120 results match your criteria: "Protothecosis Cutaneous"
Cutaneous protothecosis: a new case and review of Brazilian patients.
Dermatol Online J
October 2024
Institute of Dermatology Professor Rubem David Azulay, Rio de Janeiro, Brazil.
Protothecosis is a rare but emerging infectious disease, caused by algae from the genus Prototheca. It presents predominantly as cutaneous lesions and poses a diagnostic challenge owing to its diverse clinical presentation. Typically, it occurs in exposed areas of the skin, associated with trauma.
View Article and Find Full Text PDFCombinatory effect of ALA-PDT and itraconazole in the treatment of cutaneous protothecosis.
Photodiagnosis Photodyn Ther
October 2024
Department of Dermatology and Venereology, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, #107 Yanjiang West Rd., Guangzhou, Guangdong 510120, China. Electronic address:
Article Synopsis
- Protothecosis, a rare subcutaneous infection caused by Prototheca wicherhamii, often goes misdiagnosed and lacks a standardized treatment; combined oral itraconazole and 5-aminolevulinic acid photodynamic therapy (ALA-PDT) has been explored for therapy.* -
- The study examined the effects of different ALA concentrations and light doses on inhibiting P. wickerhamii growth and utilized transmission electron microscopy (TEM) to observe cellular changes, confirming ALA-PDT disrupts the cell structure of the fungus.* -
- Treatment of a patient showed that the combined therapy was effective over a 9-week period, with ALA-PDT enhancing the effectiveness of itraconazole
Successful Treatment of Refractory Cutaneous Protothecosis With MAT2203, an Oral Lipid Nanocrystal Formulation of Amphotericin B.
Open Forum Infect Dis
August 2024
Fungal Pathogenesis Section, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA.
Article Synopsis
- Cutaneous protothecosis is an uncommon infection that affects the skin and can spread systemically, requiring long-term treatment with medications that may have harmful side effects.
- The case study focuses on a patient whose skin infection did not respond to standard triazole treatment.
- The patient showed significant improvement after being treated with a new oral formulation of amphotericin B, which was effective without causing any toxicity.
Disseminated protothecosis: Case report and review of the literature.
J Cutan Pathol
September 2024
Department of Radiology, Advanced Diagnostic and Interventional Radiology Research Center (ADIR), Tehran University of Medical Sciences (TUMS), Tehran, Iran.
Article Synopsis
- Human protothecosis is a rare infection caused by the Prototheca species, and it primarily affects immunocompromised individuals.
- A case study of a 24-year-old man with skin lesions was reported, alongside a review of 54 disseminated protothecosis cases, showing a predominance in males and cases caused mainly by P. wickerhamii.
- Treatment options include Amphotericin B for severe infections, while localized cases may require surgical intervention; early diagnosis relies on recognizing distinct skin appearances.
Successful Treatment of Cutaneous Protothecosis Due to with Terbinafine.
Clin Cosmet Investig Dermatol
April 2024
Department of Dermatology, Guangzhou Dermatology Hospital, Guangzhou, 510095, People's Republic of China.
Protothecosis, an infrequent human infection, is caused by achlorophyllic algae belonging to the genus Prototheca, particularly Prototheca wickerhamii. The skin stands as the most commonly affected organ. This report documents a case involving an 82-year-old male with Protothecosis.
View Article and Find Full Text PDFSuccessful treatment of cutaneous protothecosis with fluconazole: A case report and epidemiology study of Prototheca infection in China.
J Cosmet Dermatol
June 2024
Department of Infectious Diseases, People's Hospital of Tiantai County, Taizhou, Zhejiang, China.
Article Synopsis
- Protothecosis is a fungal infection that can affect both immunocompromised and healthy individuals; the study focuses on its epidemiology in China.
- A successful case of cutaneous protothecosis treated with fluconazole is reported, alongside an analysis of 29 other cases, highlighting Prototheca wickerhamii as the most common infection in the region.
- The findings aim to improve understanding and clinical strategies for diagnosing and treating protothecosis in China, with itraconazole being the preferred treatment option.
Cutaneous protothecosis: contrasting case presentations.
Pathology
December 2023
Sullivan Nicolaides Pathology, Brisbane, Qld, Australia.
Protothecosis in four dogs in New Zealand.
N Z Vet J
November 2023
Eyevet Services Ltd., Feilding, New Zealand.
Article Synopsis
- - Medical records of four dogs in New Zealand diagnosed with protothecosis showed varied symptoms including ocular problems, gastrointestinal issues, and skin lesions, confirming a rare but serious condition.
- - Findings revealed severe complications such as panuveitis, retinal detachment, chronic hemorrhagic diarrhea, and skin ulcerations, with diagnosis confirmed through histopathology and PCR tests.
