporal dynamics of functional connectivity during rest may provide new insights into the dysfunction of the DMN in ASD. In this work, dynamic functional connectivity analysis based on sliding time window correlation was applied to the resting-state functional magnetic resonance imaging data of 28 young children with ASD (age range: 3-7 years) and 29 matched typically developing controls (TD group).

Parsing brain structural heterogeneity in males with autism spectrum disorder reveals distinct clinical subtypes.

Autism spectrum disorder (ASD) is a neurodevelopmental disorder with considerable neuroanatomical heterogeneity. Thus, how and to what extent the brains of individuals with ASD differ from each other is still unclear. In this study, brain structural MRI data from 356 right-handed, male subjects with ASD and 403 right-handed male healthy controls were selected from the Autism Brain Image Data Exchange database (age range 5-35 years old).

The prognostic value of programmed cell death ligand 1 expression in non-Hodgkin lymphoma: a meta-analysis.

Objective: Although the prognostic value of programmed cell death-ligand 1 (PD-L1) expression in non-Hodgkin lymphoma (NHL) has been evaluated in many studies, the results remain controversial. To investigate the prognostic role of PD-L1 expression and the association between PD-L1 expression and clinicopathological features of NHL, we performed a meta-analysis.

Methods: The PubMed, EMBASE, and Cochrane Library databases were searched up to November 30, 2017.

[Apoptosis and Ca~(2+) balance disorder of BV-2 cells induced by polychlorinated biphenyl].

Objective: To study the neurotoxicity and mechanism of polychlorinated biphenyl( PCB) in BV-2 cells.

Methods: The experiment was divided into control group and PCB118, 138, 153, 180 treated group, the dosages were 0. 000, 0.

Impact of workplace incivility against new nurses on job burn-out: a cross-sectional study in China.

Unlabelled: This study had three objectives: (1) to investigate the impact of workplace incivility on job burn-out of new nursing staff, (2) to verify the partial mediating role of anxiety in the relationship between workplace incivility and job burn-out, (3) to examine the resilience moderating the relations between workplace incivility and job burn-out.

Design: A cross-sectional online survey was conducted in May 2016 in China.

Setting: The survey was conducted in 54 cities across 29 provinces of China.

Are gastrointestinal and sleep problems associated with behavioral symptoms of autism spectrum disorder?

Many children with autism spectrum disorder (ASD) suffer from concurrent medical symptoms, including gastrointestinal (GI) and sleeping problems. However, there is limited information on the correlation between co-morbidities and autistic behavioral symptoms. In this study, we estimated the prevalence of GI and sleep problems in Chinese ASD children, examined the impacts of GI and sleep problems on autistic behavioral symptoms, and investigated the factors associated with GI and sleep problems.

[The investigation on the situation of biting pencils among part pupils in Harbin, Guangzhou, and Beijing].

To investigate the prevalence of biting pencils among pupils living in Harbin, Guangzhou, and Beijing and to compare the differences among these cases. Stratified sampling method was used to select four elementary schools in Harbin and Guangzhou from April 2015 to April 2016. Firstly, Simple random sampling method was used in every grade (grade 1-grade 5) to select 3 or 4 classes (71 classes in total).

Increased breast cancer risk with HABP1/p32/gC1qR genetic polymorphism rs2285747 and its upregulation in northern Chinese women.

Object: Hyaluronic acid binding protein 1 (HABP1/p32/gC1qR) is overexpressed in breast cancer. However, it is unknown whether HABP1 gene polymorphisms affect breast cancer risk. This study aims to evaluate the potential association of single nucleotide polymorphisms (SNPs) of HABP1 with breast cancer in northern Chinese women.

Efficacy of Folic Acid Supplementation in Autistic Children Participating in Structured Teaching: An Open-Label Trial.

Autism spectrum disorders (ASD) are recognized as a major public health issue. Here, we evaluated the effects of folic acid intervention on methylation cycles and oxidative stress in autistic children enrolled in structured teaching. Sixty-six autistic children enrolled in this open-label trial and participated in three months of structured teaching.

[Effect of Individualized Low-protein Diet Intervention on Renal Function of Patients with Chronic Kidney Disease].

Objective: To investigate whether individualized low-protein diet intervention for patients with chronic kidney disease(CKD)could improve the general condition,slow the deterioration of renal function,and delay the time of entering dialysis.

Methods: Forty CKD inpatients between July 2011 and July 2012 were randomly given with normal or individualized low-protein diet for six months according to random number table after signing informed consent. The levels of urine protein and biochemical indexes of renal function were measured at baseline and at the end of dietary intervention for six months, respectively.

Molecular epidemiology is becoming complex under the dynamic HIV prevalence: The perspective from Harbin, China.

Unlike most areas of China, HIV transmission via men who have sex with men (MSM) is increasing rapidly, and has become the main route of HIV transmission in Harbin city. The purpose of the current study was to elaborate the molecular epidemiologic characteristics of the new HIV epidemic. Eighty-one HIV-1 gag gene sequences (HXB2:806-1861) from local HIV infections were isolated; CRF01_AE predominated among HIV infections (71.

Study of the serum levels of polyunsaturated fatty acids and the expression of related liver metabolic enzymes in a rat valproate-induced autism model.

To investigate whether the decreased level of serum polyunsaturated fatty acids (PUFAs) in patients with autism is associated with the expression of related liver metabolic enzymes, we selected rats that were exposed to valproic acid (VPA) on embryonic day 12.5 (E12.5) as a model of autism.

Identification of proteins responsible for adriamycin resistance in breast cancer cells using proteomics analysis.

Chemoresistance is a poor prognostic factor in breast cancer and is a major obstacle to the successful treatment of patients receiving chemotherapy. However, the precise mechanism of resistance remains unclear. In this study, a pair of breast cancer cell lines, MCF-7 and its adriamycin-resistant counterpart MCF-7/ADR was used to examine resistance-dependent cellular responses and to identify potential therapeutic targets.

Copy number variation in Han Chinese individuals with autism spectrum disorder.

Background: Autism spectrum disorders (ASDs) are a group of neurodevelopmental conditions with a demonstrated genetic etiology. Rare (<1% frequency) copy number variations (CNVs) account for a proportion of the genetic events involved, but the contribution of these events in non-European ASD populations has not been well studied. Here, we report on rare CNVs detected in a cohort of individuals with ASD of Han Chinese background.

Family-based association study of ZNF533, DOCK4 and IMMP2L gene polymorphisms linked to autism in a northeastern Chinese Han population.

Objective: A study in a Caucasian population has identified two single-nucleotide polymorphisms (SNPs) in ZNF533, one in DOCK4, and two in IMMP2L, which were all significantly associated with autism. They are located in AUTS1 and AUTS5, which have been identified as autism susceptibility loci in several genome-wide screens. The present study aimed to investigate whether ZNF533, DOCK4, and IMMP2L genes are also associated with autism in a northeastern Chinese Han population.

The HIV/AIDS epidemic characteristics in a northeast province of China--men who have sex with men have made a tremendous contribution to the growth of the HIV epidemic.

Objective: To investigate the characteristics and trends of the HIV epidemic in Heilongjiang province of China between 1993 and 2012.

Methods: Data from the provincial surveillance system for HIV infections and AIDS were reviewed. Local health staff reviewed medical records, including dates of HIV/AIDS diagnoses and deaths, exposure category, treatment, laboratory testing, and demographics.