Psoriatic skin-sensitive degradable mesoporous zinc phosphate microsphere as a photosensitizer in photodynamic therapy for anti-psoriasis.

Blue light will be a promising alternative for photodynamic therapy in psoriasis, but the photosensitizer in vivo remains unexplored. Mesoporous zinc phosphate microparticle (MZP) was synthesized successfully in this study, as evidenced by XPS, XRD, and nitrogen adsorption experiments. Its psoriatic skin-sensitive property was corroborated by SEM and the higher cumulative release rate of that impregnated with curcumin (Cur) and glycyrrhizic acid (GA), namely Cur-GA-MZP, at pH 5.

Metabolic Engineering of for Efficient Production of Ectoine.

Ectoine is a valuable compatible solute with extensive applications in bioengineering, cosmetics, medicine, and the food industry. While certain halophilic bacteria can naturally produce ectoine, as a model organism for biomanufacturing, offers significant advantages to be engineered for potentially high-level ectoine production. However, complex metabolic flux distributions and byproduct formation present bottlenecks that limit ectoine production in .

pH-Adjusted Liquid SERS Approach: Toward a Reliable Plasma-Based Early Stage Lung Cancer Detection.

Surface-enhanced Raman spectroscopy (SERS) provides a rapid and nondestructive method for biological plasma analysis, offering unparalleled sensitivity and specificity. However, most current studies predominantly employ the drop-cast method, where liquid samples are dried on the SERS substrate for spectral recording. While effective, this method is both time-consuming and inconsistent.

Eco-friendly cellulose paper based triboelectric material regulated by lignocellulose composition.

Applying cellulose paper on the triboelectric material is the trend of developing eco-friendly triboelectric nanogenerator (TENG). However, the researchers always pay attention to improve the triboelectric property of cellulose paper by the grafting of functional groups and the introduction of conductive or high dielectric property materials, while neglecting the effects of lignocellulose fiber composition including hemicellulose and lignin. In this work, the contents of hemicellulose and lignin were adjusted by sodium hydroxide and sodium chlorite, respectively; and the effects of hemicellulose and lignin on the triboelectric performance of cellulose paper were evaluated.

CRISPR/Cas12a-Enabled Amplification-Free Colorimetric Visual Sensing Strategy for Point-of-Care Diagnostics of Biomarkers.

CRISPR/Cas12a-based biosensors have garnered significant attention in the field of point-of-care testing (POCT), yet the majority of the CRISPR-based POCT methods employ fluorescent systems as report probes. Herein, we report a new CRISPR/Cas12a-enabled multicolor visual biosensing strategy for the rapid detection of disease biomarkers. The proposed assay provided vivid color responses to enhance the accuracy of visual detection.

Rising challenges in periprosthetic joint infections: a focus on rare pathogens and their clinical implications.

Objectives: The study aimed to evaluate differences in clinical characteristics and treatment outcomes of periprosthetic joint infection (PJI) attributed to rare versus common pathogens.

Methods: Data on PJI patients who underwent hip or knee arthroplasty at our center from April 2013 to December 2022 were retrospectively collected. Among the 219 enrolled patients, we compared 32 cases of PJI caused by rare pathogens with 187 controls of PJI caused by common pathogens, analyzing demographic information, clinical characteristics, and treatment outcomes.

The Frontiers of Smart Healthcare Systems.

Artificial Intelligence (AI) is poised to revolutionize numerous aspects of human life, with healthcare among the most critical fields set to benefit from this transformation. Medicine remains one of the most challenging, expensive, and impactful sectors, with challenges such as information retrieval, data organization, diagnostic accuracy, and cost reduction. AI is uniquely suited to address these challenges, ultimately improving the quality of life and reducing healthcare costs for patients worldwide.

Effect of Adjuvant Chemotherapy Cycles on Patients with Node-Negative Gastric Cancer Following Neoadjuvant Chemotherapy: Multicenter Cohort Study.

Background: Research investigating the potential impact of postoperative adjuvant chemotherapy cycles on patients with lymph node-negative gastric cancer following neoadjuvant chemotherapy is currently sparse. This study aims to explore the effect of adjuvant chemotherapy cycles on the prognosis of this specific patient group.

Patients And Methods: We analyzed clinicopathological data from patients at four institutions between 2010 and 2020.

Impacts of platform-based CBL on undergraduate nursing students' academic performance, self-efficacy, clinical decision-making and critical thinking abilities: A cluster randomized controlled trial.

