Reflections on a Passionate Dental Historian, Colleague, Clinician and Educator Dr. Edward F. Leone (1923-2002).

For years in dental school settings, the teaching of dental history was extolled and emphasized as to the roots of the dental profession. Many colleagues can probably cite the names of those who contributed to this achievement within their academic environments. Most of these academicians were also clinicians who valued the role of history in the progression of dentistry as a respected profession.

Reflections on Prolific Contributors to the Dental Literature and Dental History: Truman vs. Trueman.

Dental literature is rich in its historical evolution, which is extoled by key figures in the late 1800 and early 1900s. This paper will briefly highlight two of these individuals, both based in Philadelphia who had similar names, spelled differently, and who impacted greatly on this historical documentation.

Prevalence of Burnout of Radiologists in Private Practice.

Purpose: The aim of this study was to evaluate the prevalence and demographic factors associated with both burnout and fulfillment of private practice radiologists within the largest coalition of independent wholly physician-owned diagnostic radiology practices within the United States.

Methods: The study cohort included practicing radiologists within the largest coalition of wholly radiologist-owned, independently practicing diagnostic radiology groups within the United States. Practicing radiologists within all 31 radiology private practices within the organization were electronically mailed a web link to a confidential institutional review board-approved survey in August and September 2021.

A Framework to Develop an Immersive Virtual Reality Simulation Tool for Postpartum Hemorrhage Management Nurse Training.

Postpartum hemorrhage (PPH) is the leading cause of maternal mortality and morbidity. Effective nurse training for PPH management can reduce negative health impacts on childbearing women. This article discusses a framework for the development of an innovative immersive virtual reality simulator for PPH management training.

Comparative Pharmacokinetics and Injection Site Histopathology in Nude Mice Treated with Long-acting Buprenorphine Formulations.

Two long-acting formulations of buprenorphine are commercially available as analgesics for rodents. However, these drugs have not yet been studied in nude mice. We sought to investigate whether the manufacturer-recommended or labeled mouse doses of either drug would provide and sustain the purported therapeutic plasma concentration of buprenorphine (1 ng/mL) over 72 h in nude mice and to characterize the injection site histopathology.

Rationale and design of a randomised double-blind 2×2 factorial trial comparing the effect of a 3-month intensive statin and antiplatelet therapy for patients with acute mild ischaemic stroke or high-risk TIA with intracranial or extracranial atherosclerosis (INSPIRES).

Background: It remains unclear if intensive antiplatelet and statin treatments begun within 24-72 hours of cerebral ischaemic events from intracranial or extracranial atherosclerosis is effective or safe.

Methods: The Intensive Statin and Antiplatelet Therapy for High-risk Intracranial or Extracranial Atherosclerosis (INSPIRES) trial is a randomised, double-blind, placebo-controlled, multicentre and 2×2 factorial trial. 6100 individuals between the ages of 35 and 80 who have experienced a mild ischaemic stroke or high-risk transient ischaemic attack (TIA) within the previous 72 hours that is attributed to ≥50% atherosclerotic stenosis of a major intracranial or extracranial artery or multiple infarctions of atherosclerotic origin will be enrolled in the trial.

Lifestyle intervention in ovarian cancer enhanced survival (LIVES) study (NRG/GOG0225): Recruitment, retention and baseline characteristics of a randomized trial of diet and physical activity in ovarian cancer survivors.

Objective: The Lifestyle Intervention for oVarian cancer Enhanced Survival (LIVES) is a national study of a combined diet and physical activity intervention for stage II-IV ovarian cancer survival, an under-represented cancer in lifestyle behavioral intervention research. Here, we present the data on recruitment, retention, and baseline demographic, clinical and lifestyle behavior characteristics of the LIVES study participants.

Methods: The LIVES study (NRG Oncology/GOG 0225) is a Phase III diet plus physical activity intervention trial testing the hypothesis that ovarian cancer survivors in the lifestyle intervention will demonstrate better progression-free survival than those in the control condition.

Temporal multi-step predictive modeling of remission in major depressive disorder using early stage treatment data; STAR*D based machine learning approach.

Background: Artificial intelligence is currently being used to facilitate early disease detection, better understand disease progression, optimize medication/treatment dosages, and uncover promising novel treatments and potential outcomes.

Methods: Utilizing the Sequenced Treatment Alternatives to Relieve Depression (STAR*D) dataset, we built a machine learning model to predict depression remission rates using same clinical data as features for each of the first three antidepressant treatment steps in STAR*D. We only used early treatment data (baseline and first follow up) in each STAR*D step to temporally analyze predictive features of remission at the end of the step.

