217 results match your criteria: "Pseudoporphyria"
A review on toxic epidermal necrolysis-like superficial wound lesions: Issue and challenge on 10 clinical entities.
Int Wound J
December 2024
Student Research Committee, Isfahan University of Medical Sciences, Isfahan, Iran.
Toxic epidermal necrolysis (TEN) is a severe skin reaction caused by extensive epidermal and mucosal necrosis. This clinical phenomenon is known as an acute syndrome of apoptotic pan-epidermolysis (ASAP). The ASAP phenomenon is observed in conditions that mimic TEN, highlighting the challenge in distinguishing these conditions.
View Article and Find Full Text PDFMyocardial injury caused by Hongo.
World J Emerg Med
January 2024
Department of Emergency Medicine, the First Affiliated Hospital of Hunan Normal University (People's Hospital of Hunan Province), Changsha 410005, China.
Drug-associated porphyria: a pharmacovigilance study.
Orphanet J Rare Dis
August 2024
Department of Pharmacy, Peking Union Medical College Hospital (PUMCH), Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Article Synopsis
- * Researchers analyzed ADRs related to porphyria from January 2004 to March 2022 and narrowed down 406 drugs, ultimately identifying 52 drugs associated with adverse effects using various statistical algorithms.
- * The findings provide essential insights into the safety of drugs for porphyria carriers, helping healthcare providers make informed decisions and avoid prescribing harmful medications.
Article Synopsis
- - The goal of the educational activity is to enhance understanding of how pseudoporphyria manifests in patients.
- - It's aimed at healthcare professionals like doctors and nurses who focus on skin and wound care.
- - Participants will learn to recognize pseudoporphyria's symptoms, differentiate it from other conditions that cause blistering, and understand treatment options.
A rare case of meloxicam-induced pseudoporphyria.
Dermatol Online J
April 2024
Complete Dermatology, Conroe, Texas, USA.
Article Synopsis
- Drug-induced pseudoporphyria is often caused by NSAIDs like naproxen and ibuprofen, but this case highlights meloxicam as a potential cause.
- A 55-year-old woman with multiple health issues developed skin blisters on her feet, later diagnosed as pseudoporphyria linked to her meloxicam use.
- The patient's symptoms improved after stopping meloxicam, suggesting that awareness of this medication's risk can aid dermatologists in diagnosis and treatment.
Drug-Induced Pseudoporphyria: A Case Report.
Cureus
April 2024
Dermatology, Jawaharlal Nehru Medical College, Datta Meghe Institute of Higher Education and Research, Wardha, IND.
Article Synopsis
- - Pseudoporphyria is a rare skin condition that resembles porphyria cutanea tarda (PCT), and distinguishing between the two is crucial for accurate diagnosis.
- - It’s linked to chronic kidney failure, certain medications, and tanning bed use, and can cause skin issues like fragility, blisters, and scarring, especially in sun-exposed areas.
- - A case report highlights a 20-year-old male diagnosed with pseudoporphyria after ruling out true porphyria, who was treated with hydroxychloroquine sulfate and advised to take strict sun protection measures.
Dermatological Manifestations in Patients With Chronic Kidney Disease: A Review.
Cureus
January 2024
Digital Health, Universidad Nacional Autónoma de México, Ciudad de Mexico, MEX.
Article Synopsis
- Chronic kidney disease (CKD) progresses over time, leading to various skin-related symptoms as toxin levels and inflammation increase in the body.
- Nonspecific skin issues might include itching, dry skin, and pigmentation problems, while more specific conditions could involve serious disorders like eruptive xanthoma and nephrogenic systemic fibrosis.
- Recognizing these skin changes early is crucial for improving treatment outcomes and overall patient health, as they can indicate underlying CKD complications and the need for timely intervention.
Antineoplastic drugs-related medication-associated pseudoporphyria.
JAAD Case Rep
December 2023
Department of Dermatology, University of California, Davis Medical Center, Sacramento, California.
Olaparib-induced pseudoporphyria in a patient with ovarian cancer.
JAAD Case Rep
September 2023
Department of Dermatology, University of Oklahoma Health Science Center, Oklahoma City, Oklahoma.
Pseudoporphyria Induced by Voriconazole in a 10-year-old Boy: A Case Report and Review of the Literature.
