Leveraging artificial intelligence for advancements in reproductive health.

We are writing to address the growing interest in the role of artificial intelligence (AI) within healthcare, particularly in the field of reproductive health. As technology continues to evolve, AI offers an unprecedented opportunity to transform how we diagnose, treat, and improve access to reproductive services, especially in underserved communities. AI-driven tools, supported by machine learning and big data analytics, are already demonstrating their potential in enhancing outcomes in reproductive health.

Onco-therapeutic Effect of Novel Triterpenoid Compound Oleanolic Acid Isolated and Characterized from the Methanolic Extract of Coldenia procumbens (Linn.).

India is considered a hub for a wide range of phytochemicals due to its rich biodiversity, which indeed flourished with many folk medicines and treatments. Phytochemicals are secondary metabolites synthesized in plants to protect themselves from deteriorating environmental stress and defense against pathogens. In the present study, we aimed to explore the strong anticancer potential of the bioactive compound present in the leaf extract of Coldenia procumbens (L.

Membraneless ethanol fuel cell Pt-Sn-Re nano active catalyst on a mesoporous carbon support.

Herein, we report, for the first-time, mesoporous carbon-supported binary and ternary catalysts with different atomic ratios of Pt/MC (100), Pt-Sn/MC (50 : 50), Pt-Re/MC (50 : 50), Pt-Sn-Re/MC (80 : 10 : 10) and Pt-Sn-Re/MC (80 : 115 : 05) prepared using a co-impregnation reduction method as anode components for membraneless ethanol fuel cells (MLEFLs). Mechanistic and structural insights into binary Pt-Sn/MC, Pt-Re/MC and ternary Pt-Sn-Re/MC catalysts were obtained using scanning electron microscopy (SEM), transmission electron microscopy (TEM), X-ray diffraction (XRD) and energy-dispersive X-ray spectroscopy (EDX) methods. In particular, chemical characterization cyclic voltammetry, CO stripping voltammetry and chronoamperometry indicated that Pt-Sn-Re/MC (80 : 15 : 05) had better dynamics toward ethanol oxidation than Pt-Sn-Re/MC (80 : 10 : 10), Pt-Sn/MC (50 : 50) and Pt-Re/MC (50 : 50) catalysts.

A Structural and Investigation of Potential CDC7 Kinase Enzyme Inhibitors.

A crucial role in the regulation of DNA replication is played by the highly conserved CDC kinase. The CDC7 kinase could serve as a target for therapeutic intervention in cancer. The primary heterocyclic substance is pyrazole, and its derivatives offer great potential as treatments for cancer cell lines.

Performance of Carbapenemase Nordmann-Poirel, Modified Carbapenem Inactivation, and EDTA Carbapenem Inactivation Methods for Detecting Carbapenem-Resistant Isolates.

Infections caused by carbapenem-resistant (CRKP) are a major threat to public health. Timely detection of CRKP will help treat patients with appropriate antibiotics. This study aimed to evaluate the performance of the carbapenemase Nordmann-Poirel (CarbaNP), modified carbapenem inactivation (mCIM), and EDTA carbapenem inactivation (eCIM) methods for the detection of CRKP.

Enhanced membraneless fuel cells by electrooxidation of ethylene glycol with a nanostructured cobalt metal catalyst.

The advancement of effective and long-lasting electrocatalysts for energy storage devices is crucial to reduce the impact of the energy crisis. In this study, a two-stage reduction process was used to synthesize carbon-supported cobalt alloy nanocatalysts with varying atomic ratios of cobalt, nickel and iron. The formed alloy nanocatalysts were investigated using energy-dispersive X-ray spectroscopy, X-ray diffraction, and transmission electron microscopy to determine their physicochemical characterization.

Synthesis, Characterization, Pharmacogenomics, and Molecular Simulation of Pyridinium Type of Ionic Liquids and Their Applications.

Substituted pyridinium bromides are prepared by conventional and solvent-free greener methods. The solvent-free solid-phase (greener) method is superior to the conventional method because of its nontoxic nature, simple reaction setup procedure, and twenty times less time consumption. Column chromatography and toxic organic solvents are avoided.

Efficient Antibacterial Dimeric Nitro Imidazolium Type of Ionic Liquids from a Simple Synthetic Approach.