Fish Bones and the Challenges of Root Canal Obturation.

The dental historical literature is replete with the use of myriad of materials for root canal obturation; most notably, gutta-percha, silver cones, gold wires, orangewood sticks, gold foils, asbestos, a variety of paste/cement-type materials, iridioplatinum wires, lead points and a rather lengthy list of arbitrarily chosen substances based on the imagination and creativity of the treating professional..

Some Gleanings on the Origin, Etiology, Nature and Development of Pulp Stones - 100-year Perspective.

Quite often in today's contemporary literature, phrases, or statements such as, or similar to the following, are often seen at the beginning of published manuscript, Often these types of statements are used as a justification or a rationale for the published paper that follows. However, when looking carefully at the purported issue or issues at hand, there usually is to follow that requires a passionate inquisitiveness, an intellectual persistence, and a monumental determination to find the truth…but even what is discovered in this relentless pursuit may not necessarily represent the truth that may remain elusive. Hence, this historical exposé will focus on a specific issue about a little tissue that most contemporary authors have passed off as a mysterious, unknown entity - From 1969 to 2021, there have been over 100 publications or more that have addressed pulp stones purely from an epidemiological or management standpoint, with minimal to no effort to identify their true source or etiology, which may be locked in the vaults of antiquity.

Gleanings on the Origins of Electric Pulp Testing.

Attempts to develop a test for pulp vitality has had a somewhat convoluted history, as the concept of 'vitality' has been the pivotal focus of , especially when using electrical stimulation. Some researchers attempted histological correlations while others focused exclusively on radiographic correlations to validate electrical methods of pulp testing. Some the early literature rightfully focused on the concept of sensibility (a contemporary term in common usage) instead of vitality.

Colin Robertson, : Dentistry, History, Theater and Golf.

Many commentators argue that, until the 1980s, Brisbane and Queensland were cultural backwaters within the Australian context. However, with the hosting of the highly successful (1982) and (1988) and with the development of the Queensland Cultural (1976-) and South Bank (1974-) Precincts, Brisbane and Queensland cast aside perennial apologism to acquire prominence, maturity, and self-respect. Within these national, state, and municipal settings, the theme, timing, and venue for the (1985) involved risk.

In-line miniature 3D-printed pressure-cycled ventilator maintains respiratory homeostasis in swine with induced acute pulmonary injury.

The COVID-19 pandemic demonstrated the need for inexpensive, easy-to-use, rapidly mass-produced resuscitation devices that could be quickly distributed in areas of critical need. In-line miniature ventilators based on principles of fluidics ventilate patients by automatically oscillating between forced inspiration and assisted expiration as airway pressure changes, requiring only a continuous supply of pressurized oxygen. Here, we designed three miniature ventilator models to operate in specific pressure ranges along a continuum of clinical lung injury (mild, moderate, and severe injury).

Etiology and Pathophysiology of Hypoparathyroidism: A Narrative Review.

The approach utilized a systematic review of the medical literature executed with specifically designed criteria that focused on the etiologies and pathogenesis of hypoparathyroidism. Enhanced attention by endocrine surgeons to new knowledge about parathyroid gland viability are reviewed along with the role of intraoperative parathyroid hormone (ioPTH) monitoring during and after neck surgery. Nonsurgical etiologies account for a significant proportion of cases of hypoparathyroidism (~25%), and among them, genetic etiologies are key.

The Evolving Interplay of SBRT and the Immune System, along with Future Directions in the Field.

In this commentary, we describe the potential of highly ablative doses utilizing Stereotactic Body Radiation Therapy (SBRT) in single or few fractions to enhance immune-responsiveness, how timing of this approach in combination with immune-checkpoint inhibitors may augment treatment-effect, and whether Personalized Ultrafractionated Stereotactic Adaptive Radiation Therapy (PULSAR) is an avenue for future advancement in the continued endeavor to foster a systemic effect of therapy beyond the radiation treatment field. The ablative potential of SBRT may support an increase in tumor-antigen presentation, enhancement of immune-stimulatory components, and an improvement in tumor-microenvironment immune cell infiltration. Furthermore, the latest advancement of ablative radiation delivery is PULSAR-based therapy, whereby ablative doses are delivered in pulses of treatment that may be several weeks apart, combined with adaptive treatment to tumor changes across time.