- - Despite initial treatment efforts, only two dogs received specific medication for the infection, leading to the unfortunate decision to euthanize all four due to worsening clinical signs and quality of life concerns.
Intralesional amphotericin B in a cat with cutaneous protothecosis.
Vet Dermatol
December 2023
Department of Veterinary Medicine, School of Medicine and Life Sciences, Pontifical Catholic University of Paraná, Curitiba, PR, Brazil.
A domestic cat was presented with nodular lesions on the nose/muzzle and pinnae. Protothecosis was diagnosed through cytological and histopathological examination, and culture. Molecular identification confirmed Prototheca wickerhamii infection.
View Article and Find Full Text PDFCorrection to: Cutaneous protothecosis in a dog successfully treated with oral itraconazole in pulse dosing.
Acta Vet Scand
June 2023
Department of Veterinary Medicine, School of Life and Sciences, Pontificia Universidade Catolica do Parana, 1155 Imaculada Conceicao Street, Curitiba, PR 80215-901, Brazil.
Cutaneous protothecosis in a solid organ transplanted patient.
An Bras Dermatol
November 2023
Italian Hospital of Buenos Aires, CABA, Argentina.
The oldest patient infected with cutaneous protothecosis.
J Wound Care
April 2023
Department of Surgery, Abington-Jefferson Health, Abington, PA, US.
Article Synopsis
- Human protothecosis is a rare algal infection that primarily affects people with weakened immune systems, especially those on glucocorticoids.
- The case discusses an 89-year-old woman with difficult-to-heal wounds who was found to be infected with protothecosis.
- Treatment included surgically cleaning (debriding) the wounds, leading to improvement and granulation, marking this as the oldest known case of human protothecosis treatment.
Drug Susceptibility Profiling of Species Isolated from Cases of Human Protothecosis.
Antimicrob Agents Chemother
April 2023
Department of Medical Microbiology, Institute of Microbiology, Faculty of Biology, University of Warsaw, Warsaw, Poland.
Article Synopsis
- Unicellular, yeast-like microalgae known as prototheca can cause opportunistic infections in humans, often leading to cutaneous, joint, or systemic diseases.
- A study analyzed 23 human isolates for their susceptibility to various antifungal drugs, revealing that efinaconazole showed the most promising activity against these infections, while azoles like fluconazole had the least effectiveness.
- The findings highlight significant variability in drug resistance among different prototheca species and strains, indicating that treatment may need to be tailored based on the patient's treatment history.
Human protothecosis: A case report in northeastern Brazil.
Med Mycol Case Rep
June 2023
Universidade Federal do Maranhão (UFMA), Brazil.
Article Synopsis
- A case of extensive human cutaneous protothecosis was reported in northeastern Brazil, diagnosed through skin sample examination and culture on Sabouraud dextrose agar.
- Initial treatment with itraconazole was unsuccessful, but switching to liposomal amphotericin followed by voriconazole led to a clinical cure.
- Prothotecosis should be considered as a possible diagnosis for skin lesions that appear after trauma, especially if they evolve atypically.
Cutaneous protothecosis in a dog successfully treated with oral itraconazole in pulse dosing.
Acta Vet Scand
February 2023
Department of Veterinary Medicine, School of Life and Sciences, Pontifícia Universidade Católica do Paraná, 1155 Imaculada Conceição Street, Curitiba, PR, 80215-901, Brazil.
Article Synopsis
- A 2-year-old dog in Brazil exhibited chronic cutaneous protothecosis symptoms, including painful lesions, after exposure to sewage; diagnosis involved histopathological examination and culture studies confirming it was caused by P. wickerhamii.
- Treatment with itraconazole was initially effective, but lesions recurred; ultimately, a long-term "pulse" regimen of itraconazole led to complete resolution without recurrence over a 36-month follow-up.
Disseminated Protothecosis Due to Prototheca zopfii and Literature Review.
Am J Dermatopathol
April 2023
Stritch School of Medicine, Loyola University Chicago, Maywood, IL; and.
Article Synopsis
- - Prototheca species are a rare type of algae that can infect humans, mostly causing skin issues, but can lead to more serious infections in immunocompromised individuals.
- - The infection is more commonly linked to Prototheca wickerhamii than to Prototheca zopfii, which is reported less frequently.
- - Diagnosis involves methods like histopathology and culture, while treatment is primarily with antifungals like amphotericin B; however, effective treatments aren't well established.
Cutaneous Protothecosis.
Indian J Dermatol
January 2022
Department of Dermatology, Seth G.S. Medical College and KEM Hospital, Mumbai, Maharashtra, India.
Protothecosis in the mucosa of the pharynx mimicking pharyngeal cancer in an immunocompetent individual: a case report.