Synthesis of dimeric nitro-substituted imidazolium salts under the conventional/solvent-free method is reported. The solvent-free method is more important than the conventional one because of its shorter reaction time, higher yield from easily available starting material, environmental safety, and so forth. Counter anion exchange is carried out using inorganic salt, which is dissolved in deionized water at room temperature.

Pyridine and isoxazole substituted 3-formylindole-based chitosan Schiff base polymer: Antimicrobial, antioxidant and in vitro cytotoxicity studies on THP-1 cells.

This paper presents the synthesis of two new chitosan Schiff base (CSB) polymers, namely, 2PCT and 4MCT based on pyridin-2-ylmethyl-1H-indole-3-carbaldehyde and 1-(4-methyl-3,5-dimethylisoxazole)-1H-indole-3-carbaldehyde with chitosan (CT). The structural features of CSB polymers were confirmed by Fourier-transform infrared (FTIR) and proton nuclear magnetic resonance (H NMR) spectroscopy and their antimicrobial activity was evaluated against Staphylococcus aureus, Escherichia coli and Candida albicans. The antioxidant studies found that both 2PCT and 4MCT presented significant free radical scavenging activity with IC at 169.

Antibacterial, Antioxidant, Larvicidal and Anticancer Activities of Silver Nanoparticles Synthesized Using Extracts from Fruits of and Flowers of .

The present study aimed to analyze the in vitro antibacterial, antioxidant, larvicidal and cytotoxicity properties of green synthesized silver nanoparticles (Ag NPs) using aqueous extracts from fruits of Lagerstroemia speciosa and flowers of . Synthesized Ag NPs were characterized using UV-DRS, FTIR, XRD, DLS, and High-Resolution SEM and TEM analyses. Absorption wavelength was observed at 386 nm by UV-DRS analysis and energy band gap was calculated as 3.

3-Formylindole-based chitosan Schiff base polymer: Antioxidant and in vitro cytotoxicity studies on THP-1 cells.

Two imine derivatives of chitosan (i-CTs), namely 2FCT and 5MCT, were synthesized by reacting chitosan (CT) with 2-(3-formyl-1H-indol-1yl)acetonitrile (2F), and 5-methoxyindole-3-carbaldehyde (5M), respectively. The antimicrobial evaluation of i-CTs exhibited stronger inhibition effect against Staphylococcus aureus, Escherichia coli and Candida albicans. The antioxidant activity of 2FCT and 5MCT showed strong scavenging ability with IC 2.

Enhancement of the structure, solar cells and vibrational studies of undoped CuCr2O4 and La-doped CuCr2O4 semiconductor compounds.

In the present paper, we report the successful synthesis of spinel-type of CuCrO and La doped CuCrO semiconductor nanoparticles by a microwave method. Starting with the precursor complex, this technique includes the creation of homogenous solid intermediates, which reduces atomic diffusion pathways during the microwave process. CuCrO and La doped CuCrO were characterized by the following analytical methods for instance X-ray diffraction (XRD), transmission electron microscopy (TEM), Ultraviolet-visible (UV-Vis) spectroscopy and Fourier transform infrared spectroscopy (FTIR).

Characterization of phosphate solubilizing plant growth promoting rhizobacterium strain PCPSMR15 isolated from .

The rhizosphere soil is a source for a diversity of microorganisms which play a vital role in the enhancement of plant health through the mechanism of symbiotic interaction thereby influencing the plant growth. The present study aimed at isolating potential phosphate solubilizing rhizobacteria from rice () crop for which, four different rhizosphere soil samples were collected from different locations of Tiruvallur district, India. Isolates were cultured on nutrient agar medium followed by serial dilutions and different colonies with morphological variations were isolated from each dilution.

Occurrence of extended-spectrum β-lactamase, AmpC, and carbapenemase-producing genes in gram-negative bacterial isolates from human immunodeficiency virus infected patients.

Background: Progressive decline of immune response in HIV patients makes them susceptible to frequent bacterial infections. High usage of antibiotics influences the emergence of multidrug-resistant bacteria and worsens the clinical outcomes. In this study, the occurrence of drug-resistant genes in Gram-negative bacterial isolates from HIV patients in South India was analyzed.

Biodegradation of low-density polyethylene (LDPE) sheet by microalga, Uronema africanum Borge.

Plastic (polyethylene) pollution is a severe cause of deterioration of a healthy environment. For example, ingestion of plastics in the animal gut, clogging of water canals and retarded solid waste management. Many conventional methods of polyethylene degradation include UV photooxidation, thermal oxidation, incineration, chemical oxidation and landfill are being practiced.

