Psychosocial Distress and the Quality of Life of Cancer Patients in Rural Hospitals in Limpopo Province: A Qualitative Study.

Background: The diagnosis and treatment of cancer are associated with substantial physical, psychological, and social morbidity for most patients. Distress can be seen as an unpleasant experience of an emotional, psychological, social, or spiritual nature that interferes with the ability to cope with cancer treatment.

Purpose: The aim was to understand patients' experiences of distress in their context and to analyze and interpret the findings.

Self-Identified Employment Challenges for Young Adults with a Cleft Lip and Palate: A Qualitative Exploration.

As individuals with a cleft lip and palate (CLP) transition into adulthood, they face unique employment challenges related to income, job stability, and fewer career options. This study explored these challenges through two focus group discussions with 19 participants (aged 21-38), primarily women, to understand their employment experiences. Thematic analysis revealed the following three main themes: (1) physical factors, (2) psychosocial factors, and (3) overcoming employment challenges, with nine sub-themes including speech, hearing, appearance, health, childhood experiences, societal expectations, lack of self-confidence, communication improvement, and self-esteem building.

Decision-Making Styles, Prosociality, and Behavioral Difficulties in Adolescent Offenders: The Mediating Role of Life Satisfaction and Emotional Experiences.

Research on adolescents suggests that decision-making styles, emotional experiences, and life satisfaction play a crucial role in emotional and behavioral difficulties and the development of prosocial behaviors. This study analyzed the relationship between decision-making styles, prosociality, and difficulties among adolescent offenders, as well as the mediating role of life satisfaction and emotional experiences in this relationship. A total of 457 adolescents aged from 14 to 19 years (M = 16.

Adapting and Implementing a Blended Collaborative Care Intervention for Older Adults with Multimorbidity: Quantitative and Qualitative Results from the ESCAPE Pilot Study.

Multimorbidity poses significant challenges for patients and healthcare systems, often exacerbated by fragmented care and insufficient collaboration across providers. Blended Collaborative Care (BCC) is a promising strategy to address care complexity by partnering care managers (CMs) with primary care providers (PCPs) and specialists. This study aimed to adapt and pilot a BCC intervention for patients aged 65+ with heart failure and physical-mental multimorbidity.

Loneliness in Middle-Aged and Older Adults: Effects of Social Environments.

Loneliness is a common subjective condition that is associated with distress and negative outcomes for psychosocial functioning and well-being, and it is grounded in destructive or inadequate social functioning. Social interactions are considered one of the key factors determining loneliness, and similarly to social interactions, loneliness can occur in different domains. While a solid body of research is focused on loneliness as a general condition, there are few studies that investigate loneliness from a multidimensional perspective, particularly combining general and domain-specific loneliness.

Differential Impact of Risk Factors for Cognitive Decline in Heterosexual and Sexual Minority Older Adults in England.

Background/objectives: Sexual minority older adults (SMOAs) report greater subjective cognitive decline (SCD) than heterosexual older adults (HOAs). This study aimed to compare the impact of multiple psycho-social risk factors on objective and subjective cognitive decline in HOAs and SMOAs.

Methods: Two samples of self-identified HOAs and SMOAs were selected from the English Longitudinal Study of Ageing.

Mental Health, Emotional Regulation, and Psychosocial Work Factors Among Scientific Researchers: A Cross-Sectional Study from Paraguay.

Background: This study examined the prevalence of mental health issues among Paraguayan researchers and their relationships with emotional regulation and psychosocial factors.

Methods: A cross-sectional survey of 235 researchers was conducted using validated instruments: the Depression, Anxiety, and Stress Scale (DASS-21); the Job Content Questionnaire (JCQ); and the Difficulties in Emotion Regulation Scale (DERS). Sociodemographic, academic, and behavioral variables were also analyzed.

Dutch Validation of the Self-Evaluation of Negative Symptoms Scale (SNS).

