Comparative efficacy of combined myo-inositol and D-chiro inositol versus metformin across PCOS Phenotypes: enhancing ovarian function, ovulation, and stress response in a prospective clinical trial.

This study aimed to evaluate the comparative efficacy of Myo-inositol (MI) and D-chiro-inositol (DCI) with metformin in enhancing ovarian function, promoting ovulation, and reducing perceived stress in patients with polycystic ovary syndrome (PCOS). Women with PCOS were identified using the Androgen Excess Society's criteria, and 60 participants were enrolled and divided equally into two groups. One group received a 40:1 ratio of MI plus DCI, while the other received metformin for a 12-week period.

Oxytocin ameliorates lipopolysaccharide-induced acute orchitis model: interplay of oxidative stress and inflammatory pathways.

Introduction: Lipopolysaccharide (LPS), a constituent of the outer membrane of Gram-negative bacteria, is a powerful inducer of systemic inflammation and has been extensively utilized in experimental models to simulate inflammatory responses and septic disorders. Recent research indicates that oxytocin (OXY), a neuropeptide typically linked to social bonding and reproductive functions, may influence inflammatory processes. This work examines the impact of OXY on LPS-induced testicular damage, aiming to elucidate its therapeutic potential in addressing inflammatory disorders and broadening the comprehension of its functions beyond conventional neuroendocrine roles.

Comparing the efficacy of live vs. video instructional demonstrations in dental education: a systematic review and meta-analysis.

Background: This systematic review and meta-analysis were conducted to investigate the effects of live and video demonstrations of various dental procedures on undergraduate students' performance and satisfaction scores.

Materials And Methods: A comprehensive search was conducted across multiple databases, including MEDLINE (OVID), PubMed, Scopus, and Web of Science, supplemented by a manual search of bibliographic references from retrieved articles. The aim was to identify relevant randomized controlled trials and quasi-experimental trials that compared live demonstrations to video demonstrations in dental education, specifically focusing on undergraduate students' performance and satisfaction scores assessed using practical assessment rubrics and satisfaction questionnaires.

Targeting signaling pathways in neurodegenerative diseases: Quercetin's cellular and molecular mechanisms for neuroprotection.

Background: Neurodegenerative diseases (NDs), including Alzheimer's disease, Parkinson's disease, and Huntington's disease, are complex and challenging due to their intricate pathophysiology and limited treatment options.

Methods: This review systematically sourced articles related to neurodegenerative diseases, neurodegeneration, quercetin, and clinical studies from primary medical databases, including Scopus, PubMed, and Web of Science.

Results: Recent studies have included quercetin to impact the cellular and molecular pathways involved in neurodegeneration.

A multi-patch-based deep learning model with VGG19 for breast cancer classifications in the pathology images.

Purpose: Breast cancer encompasses various subtypes with distinct prognoses, necessitating accurate stratification methods. Current techniques rely on quantifying gene expression in limited subsets. Given the complexity of breast tissues, effective detection and classification of breast cancer is crucial in medical imaging.

Psychological wellbeing and treatment adherence among cardio-renal syndrome patients in Yemen: a cross section study.

Background: Anxiety and depression are associated with adverse outcomes in cardiorenal syndrome patients undergoing hemodialysis, including decreased quality of life, poorer clinical parameters, and lower treatment adherence.

Objective: This study aimed to examine the level of psychological wellbeing and its relationship with treatment adherence among dialysis patients with cardiorenal syndrome.

Methods: This cross-sectional descriptive study was conducted between February and May 2021 on convenience sampling of 100 patients in two dialysis centers in Hadhramout, Yemen.

Strain-dependent structural, electronic, mechanical, optical and thermoelectric properties of SrNBr perovskites for solar cell applications.

Halide perovskites are a class of materials with excellent potential for solar cell applications due to their excellent optical and electronic properties. In this study, strain-dependent physical properties of SrNBr perovskites are investigated and theoretical results are reported here. The structural properties indicate that SrNBr has a cubic structure.

