Heavy metal contamination in cow and buffalo milk from industrial and residential areas of raipur, India: A health risk assessment.

This study investigated heavy metal contamination in cow and buffalo milk from industrial and residential areas of Raipur, India, assessing health risks and identifying contamination sources. Milk samples were collected from seven sites and analyzed for Zn, Ni, Fe, Mn, Cu, Cr, Cd, Pb, and As using inductively coupled plasma-optical emission spectroscopy (ICP-OES) and atomic absorption spectroscopy (AAS). Results revealed higher contamination in industrial areas, with fodder being a primary source for Zn, Ni, Fe, and Cu, while water contributed to Mn, Cr, and As.

Optimization and Preparation of Doxycycline-Loaded Chitosan Nanoparticles Using Box-Behnken Design for Better Diabetic Wound Healing.

A diabetic wound is one of the most devastating difficulties associated with diabetes and leads to significant death and morbidity. Hence, the aim was to make Doxycycline-loaded chitosan nanoparticles (DOX-CNPs) using ionic gelation with a cross-linking technique. In the Box-Behnken design, the DOX-CNPs were optimized by considering the effects of the following 3 variables independently, namely chitosan, sodium tripolyphosphate in volume ratio, strength of chitosan and sodium tripolyphosphate, among several response variables related to nanoparticle properties.

GC-MS Analysis of Polysaccharides from an Intergeneric Hybrid of Pleurotus florida and Cordyceps militaris: A Comparative Study.

Edible and medicinal mushrooms are valuable sources of polysaccharides, known for their dual roles as immunostimulants and immunosuppressants. This study aimed to enhance polysaccharide content by fusing two mushroom species, P. florida and C.

Nitrogen Doped Carbon Quantum Dots as Fluorescence "Turn-Off-On" Sensor for Detection of Fe Ions and Ascorbic Acid in Moringa oleifera and Citrus Lemon.

In recent year, the uses of carbon quantum dots (CQDs) have increased in many fields. Herein we report, synthesis of fluorescent nitrogen doped carbon quantum dots (N-CQDs) by simple and ecofriendly hydrothermal method. The as-synthesized N-CQDs were characterized by various techniques and the quantum yield was also calculated.

Resin bound gold nanocomposites assisted SE/ATR-FTIR spectroscopy for detection of pymetrozine insecticide in vegetable samples.

The goal of this work was to assess the competence of organic hydrophobic resin bound gold nanocomposites (OH/R-AuNCs) for detection of pymetrozine insecticide from vegetable samples employing surface-enhanced/attenuated total reflectance-Fourier transform infrared (SE/ATR-FTIR) spectroscopy. The adsorption isotherm models, including the Langmuir, Freundlich and Temkin, are tested to reveal the interactive behaviour between the OH/R-AuNCs and pesticide. The adsorption occurs principally by London-Van der Waals dispersion interactions and hydrogen bonding interactions between the surface of OH/R-AuNCs materials and the hydrophobic part of pesticide molecule.

Nucleic acid binding affinity and antioxidant activity of N-m-Tolyl-4-Chlorophenoxyacetohydroxamicacid.

Hydroxamic acids represent a group of weak organic acids, both naturally occurring and synthetically derived, characterized by the general formula RC(= O)N(R'OH). In this study, we investigated the binding behavior of N-m-tolyl-4-chlorophenoxyaceto hydroxamic acid with calf thymus DNA (ct-DNA) and torula yeast RNA (t-RNA) through a combination of techniques including UV-visible spectroscopy, fluorescence emission analysis, viscometry, and computational simulations using AutoDock4 software. Our findings reveal that the mode of binding between the compound and the nucleic acids is consistent with intercalation.

Influence of Essential Oil Composition on Antioxidant and Antibacterial Activities of Three Cultivars of Cymbopogon Flexuosus: In Vitro and In Silico Study.

The present study investigates and compares the chemical composition, antioxidant, and antibacterial properties of lemongrass essential oils (LEOs) extracted from fresh leaves of three cultivars of C. flexuosus: Krishna (CF-KA), Cauvery (CF-CA), and Nima (CF-NI), grown in Chhattisgarh plains. Analysis through gas chromatography techniques revealed that citral content was highest in CF-NI (79.

Molecular interaction between three novel amino acid based deep eutectic solvents with surface active ionic liquid: A comparative study.

Interaction between a surface active ionic liquid (IL) viz. 1-decyl-3-methylimidazolium chloride [Dmim][Cl] with three novel amino acid-based deep eutectic solvents (DES, consisting of choline chloride and l-methionine (DES1), l-phenylalanine (DES2), and l-glutamine (DES3) in a 1: 2 mol ratio) is studied. Several techniques, including surface tension, fluorescence, UV-visible spectroscopy, and Fourier transform infrared (FTIR), were used to investigate the key micellar properties and intermolecular interactions between the IL and DESs.

Chitosan decorated magnetic nanobiocatalyst of Bacillus derived α-amylase as a role model for starchy wastewater treatment, detergent additive and textile desizer.

In this study, Bacillus tequilensis TB5 α-amylase from rice-milled by-products (rice bran and de-oiled rice bran) was successfully immobilized onto biologically synthesized magnetic nanoparticles fabricated with chitosan (MNP-Ch) and characterized via different biophysical techniques. Furthermore, the study emphasized incorporating this nanostructure framework (MNP@2mgchitosan_DORB-amy and MNP@3mgchitosan_RB-amy) to offer diverse applications, including enzymatic desizing, cleaning starchy stains, and treating synthetic starchy wastewater. An enzyme loading of > 90 % for both enzymes indicated increased binding sites due to the functional moieties of chitosan on the MNP.

