2,267 results match your criteria: "Primary and Secondary Prevention of Coronary Artery Disease"
Cardiac biomarkers for detection of coronary artery disease in the community.
Sci Rep
December 2024
Department of Clinical Sciences Malmö, Lund University, Malmö, Sweden.
To investigate whether coronary artery disease (CAD) burden is associated with plasma levels of the myocardial biomarkers Troponin I (TropI) and NT-proBNP in a large population-based sample using a cross-sectional design. Coronary computerized tomography (CT) angiography was performed in 25,859 subjects without a history of atherosclerotic disease from SCAPIS study (age 50-65, 52% women). TropI and NT-proBNP were measured in plasma.
View Article and Find Full Text PDF[Long-term outcomes of minimally invasive coronary artery bypass grafting].
Khirurgiia (Mosk)
December 2024
Petrovsky National Research Center of Surgery, Moscow, Russia.
Objective: To evaluate long-term clinical efficacy of MICS CABG compared to surgery through sternotomy.
Material And Methods: The study included 158 patients who underwent minimally invasive CABG through left-sided mini-thoracotomy between 2017 and 2023. The primary endpoints were in-hospital mortality and 5-year survival, secondary endpoint - freedom from adverse cardiac events.
Background: We investigated whether patients with diabetes who had good control of both low-density lipoprotein cholesterol (LDL-C) and triglycerides (TG) would be associated with better long-term clinical outcomes after percutaneous coronary intervention (PCI).
Methods And Results: Using our PCI registry (Fu-Registry), the 1,006 cases with diabetes were divided into 4 groups: Group 1, LDL-C ≥100 mg/dL and TG ≥175 mg/dL; Group 2, LDL-C <100 mg/dL and TG ≥175 mg/dL; Group 3, LDL-C ≥100 mg/dL and TG <175 mg/dL; and Group 4, LDL-C <100 mg/dL and TG <175 mg/dL. The primary endpoint during the follow-up period (median follow up of 1,984 days) was defined as major adverse cardiac events (MACEs).
Prognostic impact of intravascular imaging in percutaneous coronary intervention according to atherothrombotic risk: a post hoc analysis of a randomized clinical trial.
Rev Esp Cardiol (Engl Ed)
December 2024
Division of Cardiology, Department of Medicine, Heart Vascular Stroke Institute, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea. Electronic address:
Introduction And Objectives: Recent randomized controlled trials support the use of intravascular imaging-guided percutaneous coronary intervention (PCI) to improve patient prognosis. However, the subsequent risk of clinical events in patients with coronary artery disease is not determined solely by lesion characteristics or how these lesions are treated. The current study investigated whether the effects of intravascular imaging in complex PCI vary according to atherothrombotic risks.
View Article and Find Full Text PDF[Lipid-Lowering Therapy for Patients with Dyslipidemia].
No Shinkei Geka
November 2024
Department of Stroke Rehabilitation, National Cerebral and Cardiovascular Center.
In patients without cardiovascular disease(primary prevention), the diagnosis of dyslipidemia is the initial step in lipid management. The 2022 guidelines for atherosclerotic disease prevention provide a validated clinical scoring tool to estimate the 10-year risk of atherosclerotic disease derived from the Hisayama study. For primary prevention, patients are classified into the categories of low(<2%), intermediate(2 to<10%)and high(≧10%)risk.
View Article and Find Full Text PDFA contemporary review of sudden cardiac arrest and death in competitive and recreational athletes.
Lancet
November 2024
Department of Cardiology, Lausanne University Hospital, Lausanne, Switzerland.
Article Synopsis
- - Sudden cardiac arrest and death can affect athletes of all ages and competition levels, representing a significant and preventable public health issue globally.
- - There is uncertainty around the exact rates of these incidents due to insufficient reporting and lack of infrastructure, and disparities exist in outcomes between Black and White athletes.
- - Causes vary by age, with younger athletes often facing genetic heart issues while older athletes typically experience coronary artery disease; emergency action plans are crucial for effective cardiac care.
Polygenic Prediction of Recurrent Events After Early-Onset Myocardial Infarction.
Circ Genom Precis Med
December 2024
British Heart Foundation Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care (M.A.,S.A.L., L.G.K., M.K., M.I., E.D.A., A.S.B.).
Background: Myocardial infarction (MI) is a complex disease caused by both lifestyle and genetic factors. This study aims to investigate the predictive value of genetic risk, in addition to traditional cardiovascular risk factors, for recurrent events following early-onset MI.
Methods: The Italian Genetic Study of Early-Onset Myocardial Infarction is a cohort study enrolling patients with MI before 45 years.
Intracoronary administration of tenecteplase to prevent PCI-related myocardial infarction in patients with echo-attenuated coronary plaques: study protocol for a multicenter, prospective, randomized controlled trial.