Hyoid bone-based sex discrimination among Egyptians using a multidetector computed tomography: discriminant function analysis, meta-analysis, and artificial intelligence-assisted study.

The hyoid bone has been identified as sexually dimorphic in various populations. The current study is a forerunner analysis that used three-dimensional multidetector computed tomography (3D MDCT) images of the hyoid bone to examine sexual dimorphism in the Egyptian population. A total of 300 subjects underwent neck CT imaging, with an additional 60 subjects randomly selected for model validation.

Evaluation of the Therapeutic Potential of the Methanolic Extract and Fractions of Datura stramonium in Paracetamol-intoxicated Rabbits.

Introduction: Datura stramonium (DS) possesses strong medicinal and therapeutic potential but has been rarely evaluated in this context.

Methods: The present study was intended to evaluate the antioxidant, hepatoprotective, and nephroprotective potential of the crude methanolic leaf extract and ethyl acetate, chloroform, n-hexane, and aqueous fractions of DS in paracetamol-intoxicated rabbits. Paracetamol (2 g/Kg BW) was applied to induce liver and kidney injury in rabbits while the methanolic extract and fractions of DS were applied in the dose range of 150 mg/Kg to 300 mg/Kg body weight for 21 days.

Organisational Inequalities and the Myth of Meritocracy: How They Impede Employee Task Performance?

Previous studies have overlooked organisational inequalities and their influence on employee task performance. Anchored in equity theory, we address this gap by examining how promotion and compensation inequalities relate to employee task performance. Further, this study examines the myth of meritocracy as an underlying mechanism and overall perceived distributive justice as a boundary condition.

Alopecia Management Potential of Rosemary-Based Nanoemulgel Loaded with Metformin: Approach Combining Active Essential Oil and Repurposed Drug.

Introduction: Androgenetic alopecia (AGA) is a multifactorial and age-related dermatological disease that affects both males and females, usually at older ages. Traditional hair repair drugs exemplified by minoxidil have limitations such as skin irritation and hypertrichosis. Thus, attention has been shifted to the use of repurposing drugs.

Evaluating palliative care's role in symptom management for CKD patients in Egypt: A quasi-experimental approach.

Objectives: Chronic kidney disease (CKD) is a global health challenge that affects patients' symptom burden and quality of life. Palliative care interventions show promise in addressing the multiple needs of CKD patients, focusing on symptom management, psychosocial support, and advance care planning. This study aimed to evaluate the effectiveness of palliative care interventions in improving symptom management in patients with CKD.

The interplay of senescence and MMPs in myocardial infarction: implications for cardiac aging and therapeutics.

Aging is associated with a marked increase in cardiovascular diseases, such as myocardial infarction (MI). Cellular senescence is also a crucial factor in the development of age-related MI. Matrix metalloproteinases (MMPs) interaction with cellular senescence is a critical determinant of MI development and outcomes, most notably in the aged heart.

Targeting senescence and GATA4 in age-related cardiovascular disease: a comprehensive approach.

The growing prevalence of age-related cardiovascular diseases (CVDs) poses significant health challenges, necessitating the formulation of novel treatment approaches. GATA4, a vital transcription factor identified for modulating cardiovascular biology and cellular senescence, is recognized for its critical involvement in CVD pathogenesis. This review collected relevant studies from PubMed, Google Scholar, and Science Direct using search terms like 'GATA4,' 'cellular senescence,' 'coronary artery diseases,' 'hypertension,' 'heart failure,' 'arrhythmias,' 'congenital heart diseases,' 'cardiomyopathy,' and 'cardiovascular disease.

Atmospheric pressure spatial atomic layer deposition of p-type CuO thin films from copper(II) acetylacetonate and ozone for UV detection.

Cupric oxide (CuO) is a promising p-type semiconducting oxide used in many critical fields, such as energy conversion and storage, and gas sensors, which is attributed to its unique optoelectrical properties and cost-effectiveness. This work successfully deposited amorphous, pinhole-free, ultrathin CuO films using atmospheric pressure spatial atomic layer deposition (SALD) with copper(II) acetylacetonate and ozone as precursors. The growth rate increased from 0.