Acta Derm Venereol
May 2023
Pediatric Dermatology Unit, Department of Medicine DIMED, University of Padova, Padova, Italy.
Drug-Induced Photosensitivity: Clinical Types of Phototoxicity and Photoallergy and Pathogenetic Mechanisms.
Front Allergy
June 2022
Department of Clinical and Experimental Medicine, Dermatology, University of Messina, Messina, Italy.
Article Synopsis
- - Drug-induced photosensitivity (DIP) is a common skin reaction caused by drug interactions with UV radiation, with two main types: phototoxicity, which leads to immediate damage resembling sunburn, and photoallergy, which produces a delayed immune response. - The mini-review outlines various clinical presentations of DIP, including unique forms like hyperpigmentation, pseudoporphyria, and erythema multiforme, as well as how doctors can recognize and treat these reactions effectively. - It emphasizes the importance of educating patients at risk about DIP, promoting safer sun habits, and utilizing protective measures like sunscreens and clothing, while pointing out the current lack of sun safety programs aimed at these patients.
as a differential diagnosis for limb ulcers: case report.
J Vasc Bras
September 2022
Universidade Estadual Paulista Júlio de Mesquita Filho - UNESP, Faculdade de Medicina, Campus de Botucatu, Botucatu, SP, Brasil.
Article Synopsis
- Bullosis diabeticorum (BD) is a rare skin condition associated with diabetes, characterized by painless bloody blisters that can develop into necrotic ulcers, particularly affecting the upper limbs.
- A case study of a 77-year-old man with poor diabetes control and hypertension showed lesions that progressed from blisters to ulcers, leading to a biopsy that confirmed BD.
- Treatment involved smoking cessation, better blood sugar management, and topical corticosteroids, resulting in improvement and healing of the lesions.
Renal Transplantation Could Reverse Dialysis-Associated Porphyria.
Cureus
August 2022
Urology, Gauhati Medical College & Hospital, Guwahati, IND.
Article Synopsis
- Pseudoporphyria (PP) is a rare skin condition that mimics porphyria cutanea tarda but doesn't show porphyrin abnormalities, often affecting patients on dialysis.
- This condition is characterized by blistering skin lesions that appear in areas exposed to light, and while treatments have been ineffective, N-acetylcysteine has shown mixed results.
- In a case study, a patient developed severe skin lesions after starting hemodialysis, but these lesions completely healed within 22 days following a kidney transplant, indicating that renal transplantation is a potential cure for dialysis-induced pseudoporphyria.
Photosensitizing drug reactions.
Clin Dermatol
February 2022
Department of Dermatology, Keck School of Medicine at the University of Southern California, Los Angeles, California, USA.
Photosensitizing drug reactions are cutaneous eruptions that occur after exposure to ultraviolet radiation in patients using photosensitizing medications. The reactions can be broadly classified into phototoxic and photoallergic, with the former being much more common and well documented. There is an extensive list of photosensitizing medications, especially in the case of phototoxicity.
View Article and Find Full Text PDFPseudoporphyria-a diagnostic challenge: A case series and a proposed diagnostic algorithm.
Photodermatol Photoimmunol Photomed
November 2022
Dermatology Department, Hospital Clínic de Barcelona, Universitat de Barcelona, Barcelona, Spain.
Bullous Amyloidosis Masquerading as Pseudoporphyria.
Cutis
September 2021
Dr. Darji is from the Department of Dermatology, Saint Louis University, Missouri. Dr. Butala is from the Dermatology Department, Lancaster Medical Offices, Kaiser Permanente, California. Drs. Manders and Green are from the Department of Dermatology, Cooper University Health Care, Camden, New Jersey.
Article Synopsis
- Amyloidosis encompasses a group of diseases related to abnormal protein folding, resulting in the formation of amyloid fibrils that can affect the skin, among other systems.
- Bullous amyloidosis, though rare, is a specific form that can be diagnosed through unique histopathologic and immunohistochemical patterns, distinguishing it from other skin conditions.
- Recognizing bullous amyloidosis is crucial, as it may indicate a more serious underlying condition, such as multiple myeloma or other lymphoproliferative disorders, which can impact treatment and management.
