17,209 results match your criteria: "Primary Biliary Cirrhosis"

Article Synopsis
  • - Cholangiopathies are complex disorders with limited understanding and no effective treatments, prompting a study on the extrahepatic biliary tree (EHBD) in Mdr2 mice, a cholestatic mouse model, across different ages (2 to 40 weeks).
  • - The study assessed the effects of N-acetyl-L-Cysteine (NAC), an antioxidant and glutathione precursor, on EHBD injury both ex vivo (using bile duct samples) and in vivo (through oral administration for three weeks).
  • - Results showed that NAC treatment improved bile duct morphology and reduced liver fibrosis along with lower liver enzyme levels, suggesting a shift in cellular state from apoptosis to proliferation, indicating NAC's potential as a therapeutic
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Introduction: Adiponectin, a key adipokine, shows promise as a non-invasive biomarker for liver cirrhosis by reflecting inflammation and metabolic changes, but conflicting findings highlight the need for a systematic review and meta-analysis to clarify its role. Our study aimed to evaluate adiponectin levels across various stages of liver cirrhosis, compare them with other chronic liver diseases (CLD) and hepatocellular carcinoma (HCC), and assess its potential as a diagnostic and prognostic biomarker.

Methods: Our systematic search was conducted on September 2023 using PubMed, EMBASE and Scopus, searching for observational studies evaluating serum and plasma adiponectin levels in liver cirrhosis.

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Forty years of successful national research collaboration in liver disease - the Swedish experience.

Scand J Gastroenterol

December 2024

Department of Health, Medicine, and Caring Sciences, Linköping University and Department of Gastroenterology and Hepatology, University Hospital, Linköping, Sweden.

Aim: Sweden has historically provided a fruitful arena for research in clinical medicine. We here share 40 years of experience of collaboration in the Swedish hepatology research group (SWEHEP) (https://www.swehep.

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Identification of a novel PDC-E2 epitope in primary biliary cholangitis: Application for engineered Treg therapy.

J Autoimmun

December 2024

Center for Translational Immunology, Benaroya Research Institute at Virginia Mason, Seattle, WA, USA; Department of Medicine, University of Washington, Seattle, WA, USA; Department of Immunology, University of Washington, Seattle, WA, USA. Electronic address:

Primary biliary cholangitis (PBC) is a chronic autoimmune liver disease, characterized by progressive destruction of small intrahepatic bile ducts and portal inflammation. Treatment options are limited, with reliance on liver transplantation in advanced cases. The adaptive immune response is implicated in disease pathogenesis by the presence of anti-mitochondrial antibodies targeting the E2 subunit of the pyruvate dehydrogenase complex (PDC-E2) in 90-95 % of patients and T cells infiltrating the portal tracts.

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Amniotic membrane modulates MMP9 and MMP12 gene and protein expression in experimental model of the hepatic fibrosis.

An Acad Bras Cienc

October 2024

Universidade do Vale do Paraíba - UNIVAP, Instituto de Pesquisa e Desenvolvimento, Laboratório de Histologia e Terapia Regenerativa, Av. Shishima Hifumi, 2911, Urbanova, São José dos Campos, 12244-000 São Paulo, SP, Brazil.

Article Synopsis
  • Hepatic fibrosis involves excessive collagen buildup in the liver, affecting its normal function and structure.
  • The study shows that using human amniotic membrane (AM) as a patch on the liver significantly reduces collagen levels in a rat model of biliary fibrosis.
  • Results indicated that AM treatment increased the expression of matrix metalloproteinase 12 (MMP12), which helps lower collagen accumulation, suggesting a potential therapeutic role for AM in treating liver fibrosis.
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Background: Extracellular matrix protein 1 (ECM1) can inhibit TGFβ activation, but its antifibrotic action remains largely unknown. This study aims to investigate ECM1 function and its physical interaction with the profibrotic connective tissue growth factor (CTGF) in fibrosis and ductular reaction (DR).

Methods: Ecm1 knockouts or animals that ectopically expressed this gene were subjected to induction of liver fibrosis and DR by feeding 3,5-diethoxycarbonyl-1,4-dihydrocollidine (DDC) or α-naphthyl-isothiocyanate (ANIT).

