Sci Rep
January 2025
MIRAI Technology Institute, Shiseido Co., Ltd., 1-2-11 Takashima, Nishi-ku, Yokohama, 220-0011, Kanagawa, Japan.
Like the lines themselves, concerns about facial wrinkles, particularly glabellar lines - the prominent furrows between the eyebrows - intensify with age. These lines can inadvertently convey negative emotions due to their association with negative facial expressions. We investigated the effects of repeated frowning on the development of temporary glabellar lines through the activation of the corrugator muscle.
View Article and Find Full Text PDFJ Craniofac Surg
January 2025
Department of Oral Biology, Division in Anatomy and Developmental Biology, Human Identification Research Institute, BK21 FOUR Project, Yonsei University College of Dentistry.
This narrative review explores the various injection techniques utilized in facial filler procedures, emphasizing their applications, benefits, and potential complications. The increasing demand for total facial contouring and rejuvenation has led to a rise in the use of volumizing fillers and the integration of these procedures with other treatments such as toxins, threads, lasers, radiofrequency, and ultrasound. Achieving satisfactory results necessitates a comprehensive understanding of facial anatomy and the effects of aging on skin tissue.
View Article and Find Full Text PDFCrit Rev Toxicol
January 2025
Syngenta, Bracknell, United Kingdom.
While progress has been made in recent years, there are still no suitable and accepted , or models that can be used to accurately predict whether a chemical substance has the intrinsic property to cause immune-mediated chemical respiratory allergy, typically manifested as allergic asthma or allergic rhinitis which represents a severe health hazard. Regulatory authorities have relied primarily on clinical evidence (case reports, clinical databases, worker exposure studies) to classify substances as respiratory sensitizers, but this evidence can lack a proven immunological mechanism which is necessary to identify substances which can cause life-long sensitization and clinically relevant allergic symptoms in the respiratory tract in an exposed population (such respiratory allergens may be considered as "true" sensitizers, in analogy to the definition of skin sensitization, and in contrast to respiratory irritants). In light of this, the European Center for Ecotoxicology and Toxicology of Chemicals convened a Task Force to evaluate the types of clinical methods and data sources and the implications of relying on such data for regulatory decision making from a scientific perspective.
View Article and Find Full Text PDFJ Cosmet Dermatol
January 2025
Department of Dermatology, Hangzhou Third People's Hospital, Zhejiang, Hangzhou, China.
Background: Skin pigmentation disorders may increase patients' psychological burdens. Consequently, they are increasingly attracting attention. Dermal fibroblasts have been shown to regulate pigmentation by secreting soluble factors.
View Article and Find Full Text PDFCell Commun Signal
January 2025
School of Pharmaceutical Sciences, Southern Medical University, Guangzhou, 510515, China.
Background: Staphylococcus aureus, a known contributor to non-healing wounds, releases vesicles (SAVs) that influence the delicate balance of host-pathogen interactions. Efferocytosis, a process by which macrophages clear apoptotic cells, plays a key role in successful wound healing. However, the precise impact of SAVs on wound repair and efferocytosis remains unknown.
View Article and Find Full Text PDFSci Rep
January 2025
School of Information and Electronic Engineering and Zhejiang Key Laboratory of Biomedical Intelligent Computing Technology, Zhejiang University of Science and Technology, No. 318, Hangzhou, Zhejiang, China.
Skin cancer is common and deadly, hence a correct diagnosis at an early age is essential. Effective therapy depends on precise classification of the several skin cancer forms, each with special traits. Because dermoscopy and other sophisticated imaging methods produce detailed lesion images, early detection has been enhanced.
View Article and Find Full Text PDFForensic Sci Int
January 2025
Forensic Science Department, Kristu Jayanti College (autonomous), Bangalore, India. Electronic address:
In forensic investigations, human keratinized tissues like skin and nails are commonly encountered as trace evidence, yet the use of vibrational spectroscopy for their identification and differentiation has been underexplored. This research utilized ATR-FTIR to distinguish between human nails and skin samples collected from a group of 50 participants, employing advanced chemometric analysis techniques. The spectral signatures of human keratinized tissues, such as nails and skin, exhibit similarities consistent with previous studies.
View Article and Find Full Text PDFTher Adv Musculoskelet Dis
January 2025
The First Department of Internal Medicine, School of Medicine, University of Occupational and Environmental Health, Japan, 1-1 Iseigaoka, Yahata-nishi, Kitakyushu 807-8555, Japan.
Psoriatic arthritis (PsA) presents various clinical manifestations, including skin lesions, peripheral arthritis, axial involvement, enthesitis, nail involvement, dactylitis, and uveitis. In addition, it causes a high incidence of lifestyle-related diseases and an increase in cerebrovascular and cardiovascular events. As the pathology of PsA has been clarified, molecular-targeted drugs targeting tumor necrosis factor-α, interleukin (IL)-17A, IL-17A/F, IL-17 receptor, IL-12/23(p40), IL-23p19, Cytotoxic T-lymphocyte Antigen-4 (CTLA-4), Janus kinase, and phosphodiesterase-4 have been developed and are widely used in clinical practice.
