S-Sulfocysteine's toxic effects on HT-22 cells are not triggered by glutamate receptors, nor do they involve apoptotic or genotoxicity mechanisms.

S-Sulfocysteine (SSC) is a metabolite derived from the metabolism of sulfur-containing amino acids. It has been implicated in neurotoxicity observed in children with sulfite oxidase deficiency. The aim of our study was to confirm the neurotoxic effects of SSC using a mouse hippocampal cell line (HT-22) and to investigate the role of apoptosis in these effects, especially in terms of caspase-3 activation and genotoxicity.

[F]FDG PET/CT Beyond Staging: Prognostic Significance of Sarcopenia and Adipose Tissue Metabolism in Esophageal Carcinoma.

Aim: This study aimed to investigate the relationship between PET and CT parameters and sarcopenia, adipose tissue, and tumor metabolism in esophageal carcinoma(EC) and its impact on survival in EC.

Method: Our study included 122 EC patients who underwent PET/CT for staging. Muscle and adipose tissue characteristics were evaluated, including lumbar(L3) and cervical(C3) muscle areas, psoas major(PM) and sternocleidomastoid muscle(SCM) parameters, and PET parameters for visceral and subcutaneous adipose tissue(SAT).

The impact of artifact levels on intra- and interobserver agreement in pediatric urodynamic traces.

Introduction: In pediatric urology, urodynamic studies are considered the most reliable method for assessing the function of the lower urinary tract. These evaluations play a particularly important role in guiding treatment decisions for neurogenic bladder conditions.

Objective: The aim of this study is to assess the impact of artifacts on the interobserver and intraobserver agreement in the interpretation of pediatric urodynamic traces.

Sex differences in clinical and polysomnographic features of obstructive sleep apnea: The Turkish sleep apnea database (TURKAPNE) cohort.

Background: Previous reports from relatively small clinical cohorts have suggested that the clinical presentation of obstructive sleep apnea (OSA) differs between men and women.

Objective: We aimed to explore sex differences in clinical and polysomnographic features of OSA in a large nationwide registry.

Methods: Participants from the ongoing Turkish Sleep Apnea Database (TURKAPNE) Study from 34 centers were included in the current analysis.

Adaptation/Validity-reliability Evaluation of Menstruel Bleeding Questionnaire to Turkish Adolescent Girls.

Objective: The Menstrual Bleeding Questionnaire(MBQ) is a scale developed to identify women with heavy menstrual bleeding(HMB) and to assess its impact on quality of life. The aim of our study was to evaluate the validity and reliability of the Turkish adaptation of this scale for the adolescent age group.

Material-method: MBQ was translated into Turkish and adapted to adolescent age.

The relationship between HER2 status acquired from pathological data and metabolic parameters from pre-treatment [F]FDG PET/CT in gastric adenocarcinomas.

Objective: Overexpression of Human Epidermal Growth Factor Receptor 2 (HER2) is thought to be more aggressive in gastric cancer. This study aimed to evaluate the predictability of HER2 status and other prognostic pathologic parameters using [F]FDG PET/CT and to investigate its impact on survival.

Methods: Pretreatment metabolic parameters measured by [F]FDG PET/CT as a prognostic factor were retrospectively evaluated in 117 HER2-analysed patients.

Evaluation of the lacrimal punctum parameters in Turkish population with anterior segment optic coherence tomography.

Purpose: To determine the anatomical parameters of puncta in Turkish population without any complaint of epiphora, using anterior segment optic coherence tomography (AS-OCT).

Materials And Methods: The healthy participants between 26 and 83 years old who applied to our outpatient clinic from May 2022 to June 2022 for spectacle prescription or the accompanying person of the patients were included in the study. All participants underwent AS-OCT (Revo 60, OPTOPOL Technology, Zawiercie, Poland).

High prevalence of pancreatic steatosis in pancreatic cancer patients: A meta-analysis and systematic review.

Objective: In the last decade there has been increasing interest in defining pancreatic steatosis (PS) and establishing its association with pancreatic ductal adenocarcinoma (PDAC). However, no consensus guidelines have yet been published on the management of PS. In this systematic review and meta-analysis performed according to Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines, we investigated the association between PS and PDAC.

Anorectal manometry and urodynamics in children with spina bifida: can we predict the colonic dysmotility from bladder dysfunction?

Introduction: Spina bifida is a condition that impacts the development of the neural tube leading to urological and gastrointestinal symptoms. Both systems are influenced together due to their shared innervation and embryological origin. Despite its impact on health and well-being there has been limited research on the relationship between manometry results and urodynamic tests, in this patient population.

Analyzing emergency department presentations linked to secondary earthquake effects.

Objective: The earthquakes that struck Türkiye on February 6, 2023, significantly impacted the province of Hatay. A portion of the patients presenting to emergency departments (ED) following the earthquake were exposed to secondary effects without experiencing direct physical trauma. This study aims to evaluate the demographic, clinical, and psychosocial characteristics of patients presenting to the ED during the early post-earthquake period due to secondary effects, as well as to examine the challenges encountered during this process.

Multiple Eyelid Apocrine Hidrocystomas in a Patient With Prolactinoma.

