Assessing correlation between different temporary restorative materials for microleakage following endodontic treatment: an in-vitro study.

Background: Coronal microleakage, the passage of fluids and bacteria through the interface between the temporary restoration and the tooth structure, can potentially result in endodontic treatment failure.

Purpose: This study evaluated and compared the sealing efficacy of various temporary restorative materials utilized during endodontic procedures.

Methods: All seventy premolar teeth were extracted, measured, and restored, except for the negative control group, where the teeth were left whole.

Navigating Sensor-Skin Coupling Challenges in Magnetic-Based Blood Pressure Monitoring: Innovations and Clinical Implications for Hypertension and Aortovascular Disease Management.

Non-invasive blood pressure monitoring has emerged as a critical frontier in cardiovascular healthcare, with magnetic sensors playing an increasingly pivotal role in wearable health technologies. This comprehensive review critically examines the complex challenges of sensor-skin coupling and its profound impact on the accuracy of blood pressure measurements in patients with hypertension and aortovascular disease. Despite the growing demand for precise, real-time health monitoring, significant limitations persist in current magnetic sensor technologies.

Double extreme-cum-median ranked set sampling.

Extreme-cum-median ranked set sampling has been developed to address the problem of heterogeneity and outliers / extreme values. Double ranked set sampling has been suggested to obtain more reliable samples using the concept of degree of distinguishability. Dealing with heterogeneous and non-normal populations seems to be an area with a dearth of research.

Understanding the role of potential biomarkers in attenuating multiple sclerosis progression via multiomics and network-based approach.

Background: Multiple sclerosis (MS) is a complex neurological disorder marked by neuroinflammation and demyelination. Understanding its molecular basis is vital for developing effective treatments. This study aims to elucidate the molecular progression of MS using multiomics and network-based approach.

Metabolomics and Anticancer Potential of the Aerial Parts of Dryopteris ramosa against Cancerous Cell Lines Assisted with Advanced Computational Approaches.

Introduction: Dryopteris ramosa is a high-altitude plant of moist and shady habitat. Its aerial parts are edible and orally administered as an antibiotic and effective aphrodisiac. They are also used as pesticides, astringents, and febrifuges.

Combined and isolated effects of workstation ergonomics and physiotherapy in improving cervicogenic headache and work ability in office workers: a single-blinded, randomized controlled study.

Objective: The objective of the study is to compare and investigate the combined and individual effects of workstation ergonomics, physiotherapy and patient education in improving CgH headaches and work ability in office workers.

Methods: 96 eligible CgH participants were divided into the ergonomics modifications group (EMG;  = 24), physiotherapy group (PTG;  = 24), and ergonomics modifications combined with physiotherapy group (EPG;  = 24) and education control group (CNG;  = 24), the participants received the respective treatment for 4 weeks. Primary (CgH frequency) and secondary (CgH pain intensity, CgH disability, flexion rotation test (right and left), neck disability index and work ability) scores were measured.

Immunoinformatic based designing of highly immunogenic multi-epitope subunit vaccines to stimulate an adaptive immune response against Junin virus.

The Junin virus causes Argentine hemorrhagic fever, leading to severe complications such as high fever, malaise, muscle pain, and bleeding disorders, including hemorrhages in the skin and mucous membranes. Neurological issues like confusion, seizures, and coma can also occur. Without prompt and effective treatment, the disease can be fatal, with mortality rates reaching up to 30%.

The Influence of Early Maladaptive Schemas on Recovery and Psychological Capital in Borderline Personality Disorder Clients: Findings From Rural Dwelling Sample.

Introduction: Early maladaptive schemas (EMSs) are among the key vulnerability factors explaining the development and persistence of symptoms in borderline personality disorder (BPD). Furthermore, it was suggested that EMSs might impact recovery-related outcomes, including psychological and recovery capital, among individuals with BPD.

Aims: To investigate the relationship among EMSs, psychological and recovery capital in individuals with BPD disorder.

Examining Nursing Students' Prevalence of Nomophobia, and Psychological Alienation and Their Correlates With Fear of Missing Out: A Multisites Survey.