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Article Synopsis
  • This study explored two methods of administering indocyanine green (ICG) to improve visualization of biliary anatomy during laparoscopic cholecystectomy (LC) in patients with gallbladder disease: intravenous (IV-ICG) and direct gallbladder injection (IC-ICG).
  • Conducted from 2022 to 2024 with 60 patients, results showed that although the IV-ICG group had a slightly shorter operating time, both methods were effective in identifying critical anatomical structures like the duodenum and common hepatic duct.
  • The IV-ICG technique demonstrated better accuracy in identifying key biliary structures before dissection compared to IC-ICG,
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An observational study of the causes of an isolated elevated alkaline phosphatase level of unclear etiology.

Am J Med Sci

October 2024

Digestive Disease Research Center, Medical University of South Carolina, 96 Jonathan Lucas Street, Suite 908, Charleston, SC 29425, USA. Electronic address:

Article Synopsis
  • Serum alkaline phosphatase (ALP) is frequently tested in patients, but it lacks specific diagnostic value since it can originate from multiple tissues; this study explores causes of isolated elevated ALP levels without a clear reason.
  • A retrospective study at the Medical University of South Carolina looked at 260 adults with unexplained elevated ALP results and found that 57% of cases were linked to underlying malignancies, particularly related to the liver and bones.
  • The study highlights the importance of recognizing an isolated elevated ALP as potentially indicative of serious conditions, especially metastatic cancer, rather than just primary liver issues.
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Serum hepatitis B core-related antigen (HBcrAg) is considered a surrogate marker of the amount and activity of intrahepatic covalently closed circular DNA. This study aimed to explore the prognostic value of HBcrAg on patients with hepatitis B virus (HBV)-related hepatocellular carcinoma (HCC) after curative hepatectomy undergoing antiviral therapy (AVT). Data of 949 consecutive patients with HBV-related HCC undergoing curative resection between 2010 and 2013 were reviewed.

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Article Synopsis
  • Pulmonary complications, particularly pneumonia, are common and often fatal in critically ill patients with liver diseases in the ICU, which led to a study comparing clinical diagnoses to postmortem lung histology.
  • The study analyzed records from 108 patients with liver-related respiratory failure, revealing that only 43.4% of those diagnosed with pneumonia clinically actually had histological evidence of it, while many showed normal or nonspecific lung changes.
  • The findings indicate a significant discrepancy between clinical diagnosis and postmortem results, with poor agreement overall, emphasizing the utility of postmortem lung biopsy to clarify causes of death in these patients.
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The case involves a 33-year-old man with biliary atresia, Wilson disease (WD), and iron overload. Biliary atresia, a cholangiodestructive disease, leads to cirrhosis if untreated. WD, caused by ATP7B gene mutations, results in copper accumulation affecting the liver and brain.

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Background: Iatrogenic bile duct injuries (BDIs) prevention during laparoscopic cholecystectomy (LC) relies on meticulous anatomical dissections through direct visualization. Near-infrared fluorescence (NIRF) with indocyanine green (ICG) improves the visualization of extrahepatic biliary structures. Although ICG can be administered either intravenously or intragallbladder, there remains uncertainty regarding the optimal method for different patient populations.

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Background: The accuracy of administrative codes to capture patients with both primary biliary cholangitis (PBC) and cirrhosis could be challenging because of the potential for incorrect coding due to the old nomenclature "Primary Biliary Cirrhosis." Therefore, the aim of this study was to examine the positive predictive value (PPV) of International Classification of Diseases (ICD) codes for PBC and cirrhosis.

Methods: This was a retrospective cohort study using data from the VA Corporate Data Warehouse.

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Nano-encapsulation of drugs to target hepatic stellate cells: Toward precision treatments of liver fibrosis.

J Control Release

December 2024

Division of Gastroenterology, Department of Internal Medicine at Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology (HUST), Wuhan, China. Electronic address:

Liver fibrosis is characterized by excessive extracellular matrix (ECM) deposition triggered by hepatic stellate cells (HSCs). As central players in fibrosis progression, HSCs are the most important therapeutic targets for antifibrotic therapy. However, owing to the limitations of systemic drug administration, there is still no suitable and effective clinical treatment.

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SARS-CoV-2 mRNA vaccines do not worsen autoimmunity in patients with autoimmune liver diseases.

