Preventative Effects of Mycelial Extracts on the Early-Stage Development of Cataracts in UVB-Induced Mice Cataract Model.

Cataracts, a prevalent age-related eye condition, pose a significant global health concern, with rising rates due to an aging population and increased digital device usage. In Taiwan, cataract prevalence is particularly high, reaching up to 90% among individuals aged 70 and above. The lens of the eye absorbs short-wave light, which can lead to oxidative stress in lens epithelial cells and contribute to cataract formation.

The Association of Prenatal Antibiotic Use with Attention Deficit and Autism Spectrum Disorders: A Nationwide Cohort Study.

(1) Background: Attention deficit hyperactivity disorder (ADHD) and autism spectrum disorder (ASD) are common cognitive and behavioral disorders. Antibiotics are widely used in pregnant women and their newborns. The objective of this study was to examine the potential association between prenatal exposure to antibiotics and the risk of ADHD and ASD in childhood from a nationwide perspective.

NMDA receptor inhibitor MK801 alleviated pro-inflammatory polarization of BV-2 microglia cells.

Microglia have both protective and pathogenic properties, while polarization plays a decisive role in their functional diversity. Apart from being an energetic organelle, mitochondria possess biological capabilities of signaling and immunity involving mitochondrial dynamics. The N-methyl-D-aspartate (NMDA)-type glutamate receptor displays excitatory neurotransmission, excitatory neurotoxicity and pro-inflammatory properties in a membrane location- and cell context-dependent manner.

Surgical outcomes of anterior lumbar interbody fusion in revision lumbar interbody fusion surgery.

Backgrounds: Anterior lumbar interbody fusion (ALIF) is an attractive option for revision lumbar interbody fusion as it provides wide access for implant removal and accommodation of large interbody grafts for fusion. However, revision lumbar interbody fusion surgery has not been found to result in significantly better functional outcomes compared with other approaches. To date, no prognostic factors of anterior lumbar interbody fusion in revision lumbar interbody fusion have been reported.

CDN1163, a SERCA activator, causes intracellular Ca leak, mitochondrial hyperpolarization and cell cycle arrest in mouse neuronal N2A cells.

Objective: Activity or expression of sarcoplasmic/endoplasmic reticulum Ca ATPase (SERCA) is diminished in some disease states such as cardiac failure and diabetes mellitus. A newly developed activator of SERCA, CDN1163, reportedly rescued or alleviated pathological conditions attributed to dysfunctional SERCA. We examined whether CDN1163 could relieve mouse neuronal N2A cell growth inhibition caused by cyclopiazonic acid (CPA, SERCA inhibitor).

Binuclear Copper(I) Complexes for Near-Infrared Light-Emitting Electrochemical Cells.

Two binuclear heteroleptic Cu complexes, namely Cu-NIR1 and Cu-NIR2, bearing rigid chelating diphosphines and π-conjugated 2,5-di(pyridin-2-yl)thiazolo[5,4-d]thiazole as the bis-bidentate ligand are presented. The proposed dinuclearization strategy yields a large bathochromic shift of the emission when compared to the mononuclear counterparts (M1-M2) and enables shifting luminescence into the near-infrared (NIR) region in both solution and solid state, showing emission maximum at ca. 750 and 712 nm, respectively.

A new federated learning-based wireless communication and client scheduling solution for combating COVID-19.

Federated learning is a machine learning method that can break the data island. Its inherent privacy-preserving property has an important role in training medical image models. However, federated learning requires frequent communication, which incur high communication costs.

Suppressive Effects of on Depression through Regulating the Gut Microbiota and Metabolites in C57BL/6J Mice Induced by Ampicillin.

Depression is a medical and social problem. Multiple metabolites and neuroinflammation regulate it. Modifying the gut microbiota with probiotics to reduce depression through the gut-brain axis is a potential treatment strategy.

Evaluation of antioxidant and anti-obesity potential of extracts.

Unlabelled: are brown algae belonging to the class . Brown algae are rich in nutrients and widely used in food. Most previous experiments have focused on the functional evaluation of organic solvent extracts of .

Anti-aging biomaterial sturgeon chondroitin sulfate upregulating anti-oxidant and SIRT-1/c-fos gene expression to reprogram stem cell senescence and prolong longevity.

Aging involves tissue and cell potential dysfunction characterized by stem cell senescence and extracellular matrix microenvironment (ECM) alteration. Chondroitin sulfate (CS), found in the ECM of normal cells and tissues, aids in maintaining tissue homeostasis. Here, CS-derived biomaterial (CSDB) from sturgeon is extracted to investigate its antiaging effect in senescence-accelerated mouse prone-8 (SAMP8) mice and elucidate the underlying mechanism of its action.

The classification of stages of epiretinal membrane using convolutional neural network on optical coherence tomography image.

Background And Objective: The gold standard for diagnosing epiretinal membranes is to observe the surface of the internal limiting membrane on optical coherence tomography images. The stages of the epiretinal membrane are used to decide the condition of the health of the membrane. The stages are not detected because some of them are similar.

Joint Data Transmission and Energy Harvesting for MISO Downlink Transmission Coordination in Wireless IoT Networks.

The advent of simultaneous wireless information and power (SWIPT) has been regarded as a promising technique to provide power supplies for an energy sustainable Internet of Things (IoT), which is of paramount importance due to the proliferation of high data communication demands of low-power network devices. In such networks, a multi-antenna base station (BS) in each cell can be utilized to concurrently transmit messages and energies to its intended IoT user equipment (IoT-UE) with a single antenna under a common broadcast frequency band, resulting in a multi-cell multi-input single-output (MISO) interference channel (IC). In this work, we aim to find the trade-off between the spectrum efficiency (SE) and energy harvesting (EH) in SWIPT-enabled networks with MISO ICs.

The role of employee assistance programs under COVID-19-induced work-family conflict: Effects on service employees' work engagement and burnout.

The COVID-19 pandemic places substantial stress on service employees' work and home lives. Little research has explored the negative effects of perceived stress from COVID-19 on work and home domains in terms of employees' attitudes toward work. We adopt a job demands-resources perspective to examine how perceived stress from COVID-19 affects employees' work (i.

Sex-specific genetic variants associated with adult-onset inguinal hernia in a Taiwanese population.

Inguinal hernia repair is one of the most common surgeries worldwide. However, there is limited information on its underlying genetic mechanism. Studies on the genetic factors related to inguinal hernia in Han Chinese are lacking.

Developing a Robotic Surgical Platform Is Beneficial to the Implementation of the ERAS Program for Colorectal Surgery: An Outcome and Learning Curve Analysis.

Background: Robotic surgery and ERAS protocol care are both prominent developments and have each become global trends. However, the effects and learning curves of combining robotic surgery and ERAS care in colorectal resection have not yet been well validated. This study aimed to present our real-world experience and establish the learning curves necessary for the implementation of an ERAS program in minimally-invasive surgery for colorectal resection, while also evaluating the impact that the development of the robotic technique has on ERAS outcomes.

Effects of Water Extract on Immune Responses and Digestive Enzymes in White Shrimp .

(Burk) F. H. Chen is a traditional Chinese herbal medicine commonly used in clinical applications.

Systemic Anticoagulation and Inpatient Outcomes of Pancreatic Cancer: Real-World Evidence from U.S. Nationwide Inpatient Sample.

Pancreatic cancer can induce a hypercoagulable state which may lead to clinically apparent thrombosis. However, the effect of anticoagulants remains ambiguous. This study aimed to investigate the potential effect of long-term systemic anticoagulant usage on hospitalization outcomes of patients with pancreatic cancer.