36 results match your criteria: "Psychiatric University Hospitals Basel[Affiliation]"
Br J Nutr
September 2024
Laboratory of Nutrition and Metabolic Epigenetics, Institute of Food, Nutrition and Health, ETH Zürich, Zürich8092, Switzerland.
Depression has been associated with subclinical hypothyroidism and altered hypothalamic-pituitary-thyroid axis functioning. Adequate iodine nutrition is essential for healthy thyroid functioning. We therefore determined associations of iodine and thyroid status with paediatric major depressive disorder (pMDD) among Swiss adolescents and explored whether associations are sex-specific and mediated by stress.
View Article and Find Full Text PDFEur J Nutr
April 2024
Laboratory of Human Nutrition, Institute of Food, Nutrition and Health, ETH Zürich, Zurich, Switzerland.
Purpose: Depression is associated with low-grade systemic inflammation and impaired intestinal function, both of which may reduce dietary iron absorption. Low iron status has been associated with depression in adults and adolescents. In Swiss adolescents, we determined the associations between paediatric major depressive disorder (pMDD), inflammation, intestinal permeability and iron status.
View Article and Find Full Text PDFChildren (Basel)
July 2023
Department of Forensic Child and Adolescent Psychiatry, Psychiatric University Hospitals Basel, 4002 Basel, Switzerland.
To investigate if the Personality Disorder (PD) severity concept (Criterion A) of the ICD-11 and DSM-5 AMPD is applicable to children and adolescents, following the ICD-11 lifespan perspective of mental disorders, age-specific and informant-adapted assessment tools are needed. The (Levels of Personality Functioning Questionnaire Parent Rating) was developed to assess Impaired Personality Functioning (IPF) in children aged 6-18 in parent-reported form. It is based on the established self-report questionnaire .
View Article and Find Full Text PDFJ Affect Disord
October 2023
Laboratory of Human Nutrition, Institute of Food, Nutrition and Health, ETH Zürich, Switzerland; Department of Nutritional Sciences, King's College London, London, United Kingdom. Electronic address:
Background: Observational studies suggest a link between n-3 polyunsaturated fatty acid (PUFA) intake, n-3 PUFA status, and depression in adults, but studies in adolescents are scarce. This study aimed to determine associations of n-3 PUFA status and intake with paediatric major depressive disorder (pMDD) in Swiss adolescents.
Methods: We conducted a matched case-control study in 95 adolescents diagnosed with pMDD and 95 healthy controls aged 13 to <18 years.
Front Hum Neurosci
June 2023
Department of Child and Adolescent Psychiatry and Psychotherapy, University Hospital of Psychiatry Zurich, University of Zurich, Zürich, Switzerland.
Background: Executive functions (EF) consolidate during adolescence and are impaired in various emerging psychiatric disorders, such as pediatric Major Depressive Disorder (pMDD) and Borderline Personality Disorder. Previous studies point to a marked heterogeneity of deficits in EF in pMDD. We examined the hypothesis that deficits in EF in adolescents with pMDD might be related to comorbid Borderline Personality features (BPF).
View Article and Find Full Text PDFFront Psychiatry
June 2023
Center of Excellence on Personality Disorder, Psychiatric Research Unit, Region Zealand, Slagelse Psychiatric Hospital, Slagelse, Denmark.
While for decades, temporal stability has been conceived as a defining feature of personality disorders (PDs), cumulative findings appear to question the stability of PDs and PD symptoms over time. However, stability itself is a complex notion and findings are highly heterogenous. Building upon a literature search from a systematic review and meta-analysis, this narrative review aims to capture key findings in order to provide critical implications, both for clinical practice and future research.
View Article and Find Full Text PDFClin Psychol Rev
June 2023
Department of Clinical Research, Medical Faculty, University of Basel, Basel, Switzerland.
The aim of this systematic review and meta-analysis was to investigate the diagnostic, the dimensional mean-level, and rank-order stability of personality disorders (PDs) and PD criteria over time. EMBASE, PsycInfo, PubMed, and Web of Science were searched for peer-reviewed studies published in either English, German, or French between the first publication of the third edition of the Diagnostic and Statistical Manual of Mental Disorders (DSM-III) in 1980 and December 20, 2022. Inclusion criteria were a prospective longitudinal study design, assessing the stability of PDs or PD criteria over at least two measurement occasions at least one month apart, and using the same assessment at baseline and follow-up.