J Autoimmun

December 2024

Università della Svizzera Italiana, Facoltà di Scienze Biomediche, Lugano, Switzerland; Institute for Research in Biomedicine (IRB), Bellinzona, Switzerland; MowatLabs, Faculty of Life Sciences & Medicine, King's College London, King's College Hospital, London, UK; Epatocentro Ticino, Lugano, Switzerland. Electronic address:

Article Synopsis
  • Researchers studied the impact of mRNA SARS-CoV-2 vaccines on patients with autoimmune liver diseases to see if vaccination worsened their conditions.
  • A total of 49 patients with primary biliary cholangitis (PBC), 35 with autoimmune hepatitis (AIH), and 9 with primary sclerosing cholangitis (PSC) were tested for autoantibodies before and after vaccination, with results indicating higher rates of autoantibody positivity in liver disease patients compared to healthcare workers.
  • Despite some fluctuations in autoantibody levels following vaccination, the study concluded that mRNA vaccines do not cause significant short-term worsening of autoimmunity in these patients.
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Data regarding the outcomes of liver transplantation in disabled, highly dependent, and legally incapacitated adults are scarce, likely due to the infrequency of these procedures in such populations. Multicenter studies in adult transplant centers have shown that patients with coexisting intellectual and developmental disabilities (IDDs) may be denied transplantation because of their expected low longevity and the complexities associated with managing post-transplant care. We examined the long-term patient and graft outcomes in highly dependent, incapacitated patients with IDDs who underwent elective transplantation for chronic liver disease.

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Biliary tract cancers (BTC) are rare lethal malignancies arising along the biliary tree. Unfortunately, effective therapeutics are lacking and the prognosis remains dismal even for patients eligible for surgical resection. Therefore, novel therapeutic approaches along with early detection strategies and prognostic markers are urgently needed.

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The control of bleeding during laparoscopic liver resection (LLR) is still a focus of research. However, the advantages of the main bleeding control methods, including total hepatic inflow occlusion (TIO) vs. hemihepatic inflow occlusion (HIO), during LLR remain controversial.

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Background: In cirrhosis, activation of renin-angiotensin-aldosterone system leads to sodium and water retention causing ascites. Dapagliflozin, a sodium glucose linked transporter-2 inhibitor, induces natriuresis in patients with heart failure. A similar natriuretic effect may improve ascites in patients with cirrhosis.

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Article Synopsis
  • Metabolic dysfunction-associated steatotic liver disease (MASLD) is becoming more common and is linked to serious health issues like liver cancer and cardiovascular disease.
  • A study evaluated the risk of developing cholangiocarcinoma (CCA) in MASLD patients compared to a matched control group, using data from the Swedish National Patient Register over a span of 33 years.
  • The results showed that only 0.1% of MASLD patients developed CCA, which is similar to the 0.3% occurrence in the general population, suggesting that there's no need for increased monitoring for CCA in MASLD patients.
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Single-cell RNA sequencing reveals the pro-inflammatory roles of liver-resident Th1-like cells in primary biliary cholangitis.

Nat Commun

October 2024

State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, National Clinical Research Center for Infectious Diseases, National Medical Center for Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Department of Infectious Diseases, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.

Article Synopsis
  • Primary biliary cholangitis (PBC) is a serious disease affecting the liver, causing inflammation and damage over time.
  • Scientists used a special technique called single-cell RNA sequencing to study immune cells in PBC patients and learned more about how the disease damages the liver.
  • They found that certain cells in the liver are involved in the problem and blocking a specific pathway could help reduce inflammation and improve the situation in experiments.
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Article Synopsis
  • * In a study of 149 patients aged 60 and older who underwent liver resection between 2014 and 2018, 24.8% were found to be sarcopenic, which significantly impacted their mortality and overall survival rates post-surgery.
  • * The findings suggest that sarcopenic patients face poorer outcomes, especially if they experience complications and fail to achieve 'Textbook Outcome' (TO), which correlates with better 5-year survival rates compared to non-s
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Article Synopsis
  • There’s a rare bacteria that can infect heart valves, usually found in the mouths of pets like cats and dogs, and it can cause serious infections in humans, especially after bites or scratches.
  • A 73-year-old woman with liver problems got very sick after recently having a skin infection and hospital stay, showing symptoms like weakness and fever.
  • Doctors found a dangerous mass on her heart valve but couldn’t do surgery, so they treated her with strong antibiotics, which eventually helped her get better before she went home.
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