Pseudoporphyria induced by ultraviolet radiation.
Australas J Dermatol
May 2020
St John's Institute of Dermatology, Guy's and St Thomas' NHS Foundation Trust, London, UK.
An unusual bullous eruption: olanzapine induced pseudoporphyria.
BMJ Case Rep
November 2019
Endocrinology, Royal Liverpool University Hospital, Liverpool, UK.
Article Synopsis
- - A 27-year-old man with schizophrenia developed blistering skin eruptions on his hands, forearms, and face over two days during summer, with no known exposure to chemicals or toxins.
- - Medical examinations showed large, tense blisters, and lab tests ruled out common causes, leading to a diagnosis of pseudoporphyria.
- - The patient's recent introduction of olanzapine, an atypical antipsychotic, was identified as the likely cause of his condition, emphasizing the need for thorough medication history inquiries in clinical settings.
The Potential Uses of N-acetylcysteine in Dermatology: A Review.
J Clin Aesthet Dermatol
May 2019
Drs. May, Reservo, Tung, and Swan are with the Department of Dermatology at the Stritch School of Medicine at Loyola University Chicago in May wood, Illinois. Mses. Janeczek, Riopelle, and Vetter are with the Stritch School of Medicine at Loyola University Chicago in May wood, Illinois.
Article Synopsis
- * The review included a range of clinical studies published from 1966 to 2017, showcasing its efficacy in conditions like acne, excoriation disorder, and more.
- * Overall, N-acetylcysteine appears to be a safe and effective treatment option for numerous dermatological issues, including aiding in wound healing and protecting the skin.
A Case of Voriconazole-Induced Pseudoporphyria.
J Allergy Clin Immunol Pract
February 2019
Division of Allergy and Clinical Immunology, Department of Medicine, East Tennessee State University, Johnson City, Tenn. Electronic address:
N-acetylcysteine in dermatology.
Indian J Dermatol Venereol Leprol
January 2019
Department of Dermatology, Jawaharlal Nehru Medical College, Aligarh Muslim University, Aligarh, Uttar Pradesh, India.
Article Synopsis
- N-acetylcysteine is a mucolytic and antioxidant drug commonly used as an antidote for acetaminophen toxicity and has various applications in dermatology.
- It offers potential benefits for conditions like toxic epidermal necrolysis, drug hypersensitivity syndrome, and several skin disorders, though most evidence comes from small studies and case reports.
- N-acetylcysteine is affordable, generally safe with few side effects, and could have a more significant role in treating skin conditions if supported by higher-quality research.
Direct Immunofluorescence of Mechanobullous Epidermolysis Bullosa Acquisita, Porphyria Cutanea Tarda and Pseudoporphyria.
Acta Derm Venereol
January 2019
Center for Blistering Diseases, Department of Dermatology, University Medical Center Groningen, Hanzeplein 1, NL-9700 RB Groningen, The Netherlands.
Article Synopsis
- Mechanobullous epidermolysis bullosa acquisita (mEBA) shares similar blistering symptoms with other diseases like porphyria cutanea tarda (PCT) and pseudoporphyria, making diagnosis challenging.
- A study analyzed biopsies from patients with mEBA, PCT, and pseudoporphyria to see if direct immunofluorescence could distinctly identify mEBA from the other conditions.
- Results showed overlapping features in staining patterns, but also key differences, emphasizing the need for a comprehensive review of clinical and laboratory data for accurate diagnosis.
Furosemide-induced pseudoporphyria in a patient with chronic kidney disease: case report.
J Bras Nefrol
June 2019
Universidade Federal do Paraná, Complexo Hospital de Clínicas, Departamento de Nefrologia, Curitiba, PR, Brasil.
Article Synopsis
- Pseudoporphyria is a rare skin condition similar to porphyria cutanea tarda but without the porphyrin metabolism issues, often linked to chronic kidney disease, UV exposure, and certain medications.
- A case described a 76-year-old man with stage 4 chronic kidney disease who developed ulcerated skin lesions while on furosemide, leading to a diagnosis of furosemide-induced pseudoporphyria after ruling out infections.
- Prompt diagnosis and treatment are crucial as, although the lesions are mostly benign, they can affect patient health significantly, especially in those with pre-existing conditions like chronic kidney disease.