22 results match your criteria: "Príncipe de Asturias Teaching Hospital[Affiliation]"
Characterization of thrombosis risk in ambulatory patients with cancer: results of the observational, prospective, multicenter CARTAGO study.
Oncologist
December 2024
Medical Oncology Department, Virgen de la Arrixaca Clinical University Hospital, 30120 Murcia, Spain.
Background: Venous thromboembolism (VTE) is one of the leading causes of death in patients with cancer. Currently, there is a need to develop an easily applicable risk model that can identify patients who will benefit from receiving primary thromboprophylaxis to reduce the incidence of VTE.
Patients And Methods: This was a non-interventional, multicenter, observational, prospective study carried out in 62 Oncology and Hematology services in Spain and Portugal between January 2018 and December 2019.
Effect of Tumor Regression Grade on Survival and Disease-Free Interval in Patients Operated on for Locally Advanced Rectal Cancer.
Cancers (Basel)
May 2024
Department of General and Digestive Surgery, Príncipe de Asturias Teaching Hospital, 28805 Alcala de Henares, Spain.
Article Synopsis
- Colorectal cancer is a major health issue, being the fourth leading cause of cancer deaths, with rectal cancer contributing significantly to these statistics; recent studies show promising advancements in neoadjuvant therapies.
- * A study involving 181 patients with locally advanced rectal cancer examined the effects of neoadjuvant chemoradiotherapy on tumor regression and surgical outcomes, utilizing the Mandard grading system for analysis.
- * The findings indicated that greater tumor regression correlates with improved disease-free survival rates and reduced local recurrence and distant metastasis, highlighting the importance of tumor response to therapy on long-term disease progression.
Thyroid abscess, an uncommon diagnosis: A case report and mini‑review of the literature.
Med Int (Lond)
April 2024
Department of General and Digestive Surgery, Príncipe de Asturias Teaching Hospital, 28805 Madrid, Spain.
Article Synopsis
- Thyroid abscesses are rare but can occur in patients with weakened immune systems or existing thyroid issues; early diagnosis and treatment with antibiotics and abscess drainage is essential.
- A case study highlights a 48-year-old healthy male who developed a thyroid abscess after recent acute prostatitis treatment, presenting with neck pain and swelling that blocked airway movement.
- After confirming the abscess with imaging, the patient underwent an emergency hemithyroidectomy, resulting in a successful recovery without complications like voice changes or recurrence.
Elevated tissue expression of RANKL and RANK is associated with poorer survival rates in pancreatic cancer patients.
Histol Histopathol
September 2024
Ramón y Cajal Institute of Sanitary Research (IRYCIS), Madrid, Spain.
Article Synopsis
- Pancreatic cancer, particularly pancreatic ductal adenocarcinoma (PDAC), is a deadly cancer often diagnosed late, making treatment and prognosis challenging.* -
- The study explored the prognostic value of RANK and RANKL proteins in relation to survival outcomes of 41 pancreatic cancer patients over 60 months.* -
- It found that higher levels of RANK and RANKL are linked to poorer survival rates, suggesting potential targets for further research on treatment options.*
Spontaneous cervical hematoma caused by giant parathyroid adenoma in an elderly patient: A case report.
Med Int (Lond)
November 2023
Department of General and Digestive Surgery, Príncipe de Asturias Teaching Hospital, 28805 Madrid, Spain.
Article Synopsis
- Spontaneous cervical hematoma often arises from bleeding in or around the parathyroid gland, typically linked to conditions like giant adenomas or hyperplasia, and can lead to severe complications if it compresses the airway.
- For stable patients, treatment generally includes monitoring and possible delayed surgery, while those with airway issues require urgent surgical intervention.
- The case study discusses a 78-year-old patient with multiple health issues who experienced neck pain and respiratory problems due to a spontaneous cervical hematoma from a giant parathyroid adenoma, resulting in complicated post-operative recovery.
Malignant Bowel Obstruction Due to Intraluminal Metastasis of Endometrial Adenocarcinoma Located in the Sigmoid Colon After Nine Years of Follow-Up.
Cureus
October 2023
General Surgery, Príncipe de Asturias Teaching Hospital, Alcalá de Henares, ESP.
Article Synopsis
- * A case involving a 77-year-old woman who had surgery for this cancer showed an unusual recurrence in the sigmoid colon nine years after her initial treatment.