Background/objectives: Negative symptoms in schizophrenia spectrum disorders are related to impaired social functioning and lower quality of life, making accurate assessment important. To date, most tools for assessing negative symptoms are observational, which can be influenced by the raters' experience and opinion. Self-rating scales, like the Self-Evaluation of Negative Symptoms (SNS), could complement observer ratings by adding information from the patient's perspective.

Relations between Distress Tolerance and Psychosocial Variables in Adults Experiencing Homelessness.

Background: Distress Tolerance (DT) is a transdiagnostic factor that may help better understand vulnerability to mental health problems. This study explores DT among recently incarcerated adults experiencing homelessness (RIHAs).

Methods: Participants (298) were recruited from an ongoing clinical trial at a homeless shelter in Texas.

Multidimensional 1-Year Outcomes After Intensive Care Admission for Multisystem Inflammatory Syndrome in Children.

Objectives: The COVID-19 pandemic gave rise to uncertainty concerning potential sequelae related to a severe acute respiratory syndrome coronavirus 2 infection. This landscape is currently unfolding with studies reporting sequelae on various domains (physical, cognitive, and psychosocial), although most studies focus on adults or only one domain. We sought to investigate concurrent sequelae on multiple domains 1 year after PICU admission for Multisystem Inflammatory Syndrome in Children (MIS-C).

Depressive symptoms and quality of life among women experiencing infertility: The moderating effect of perceived social support.

Background: Infertility constitutes a leading reproductive health problem with profound psychosocial outcomes, including elevated depressive symptoms that compromise quality of life (QoL). While the literature has suggested social support as a protective psychological mechanism, its role in depressive symptoms and QoL among women with infertility remains underexplored. This study aimed to examine the moderating effect of perceived social support on the relationship between depressive symptoms and QoL among South Korean women experiencing infertility.

Determine the psychosocial well-being of elderly residents living in old-age homes.

Background: Old-age homes provide crucial care for elderly individuals facing physical, mental, or social challenges. Ensuring their psychosocial well-being is vital for fulfilling life. This study addresses the gap in the literature by comprehensively assessing factors like anxiety, feeling of security, and desire for longevity aiming to inform interventions for better support systems in old-age homes.

Tele-counseling services for COVID-19 patients: Experiences from a state mental health institute in South India.

Background: The COVID-19 pandemic has had profound implications for individuals' physical and mental health (MH), as well as well-being of populations worldwide. Several underlying issues which have a significant impact on MH, such as stress, worry, frustration, and uncertainty, were widespread during the COVID-19 pandemic. One of the common measures resorted to was to provide MH services to the population using information technology.

Prevalence and Risk Factors of Postpartum Depression in Palestinian Women in the Hebron Governorate, Palestine.

Background: Despite the increased interest from researchers in Postpartum depression (PPD) globally, related studies are limited in Palestine and do not provide a comprehensive understanding of PPD.

Objective: We examined the factors that determine post-partum depression among Palestinian mothers in Hebron governorate.

Methods: A cross-sectional study was conducted in 122 governmental primary healthcare clinics in Hebron Governorate.

Effectiveness of rehabilitation interventions in patients with colorectal cancer: an overview of systematic reviews.

Objective: To evaluate existing evidence from published systematic reviews for the effectiveness and safety of rehabilitation interventions in adult patients with colorectal cancer.

Methods: A comprehensive literature search was conducted using medical/health science databases up to October 2024. Bibliographies of pertinent articles, journals, and grey literature were searched.

Healing beyond bone: a qualitative study of the core decompression experience of physically active patients with stage II hip avascular necrosis.

Background: Avascular necrosis (AVN) of the femoral head is a degenerative condition characterized by ischemic bone death, resulting in pain and impaired mobility. Core decompression, a surgical intervention, is widely performed for stage II AVN to alleviate symptoms and delay disease progression. While clinical and radiological outcomes are well-documented, the psychosocial dimensions of recovery remain underexplored.

Chest wall perforator flap reconstruction in breast conserving surgery: quality of life and limited complications in outpatient treatment.

Background: Breast conserving surgery (BCS) with partial breast reconstruction (PBR) results in less morbidity, better cosmetic outcomes, and improved patient satisfaction compared to mastectomy. Perforator flap reconstruction can attenuate defects prone to breast deformity after BCS. Usually, postoperative drains and inpatient admission are part of this treatment.

