596 results match your criteria: "Pseudolymphoma Cutaneous"

Article Synopsis
  • Cutaneous reactive lymphoid proliferation (CRLP) mimics cutaneous lymphoma, making it essential to differentiate between the two for correct diagnosis and treatment.* -
  • CRLP can be caused by factors like viruses, drugs, or skin trauma, and requires careful evaluation of clinical and histopathological features for accurate diagnosis.* -
  • A case study highlighted CRLP linked to antidepressant and antihypertensive medications, where excision confirmed the diagnosis, showing benign characteristics with no clonality and prompting ongoing monitoring for recurrence.*
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Article Synopsis
  • Pseudolymphomatous cutaneous angiosarcoma (cAS) is a rare cancer that can be difficult to diagnose due to its similarity to other lymphoid conditions, showcasing notable lymphocyte presence.
  • A unique case involving a 47-year-old woman with systemic sclerosis (SSc) is presented, characterized by facial swelling and specific imaging findings that led to a skin biopsy showing unusual vascular patterns and dense lymphocyte growth.
  • This case highlights the connection between SSc and higher cancer risk, emphasizing the diagnostic challenges of cAS and the need for early detection and comprehensive management strategies.
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Ex Vivo Confocal Laser Scanning Microscopy in Rare Skin Diseases.

Cancers (Basel)

April 2024

Department of Dermatology and Allergy, LMU University Hospital, LMU Munich, 80337 Munich, Germany.

Article Synopsis
  • Ex vivo confocal laser scanning microscopy (CLSM) has been primarily used for common skin diseases, with limited exploration of its effectiveness in rare skin tumors and inflammatory conditions.
  • The study involved imaging 50 tissue samples, including rare disorders, to evaluate diagnostic efficacy and involved three blinded investigators assessing the images for distinct features.
  • Results indicated that imaging expertise significantly improved diagnostic accuracy, with the trained dermatopathologists achieving up to 92% agreement with standard dermatohistopathology, showcasing CLSM's potential as a valuable tool for identifying rare skin disorders.
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Article Synopsis
  • The classification of primary cutaneous lymphomas and lymphoproliferative disorders is evolving, with two new systems: the 5th edition of the WHO classification and the International Consensus Classification (ICC).
  • Significant updates include reclassifying CD8+ acral T-cell lymphoma to LPD and officially recognizing certain provisional entities as definitive.
  • Both classifications emphasize the integration of clinical and molecular data and introduce new diagnostic criteria, highlighting the distinction between terminology used for similar diseases.
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Article Synopsis
  • Borreliosis, or Lyme disease, is caused by the Borrelia burgdorferi bacteria and primarily transmitted by ixodoid ticks, especially affecting children aged five to nine.
  • In Europe, the main early symptom is erythema migrans, while in North America, arthritis is more common.
  • The review highlights cutaneous manifestations such as erythema migrans and lymphocytoma in Europe, discusses diagnosis challenges due to non-specific symptoms, and emphasizes treatment approaches for childhood cases.
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Article Synopsis
  • Tattoos have a long history, but complications can arise from different pigments and application methods; these reactions can be categorized into inflammatory, infectious, neoplastic, aesthetic, and miscellaneous types.
  • Histopathological studies of inflammatory reactions show various patterns, such as lichenoid or granulomatous changes.
  • A significant number of tattooed individuals (up to 67%) report adverse reactions, with certain pigments, especially red ink, being common culprits; pre-existing skin conditions may worsen with tattoos, highlighting the importance of a dermatological consult before getting inked.
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Cutaneous lymphoproliferative disorders: Back to the future.

J Cutan Pathol

June 2024

Department of Dermatology, Leiden University Medical Center, Leiden, The Netherlands.