Introduction: Smartphones have significantly increased digital engagement among young people due to their ease of use and constant internet access. Nomophobia and the fear of missing out are associated with mobile and internet use, potentially impacting students' mental health and academic performance.

Objectives: To provide the prevalence of nomophobia and fear of missing out while shedding light on the role of psychological alienation between them.

Enhanced targeting efficacy of baicalein analogues on the dimeric state of SARS-CoV-2 3CL protease compared to monomeric state.

The COVID-19 pandemic caused by the novel coronavirus, SARS-CoV-2, has been a global threat affecting the entire world. It is a single-stranded RNA virus that belongs to the coronavirus family. In SARS-CoV2, the 3CL protease protein significantly contributes to viral replication and is responsible for viral polyprotein cleavage.

Chiral nanosystem and chiral supraparticles for drug delivery: an expert opinion.

Introduction: Chiral nanocarriers enhance therapeutic efficacy by improving in vivo stability and cellular uptake. Chemical functionalization reduces cytotoxicity, resulting in favorable biocompatibility. Nanoparticles self-assemble into supraparticles, enhancing drug delivery through improved retention and drug loading.

An assessment of the knowledge, perception, and willingness to use telepharmacy services among the general public in Riyadh.

The studies concerning Saudis' perceptions and awareness of telepharmacy, as well as their readiness to use this service, are critical for policymakers to devise measures to increase the acceptability of telepharmacy. The present study aimed to assess their knowledge, perceptions, and willingness to use telepharmacy services in Riyadh. The present study was a cross-sectional survey conducted between March 2024 and June 2024.

Optimizing Tomato () Yield Under Salt Stress: The Physiological and Biochemical Effects of Foliar Thiourea Application.

A pot experiment was conducted to investigate the role of thiourea exogenous application (0 mg/L and 100 mg/L) on the morphological, physiological, and yield traits of two varieties of tomato (Naqeeb and Nadir) under different salt stress treatments (0, 60, and 120 mM) in completely randomized design (CRD). The imposition of salinity by rooting medium showed that salt stress reduced plant height by 20%, fresh shoot weight by 50%, dry shoot weight by 78%, fresh root weight by 43%, dry root weight by 84%, root length by 34%, shoot length by 32%, shoot K by 47%, Ca by 70%, chlorophyll a by 30%, chlorophyll b by 67%, and the number of seeds per berry by 53%, while shoot Na ions were increased by 90% in comparison to those grown with control treatment. However, the exogenous application of thiourea significantly enhanced dry root weight by 25% and the number of seeds per berry by 20% in comparison to untreated plants with thiourea when grown under salt stress.

Use of Artificial Intelligence in Imaging Dementia.

Alzheimer's disease is the most common cause of dementia in the elderly population (aged 65 years and over), followed by vascular dementia, Lewy body dementia, and rare types of neurodegenerative diseases, including frontotemporal dementia. There is an unmet need to improve diagnosis and prognosis for patients with dementia, as cycles of misdiagnosis and diagnostic delays are challenging scenarios in neurodegenerative diseases. Neuroimaging is routinely used in clinical practice to support the diagnosis of neurodegenerative diseases.

Emerging Use of Social Media in Clinical Urology Practice in the 21st Century: Survey Study.

Background: Social media (So-Me) platforms are valuable resources for health care professionals and academics to discover, discuss, and distribute current advances in research and clinical practices, including technology trends.

Objective: This study aims to assess the role of So-Me in urological practice in Saudi Arabia. It explores the influence of digital platforms on patient interaction, professional communication, decision-making, and education.

Influence of Work-Life Balance on Mental Health Among Nurses: The Mediating Role of Psychological Capital and Job Satisfaction.

Background: Nurses constitute the backbone of the healthcare sector, often confronting elevated levels of work-related stress and emotional demands that can profoundly impact their mental well-being. Mental health is critical to nursing practice as it directly influences job performance, patient care quality, and workforce sustainability. This study examines the effects of work-life balance on the mental health of nurses in Pakistan while examining the intermediary effects of psychological capital and job satisfaction.

Perception, knowledge, and factors influencing Saudi nursing students toward practicing testicular self-examination: A cross-sectional study.