A two-tier optimization strategy for feature selection in robust adversarial attack mitigation on internet of things network security.

Adversarial attacks were commonly considered in computer vision (CV), but their effect on network security apps rests in the field of open investigation. As IoT, AI, and 5G endure to unite and understand the potential of Industry 4.0, security events and incidents on IoT systems have been enlarged.

Evaluating and upgrading the performance of a bridge network structure with Rayleigh distribution lifetimes.

In this work, bridge network model with Rayleigh distribution lifetimes is used. Two main techniques are calculated to upgrade this model: reduction and redundancy techniques. In order to compare the effectiveness of the various approaches, the survival function, the mean time to failure and gamma-fractiles for the original and upgraded model are calculated.

Empowering nurse leaders: readiness for AI integration and the perceived benefits of predictive analytics.

Introduction: Artificial Intelligence (AI) is increasingly being integrated into healthcare, particularly through predictive analytics that can enhance patient care and operational efficiency. Nursing leaders play a crucial role in the successful adoption of these technologies.

Aim: This study aims to assess the readiness of nursing leaders for AI integration and evaluate their perceptions of the benefits of AI-driven predictive analytics in healthcare.

Ginsenoside Rg3 in Cancer Research: Current Trends and Future Prospects - A Review.

Cancer is one of the most devastating illnesses in the world, impacting millions of individuals every year. Despite various therapies, the final effect is unsatisfactory. Chemotherapy currently dominates as the primary option of treatment.

Decent work and nurses' work ability: A cross-sectional study of the mediating effects of perceived insider status and psychological well-being.

Background: While the benefits of decent work-employment that respects fundamental human rights, ensures fair income, guarantees workplace security, and provides social protection for families-have recently gained scholarly attention regarding job satisfaction, psychological empowerment, and work engagement, its potential to enhance nurses' work ability-defined as the ability to carry out job responsibilities-remains unaddressed. Furthermore, a gap exists in understanding the mechanisms through which decent work influences its outcomes.

Purpose: We aimed to investigate: (1) if securing decent work is associated with elevated nurses' work ability, and (2) if perceived insider status and psychological well-being mediate the association between decent work and nurses' work ability.

Comparative phytochemical and pharmacological analysis of two cultivars of Annona squamosa L. cultivated in Egypt.

This study compared two Annona squamosa L. cultivars, Abdelrazik (Annona A.) and Balady (Annona B.

Phytochemical analysis and biological activities of solvent extracts and silver nanoparticles obtained from Woodwardia unigemmata (Makino) Nakai.

Multidrug resistant bacteria are causing health problems and economic burden worldwide; alternative treatment options such as natural products and nanoparticles have attained great attention recently. Therefore, we aimed to determine the phytochemicals, antibacterial potential, and anticancer activity of W. unigemmata.

Quality of life for patients on oncology treatments in the Kingdom of Saudi Arabia: a systematic review.

Background: Cancer cases in the Kingdom of Saudi Arabia (KSA) have tripled in recent years. Quality of Life (QoL) measurements are crucial for healthcare professionals because they reveal important information about how patients respond to drugs and their general health. This study aimed to collect and summarise articles exploring the QoL of patients undergoing oncology treatments in KSA.

Resveratrol attenuates cyclophosphamide-induced hepatic apoptosis in association with the inhibition of oxidative stress and inflammation in a rat model of acute liver injury.

Cyclophosphamide (CP) is an alkylating chemotherapy agent that induces liver toxicity by cross-linking DNA, causing cell apoptosis. While CP is effective in cancer treatment, its side effects on the liver are significant. Recent studies have indicated that antioxidants, such as resveratrol, may reduce these toxic effects.

Trends and predictors of leaving before medically advised in US emergency departments from 2016 to 2021.

Background: Leaving before medically advised (BMA) is a significant issue in the US healthcare system, leading to adverse health outcomes and increased costs. Despite previous research, multi-year studies using up-to-date nationwide emergency department (ED) data, are limited. This study examines factors associated with leaving BMA from EDs and trends over time, before and during the COVID-19 pandemic.