Aim: To compare the effects of traditional and platform-based case-based learning (CBL) on undergraduate nursing students' academic performance, self-efficacy, clinical decision-making and critical thinking abilities.

Background: Traditional CBL can improve students' academic performance but faces challenges in the era of "Internet + education." It is unclear whether platform-based CBL is as effective as traditional CBL.

Multiomics Analyses Reveal that Fatty Acid Metabolism and TCA Cycle Contribute to the Achievement of Functional Cure in Chronic Hepatitis B.

Peg-IFNα is one of the current therapeutic strategies for Hepatitis B virus (HBV) seroclearance. Nevertheless, the underlying mechanisms are not yet adequately understood. The objective of this study was to explore the potential mechanisms using multiomics approach.

N-heterocyclic nitrenium-catalyzed photosynthesis of 3,3-disubstituted oxindoles from α-chloroanilides.

The radical cascade reaction of α-halogenated anilides represents an efficient approach for synthesizing 3,3-oxindoles. However, most methods have focused on α-bromoanilides, with limited utilization of the more stable and readily available α-chloroanilides. In addition, the transition-metal-free preparation of 3,3-oxindoles has been far less explored.

Left Ventricular False Tendons: A Morphological Study by Echocardiography.

Purpose: This is a prospective study aimed to investigate the morphology of left ventricular false tendons (LVFTs) using echocardiography and explore its associations with age, sex, body mass index (BMI), congenital heart structural abnormalities, and premature ventricular contractions (PVCs).

Methods And Results: We analyzed data from 889 individuals who underwent consecutive echocardiograms at our ultrasound department between December 2023 and February 2024. Routine echocardiograms were performed to detect congenital structural abnormalities, with a focus on identifying LVFT.

Transition Metal Chalcogenides/Nonconjugated Polymer Artificial Photosystems for Photoredox Catalysis.

Surface charge transfer doping (SCTD) has been established as an efficient strategy to achieve strong electronic coupling interactions between semiconductors and dopants, which lead to highly efficient electron transport over semiconductors. Herein, we report a facile, easily accessible, and effective SCTD strategy to exquisitely modulate the interfacial charge transfer over transition metal chalcogenides (TMCs: CdS, ZnCdS, CdInS, and ZnInS) through surface modification with a nonconjugated polymer, poly(dimethyldiallylammonium chloride) (PDDA). We provide evidence that PDDA, as a surface electron transfer acceptor, can be used to enable rapid, directional, and tunable charge transfer along with an optimal charge lifetime over TMCs in photoredox catalysis because of the high-efficiency electron-trapping property of quaternary ammonium functional groups in the molecular structure of PDDA.

The Impact of Running-Based and Drop Jumping Interval Interventions on Cardiorespiratory Fitness and Anaerobic Power of Collegiate Volleyball Players: A Comparative Analysis of Inter-Individual Variability in the Adaptive Responses.

This study compared inter-individual variability in the adaptive responses of cardiorespiratory fitness, anaerobic power, and motor abilities of male volleyball players to high-intensity interval training (HIIT) prescribed as repetitive drop jumps (interval jumping) and running-based intervals (interval running). Twenty-four collegiate volleyball players were equally randomized to two training groups executing 11 minutes of interval running or interval jumping during which they ran or repeated drop-jumps for 15 seconds, alternating with 15 seconds of passive recovery. Before and after the 6-week training period, aerobic fitness, cardiac function, and anaerobic power were evaluated using a graded exercise test, impedance cardiography, and a lower-body Wingate test, respectively.

Significance of the APPLE score and the monocyte-HDL cholesterol ratio in predicting late recurrence of atrial fibrillation following catheter ablation based on a retrospective study.

Objective: Collect the characteristics of patients' baseline data, and explore the predictive factors of late recurrence of atrial fibrillation (AF) after catheter ablation according to whether late recurrence or not. The purpose of this study was to determine the significance of the APPLE score in conjunction with the monocyte-high-density lipoprotein cholesterol ratio (MHR) in predicting the late recurrence of AF after catheter ablation in patients with AF.

Methods: Baseline data were collected to explore the predictors of late recurrence after AF catheter ablation.

The influence of transportation, social norms, cultural identity, and affective disposition in transnational media enjoyment.

Background: The globalization of the media market is forcing decision-makers to understand the psychological processes behind local audiences' enjoyment of foreign TV dramas. Transportation is a well-established psychological theory and framework utilized to elucidate and anticipate audience engagement and enjoyment in the cognitive process of experiencing a narrative text. Although there is a substantial body of literature on transportation and media enjoyment, there is a noticeable absence of studies on the relationship between audiences being "transported" into the narrative world of TV dramas and, particularly, the pleasure audiences derive from interacting with media content within a cross-cultural acceptance context.