Background: Testicular cancer poses a substantial health burden globally, and early detection through testicular self-examination (TSE) is vital for improving prognosis. The study aims to assess the perception, awareness, knowledge, and factors associated with TSE among Saudi nursing students.

Materials And Methods: A structured questionnaire was distributed to 418 participants.

The psychological impact of COVID-19 on front-line healthcare providers in the United Arab Emirates: A cross-sectional study.

Background: The COVID-19 pandemic has significantly impacted the psychological well-being of healthcare providers (HCPs) worldwide. Understanding the prevalence and associated factors of depression, generalized anxiety disorder (GAD), and posttraumatic stress disorder (PTSD) among these providers is crucial. Assess the prevalence of major depression, GAD, and PTSD symptoms among HCPs in the United Arab Emirates (UAE) during the COVID-19 pandemic.

The benefits of social insurance system prediction using a hybrid fuzzy time series method.

Decision-making in many industries relies heavily on accurate forecasts, including the insurance sector. The Social Insurance System (SIS) in Egypt, operating under a fully funded paradigm, depends on reliable predictions to ensure effective financial planning. This research introduces a hybrid predictive model that combines fuzzy time series (FTS) Markov chains with the tree partition method (TPM) and difference transformation to forecast total pension benefits within Egypt's SIS.

Intelligent algorithmic framework for detection and mitigation of BeiDou spoofing attacks in vehicular ad hoc networks (VANETs).

This research tackles the critical challenge of BeiDou signal spoofing in vehicular ad-hoc networks and addresses significant risks to vehicular safety and traffic management stemming from increased reliance on accurate satellite navigation. The study proposes a novel hybrid machine learning framework that integrates Autoencoders and long short-term memory (LSTM) networks with an advanced cryptographic method, attribute-based encryption, to enhance the detection and mitigation of spoofing attacks. Our methodology leverages both real-time and synthetic navigational data in a comprehensive experimental setup that simulates various spoofing scenarios to test the resilience of the proposed system.

A new two-parameter Rayleigh distribution: Statistical properties, actuarial measures, regression analysis, and applications.

This paper presents a novel two-parameter distribution derived from the Rayleigh distribution, thoroughly investigating its essential mathematical properties. We employ estimation techniques to determine the proposed distribution's estimated parameters. Through extensive simulation studies, we analyze and evaluate the asymptotic behavior of the model estimators.

Undergraduate nursing students' perspectives of trauma-informed care in pediatric nursing: A cross-sectional Egyptian study.

Introduction: Trauma-Informed Care (TIC) is a critical approach in pediatric nursing, addressing the unique challenges and high trauma susceptibility in children. Including TIC in nursing education aims to equip students with the necessary skills for empathetic and efficient care, enhancing patient outcomes and professional competence. This study investigates the perspectives of undergraduate pediatric nursing students on TIC.

Targeting tau in Alzheimer's and beyond: Insights into pathology and therapeutic strategies.

Tauopathies encompass a group of approximately 20 neurodegenerative diseases characterized by the accumulation of the microtubule-associated protein tau in brain neurons. The pathogenesis of intracellular neurofibrillary tangles, a hallmark of tauopathies, is initiated by hyperphosphorylated tau protein isoforms that cause neuronal death and lead to diseases like Alzheimer's, Parkinson's disease, frontotemporal dementia, and other complex neurodegenerative diseases. Current applications of tau biomarkers, including imaging, cerebrospinal fluid, and blood-based assays, assist in the evaluation and diagnosis of tauopathies.

Novel bis-benzimidazole-triazole hybrids: anticancer study, in silico approaches, and mechanistic investigation.

Aim: Benzimidazole-triazole conjugates are very active hotspot for design and synthesis of promising anticancer agents. The target analogs showed potent and selective cytotoxicity over different cancer cell lines for breast and lung ones.

Materials & Methods: A new series of bis-1,4-disubstituted-1,2,3-triazoles moieties conjugated with a 2-mercapto-benzimidazole 4a-h and 7a-g was synthesized via the click cycloaddition (CuAAC) reaction.