- * After performing surgery to remove the affected part of the colon, it was confirmed that the tumor was a metastasis from the original endometrial adenocarcinoma, but the patient responded well and has been disease-free for 18 months post-treatment.
Gallbladder Volvulus in an Elderly Patient: A Case Report and Review of Literature.
Cureus
September 2023
General Surgery, Príncipe de Asturias Teaching Hospital, Alcalá de Henares, ESP.
Article Synopsis
- Gallbladder volvulus is a rare cause of acute cholecystitis where the gallbladder twists around its own blood supply, leading to abdominal pain and complications.
- An 87-year-old woman was diagnosed after a CT scan and ultrasound revealed a twisted and distended gallbladder without gallstones, prompting an emergency cholecystectomy.
- Early detection and surgical intervention are critical due to the risk of severe complications like necrosis and perforation, but misdiagnosis is common due to similar symptoms with acute cholecystitis.
Malignant adipocytic tumours: A 20‑year single‑centre retrospective study.
Oncol Lett
June 2023
Department of General and Digestive Surgery, Príncipe de Asturias Teaching Hospital, 28805 Alcalá de Henares, Spain.
Article Synopsis
- Adipocytic tumors are the most common soft tissue cancers, with liposarcoma being the most prevalent malignant type; however, their evolution and prognosis, especially in retroperitoneal areas, haven't been well studied before.
- A retrospective analysis was conducted on 52 patients diagnosed with liposarcoma from 2000 to 2020, categorizing them based on tumor location (retroperitoneal vs. non-retroperitoneal) and examining factors like recurrence, treatment, and mortality.
- The study found significant differences in survival rates of liposarcoma subtypes based on their location, with better outcomes for certain types in non-retroperitoneal regions; surgical margins were crucial for prognosis,
An Overview of the Role of MicroRNAs on Carcinogenesis: A Focus on Cell Cycle, Angiogenesis and Metastasis.
Int J Mol Sci
April 2023
Department of Medicine and Medical Specialities, Faculty of Medicine and Health Sciences, University of Alcalá, 28801 Alcala de Henares, Spain.
Article Synopsis
- Recent studies highlight the role of epigenetic markers, particularly microRNAs, in cancer development and progression, including their impact on metastasis and tumor behavior.
- MicroRNAs regulate gene expression and can either promote or inhibit cancer processes, affecting cell proliferation and invasion through complex interactions with various genes.
- Despite evidence supporting the diagnostic and prognostic value of different microRNAs in cancer, there are currently no standardized diagnostic kits available for initial diagnosis or tracking cancer recurrences.
Updated Views in Targeted Therapy in the Patient with Non-Small Cell Lung Cancer.
J Pers Med
January 2023
Department of Medicine and Medical Specialities, Faculty of Medicine and Health Sciences, University of Alcala, 28801 Alcalá de Henares, Spain.
Article Synopsis
- * Advances in diagnosis and treatment, particularly through analyzing molecular markers, have led to new targeted therapies that improve the outlook for some patients, although many are diagnosed late and have limited life expectancy.
- * The article aims to summarize NSCLC's key features and the progress in targeted therapies, while also discussing the challenges faced in managing this form of cancer.
Hyperthermic Intraperitoneal Chemotherapy and Recirculation with CO: A Safe Technique.
J Clin Med
October 2022
Department of General and Digestive Surgery, Príncipe de Asturias Teaching Hospital, 28805 Madrid, Spain.
Article Synopsis
- HIPEC (Hyperthermic IntraPEritoneal Chemotherapy) is a promising treatment for peritoneal carcinomatosis that shows improved survival rates compared to traditional therapies, following a thorough cytoreductive surgery.
- A study involving 482 patients from 11 Spanish hospitals evaluated the safety and effectiveness of HIPEC using a closed technique with a CO-agitation system called Combat PRS.
- Results indicated that the mortality rate (1.66%) and morbidity rate (9.96% of serious complications) were comparably low and favorable when compared to standard treatment techniques, with overall survival rates of 86% at one year and 54% at three years.
Prognostic Factors of Survival in Patients with Peritoneal Metastasis from Colorectal Cancer.
J Clin Med
August 2022
Department of General and Digestive Surgery, General and Digestive Surgery, Príncipe de Asturias Teaching Hospital, 28805 Alcalá de Henares, Spain.