In this case report, we demonstrate a rare co-occurrence of multiple eyelid apocrine hidrocystomas with a prolactinoma.

The role of radiotherapy in intracranial hemangiopericytoma/solitary fibrous tumors : A Turkish Society for Radiation Oncology Central Nervous System Tumors Group Study (TROD 07-008).

Objective: Intracranial hemangiopericytomas (HPC) are rare tumors. Radiotherapy (RT) is frequently performed after surgery, depending on tumor size, location, and the type of resection. Moreover, RT is preferred as an effective treatment for local recurrence and metastasis.

Assessing the performance of chat generative pretrained transformer (ChatGPT) in answering chronic kidney disease-related questions.

Background: Chatbots produced by artificial intelligence are frequently used in health information today. We aimed to investigate the reliability and reproducibility of the answers given by Chat Generative Pretrained Transformer (ChatGPT), one of the most used chatbots, to frequently asked questions related to chronic kidney failure.

Methods: We reviewed frequently asked questions related to chronic kidney disease (CKD) from social media platforms and Internet.

The effects of Korean hand acupressure on postoperative pain, nausea, vomiting, and retching after thyroidectomy: A randomized controlled study protocol.

Background: The aim of this study is to determine the effect of Korean hand acupressure applied after thyroidectomy on postoperative pain, nausea, vomiting, and retching of number and severity.

Materials And Methods: The type of study is a randomized study with a post-test-control group. The protocol was prepared according to the SPIRIT (Standard Protocol Items: Recommendations for Interventional Trials) 2013 checklist.

Stereotactic radiosurgery vs. fractionated radiotherapy for large vestibular schwannomas: should FSRT be the preferred treatment?

Introduction: To evaluate the effect of fractionation and prognostic factors on local control (LC) in the treatment of vestibular schwannoma (VS).

Methods: The medical records of 104 patients with vestibular schwannoma who were treated with stereotactic radiosurgery (SRS) from January 2015 to September 2023 were retrospectively collected. SRS was performed using Cyberknife robotic lineer accelerator.

Mortality Prediction of Biochemical Parameters in Patients Intubated in the Emergency Department.

Introduction Tracheal intubation is a high-risk airway management protocol frequently applied in patients with critical illnesses. Numerous parameters have been suggested to predict mortality in these patients. Blood gas analysis, electrolyte levels, enzyme activities, and other biochemical measurements provide insights into a patient's metabolic status and organ functions.

Ultrahigh-resolution 7-Tesla anatomic magnetic resonance imaging and diffusion tensor imaging of formalin-fixed human brainstem-cerebellum complex.

Introduction: Brain cross-sectional images, tractography, and segmentation are valuable resources for neuroanatomical education and research but are also crucial for neurosurgical planning that may improve outcomes in cerebellar and brainstem interventions. Although ultrahigh-resolution 7-Tesla (7T) magnetic resonance imaging (MRI) and diffusion tensor imaging (DTI) reveal such structural brain details in living or fresh unpreserved brain tissue, imaging standard formalin-preserved cadaveric brain specimens often used for neurosurgical anatomic studies has proven difficult. This study sought to develop a practical protocol to provide anatomic information and tractography results of an human brainstem-cerebellum specimen.

Diagnostic Performance of Imaging Methods in Predicting Lung Cancer Metastases.

Objective: This study aimed to investigate the possibility of distant organ metastasis using an algorithm developed to evaluate the morphology and localization of lung masses.

Methods: Patients diagnosed with lung cancer between 2016 and 2023 were included. The lesion's morphological characteristics, proximity to important structures, and maximum standardized uptake value were recorded.

Evaluation of Clinical and Laboratory Findings and Outcomes in Patients Suffering from Earthquake-Related Crush Injury: Who Needs Renal Replacement Therapy?

Objectives: Many people who are rescued alive from rubble after earthquakes suffer from crush injuries and associated acute kidney injury (AKI). McMahon score is used to determine the risk of AKI and mortality due to rhabdomyolysis in hospitalized patients. In this study, we aimed to evaluate the clinical findings, biochemical characteristics, and outcomes of crush injury patients admitted to our tertiary hospital and the use of the McMahon score in determining the need for renal replacement therapy (RRT) in this patient group.

Risk of Spreading in Adult-onset Dystonia.

Background: Adult-onset dystonia can also spread to other parts of the body, although it is not as common as childhood-onset dystonia.

Objective: Our study aimed to examine the clinical factors determining spreading patterns in all adult-onset dystonia types.

Methods: We retrospectively analyzed the medical records of patients with a diagnosis of isolated dystonia followed longitudinally at our center.

Documentation of the current state of cardiopulmonary bypass management in Türkiye.

Since the first successful use of cardiopulmonary bypass (CPB), much has changed in its technology, area of use, and management. Despite suggestions in guidelines, the institutional behavior may change based on institutional experience and established habits. This so-called "deviation" may alter management strategies in favorable or unfavorable ways.

Transcatheter pulmonary artery debanding: Is it effective in every patient?

Background: This study aimed to present our experience with transcatheter pulmonary debanding, focusing on patient outcomes.

Methods: The retrospective study was conducted with 32 patients (17 males, 15 females; mean age: 3.6±2 years; range, 0.