View Article and Find Full Text PDFCureus
December 2024
Department of Pharmaceutics, Krishna Institute of Pharmacy, Krishna Vishwa Vidyapeeth (Deemed to Be University), Karad, IND.
The field of wound healing faces significant challenges, particularly in the treatment of chronic wounds, which often result in prolonged healing times and complications. Recent advancements in 3D printing technology have provided innovative solutions to these challenges, offering tailored and precise approaches to wound care. This review highlights the role of 3D printing in enhancing wound healing, focusing on its application in creating biocompatible scaffolds, custom wound dressings, and drug delivery systems.
View Article and Find Full Text PDFMethods Mol Biol
January 2025
Department of Dermatology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
This study describes an intramolecular quenching assay to evaluate gamma-secretase (GS) enzyme activity in human dermal cells. The method utilizes a fluorogenic peptide substrate, mimicking a fragment of amyloid precursor protein (APP), in which a quencher suppresses the fluorescence of a fluorophore until enzymatic cleavage occurs, resulting in a measurable increase in fluorescence. This real-time, direct measurement of GS activity allows for precise kinetic analysis using Michaelis-Menten modeling to define Kd and Vmax.
View Article and Find Full Text PDFNanoscale
January 2025
Department of Pharmaceutical Sciences, University of Vienna, Vienna, Austria.
Targeted delivery has emerged as a critical strategy in the development of novel therapeutics. The advancement of nanomedicine hinges on the safe and precise cell-specific delivery of protein-based therapeutics to the immune system. However, major challenges remain, such as developing an efficient delivery system, ensuring specificity, minimizing off-target effects, and attaining effective intracellular localization.
View Article and Find Full Text PDFArch Dermatol Res
January 2025
Assisted Reproduction Unit, Department of Obstetrics and Gynecology, Zhejiang Provincial Clinical Research Center for Obstetrics and Gynecology Zhejiang Key Laboratory of Precise Protection and Promotion of Fertility, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou, 310016, China.
The human skin microbiome is closely associated with various diseases. We aimed to find the causal association of the human skin microbiome with vaginitis. A two-way two-sample Mendelian randomization study used summary statistics of the human skin microbiota from the largest genome-wide association study meta-analysis.
View Article and Find Full Text PDFInt J Legal Med
January 2025
Institute of Legal Medicine, University Hospital of Cologne, Melatengürtel 60-62, 50823, Cologne, Germany.
The so-called "shedder status", which can more precisely be referred to as "individual shedding propensity" (ISP), has been the subject of forensic genetic research for more than two decades. Numerous studies have been published on this topic many of which report contradictory and/or insufficiently documented results regarding the existence, influencing factors, classifications of and test methodologies for the ISP of skin material. To date, there is no scientific consensus on the best way to register and conceptualize this variable, that is essential for the assessment of DNA transfer events.
View Article and Find Full Text PDFSci Rep
January 2025
School of Computer Science Engineering (SCOPE), VIT-AP University, Amravati, Andhra Pradesh, India.
In the present scenario, cancerous tumours are common in humans due to major changes in nearby environments. Skin cancer is a considerable disease detected among people. This cancer is the uncontrolled evolution of atypical skin cells.
View Article and Find Full Text PDFMed J Malaysia
January 2025
Department of General Surgery, Saveetha Medical College and Hospital, Saveetha Institute of Medical and Technical Sciences (SIMATS), Saveetha University, Thandalam, Chennai, Tamil Nadu, India.
Seborrheic keratosis (SK) is a prevalent hyperkeratotic dermatological condition characterized by benign proliferation of epidermal keratinocytes, typically occurring in the middle to advanced stages of life. While the trunk is the primary site for lesions, they can also manifest on the extremities, face, and scalp. Although SK is typically benign, there can be morphological overlap with malignant skin lesions, necessitating meticulous differentiation for an accurate diagnosis.
View Article and Find Full Text PDFSci Adv
January 2025
Neural Engineering Centre, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518055, China.
Neuromuscular abnormality is the leading cause of disability in adults. Understanding the complex interplay between muscle structure and function is crucial for effective treatment and rehabilitation. However, the substantial deformation of muscles during movement (up to 40%) poses challenges for accurate assessment.
View Article and Find Full Text PDFSensors (Basel)
December 2024
School of Mechanical Engineering, Beijing Institute of Technology, Beijing 100081, China.
The geometric error distributed on components' contact surfaces is a critical factor affecting assembly accuracy and precision instrument stability. Effective error separation methods can improve model accuracy, thereby aiding in performance prediction and process optimization. Here, an error separation method for geometric distribution error modeling for precision machining surfaces based on the K-space spectrum is proposed.
