A spiro-type self-assembled hole transporting monolayer for highly efficient and stable inverted perovskite solar cells and modules.

Self-assembled monolayers (SAMs) have significantly contributed to the advancement of hole transporting materials (HTMs) for inverted perovskite solar cells (PSCs). However, uneven distribution of SAMs on the substrate largely decreases the PSC performance, especially for large-scale devices. Herein, the first spiro-type SAM, termed 4PA-spiro, with an orthogonal spiro[acridine-9,9'-fluorene] as the skeleton and phosphonic acid as the anchoring group were proposed.

Mechanistic insights into carbonic anhydrase IX inhibition by coumarins from : and approaches.

Given the critical role of carbonic anhydrase IX (CA IX) in various pathological conditions, there is a significant demand for new inhibitors to enhance patient outcomes and clinical management. In this study, we examined the inhibitory effectiveness of five coumarins derived from against CA IX using assays and computational modeling. Among the coumarins tested, xeroboside and isobaisseoside were identified as the most potent inhibitors.

Photovoltaic properties of halide perovskites for solar cell application with efficiency greater than 18.

The opto-electronic properties and solar cell efficiency of halide perovskites ALiInBr (A = Rb, Cs) are investigated using density functional theory (DFT) through WEIN2k and SCAPS-1D. The electronic characteristic of ALiInBr (A = Rb, Cs) compounds reveal their direct bandgap semiconductor nature and are active in visible rang. The results indicate that substituting Cs with Rb causes a slight narrowing of the bandgap.

Benzenesulfonohydrazide-tethered non-fused and fused heterocycles as potential anti-mycobacterial agents targeting enoyl acyl carrier protein reductase (InhA) with antibiofilm activity.

Because resistant variants of the disease are always emerging, tuberculosis is a global issue that affects economies. New antitubercular medications should be developed, and this can be done by inhibiting druggable targets. Enoyl acyl carrier protein (ACP) reductase (InhA) is a crucial enzyme for the survival of (MTB).

Synthesis of a new series of 4-pyrazolylquinolinones with apoptotic antiproliferative effects as dual EGFR/BRAF inhibitors.

The current study focuses on developing a single molecule that acts as an antiproliferative agent with dual or multi-targeted action, reducing drug resistance and adverse effects. A new series of 4-pyrazolylquinolin-2-ones (5a-j) with apoptotic antiproliferative effects as dual EGFR/BRAF inhibitors were designed and synthesized. Compounds 5a-j were investigated for their cell viability effect against a normal cell line (MCF-10A).

Copper-Vit B MOF preparation, characterization and catalytic evaluation in a one-pot synthesis of benzoxanthenones with docking validation as anti .

Copper-Vit B MOF was successfully prepared by efficient and eco hydrothermal method. The prepared MOF was characterized as a tetragonal crystal copper-MOF nanoparticles by FTIR, SEM, TEM, EDX and XRD. The prepared nanoparticles were used as an effective, inexpensive and low-toxic catalyst in the one-pot synthesis of some new benzoxanthenone derivatives.

Characterization of chitosan- and β-cyclodextrin-modified forms of magnesium-doped hydroxyapatites as enhanced carriers for levofloxacin: loading, release, and anti-inflammatory properties.

An advanced form of magnesium-rich hydroxyapatite (Mg·HAP) was modified with two types of biopolymers, namely chitosan (CH/Mg·HAP) and β-cyclodextrin (CD/Mg·HAP), producing two types of bio-composites. The synthesized materials were developed as enhanced carriers for levofloxacin to control its loading, release, and anti-inflammatory properties. The polymeric modification significantly improved the loading efficiency to 281.

Hypoglycemic, anti-inflammatory, and neuroprotective potentials of crude methanolic extract from L. - results of an in vitro study.

L., also known as babul, belonging to the Fabaceae family and the genus, is typically used for ornamental purposes and also as a medicinal plant found in tropical and subtropical areas. This plant is a rich source of bioactive compounds.

Anti-inflammatory effects of bay laurel ( L.) towards the gut microbiome in dextran sodium sulfate induced colitis animal models.

Bay laurel ( L.) contains active antioxidative phenolic components that are beneficial to human health. However, none was examined and reported utilizing health effects related to inflammatory bowel diseases (IBD) mainly ulcerative colitis (UC) in correlation to gut microbiota (GM).

(L.) (Orthoptera) in a warming world: unravelling the ecological consequences of climate change using GIS.

The migratory locust, (L.), a significant grasshopper species known for its ability to form large swarms and cause extensive damage to crops and vegetation, is subject to the influence of climate change. This research paper employs geographic information system (GIS) and MaxEnt ecological modelling techniques to assess the impact of climate change on the distribution patterns of .

The moderating role of just culture between nursing practice environment and oncology nurses' silent behaviors toward patient safety: A multicentered study.

Background: Patient safety is a critical part of healthcare delivery that must be prioritized to guarantee optimal patient outcomes. Oncology nursing is a specialized area of nursing that demands great focus on patient safety because of the high-risk nature of this patient group. Nurses play an important role in ensuring that patients receive safe and effective care.