Trials
November 2024
Department of Cardiology, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, China.
Article Synopsis
[Effects of perioperative use of renin-angiotensin system inhibitor on renal function and clinical outcomes in patients undergoing coronary artery bypass grafting surgery].
Zhonghua Wei Zhong Bing Ji Jiu Yi Xue
October 2024
Department of Cardiac Surgery ICU, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100037, China.
Article Synopsis
- The study aimed to evaluate how preoperative use of renin-angiotensin system inhibitors (RASi) affects kidney function and patient outcomes after coronary artery bypass grafting (CABG).
- Researchers analyzed data from 33,884 CABG patients over nearly a decade, looking specifically at the rates of acute kidney injury (AKI) and mortality.
- Results indicated that patients using RASi pre-surgery had a specific incidence of AKI, with subgroup analyses further examining the effects in patients with hypertension and heart failure.
Epidemiology of ischaemic heart disease in France.
Arch Cardiovasc Dis
December 2024
Santé Publique France, 94410 Saint-Maurice, France.
Article Synopsis
- - In 2022, France recorded 242,227 hospitalizations due to ischaemic heart disease (IHD), affecting 5.6% of the adult population, with a significant mortality rate of 4.8% of all deaths being IHD-related.
- - Patients hospitalized for IHD had an average age of 69.3 years, with 29% being women; there was a high prevalence of cardiovascular risk factors, and many underwent interventions like percutaneous coronary interventions.
- - One year post-hospitalization, 29.9% of patients were rehospitalized for IHD, and 9.3% died from all causes, highlighting the need for improved prevention strategies for IHD in France.*
Different antithrombotic strategies to prevent cardiovascular complications in Kawasaki patients: a systematic review and meta-analysis.
BMC Pediatr
November 2024
Tehran Heart Center, Cardiovascular Diseases Research Institute, Tehran University of Medical Sciences, North Kargar Ave, Tehran, 1995614331, Iran.
Article Synopsis
- - The study focuses on the effectiveness of different antithrombotic strategies in preventing coronary artery aneurysm (CAA) complications in patients with Kawasaki disease (KD).
- - Results from the analysis of 21 studies indicated that combining warfarin with aspirin significantly reduced the risk of myocardial infarction and mortality compared to aspirin alone, though no major differences were found in overall cardiovascular events.
- - It concluded that adding high-dose aspirin to the standard IVIG treatment during the acute phase of KD does not provide additional benefits.
Guanxinning for Residual Inflammation of Stable Coronary Artery Disease: A Pilot Randomized Controlled Trial.
J Inflamm Res
November 2024
Department of Cardiology, Hangzhou TCM Hospital Affiliated to Zhejiang Chinese Medical University, Hangzhou, Zhejiang, People's Republic of China.
Article Synopsis
- This study investigates the impact of adding Guanxinning to standard treatments for stable coronary artery disease (SCAD) patients, who still face high cardiovascular risks despite being on medications like statins.
- After a 12-week trial with 50 SCAD patients, those taking Guanxinning showed significant reductions in several inflammation markers and improvements in endothelial function and blood lipid profiles compared to the control group.
- However, there was no notable difference in levels of IL-4, triglycerides, or other health indicators like liver and kidney function between the two groups, suggesting that while Guanxinning may help reduce inflammation, not all health metrics are significantly impacted.
Reassessing the role of aspirin in patients with coronary artery disease.
Expert Opin Pharmacother
December 2024
Sinai Center for Thrombosis Research and Drug Development, Sinai Hospital of Baltimore, Baltimore, MD, USA.
Article Synopsis
- * Ongoing research is evaluating whether aspirin can be safely discontinued in favor of P2Y receptor inhibitor therapy, but there is still no consensus on the best timing for discontinuation.
- * New findings suggest that using P2Y inhibitors alone may pose a lower risk of bleeding, prompting a reevaluation of aspirin's role, while exploring innovative formulations and delivery methods like inhaled aspirin for improved patient care.
Omega-3 fatty acids for intermittent claudication.
Cochrane Database Syst Rev
October 2024
Imperial Clinical Trials Unit (ICTU), School of Public Health, Imperial College London, London, UK.
Article Synopsis
- Peripheral artery disease (PAD) is marked by artery narrowing and symptoms like intermittent claudication, leading to reduced walking ability; omega-3 fatty acids are explored for potential benefits despite mixed prior evidence.* -
- The review updates findings from 2004 and 2013, focusing on randomized controlled trials (RCTs) to evaluate the efficacy of omega-3 supplementation specifically for individuals with intermittent claudication.* -
- Fifteen RCTs involving 1830 participants were included, assessing outcomes such as quality of life and walking distances, with the follow-up duration ranging from four weeks to six years, though most studies had unclear risk of bias.*
Efficacy of Colchicine for Prevention of Stroke and Adverse Cardiovascular Events: A Meta-analysis of 16 Randomized Controlled Trials.