Article Synopsis
  • In the 1980s, immunohistochemistry and clonality analyses advanced the understanding and classification of cutaneous T-cell lymphoma (CTCL) and cutaneous B-cell lymphoma (CBCL), allowing for more accurate diagnoses.
  • New criteria based on T-cell antigen loss and clonal gene rearrangements shifted many previously misclassified cases to legitimate lymphoma categories, such as primary cutaneous CD4+ small/medium T-cell lymphoma and primary cutaneous marginal zone lymphoma.
  • Recent findings have indicated that low-grade CTCL and CBCL exhibit indolent behavior and high survival rates, prompting revisions in classifications, with some malignancies now identified as lymphoproliferative disorders (LPD) rather than true malignancies.
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Article Synopsis
  • The popularity of tattoos has led to more skin reactions, including infections, allergies, and a rare condition called tattoo-induced cutaneous lymphoid hyperplasia (CLH), which mimics skin cancer.
  • A study from September 2021 to May 2023 used advanced non-invasive tools like reflectance confocal microscopy (RCM) and line-field confocal optical coherence tomography (LC-OCT) to analyze suspicious tattoo-related lesions in five patients diagnosed with CLH.
  • Findings showed that both RCM and LC-OCT effectively identified features of CLH, such as lymphocyte infiltration patterns, and they may offer a cost-effective and efficient alternative to traditional biopsies for diagnosing tattoo-related skin complications in the future.
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Article Synopsis
  • Cutaneous pseudolymphomas are a diverse group of skin diseases that look like cutaneous lymphoma but have different causes and symptoms, and they may appear without any known trigger or following factors like medications, tattoos, or infections.
  • These conditions can present in various ways, from single lesions to widespread issues, with some cases lasting from weeks to years and potentially recurring after disappearing on their own or after treatment.
  • The case study discussed involves a man with a single nodule that was identified as resembling a primary cutaneous CD30+ T-cell lymphoproliferative disorder, highlighting the complex nature of diagnosing these skin diseases.
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Article Synopsis
  • The 2022 Euro-PDT Annual Congress highlighted advancements in photodynamic therapy (PDT) for treating various skin conditions, including acne, mycosis fungoides, and resistant warts.
  • Innovative delivery methods, such as light-emitting fabrics and mobile app-controlled devices, were introduced to enhance the efficacy of PDT across challenging anatomical sites.
  • New strategies, like pre-treatment with calcitriol for actinic keratoses and potential biomarkers for predicting treatment response, indicate a growing understanding of how to optimize PDT for dermatological patients.
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Decrease of 5-hydroxymethylcytosine in primary cutaneous CD4 small/medium sized pleomorphic T-cell lymphoproliferative disorder.

An Bras Dermatol

January 2024

Department of Dermatology, The Second Affiliated Hospital, School of Medicine, Xian Jiaotong University, Xian, China. Electronic address:

Article Synopsis
  • PC-SMTLD is a skin disorder that often resembles pseudolymphoma, making it difficult to diagnose, typically appearing as nodules or plaques, especially on the head and neck.!* -
  • The study found that levels of 5-hydroxymethylcytosine (5-hmC) were significantly lower in PC-SMTLD compared to pseudolymphoma, indicating a potential marker for distinguishing between the two disorders.!* -
  • Although the study had a small sample size, the results suggest that low 5-hmC levels in CD4 lymphocytes could indicate a more serious condition like PC-SMTLD, while higher levels could suggest a benign condition like pseudolymphoma.!*
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Article Synopsis
  • Cutaneous B-cell pseudolymphoma (CBPL) is a skin condition that can show up on areas like the face and chest, presenting as nodules or masses, often without symptoms, and is usually considered idiopathic.
  • Potential triggers for CBPL include trauma, insect bites, tattoos, and certain medications.
  • Diagnosis typically requires a biopsy, and early treatment can prevent serious complications, with some cases resolving spontaneously.
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Article Synopsis
  • T-cell-rich angiomatoid polypoid pseudolymphoma (TRAPP) is a rare skin condition that can be mistaken for other low-grade lymphomas or vascular growths.
  • A case study of a 28-year-old male revealed a solitary red polyp on his neck, which was examined to show specific characteristics like lymphovascular spaces and T-cell-rich infiltrates.
  • The article highlights the importance of distinguishing TRAPP from similar conditions, such as pyogenic granuloma and low-grade cutaneous lymphomas, emphasizing the distinctive features that aid in proper diagnosis.
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