Article Synopsis
- - The study analyzed survival factors in patients with peritoneal metastasis (PM) from colorectal cancer (CRC), focusing on whether PM was detected simultaneously with the primary tumor or developed later.
- - Out of 1882 colorectal cancer patients treated, 240 (12.8%) were included, revealing that certain factors like KRAS mutation and peritoneal carcinomatosis index (PCI) significantly influenced survival rates, with better outcomes for patients with lower PCI scores.
- - The findings emphasized that PCI remains a critical prognostic indicator, with specific survival rates highlighted based on the categorization of patients by PCI scores and other tumor characteristics.
Upper Gastrointestinal Bleeding as a Debut Form of Groove Pancreatitis: A Diagnostic Challenge.
Case Rep Surg
March 2022
General and Digestive Surgery Department of Rey Juan Carlos Teaching Hospital, Móstoles, Madrid, Spain.
Article Synopsis
- Groove pancreatitis (GP) is a rare form of chronic pancreatitis that can be mistaken for pancreatic carcinoma (PC), creating diagnostic challenges.
- A 53-year-old man with a history of alcohol and tobacco use developed upper gastrointestinal bleeding and was found to have a lesion in the distal stomach, but biopsies showed no cancer.
- Following surgery, the patient was diagnosed with segmental GP, highlighting the need for improved diagnostic techniques to differentiate GP from PC in clinical practice.
Prognostic Value of KRAS Gene Mutation on Survival of Patients with Peritoneal Metastases of Colorectal Adenocarcinoma.
Int J Surg Oncol
October 2021
Department of General and Digestive Surgery, Príncipe de Asturias Teaching Hospital, Alcalá de Henares, Madrid, Spain.
Article Synopsis
- The study aimed to investigate how KRAS gene mutations affect survival rates in patients with colorectal cancer and peritoneal metastases.
- It included a cohort of 149 patients diagnosed between 2006 and 2019, revealing that those with wild-type KRAS had better survival rates compared to those with KRAS mutations (35% vs. 14% at 36 months).
- The findings suggest that the KRAS mutation serves as an important prognostic factor for survival in these patients, highlighting its significance in treatment planning.
Prognostic factors of survival in stage IV colorectal cancer with synchronous liver metastasis: Negative effect of the KRAS mutation.
Mol Clin Oncol
May 2021
Department of General and Digestive Surgery, Príncipe de Asturias Teaching Hospital, Alcalá de Henares, Madrid 28805, Spain.
Article Synopsis
- - The study focused on identifying survival predictors for stage IV colorectal cancer patients with liver metastases, using data from 104 patients diagnosed between 2013 and 2018.
- - Key findings revealed that patients with wild-type KRAS tumors had a significantly higher survival rate (42%) compared to those with mutated KRAS tumors (9%).
- - Variables like KRAS mutation, tumor stage, and treatment approaches showed independent predictive value for survival, but the type of initial treatment (chemotherapy vs. tumor resection) did not significantly affect survival outcomes.
Unusual Case of Gallbladder Adenocarcinoma Metastasis to the Abdominal Wall 11 Years Later: Synchronous Presentation with Two Malignant Colon Tumors, Coincidence or Not?
Case Rep Surg
February 2021
Department of General and Digestive Surgery, Príncipe de Asturias Teaching Hospital, Alcalá de Henares, Madrid, Spain.
Article Synopsis
- A case study is presented of a 75-year-old male who developed a malignant abdominal wall mass 11 years post-surgery for gallbladder adenocarcinoma, along with two new adenocarcinomas in the colon and sigmoid.
- The initial surgery faced complications, resulting in the gallbladder being opened, which raises concerns for potential spread of cancer cells.
- The patient underwent further surgery to remove the abdominal mass and affected colon sections, revealing that the abdominal wall mass was a metastasis from the original gallbladder cancer, highlighting rare but possible recurrence risks following laparoscopic procedures.
Desmoid-type Fibromatosis of the Splenic Hilum: A Rare Tumor at an Unusual Location.
Niger J Surg
July 2020
Department of General and Digestive Surgery, Príncipe de Asturias Teaching Hospital, Alcalá de Henares, Madrid, Spain.