Am J Cardiovasc Drugs
October 2024
Division of Cardiology, University of Louisville School of Medicine, Louisville, KY, 40202, USA.
Article Synopsis
- Colchicine has shown some effectiveness in reducing adverse cardiovascular events (ACE) and myocardial infarctions (MI) in patients with coronary artery disease, but its impact on stroke risk is unclear, with conflicting results.
- A systematic review of 16 randomized controlled trials involving nearly 25,000 patients revealed that while colchicine significantly lowered ACE and MI risks by 33% and 21% respectively, it did not significantly affect stroke incidence or mortality rates.
- Overall, colchicine might be beneficial for certain cardiovascular outcomes, but it does not appear to reduce the risk of stroke or affect mortality rates in the studied population.
Effect of mild hypothermia vs normothermia cardiopulmonary bypass on postoperative bleeding in patients undergoing coronary artery bypass grafting: protocol of a multi-center, randomized, controlled trial.
BMC Surg
October 2024
Department of Cardiopulmonary Bypass, National Center for Cardiovascular Disease, Chinese Academy of Medical Sciences & Peking Union Medical College, National Clinical Research Center for Cardiovascular Diseases, Fuwai Hospital, No. 167 Beilishi Road, Xicheng District, Beijing, 10010, China.
Article Synopsis
- - The study focuses on comparing the effects of mild hypothermia and normothermia during coronary artery bypass grafting (CABG) with cardiopulmonary bypass (CPB) on postoperative bleeding and complications.
- - A total of 336 patients will be enrolled from September 2023 to December 2024 and randomly assigned to either a mild hypothermia group (32-33℃) or a normothermia group (35-36℃).
- - The primary outcome is measured by the Universal Definition of Perioperative Bleeding, while secondary outcomes include coagulation and inflammatory factors, complications, and lengths of stay in the ICU and hospital.
Colchicine for secondary prevention of ischaemic stroke and atherosclerotic events: a meta-analysis of randomised trials.
EClinicalMedicine
October 2024
Mater Misericordiae University Hospital and School of Medicine, University College Dublin, Ireland.
Article Synopsis
- Guidelines suggest low-dose colchicine can help prevent secondary cardiovascular issues, but its effectiveness for stroke and safety risks are still uncertain.
- A meta-analysis of six trials with nearly 15,000 patients showed colchicine reduces the risk of ischaemic stroke and major cardiovascular events by 27% without increasing serious safety concerns.
- Colchicine's benefits were consistent across different patient groups, and it didn't raise the risk of hospitalization for serious conditions or all-cause mortality.
Impact of an enhanced recovery after surgery program integrating cardiopulmonary rehabilitation on post-operative prognosis of patients treated with CABG: protocol of the ERAS-CaRe randomized controlled trial.
BMC Pulm Med
October 2024
Department of Rehabilitation Medicine, the First Affiliated Hospital of Nanjing Medical University, No.300 Guangzhou Road, Nanjing, 210029, China.
Article Synopsis
- The ERAS-CaRe trial aims to determine if integrating cardiopulmonary rehabilitation into enhanced recovery after surgery (ERAS) can lower postoperative complications for patients undergoing coronary artery bypass grafting (CABG).
- It involves a randomized-controlled study with 360 patients split into four groups: standard ERAS, pre-operative ERAS-CaRe, post-operative ERAS-CaRe, and perio-operative ERAS-CaRe.
- The primary focus is on the incidence of cardiopulmonary complications within 10 days of surgery, with additional attention to various other complications and patient outcomes.
The effect of colchicine on myocardial infarction: An updated systematic review and meta-analysis of randomized controlled trials.
Curr Probl Cardiol
January 2025
Nursing & Midwifery Research Department (NMRD), Hamad Medical Corporation, Doha, Qatar; Department of Public Health, College of Health Sciences, QU Health, Qatar University, Doha, Qatar. Electronic address:
Article Synopsis
- Myocardial infarction (MI) causes significant inflammation that affects recovery, and colchicine, an anti-inflammatory drug, may help reduce adverse cardiovascular events in post-MI patients.
- This meta-analysis reviewed randomized controlled trials to assess colchicine's effectiveness and safety, focusing on multiple cardiovascular outcomes including mortality and adverse events.
- Results from eleven studies involving over 7,000 patients showed that colchicine significantly lowered the risk of adverse cardiovascular events and hospitalization urgency, but it also increased gastrointestinal issues without affecting overall mortality rates.