View Article and Find Full Text PDFPharmaceutics
December 2024
Department of Pharmacy and Pharmaceutical Technology and Parasitology, University of Valencia, 46100 Valencia, Spain.
Patient care and control of inflammatory disorders, such as psoriasis, can be improved by model-informed precision dosing (MIPD) techniques based on population pharmacokinetic/pharmacodynamic (PK/PD) models. Clinical dose selection decisions based on MIPD strategies need to take account of the uncertainty associated with the individual PK/PD model parameters, which is determined by the quantity of individual observational data collected in clinical practice. The aim of this study was to propose an approach for personalized dosage regimens of secukinumab (SCK) in 22 Spanish patients with plaque psoriasis, whose severity level was considered moderate to severe, taking into account the uncertainty associated with individual parameters in a population-based PK/PD model.
View Article and Find Full Text PDFMaterials (Basel)
December 2024
School of Mechanical Engineering, Xi'an Jiaotong University, Xi'an 710049, China.
The thin-walled hyperbolic structures made from titanium alloy primarily encompass two typical forms: hyperbolic convex and hyperbolic concave (saddle). This paper addresses the technical challenges associated with the forming processes that frequently result in ripples or wrinkles in these configurations. Specifically, it investigates precision control techniques for the hot forming process of thin-walled hyperbolic skins from TC4 titanium alloy.
View Article and Find Full Text PDFBioengineering (Basel)
December 2024
Movement Control and Neuroplasticity Research Group, KU Leuven, Tervuursevest 101, 3001 Leuven, Belgium.
Electromyographic (EMG) sensors are essential tools for analyzing muscle activity, but traditional designs often face challenges such as motion artifacts, signal variability, and limited wearability. This study introduces a novel EMG sensor fabricated using Aerosol Jet Printing (AJP) technology that addresses these limitations with a focus on precision, flexibility, and stability. The innovative sensor design minimizes air interposition at the skin-electrode interface, thereby reducing variability and improving signal quality.
View Article and Find Full Text PDFDiagnostics (Basel)
December 2024
Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Via Montpellier 1, 00133 Rome, Italy.
Cutaneous malignant melanoma (MM) is the most aggressive form of skin cancer, associated with high mortality and rising incidence rates in Europe despite prevention efforts. Nodular MM, the most aggressive subtype, often mimics other skin tumors, complicating diagnosis. We present the case of a 66-year-old woman with a large, ulcerated tumor beneath the left scapula, along with multiple nodular lesions on the left arm and chest.
View Article and Find Full Text PDFDiagnostics (Basel)
December 2024
Department of Neurosciences, Institute of Human Anatomy, University of Padova, 35121 Padova, Italy.
Background: Lymphedema represents a frequent cause of disability for patients undergoing oncological treatments and, being a chronic, non-reversible pathology, requires targeted and continuous rehabilitation treatments. To date, the studies available on the use of ultrasound in patients with lymphedema mainly report descriptive data; therefore, with this study, we wanted to describe in a more objective way the typical ultrasound alterations found in these patients, measuring the thickness of the different superficial structures, and defining subcutis echogenicity.
Methods: 14 patients affected by secondary lymphedema of the upper limbs were enrolled in this cross-sectional observational study (12 had breast cancer and 2 with melanoma as their primary diagnosis).
Cancers (Basel)
December 2024
Division of Early Drug Development, European Institute of Oncology, IRCCS, 20141 Milan, Italy.
Background: Early-phase clinical trials offer a unique opportunity for patients with cancer. These trials often mandate biopsies to collect tumor tissue for research purposes, requiring patients to undergo invasive procedures. Some trials mandate molecular prescreening, but the success of these analyses relies on the quality and quantity of the tested materials.
View Article and Find Full Text PDFAesthetic Plast Surg
January 2025
Division in Anatomy and Developmental Biology, Department of Oral Biology, Human Identification Research Institute, BK21 FOUR Project, Yonsei University College of Dentistry, 50-1 Yonsei-ro, Seodaemun-gu, Seoul, 03722, Korea.
Background: Hollowness in the anteromedial, buccal, and lateral cheek regions is a common concern in aesthetic medicine, often resulting from age-related volume loss and structural changes. Advanced filler injection techniques that incorporate a thorough understanding of facial anatomy are critical for achieving optimal and safe outcomes.
Objective: To review and detail anatomically guided filler injection techniques for addressing hollowness in specific cheek regions, considering facial anatomy, ethnic variations, and patient-specific aesthetic goals.
J Cosmet Dermatol
January 2025
Made-Young Plastic Surgery Clinic, Seoul, Korea.
Background: Thread lifting is a minimally invasive technique for addressing facial aging and skin laxity. Despite its popularity, it carries risks of complications ranging from minor bruising to severe structural injuries. Comprehensive understanding of these complications is vital for optimizing outcomes.
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