View Article and Find Full Text PDFJ Neuroendocrinol
July 2023
Department of Psychiatry, The Hospital for Sick Children, Toronto, ON, Canada.
Digital media screens have become an essential part of our family life. However, we have insufficient knowledge about parental screen use patterns and how these affect children's socio-emotional development. In total, 867 Canadian parents of 5-year-old children from the TARGet Kids! Cohort (73.
View Article and Find Full Text PDFSci Rep
March 2023
Division of Neuropsychology, Department of Psychology, University of Konstanz, Fach 905, Universitaetsstrasse 10, 78464, Constance, Germany.
While many studies investigated basic facets of empathy, less is known about the association with early life adversity (ELA). To investigate a possible association of empathy with ELA, we assessed self-reported ELA, using the Childhood Trauma Questionnaire (CTQ), the Parental Bonding Instrument (PBI) for mother and father, and empathy, using the Interpersonal Reactivity Index (IRI), in a sample of N = 228 (83% female, age = 30.51 ± 9.
View Article and Find Full Text PDFFront Psychiatry
November 2022
Department of Child and Adolescent Psychiatric Research, Psychiatric University Hospitals Basel, Basel, Switzerland.
Child Adolesc Psychiatry Ment Health
November 2022
Department of Child and Adolescent Psychiatric Research, Psychiatric University Hospitals Basel, Basel, Switzerland.
Background: While the psychopathological sequalae of childhood maltreatment are widely acknowledged, less is known about the underlying pathways by which childhood maltreatment might lead to an increased risk for mental health problems. Recent studies indicated that impaired personality functioning might mediate this relationship. The aim of the present paper was to extend the current literature by investigating the mediating effect of impaired personality functioning between different types of childhood maltreatment and self-reported mental health problems in a high-risk sample.
View Article and Find Full Text PDFFront Psychiatry
September 2022
Department of Child and Adolescent Psychiatric Research, Psychiatric University Hospitals Basel (UPK), Basel, Switzerland.
Objective: Within a longitudinal study (10-year follow-up), we aim to examine the role of anger/irritability and limited prosocial emotion/callous-unemotional traits in predicting externalizing symptoms and adjustment problems in individuals formerly in youth residential care institutions.
Method: These dimensions were assessed in 203 young adults, with baseline assessments during youth residential care and a follow-up 10 years later.
Results: In general, emotional problems and psychopathological symptoms did not reduce over time.
Int J Offender Ther Comp Criminol
September 2024
University Clinics for Child and Adolescent Psychiatry and Psychotherapy, Salzburger Landeskliniken, Paracelsus Medical University, Salzburg, Austria.
The aim of the current paper was to examine temperament profiles and temperament dimensions as risk factors for persistent criminal behavior in juveniles who offended (JOs). A sample of 137 male adolescents from a Swiss detention center and 137 age and sex matched community controls were included in the present study. Temperament was measured with the Junior Temperament and Character Inventory (JTCI).
View Article and Find Full Text PDFFront Psychol
June 2022
Department of Psychology, Division of Neuropsychology, University of Konstanz, Konstanz, Germany.
Growing evidence suggests that natural environments - whether in outdoor or indoor settings - foster psychological health and physiological relaxation, indicated by increased wellbeing, reduced stress levels, and increased parasympathetic activity. Greater insight into differential psychological aspects modulating psychophysiological responses to nature-based relaxation videos could help understand modes of action and develop personalized relaxation interventions. We investigated heart rate variability (HRV) as an indicator of autonomic regulation, specifically parasympathetic activity, in response to a 10-min video intervention in two consecutive studies as well as heart rate (HR).
View Article and Find Full Text PDFPsychoneuroendocrinology
October 2021
Department of Psychology, Division of Neuropsychology, University of Constance, Universitätsstraße 10, 78467 Constance, Germany; Child, and Adolescent Research Department, Psychiatric University Hospitals Basel (UPK), University of Basel, Switzerland.
The stress response supports survival through energy mobilization. Paradoxically, a low blood glucose level dampens the endocrine stress response, and sugar consumption prior to stress restores it. Thus, energy availability may play a causal role in the endocrine stress response.
View Article and Find Full Text PDFSci Rep
September 2021
Department of Psychology, Centre for Psychiatry, University of Konstanz, Feuerstein-Strasse. 55, Haus 22, 78479, Konstanz, Germany.