Bayesian Optimization of Bose-Einstein Condensates.

Machine Learning methods are emerging as faster and efficient alternatives to numerical simulation techniques. The field of Scientific Computing has started adopting these data-driven approaches to faithfully model physical phenomena using scattered, noisy observations from coarse-grained grid-based simulations. In this paper, we investigate data-driven modelling of Bose-Einstein Condensates (BECs).

Cellular alterations and damage to the renal tissue of marine catfish Arius arius following Cd exposure and the possible sequestrant role of Metallothionein.

Cd is a non-degradable heavy metal pollutant with no known biological role. When taken up by living organisms from the environment, it causes extensive tissue damage. Here, we studied the effects of exposure to 20 mg/LCdClfor 0, 24, 48, and 72 h on the renal tissue of marine catfish Arius arius.

Raltegravir, Indinavir, Tipranavir, Dolutegravir, and Etravirine against main protease and RNA-dependent RNA polymerase of SARS-CoV-2: A molecular docking and drug repurposing approach.

Background: Outbreak of COVID-19 has been recognized as a global health concern since it causes high rates of morbidity and mortality. No specific antiviral drugs are available for the treatment of COVID-19 till date. Drug repurposing strategy helps to find out the drugs for COVID-19 treatment from existing FDA approved antiviral drugs.

Computational selection of flavonoid compounds as inhibitors against SARS-CoV-2 main protease, RNA-dependent RNA polymerase and spike proteins: A molecular docking study.

An outbreak of Coronavirus disease 2019 (COVID-19) caused by SARS-CoV-2 has been recognized as a global health concern. Since, no specific antiviral drug is proven effective for treatment against COVID-19, identification of new therapeutics is an urgent need. In this study, flavonoid compounds were analyzed for its inhibitory potential against important protein targets of SARS-CoV-2 using computational approaches.

Antiviral activity of astragaloside II, astragaloside III and astragaloside IV compounds against dengue virus: Computational docking and in vitro studies.

This study was aimed to identify the phytocompounds possessing anti-dengue virus activity using in silico and in vitro approaches. A total of 7000 phytocompounds were virtually screened against protein targets (envelope, NS2b/NS3, and NS5) of dengue virus using iGEMDOCK and individually docked using Maestro 10.7 module of Schrödinger software.

Synthesis and characterization of cellulose/TiO nanocomposite: Evaluation of in vitro antibacterial and in silico molecular docking studies.

Cellulose/TiO nanocomposite was synthesized using coagulation in sodium hydroxide-thiourea-urea aqueous solution medium by precipitation method. This method was accomplished green and cost-effective for the fabrication of composite nanomaterials. Structure, morphology and optical properties of the nanocomposite were characterized by X-ray diffraction, energy dispersive X-ray spectroscopy, field emission scanning electron microscopy, transmission electron microscopy, and ultraviolet diffuse reflectance spectra respectively.

Tris(ethane-1,2-di-amine-κ ,')zinc(II) tetra-chlorido-zincate(II).

The title complex, [Zn(CHN)][ZnCl], exists as discrete ions. The [Zn(CHN)] cation exhibits a distorted octa-hedral shape. In the [ZnCl] anion, the Zn atom is in an almost regular tetra-hedral environment.

Baseline survey of micro and mesoplastics in the gastro-intestinal tract of commercial fish from Southeast coast of the Bay of Bengal.

Plastics pollution is ubiquitous. Microplastics (<5 mm in diameter) and mesoplastics (5-20 mm in diameter) are emerging as the most common plastic particulates found in the marine environment. In this study, the occurrence of microplastics and mesoplastics in the gastrointestinal tract (GI) of some commercially important fish collected from Chennai and Nagapattinam of Tamil Nadu, Southeast coast of Bay of Bengal was assessed.

In vitro anti-HIV-1 activity of the bioactive compound extracted and purified from two different marine macroalgae (seaweeds) (Dictyota bartayesiana J.V.Lamouroux and Turbinaria decurrens Bory).

Highly active antiretroviral therapy (HAART) is the only available remedial measure to treat HIV infected patients, as recognized by the WHO. However, it is associated with toxicity (nephrotoxicity), high cost and most preferably drug resistance in the first-line treatment. Wherefore, potential and novel natural source is the only option for the modern world to challenge this global issue.