4 results match your criteria: "Psychiatric Centre Copenhagen and University of Copenhagen[Affiliation]"
Effects of muscarinic M and M acetylcholine receptor stimulation on extinction and reinstatement of cocaine seeking in male mice, independent of extinction learning.
Psychopharmacology (Berl)
March 2018
Alcohol and Drug Abuse Research Center, McLean Hospital/Harvard Medical School, Belmont, MA, USA.
Article Synopsis
- Stimulation of muscarinic M/M receptors can reduce the reinforcing effects of cocaine and may help with cravings and relapse in addiction.
- A study tested whether activating these receptors could speed up the extinction process in mice trained to self-administer cocaine, finding that certain agonists significantly reduced the number of sessions needed for extinction.
- Results indicated that treating mice with receptor stimulation not only hastened extinction but also minimized relapse risk to cocaine, suggesting a lasting neurochemical change beyond just the learning process.
Muscarinic receptor M positive allosteric modulators attenuate central effects of cocaine.
Drug Alcohol Depend
July 2017
Laboratory of Neuropsychiatry, Psychiatric Centre Copenhagen and University of Copenhagen, Copenhagen, Denmark; Alcohol and Drug Abuse Research Center, McLean Hospital/Harvard Medical School, Belmont, MA, USA. Electronic address:
Background: Cocaine addiction is a chronic brain disease affecting neurotransmission. Muscarinic cholinergic receptors modulate dopaminergic signaling in the reward system, and muscarinic receptor stimulation can block direct reinforcing effects of cocaine. Here, we tested the hypothesis that specific muscarinic M receptor stimulation can attenuate the discriminative stimulus effects and conditioned rewarding effects of cocaine, measures believed to predict the ability of cocaine and cocaine-associated cues to elicit relapse to drug taking.
View Article and Find Full Text PDFEffects of muscarinic receptor antagonists on cocaine discrimination in wild-type mice and in muscarinic receptor M, M, and M receptor knockout mice.
Behav Brain Res
June 2017
Alcohol and Drug Abuse Research Center, McLean Hospital/Harvard Medical School, Belmont, MA, USA; Laboratory of Neuropsychiatry, Psychiatric Centre Copenhagen and University of Copenhagen, Copenhagen, Denmark. Electronic address:
Muscarinic M/M receptor stimulation can reduce abuse-related effects of cocaine and may represent avenues for treating cocaine addiction. Muscarinic antagonists can mimic and enhance effects of cocaine, including discriminative stimulus (S) effects, but the receptor subtypes mediating those effects are not known. A better understanding of the complex cocaine/muscarinic interactions is needed to evaluate and develop potential muscarinic-based medications.
View Article and Find Full Text PDFExposure characteristics and peri-trauma emotional reactions during the 2004 tsunami in Southeast Asia--what predicts posttraumatic stress and depressive symptoms?
Compr Psychiatry
February 2012
Centre for Crisis and Disaster Psychiatry, Psychiatric Centre Copenhagen and University of Copenhagen, DK-2100 Copenhagen, Denmark.
This study examined the impact of disaster-related stressors and peri-trauma emotional reactions on mental health 10 months after the 2004 Southeast Asian tsunami disaster in a sample of 660 Danish tourists evacuated from the disaster area. The estimated rates of posttraumatic stress disorder and depression were 10.2% and 6.
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