Psychosocial working conditions and violence prevention climate in German emergency departments - a cross-sectional study.

Background: Emergency departments (EDs) are high pressure work environments with several psychosocial job demands, e.g., violence, and job resources, e.

Implementation of stop smoking support by mental healthcare professionals: cross-sectional analysis of why nothing much happens.

Smoking is highly prevalent and persistent among people with mental illness, but implementation of smoking cessation care by mental healthcare professionals (MHCPs) is lagging behind. This study took a broad approach to understanding implementation of stop smoking support (SSS) by MHCPs (N = 220 for main analyses), incorporating background characteristics, psychosocial factors, client factors, and organizational/environmental factors. Variable selection was based on previous work and the Consolidated Framework for Implementation Research.

Psychosocial situation, burden, and unmet needs among informal caregivers prior to hematopoietic stem cell transplantation: a systematic review of quantitative and qualitative data.

Background: Informal caregivers may face challenges, especially during the pre-transplant phase. We have learned about the challenges faced by informal caregivers during hematopoietic stem cell transplantation; there is a lack of consensus about the challenges faced by them before transplantation. We identified the psychosocial well-being of informal caregivers to patients before hematopoietic stem cell transplantation.

Glucose Lowering through Weight management (GLoW): a randomised controlled trial of the clinical and cost effectiveness of a diabetes education and behavioural weight management programme vs a diabetes education programme in adults with a recent diagnosis of type 2 diabetes.

Aims/hypothesis: UK standard care for type 2 diabetes is structured diabetes education, with no effects on HbA, small, short-term effects on weight and low uptake. We evaluated whether remotely delivered tailored diabetes education combined with commercial behavioural weight management is cost-effective compared with current standard care in helping people with type 2 diabetes to lower their blood glucose, lose weight, achieve remission and improve cardiovascular risk factors.

Methods: We conducted a pragmatic, randomised, parallel two-group trial.

Perceived financial hardship and sleep in an adult population-based cohort: The mediating role of psychosocial and lifestyle-related factors.

Background: Social inequalities in sleep have been reported, but there is less research on the mechanisms underlying this association. This study investigates the relationship between financial hardship and sleep within the general adult population, focusing on the mediating effects of psychosocial and lifestyle-related factors.

Methods: We used data from the Specchio cohort, a population-based study in Geneva, Switzerland, initiated in December 2020.

KDIGO 2025 clinical practice guideline for the evaluation, management, and treatment of autosomal dominant polycystic kidney disease (ADPKD): executive summary.

The Kidney Disease: Improving Global Outcomes (KDIGO) 2025 Clinical Practice Guideline for the Evaluation, Management, and Treatment of Autosomal Dominant Polycystic Kidney Disease (ADPKD) represents the first KDIGO guideline on this subject. Its scope includes nomenclature, diagnosis, prognosis, and prevalence; kidney manifestations; chronic kidney disease (CKD) management and progression, kidney failure, and kidney replacement therapy; therapies to delay progression of kidney disease; polycystic liver disease; intracranial aneurysms and other extrarenal manifestations; lifestyle and psychosocial aspects; pregnancy and reproductive issues; pediatric issues; and approaches to the management of people with ADPKD. The guideline has been developed with patient partners, clinicians, and researchers around the world, with the goal to generate a useful resource for healthcare providers and patients by providing actionable recommendations.

Cardiovascular disease and bipolar disorder: A review of pathophysiology and treatment implications.

Objective: Despite the well-established increased risk of cardiovascular mortality in individuals with bipolar disorder (BD), prevention and treatment of cardiovascular risk factors and diseases have been largely overlooked in this population. This manuscript reviews the pathophysiological basis of the connection between BD and cardiovascular diseases, highlighting their shared mechanisms, reciprocal interactions, and relevant prevention and treatment strategies.

Methods: For this narrative review, a search was carried out on PubMed using the keywords bipolar disorder, cardiovascular diseases, and cardiovascular risk factors.