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Massive infiltration of bone marrow in colon carcinoma after treatment with activated protein C.
Wien Klin Wochenschr
October 2007
IIIrd Medical Department (Hematology, Medical Oncology, Hemostaseology, Rheumatology and Infectious Diseases), Private Medical Paracelsus University Salzburg, Salzburg, Austria.
We present an unusual case of localized colorectal carcinoma complicated by sepsis which was treated with activated protein C (APC). Shortly after treatment the patient developed symptomatic metastases to the bone marrow (BM). Destruction of bones by colorectal cancer (CRC) is rare, although BM micrometastases are frequently observed.
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