Ann Clin Microbiol Antimicrob
February 2022
Department of Infectious Diseases, The University of Tokyo Hospital, 7-3-1, Hongo, Bunkyo-ku, Tokyo, 113-8655, Japan.
Article Synopsis
- Protothecosis is a rare infection caused by algae and is often found in immunocompromised patients, with skin infections being the most common type.
- A case of Prototheca wickerhamii was identified in the throat of a healthy 53-year-old woman, initially misdiagnosed as cryptococcosis, but confirmed through DNA analysis.
- Effective treatment involved surgical removal of the mass and antifungal medications, with no deterioration observed in the lesion over the following year, highlighting the need for accurate diagnosis and tailored treatments.*
Annular infectious dermatoses.
Clin Dermatol
December 2022
Department of Dermatology and Allergy, Technische Universität München, Munich, Germany. Electronic address:
Article Synopsis
- * These lesions can appear in several forms, including ring-shaped and serpiginous patterns, resulting from infections caused by viruses, bacteria, and fungi.
- * Understanding the interplay between infectious agents and the host's immune response is essential for comprehending their patterns and improving diagnosis of conditions like Lyme disease and cutaneous larva migrans.
Cutaneous Protothecosis.
Cutis
August 2021
Drs. Baigrie and Sandoval are from the Department of Dermatology, Sampson Regional Medical Center, Clinton, North Carolina, and Campbell University, Buies Creek, North Carolina. Drs. WJ White and WC White are from Coastal Carolina Pathology, Wilmington, North Carolina. Dr. Tanner is from the Department of Dermatology, Wilmington Health, North Carolina.
Cutaneous Protothecosis with Meningitis Due to in an Immunocompetent Teenager: Case Report and Literature Review.
Infect Drug Resist
July 2021
Department of Laboratory Medicine, Jiangsu Province Hospital and Nanjing Medical University First Affiliated Hospital, Nanjing, People's Republic of China.
Article Synopsis
- - Human protothecosis is a rare infection caused by a type of algae that usually leads to localized skin infections, particularly in immunocompromised individuals.
- - A case report describes an uncommon instance of both skin and meningitis caused by this algae in a healthy teenager who had just gotten full-body tattoos.
- - This report is significant as it marks the first time this specific algae has been identified in both skin tissue and cerebrospinal fluid, helping to expand knowledge and treatment options for this infection.
Case for diagnosis. Ulcer and papular lesions in a patient with diabetes mellitus. Protothecosis.
An Bras Dermatol
September 2021
Fundação de Dermatologia Tropical e Venereologia Alfredo da Matta, Manaus, AM, Brazil.
Article Synopsis
- Protothecosis is a rare disease caused by a type of algae called Prototheca spp., which can present in three main clinical forms: cutaneous, articular, and systemic.
- The cutaneous form is the most frequently observed, often presenting as skin lesions.
- In this study, a patient was initially misdiagnosed with cryptococcosis but was later correctly diagnosed with protothecosis caused by Prototheca wickerhamii, showing specific skin symptoms like erythematous papules and plaques on the scapula.
Protothecosis algaemia in a patient presenting with septic arthritis: A rare case of isolated from Malaysia.
IDCases
April 2021
Mycology Section, Bacteriology Unit, Infectious Disease Research Centre, Institute for Medical Research, National Institutes of Health, Ministry of Health Malaysia.
Article Synopsis
- Prototheca species can cause infections in humans, leading to symptoms like skin infections, bursitis, and systemic disease.
- A case is reported where Prototheca was found in a patient's blood, triggering septic arthritis, but no other pathogens were detected in joint cultures.
- The blood isolate was identified using PCR, and the patient's condition improved after treatment with intravenous itraconazole.
Molecular characterization of in 11 symptomatic dogs.
J Vet Diagn Invest
January 2021
Istituto Zooprofilattico Sperimentale delle Venezie, Legnaro, Padua, Italy.
Protothecosis is an uncommon disease caused by algae of the genus . In dogs, the infection is usually first localized to the colon but has the propensity to later disseminate hematogenously to many other organs, with marked tropism for the eyes and central nervous system. Diagnosis is established by culture and/or evidence of organisms in cytologic or histologic preparations.
View Article and Find Full Text PDFRefractory Human Cutaneous Protothecosis.
Skinmed
October 2021
Pathology Department, University Hospital Crosshouse, NHS Ayrshire & Arran, Scotland, UK;
Article Synopsis
- A 67-year-old Scottish woman visited her doctor with a small lump between her shoulder blades, suspected to be an epidermal cyst.
- After the lump was surgically removed, it reappeared in the same spot after six months and was removed again.
- Both procedures were done in a primary care setting without any laboratory examination of the tissue.