[The application of the Multi-Touch pad for the evaluation of the fine motor activity of the wrist].

Aim: The objective of the present study was to elaborate the method for the evaluation of the fine motor activity of the wrist in the patients presenting with wrist movement disorders resulting from central hemiparesis and to demonstratee the reliability of such method through the calculation of the standard error of measurements and minimal the detectable change (MDC95%).

Material And Methods: The study population was comprised of 42 patients who had undergone ischaemic stroke and suffered from the impairment of the upper limb functions . The deficit of the fine motor skills was estimated with the use of the original multi-touch diagnostic technique.

[The specific clinical features of otogenic intracranial complications: the current views].

The objective of the present study was to elucidate the specific clinical features of otogenic intracranial complications (ICC) encountered in the current otorhinolaryngological practice. The work is based on the results of the retrospective analysis of 106 adult patients presenting with otogenic intracranial complications admitted for the treatment to multidisciplinary clinics of Sankt-Peterburg and Krasnoyarsk. Forty six (42.

[Molecular and pathomorphological prognostic markers for melanoma: Current approaches and prospects].

The incidence of melanoma demonstrates a persistent increasing tendency, which justifies the need to study and identify new prognostic markers for the development and course of this disease. The given paper shows current approaches to melanoma staging, including those to applying pathomorphological prognostic criteria, and discusses prospects for using the results of genomic and epigenomic studies of the carcinoma in clinical practice.

[Inhibition of matrix metalloproteinases 9 and 13 affects the degree of lymphocytic infiltration and the expression levels of microRNA miR-21 and miR-let-7b in melanoma cells in vivo].

Objective: To estimate changes in the trend of growth of primary tumor nodules, the degree of lymphocytic infiltration, and the expression levels of oncomicroRNA miR-21 and miR-let-7b when inhibiting matrix metalloproteinases 9 and 13 (MMP-9 and MMP-13) in vivo in C57B16 mice with transplantable melanoma B-16.

Material And Methods: Tumor growth was evaluated measuring the volume of primary tumor nodules; the degree of lymphocytic infiltration was microscopically estimated using hematoxylin-eosin-stained tissue specimens, by calculating intratumoral lymphocytes. The expression of oncomicroRNA was quantified by real-time PCR.

[The modern epidemiological characteristics of oto- and rhinosinusogenic intracranial complications].

The objective of the present study was to survey epidemiology of oto- and rhinosinusogenic intracranial complications that are currently diagnosed at the territory of the Russian Federation. The work was based on the analysis of the official statistical reports together with the data obtained from the chief specialists responsible for the otorhinolaryngological services in 32 subjects of the Russian Federation during the period from 2009 to 2014. It was shown that the state of the otorhinolaryngological service in the period covered by the study was characterized by the reduction in the number of beds available for the patients presenting with ENT pathology by 14.