One-month DAPT after biodegradable-polymer everolimus-eluting stent implantation in women at high-bleeding risk: Insights from the POEM trial.
Catheter Cardiovasc Interv
November 2024
Department of Biomedical Sciences, Humanitas University, Via Rita Levi Montalcini 4, Pieve Emanuele, Milan, Italy.
Article Synopsis
- The study aimed to analyze the impact of gender on clinical outcomes after a 1-month dual-antiplatelet therapy (DAPT) period in patients at high bleeding risk undergoing percutaneous coronary intervention (PCI) with bioresorbable polymer everolimus-eluting stent (BP-EES).
- The research found that while women had additional risk factors such as older age and lower hemoglobin levels, they did not show a significantly higher risk for serious complications compared to men after the 1-month DAPT period.
- The results suggest that a short DAPT strategy post-PCI may be a safe and effective option for high bleeding risk women, indicating that sex may not be a critical factor in determining adverse outcomes in this context
Pathophysiology and clinical implications of coronary artery calcifications.
Curr Opin Cardiol
November 2024
Department of Radiology, Azienda Ospedaliero Universitaria (A.O.U.), Monserrato (Cagliari).
Article Synopsis
- The review highlights the significance of coronary artery calcifications (CAC) as a crucial indicator of coronary artery disease (CAD) and its relation to cardiovascular events.
- Recent guidelines now include CAC assessment in risk evaluation protocols, facilitating a noninvasive method for better understanding and stratifying patients' cardiovascular risk.
- By using CAC imaging, healthcare providers can tailor prevention strategies, such as lifestyle changes and medication management, to effectively reduce the risk of future cardiovascular problems.
Role of the screening with coronary computed tomography angiography on lipid management and risk factors control in an asymptomatic Chinese population: a community-based, parallel-group, open-label, randomized clinical trial (RESPECT2).
Trials
September 2024
Department of Radiology, Jinling Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, China.
Article Synopsis
- - The trial explores whether using coronary computed tomography angiography (CCTA) is more effective than traditional cardiovascular risk scoring for managing lipid levels to prevent coronary artery disease (CAD) in asymptomatic individuals.
- - About 3,400 middle-aged participants will be randomly assigned to two groups: one receiving usual care based on traditional risk scores and the other guided by CCTA results, with both requiring lifestyle changes and monitoring of blood pressure and glucose.
- - The primary focus is on the percentage of participants taking lipid-lowering medication regularly after 6 and 12 months, while secondary outcomes include LDL cholesterol targets and barriers to treatment adherence.
Peripheral artery disease in patients with stable coronary artery disease in general practice: results from an Italian nationwide study-PAD & CAD study.
Intern Emerg Med
September 2024
Arianna Foundation on Anticoagulation, Via Paolo Fabbri, 1/3, 40138, Bologna, Italy.
Article Synopsis
- Peripheral artery disease (PAD) is often undiagnosed in patients with coronary artery disease (CAD), and there's a need for better screening methods in clinical settings.
- A study involving 713 CAD patients in Italy found that 20.8% also had PAD, with about 15% of those being asymptomatic.
- Using an automatic instrument to measure the ankle brachial pressure index (ABI) improved the detection of PAD, highlighting the importance of routine screening to better manage cardiovascular risks.
Do nonfatal events during the first 5 years after coronary artery bypass surgery influence 10 year outcomes?
J Thorac Cardiovasc Surg
September 2024
Division of Cardiovascular Surgery, Peter Munk Cardiac Centre, University Health Network, University of Toronto, Toronto, Ontario, Canada. Electronic address:
Article Synopsis
- The study examined how early adverse events after coronary artery bypass grafting (CABG) affect long-term survival and future adverse events over a 10-year period.
- Out of 20,444 patients who survived the first 5 years post-CABG, 11% experienced nonfatal major adverse cardiac and cerebrovascular events (MACCE), resulting in worse outcomes compared to those without such events.
- Findings suggest that preventing these early adverse events may improve survival and reduce further complications in the long run.
Self-reported smoking status and exhaled carbon monoxide in secondary preventive follow-up after coronary heart events: Do our patients tell the truth?
Tob Prev Cessat
September 2024
Department of Cardiology, Sorlandet Hospital Trust, Arendal, Norway.
Article Synopsis
- - The study investigates the accuracy of self-reported smoking status compared to objective measurements (exhaled carbon monoxide) in patients with coronary heart disease after procedures like myocardial infarction, PCI, and CABG.
- - It includes data from 1,540 participants, revealing that 22% had elevated CO levels one year post-event, with 25% of those incorrectly declaring themselves as non-smokers.
- - The results indicate that those with falsely reported non-smoking statuses were less likely to meet blood pressure treatment goals, highlighting the importance of using objective measures for smoking cessation in clinical settings.