Key Decision-Making in Post-Failed Internal Fixation of Intertrochanteric Fractures Hip Arthroplasty: A Multicenter Retrospective Study on Fracture Healing's Impact on Femoral Component Selection.

Purpose: Following failed internal fixation of intertrochanteric fractures (FIF-ITF), the decision to use a long-stem or standard-stem femoral implant in hip arthroplasty is still debated. This study aimed to explore how the healing status of fractures after FIF-ITF failure affects the choice of femoral stem and clinical outcomes.

Methods: Our retrospective cohort study reviewed 105 cases of patients with FIF-ITF who underwent hip arthroplasty at three tertiary Grade A hospitals between December 2012 and December 2022.

EKFNet: edge-based Kalman filter network for real-time EEG signal denoising.

Signal denoising methods based on deep learning have been extensively adopted on electroencephalogram devices. However, they are unable to deploy on edge-based portable or wearable (P/W) electronics due to the high computational complexity of the existed models. To overcome such issue, we propose an edge-based lightweight Kalman filter network (EKFNet) that does not require manual prior knowledge estimation.

Instant oxidase- and peroxidase-mimic activities of in-situ reductive coordinated Cu(I)-polytrithiocyanuric acid for HS colorimetric detection and antibacterial.

Integrating preparation and utilization of nanozymes in a "one-pot" approach offers advantages over conventional discrete synthesis and application methods by eliminating laborious syntheses, reducing energy consumption, and minimizing chemical waste. Herein, we revealed the instant oxidase- and peroxidase-mimic (OD-/POD-mimic) activities of in-situ formed Cu(I)-polytrithiocyanuric acid (i:Cu(I)-pTTCA) polymers. The polymers were assembled through reductive coordination between Cu and trithiocyanuric acid and immediately exhibited intrinsic OD- or POD-mimic activities.

Effect of Acetyl tributyl citrate on bone metabolism based on network toxicology and molecular docking technology.

This study aims to elucidate the intricate effects of Acetyl tributyl citrate (ATBC) on bone metabolism, disentangling the underlying molecular mechanisms that govern the impact of environmental contaminants on disease processes. Leveraging the exhaustive exploration of databases such as ChEMBL, STITCH, GeneCards, and OMIM, we have identified a comprehensive list of 164 potential targets intimately associated with both ATBC and bone metabolism. Following rigorous refinement using the STRING platform and Cytoscape software, we pinpointed ten core targets, encompassing KDM1A, EP300, HDAC2, EHMT2, DNMT1, and several others.

Design, fabrication, and evaluation of antimicrobial sponge microneedles for the transdermal delivery of insulin.

Transdermal drug delivery systems hold promise, but their effectiveness is often constrained by the skin's barrier. Microneedles (MNs) improve drug permeability by creating micro-channels in the skin, yet they continue to face challenges such as infection risks and safety concerns. To overcome these challenges, a novel antimicrobial sponge MNs (ASMNs@PVP-INS) modified with polyvinylpyrrolidone (PVP) for insulin (INS) delivery was designed.

Inhibition of CISD2 enhances sensitivity to doxorubicin in diffuse large B-cell lymphoma by regulating ferroptosis and ferritinophagy.

Background: CDGSH iron-sulfur domain 2 (CISD2), an iron-sulfur protein with a [2Fe-2S] cluster, plays a pivotal role in the progression of various cancers, including Diffuse Large B-cell Lymphoma (DLBCL). However, the mechanisms by which CISD2 regulates the occurrence and development of DLBCL remain to be fully elucidated.

Methods: The potential role of CISD2 as a predictive marker in DLBCL patients treated with the R-CHOP regimen was investigated through bioinformatics analysis and clinical cohort studies.

Levamisole Ameliorates Rheumatoid Arthritis by Downregulating the PI3K/Akt Pathway in SD Rats.

Rheumatoid arthritis (RA) is a systemic chronic autoimmune disease characterized by a protracted course, high rates of morbidity, and disability yet lacks effective therapeutic modalities. Levamisole (LVM), an immunomodulatory drug, has been clinically reported for its potential in RA treatment, while its therapeutic mechanism toward RA remains to be elucidated. Hence, this study provides theoretical support for the application of LVM in the treatment of RA.