The aftermath of traumatization lives on in the neural and epigenetic traces creating a momentum of affliction in the psychological and social realm. Can psychotherapy reorganise these memories through changes in DNA methylation signatures? Using a randomised controlled parallel group design, we examined methylome-wide changes in saliva samples of 84 female former child soldiers from Eastern DR Congo before and six months after Narrative Exposure Therapy. Treatment predicted differentially methylated positions (DMPs) related to ALCAM, RIPOR2, AFAP1 and MOCOS.
View Article and Find Full Text PDFJ Neural Transm (Vienna)
September 2021
University of Konstanz, Konstanz, Germany.
Physiological synchrony (PS) is defined as the co-occurrence and interdependence of physiological activity between interaction partners. Previous research has uncovered numerous influences on the extent of PS, such as relationship type or individual characteristics. Here, we investigate the influence of acute stress on PS.
View Article and Find Full Text PDFJ Neural Transm (Vienna)
September 2021
Department of Psychology, Division of Neuropsychology, University of Constance, Constance, Germany.
Individuals with a history of low maternal care (MC) frequently present a blunted, yet sometimes also show an increased cortisol stress response. Fasted individuals with low blood glucose levels who are exposed to acute stress typically show an attenuated response pattern in this endocrine marker. Despite well-documented metabolic dysregulations after low MC, a possible interaction of both factors has not been investigated yet.
View Article and Find Full Text PDFNutrients
November 2020
Department of Child and Adolescent Psychiatry and Psychotherapy, Psychiatric Hospital, University of Zurich, 8032 Zurich, Switzerland.
Omega-3 polyunsaturated fatty acids (n-3 PUFAs) have been described as positively associated with cognitive functioning. Current meta-analyses have identified eicosapentaenoic acid (EPA) as potentially more effective than docosahexaenoic acid (DHA). An especially vulnerable subgroup that might benefit from these beneficial effects are depressed youths.
View Article and Find Full Text PDFSci Rep
September 2020
Department of Psychology, Division of Clinical Neuropsychology, University of Constance, Constance, Germany.
Health and disease are strongly linked to psychophysiological states. While stress research strongly benefits from standardized stressors, no established protocol focuses on the induction of psychophysiological relaxation. To maintain health, functioning regenerative systems are however likely as important as functioning stress systems.
View Article and Find Full Text PDFChild Psychiatry Hum Dev
October 2020
Child and Adolescent Psychiatric Hospital, Psychiatric University Hospitals Basel, Basel, Switzerland.
The original version of this article were unfortunately published with an error in "Methods" section. This has been corrected by publishing this correction article.
View Article and Find Full Text PDFJ Affect Disord
July 2020
Department of Child and Adolescent Psychiatry and Psychotherapy, Psychiatric University Hospital Zurich, University of Zurich, Switzerland.
Background: Parents and their children often disagree on the existence and severity of psychopathological symptoms, especially in major depressive disorder (MDD). Discrepant estimations pose a problem for the validity of diagnoses and illness severity with major implications for treatment evaluation.
Methods: 118 adolescents aged 13-18 years and their parents were interviewed and their reports were compared regarding the presence of a MDD diagnosis.
Neurosci Biobehav Rev
May 2020
Department of Child and Adolescent Psychiatry and Psychotherapy, Psychiatric Hospital, University of Zurich, Switzerland. Electronic address:
Omega-3 fatty acids are vital for brain development. The aim of this meta-analysis was to broaden current knowledge of the effects of omega-3 supplementation on cognitive test performance in youths. Randomized controlled trials (RCTs) meeting selection criteria were identified through two independent literature searches on PubMed, Cochrane Library, PsycARTICLES and PsycINFO (last search June 2019).
View Article and Find Full Text PDFPsychopathology
April 2020
Child and Adolescent Research Department (UPKKJ), Psychiatric University Hospitals Basel (UPK), University of Basel, Basel, Switzerland.
Introduction: Attachment disorder (AD), including reactive AD and disinhibited social engagement disorder, is a prevalent, yet underdiagnosed disorder in severely maltreated children. Because the condition is associated with significant psychiatric morbidity over the entire lifespan, a valid and economic screening tool to identify children with clinical symptoms of AD is needed to avoid unspecific or ineffective treatment. The present study aimed to assess the effectiveness and efficiency of the German version of the Relationship Problems Questionnaire (RPQ).
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