14 results match your criteria: "Poznan University of Medicinal Sciences[Affiliation]"

Alopecia constitutes one of the most common dermatological disorders, and its steadily increasing prevalence is a cause for concern. Alopecia can be divided into two main categories, cicatricial/scarring and non-cicatricial/non-scarring, depending on the causes of hair loss and its patterns. The aim of this study was to investigate the relationship between anthropometric and nutritional laboratory parameters in Caucasian adult women and men with non-cicatricial alopecia.

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Fatty Acids Profile and the Relevance of Membranes as the Target of Nutrition-Based Strategies in Atopic Dermatitis: A Narrative Review.

Nutrients

September 2023

Istituto per la Sintesi Organica e la Fotoreattività, Consiglio Nazionale Delle Ricerche, Via Piero Gobetti 101, 40129 Bologna, Italy.

Recently, the prevalence of atopic dermatitis has increased drastically, especially in urban populations. This multifactorial skin disease is caused by complex interactions between various factors including genetics, environment, lifestyle, and diet. In eczema, apart from using an elimination diet, the adequate content of fatty acids from foods (saturated, monounsaturated, and polyunsaturated fatty acids) plays an important role as an immunomodulatory agent.

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Phytoecdysteroids from L. for Psoriatic Skincare.

Molecules

May 2022

Department and Division of Practical Cosmetology and Skin Diseases Prophylaxis, Poznan University of Medicinal Sciences, 3 Rokietnicka St., 60-806 Poznań, Poland.

Phytoecdysones from seem to be promising agents for skincare in patients with psoriasis. The aim of the study was to determine the effects of creams containing the extract of on psoriatic lesions. Creams with different formulas were prepared: 0-Lekobaza, 1-Lekobaza, , 2-Lekobaza, Salicylic acid, 3-Lekobaza, , Salicylic acid.

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3D Bioprinting in Skin Related Research: Recent Achievements and Application Perspectives.

ACS Synth Biol

January 2022

Department and Division of Practical Cosmetology and Skin Diseases Prophylaxis, Poznan University of Medicinal Sciences, Mazowiecka 33, 60-623 Poznań, Poland.

In recent years, significant progress has been observed in the field of skin bioprinting, which has a huge potential to revolutionize the way of treatment in injury and surgery. Furthermore, it may be considered as an appropriate platform to perform the assessment and screening of cosmetic and pharmaceutical formulations. Therefore, the objective of this paper was to review the latest advances in 3D bioprinting dedicated to skin applications.

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Hemp fiber variety, Bialobrzeskie, contains phenolic acids in its chemical composition giving it inherent antioxidant and antibacterial activity. The use of this raw material in fabric manufacture allows the creation of functional clothing with a positive effect on human skin. The aim of the study was to develop biologically active functional clothing made of pure industrial hemp raw materials, where cannabidiol (CBD) extract applied on the fabric surface strengthened the fiber bioactivity.

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Taxifolin as a Promising Ingredient of Cosmetics for Adult Skin.

Antioxidants (Basel)

October 2021

Department and Division of Practical Cosmetology and Skin Diseases Prophylaxis, Poznan University of Medicinal Sciences, Mazowiecka 33, 60-623 Poznan, Poland.

Article Synopsis
  • The study investigated the effects of two creams containing 3% extract and 3% taxifolin (TXF) on skin aging in 97 Caucasian women.
  • Measurements of skin parameters and patch tests showed that both creams were nonirritant, with the 3% TXF cream demonstrating a higher penetration rate.
  • Results indicated that the 3% TXF cream significantly improved skin viscoelasticity and reduced hyperpigmentation, suggesting both ingredients are beneficial for anti-aging skincare products.
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Introduction: Patients qualified for the Polish government programme of treating severe pemphigus diseases with rituximab (RTX) available in 2018-2019 had to meet numerous criteria, including no active infectious disease.

Aim: The clinical usefulness of tuberculosis screening with the QuantiFERON-TB Gold Plus (QFT-Plus) in native pemphigus patients selected for RTX treatment was statistically evaluated.

Material And Methods: Eighteen pemphigus patients were examined with QFT-Plus prior to the intended RTX therapy.

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Sjögren's syndrome (SS) is an autoimmune disorder that affects the salivary glands, leading to reduced secretory functions and oral and ocular dryness. The salivary glands are composed of acinar cells that are responsible for the secretion and production of secretory granules, which contain salivary components, such as amylase, mucins and immunoglobulins. This secretion process involves secretory vesicle trafficking, docking, priming and membrane fusion.

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Adipocytes are a known source of stem cells. They are easy to harvest, and are a suitable candidate for autogenous grafts. Adipose derived stem cells (ADSCs) have multiple target tissues which they can differentiate into, including bone and cartilage.

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Three germacranolides, as well as five flavonoids, natural steroid and simple phenolic compounds, were isolated from the inflorescence of growing in Iran. The paper presents active compounds found for the first time in the inflorescence of this species. The flavonoids, simple phenolic compounds and natural steroids have been isolated for the first time in the genus .

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By attaching to the angiotensin converting enzyme 2 (ACE2) protein on lung and intestinal cells, Sudden Acute Respiratory Syndrome (SARS-CoV-2) can cause respiratory and homeostatic difficulties leading to sepsis. The progression from acute respiratory failure to sepsis has been correlated with the release of high-mobility group box 1 protein (HMGB1). Lack of effective conventional treatment of this septic state has spiked an interest in alternative medicine.

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The presence of dominant active compounds in standardised methanol extract from the leaves of () was examined using HPLC with a diode-array detector. The extract and three dominant parthenolide derivatives were tested with Serotonin Research ELISA for their ability to inhibit the serotonin release from platelets. The antiserotonin effect of the extract was compared with that of parthenolide, a compound with proven antiserotonin and antimigraine effects.

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Hepatitis C - New drugs and treatment prospects.

Eur J Med Chem

March 2019

Poznan University of Medicinal Sciences, Department of Pharmaceutical Chemistry, Grunwaldzka Str. 6, 60-780, Poznań, Poland.

Article Synopsis
  • Hepatitis C virus (HCV) affects around 3% of the global population, leading to about 300,000 deaths annually, with 80% of those infected developing chronic symptoms that can result in severe liver complications.
  • HCV is a (+)ssRNA virus belonging to the Flaviviridae family, with seven main genotypes; treatment has evolved from interferons in the 1990s to more advanced anti-HCV medications since 2011, which include various inhibitors.
  • The reviewed literature covers 113 papers detailing the molecular targets and chemical structures of HCV drugs, along with their indications, contraindications, and recommended treatment regimens.
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Tuberculosis - Present Medication and Therapeutic Prospects.

Curr Med Chem

April 2020

Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Poznan University of Medicinal Sciences, Grunwaldzka Str. 6, 60-780, Poznan, Poland.

Background: Tuberculosis (TB) has been present in the history of human civilization since time immemorial and has caused more deaths than any other infectious disease. It is still considered one of the ten most common epidemiologic causes of death in the world. As a transmissible disease, it is initiated by rod-shaped (bacillus) mycobacteria.

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