Chalcones: The flavonoid derivatives synthesis, characterization, their antioxidant and in vitro/in vivo antidiabetic potentials.

Chalcones (designated , and were prepared from aromatic aldehyde and acetophenone which were then characterized using various spectroscopic techniques. The antioxidant potential of synthesized compounds was evaluated against DPPH free radical whereas the antidiabetic potential was determined against alpha glucosidase. Further the antidiabetic potential of the synthesized compounds was evaluated in rat model which were given orally experimental animals in doses 10 and 20 mg/kg body weight.

A combined crystallographic and theoretical investigation of noncovalent interactions in 1,3,4-oxadiazole-2-thione--Mannich derivatives: bioactivity and molecular docking.

Two 1,3,4-oxadiazole-2-thione--Mannich derivatives, specifically 5-(4-chlorophenyl)-3-[(2-trifluoromethylphenylamino)methyl]-1,3,4-oxadiazole-2(3)-thione (1) and 5-(4-chlorophenyl)-3-[(2,5-difluorophenylamino)methyl]-1,3,4-oxadiazole-2(3)-thione (2), were synthesized and then characterized by elemental analysis and NMR (H and C) spectroscopy and the single crystal X-ray diffraction method. The formed weak intermolecular interactions in the solid-state structures of these derivatives were thoroughly investigated utilizing a variety of theoretical tools such as Hirshfeld surface analysis and quantum theory of atoms in molecules (QTAIM). Furthermore, the CLP-PIXEL and density functional theory calculations were used to study the energetics of molecular dimers.

Shelf-life extension of Duch. using selenium nanoparticles synthesized from Linn. leaves.

Duch. (Strawberry) fruit is susceptible to postharvest diseases, thus decrease in quality attributes, such as physiological and biochemical properties leads to decrease in shelf life. The objective of the present study was to check the effect of Selenium NP's and packaging conditions on the shelf life of strawberry ( Duch) fruits.

The relationship between nursing students' readiness and attitudes for E-learning: The mediating role of self leadership: An online survey (comparative study).

Background: To meet the learning demands of new generation students, higher education institutions should apply relevant breakthroughs in science, technology, and education to update their educational policies or teaching techniques. Aim To investigate the relationship between nursing students' readiness and attitudes toward e-learning, as well as the role of self‑leadership in mediating this relationship.

Methods: This is a descriptive comparative research.

Molecular modeling and DFT studies on the antioxidant activity of flavonoids and molecular dynamics simulation of their interaction with β-lactoglobulin.

Plants of the genus have been widely used as natural therapeutics in different countries. This study investigated the antioxidant-structure activity relationship of eight flavonoids isolated from using DFT studies and radical scavenging and xanthine oxidase (XO) inhibition assays, and to correlate the theoretical values with the experimental findings. Docking analysis was carried out to explore the binding modes of the isolated phytochemicals with XO and bovine β-lactoglobulin (BLG).

Prevalence of fast-food intake among a multi-ethnic population of middle-aged men and connection with sociodemographic factors and obesity.

Adults are increasingly eating fast-food, which is connected to adverse health outcomes such as obesity and chronic diseases. This work was carried out to study the prevalence of fast-food intake among a multi-ethnic population of middle-aged men and its connection with sociodemographic factors and obesity. This cross-sectional study enrolled 1800 middle-aged men from Riyadh, Kingdom of Saudi Arabia.

Generalized morphea following COVID-19 vaccine: Case report and literature review.

Physicians should be vigilant for COVID-19 vaccine side effects and investigate any associated cutaneous manifestations. This will ultimately facilitate better understanding and recognition of various skin reactions related to the vaccine.

Physicochemical properties and sensory attributes of cookies prepared from sorghum and millet composite flour.

Sorghum and millet are rich in nutrients and bioactive compounds. They can enhance nutrition and health. This study was aimed to develop sorghum-millet gluten-free cookies from sorghum and millet composite flour.

Endocrowns Versus Post-core Retained Crowns as a Restoration of Root Canal Treated Molars - A Review Article.

Normally root canal-treated teeth are covered with crowns to prevent fracture, which becomes challenging in cases where the tooth is extensively damaged. In such instances, various restorative methods such as post-core and endocrowns have been in use. The former methodology in recent times is being discouraged owing to impending tooth weakening.

Investigation of the anticorrosion and adsorption properties of two polymer compounds on the corrosion of SABIC iron in 1 M HCl solution by practical and computational approaches.

The anticorrosion efficiency of two polymer compounds, namely polystyrene (PS), polybutylene terephthalate (PBT), against the corrosion of SABIC iron (S-Fe) in 1.0 M HCl solution was investigated. The anticorrosion efficiency was estimated by chemical and electrochemical measurements.

The Effectiveness of Perturbation-Based Training in the Treatment of Patients With Stroke: A Systematic Review and Meta-Analysis.

Purpose: To investigate the effectiveness of perturbation-based training (PBT) on balance and balance confidence in patients with stroke.

Methods: Systematic searching was performed from inception to November 2021. The inclusion criteria were RCTs assessed the effectiveness of PBT in patients with stroke.