Green synthesis of silver nanoparticles from leaf extract for the detection of aminoglycoside antibiotics and other applications.

Antibiotics of aminoglycoside (AMG) class, such as streptomycin (STR), have been widely used to treat infectious diseases caused by Gram-negative bacteria in livestock and humans. In this study, a selective and sensitive colorimetric probe for the determination of STR was proposed based on eco-friendly green synthesized AgNPs from the leaf extract of . The mechanism for the detection of STR is based on the electrostatic interaction of opposite charges between negatively charged silver nanoparticle- leaf (AgNP-MZL) and STR, causing an aggregation-induced characteristic shift of the SPR band (from 390 nm to 570 nm wavelength) of AgNP-MZL.

Inner-filter effect of nitrogen-doped carbon quantum dots-MnO nanotubes for smartphone-integrated dual-mode sensing of glutathione and captopril.

Nitrogen-doped carbon quantum dots (N-CQDs) exhibit unique fluorescence properties and are considered one of the best candidates for the development of fluorescence-based sensors for the detection of many analytes. In this work, a smartphone-assisted fluorescent sensor has been developed using N-CQDs and MnO nanotubes (MnO NTs) for the detection of glutathione (GSH) and captopril (CAP). N-CQDs were facilely synthesized the solvothermal method, where -phenylenediamine (-PD) and urea were used as nitrogen precursors.

Development and characterization of ferulic acid-loaded chitosan nanoparticle embedded- hydrogel for diabetic wound delivery.

Diabetic wounds present a significant global health challenge exacerbated by chronic hyperglycemia-induced oxidative stress, impeding the natural healing process. Despite various treatment strategies, diabetic foot ulceration lacks standardized therapy. Ferulic acid (FA), known for its potent antidiabetic and antioxidant properties, holds promise for diabetic wound management.

Why does the orientation of azulene affect the two-photon activity of a porphyrinoid-azulene system?

Attaching a dipolar molecule in a symmetric system induces a major change in the electronic structure, which may be reflected as the enhancement of the optical and charge-transfer properties of the combined system as compared to the pristine ones. Furthermore, the orientation of the dipolar molecule may also affect the said properties. This idea is explored in this work by taking porphyrinoid molecules as the pristine systems.

COVID-19: Recent Insight in Genomic Feature, Pathogenesis, Immunological Biomarkers, Treatment Options and Clinical Updates on SARS-CoV-2.

SARS-CoV-2 is a highly contagious and transmissible viral infection that first emerged in 2019 and since then has sparked an epidemic of severe respiratory problems identified as "coronavirus disease 2019" (COVID-19) that causes a hazard to human life and safety. The virus developed mainly from bats. The current epidemic has presented a significant warning to life across the world by showing mutation.

Development of Simultaneous HPTLC Method and Validation for the Quality Assessment of Ayurvedic Formulation-Ayush Kvatha Churna by Using Marker Compound Rosmarinic Acid, Trans-Cinnamaldehyde and Piperine.

Ayurveda emphasizes the propagation of nature in maintaining health. In the present scenario, we have seen the faith of people in herbal drugs during the Covid 19 outbreak. The raises in the number of peoples have been using herbal drugs to boost immunity against infectious diseases shows the popularity of this ancient system of medicine.

Role and uptake of metal-based nanoconstructs as targeted therapeutic carriers for rheumatoid arthritis.

Rheumatoid Arthritis (RA) is a chronic autoimmune systemic inflammatory disease that affects the joints and other vital organs and diminishes the quality of life. The current developments and innovative treatment options have significantly slowed disease progression and improved their quality of life. Medicaments can be delivered to the inflamed synovium via nanoparticle systems, minimizing systemic and undesirable side effects.

In-vitro and in-silico analysis and antitumor studies of novel Cu(II) and V(V) complexes of N-p-Tolylbenzohydroxamic acid.

Copper(LCu) and vanadium(LVOCl) complexes of N-p-tolylbenzohydroxamic acid (LH) ligand have been investigated for DNA binding efficacy by multiple analytical, spectral, and computational techniques. The results revealed that complexes as groove binders as evidenced by UV absorption. Fluorescence studies including displacement assay using classical intercalator ethidium bromide as fluorescent probe also confirmed as groove binders.

Prominent Perspective on Existing Biological Hallmarks of Alzheimer's Disease.

Biomarkers are the most significant diagnosis tools tending towards unique approaches and solutions for the prevention and cure of Alzheimer's Disease (AD). The current report provides a clear perception of the concept of various biomarkers and their prominent features through analysis to provide a possible solution for the inhibition of events in AD. Scientists around the world truly believe that crucial hallmarks can serve as critical tools in the early diagnosis, cure, and prevention, as well as the future of medicine.

Nano zinc oxide mediated resuscitation of aged Cajanus cajan via modulating aquaporin, cell cycle regulatory genes and hormonal responses.

Nanoparticle pretreatment improved the health of aged Cajanus cajan seeds viz., regulation of redox status, gene expression, and restoration of hormonal homeostasis. Ageing deteriorates the quality of seeds by lowering their vigor and viability, and terminating with loss of germination.