Desmoid-type fibromatoses (DTFs), also known as desmoid tumors, are benign but infiltrative neoplasms that often appear next to previous surgical site. Intra-abdominal tumors usually involve the mesentery, but splenic hilum is an unusual localization. We present a case of a desmoid tumor of the splenic hilum laparoscopically resected in a 70-year-old male with a previous history of chromophobe renal cell carcinoma and ocular spindle melanoma.
View Article and Find Full Text PDFDuodenal Rupture after Blunt Abdominal Trauma by Bicycle Handlebar: Case Report and Literature Review.
Niger J Surg
January 2019
Department of General and Digestive Surgery, Príncipe de Asturias Teaching Hospital, Alcalá de Henares, Madrid, Spain.
Article Synopsis
- Blunt abdominal trauma is common in children, particularly from bicycle accidents, but duodenal injuries are rare and typically occur in males aged 16-30 due to high-energy impact.
- * A 17-year-old boy presented to the emergency room after a bicycle fall, showing symptoms like epigastric swelling and hematemesis, leading to a diagnosis of third-part duodenal rupture.
- * The patient underwent surgery to repair the rupture and had a smooth recovery, emphasizing the importance of early diagnosis to minimize complications.*
Analysis of the Increase in Bone Mineral Density After Surgical Treatment of Primary Hyperparathyroidism.
J Clin Densitom
June 2020
MD, General and Digestive Surgeon, Department of General and Digestive Surgery, Endocrine Surgery Unit, Príncipe de Asturias Teaching Hospital, Alcalá de Henares, Madrid, Spain.
Article Synopsis
- The study aimed to evaluate how surgery for primary hyperparathyroidism affects bone mineral density (BMD) in postmenopausal women, and to identify preoperative factors that might predict improvements in bone density.
- A total of 108 women participated in the study, with significant increases in BMD observed post-surgery, especially in the lumbar spine compared to the femoral neck.
- The findings suggest that patients with lower bone density before surgery had a higher chance of experiencing an increase in BMD afterward, and those who improved also showed lower preoperative levels of parathyroid hormone.
Mixed Adenoneuroendocrine Carcinoma of the Esophagus: A Case Report and Review of the Literature.
Niger J Surg
January 2018
Department of General and Digestive Surgery, Sanitas La Moraleja Teaching Hospital, Madrid, Spain.
Article Synopsis
- Esophageal cancer commonly presents as adenocarcinoma and squamous cell carcinoma, but recently, mixed adenoneuroendocrine carcinoma (MANEC) has emerged as a rare type, combining both adenocarcinoma and neuroendocrine components.
- A case study highlights a 68-year-old male diagnosed with a malignant esophageal neoplasm after gastroscopy, revealing a tumor composed of 60% adenocarcinoma and 40% neuroendocrine components, leading to a final diagnosis of MANEC.
- MANECs are infrequent in the esophagus, making preoperative diagnosis challenging; definitive identification usually occurs post-surgery through immunohistochemical analysis, while treatment primarily involves surgical intervention, with unclear
Primary Hyperparathyroidism due to Parathyroid Adenoma Originated from Supernumerary Gland.
Case Rep Otolaryngol
September 2018
Department of General and Digestive Surgery, Príncipe de Asturias Teaching Hospital, Alcalá de Henares, Madrid, Spain.
Introduction: The variability of the location of the parathyroid glands is directly related to the events that occur during embryonic development. The impact that an individual submits more than four parathyroid glands is close to 13%. However the presentation of a parathyroid adenoma in a supernumerary gland is an uncommon event.
View Article and Find Full Text PDFPresentation of a large jejunal artery aneurysm: Management and review of the literature.
Int J Surg Case Rep
May 2018
Vascular Surgery Department, Principe de Asturias Teaching Hospital, Alcalá de Henares, 28805, Madrid, Spain. Electronic address:
Article Synopsis
- Jejunal artery aneurysms (JAAs) are very rare, accounting for less than 1% of all visceral artery aneurysms and typically affect middle-aged men.
- A case of a 49-year-old woman with a 4×5 cm intact JAA was discovered incidentally during a CT scan, prompting successful elective surgery for its complete removal.
- Management of JAAs lacks a clear consensus due to limited case reports, but they are generally treated similarly to other visceral artery aneurysms, especially if they are larger than 2 cm or symptomatic, with surgery being the preferred method in emergencies.