2,472 results match your criteria: "Posttraumatic Epilepsy"
Epilepsia Open
December 2024
Donders Centre for Cognition, Radboud University, Nijmegen, the Netherlands.
Epilepsia
November 2024
Department of Neuroscience and Rehabilitation, University of Ferrara, Ferrara, Italy.
Objective: Structural epilepsies can manifest months or years after the occurrence of an initial epileptogenic insult, making them amenable for secondary prevention. However, development of preventive treatments has been challenged by a lack of biomarkers for identifying the subset of individuals with the highest risk of epilepsy after the epileptogenic insult.
Methods: Four different rat models of epileptogenesis were investigated to identify differentially expressed circulating microRNA (miRNA) and isomiR profiles as biomarkers for epileptogenesis.
J Int Neuropsychol Soc
October 2024
Department of Psychology, Chung Shan Medical University, Taichung, Taiwan.
Objective: This study investigates neuropsychological and psychosocial outcomes in patients with traumatic brain injury (TBI) and post-traumatic epilepsy (PTE) compared to a healthy control group.
Method: Utilizing a quasi-experimental cross-sectional design, the research involved patients with TBI and PTE referred from a Taiwanese medical center. An age- and education-matched control group of healthy adults without traumatic injuries was also recruited.
Ecotoxicol Environ Saf
October 2024
Department of Neurosurgery, The Affiliated Hospital of Guizhou Medical University, Guiyang, Guizhou, PR China. Electronic address:
Pediatr Neurol
December 2024
Departments of Pediatrics and Population Health Sciences, Duke University School of Medicine, Durham, NC, USA, Duke-Margolis Center for Health Policy, Washington, District of Columbia. Electronic address:
J Neurotrauma
October 2024
Department of Neurosurgery, University of Maryland School of Medicine, Baltimore, Maryland, USA.
Exp Neurol
December 2024
Department of Neurology and FM Kirby Neurobiology Center, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA; PrevEp, Inc., Bethesda, MD, USA. Electronic address:
Post-traumatic epilepsy (PTE) is a recurrent and often drug-refractory seizure disorder caused by traumatic brain injury (TBI). No single drug treatment prevents PTE, but preventive drug combinations that may prophylax against PTE have not been studied. Based on a systematic evaluation of rationally chosen drug combinations in the intrahippocampal kainate (IHK) mouse model of acquired epilepsy, we identified two multi-targeted drug cocktails that exert strong antiepileptogenic effects.
View Article and Find Full Text PDFNutrients
September 2024
Department of Pediatrics, Herbert Wertheim School of Public Health and Human Longevity Science and Psychiatry, University of California San Diego, San Diego, CA 92161, USA.
Front Neurosci
August 2024
Department of Neuroscience, Ohio State University, Columbus, OH, United States.
Cureus
July 2024
Psychiatry and Behavioral Sciences, Sri Ramachandra Institute of Higher Education and Research, Chennai, IND.
Front Pediatr
August 2024
Department of Pediatrics, Xiangyang NO.1 People's Hospital, Xiangyang, Hubei, China.
Objective: To explore whether early quantitative electroencephalograph (EEG) can predict the development of epilepsy in pediatric patients with severe traumatic brain injury (TBI).
Methods: A total of 78 children with severe TBI who were admitted to our hospital were divided into post-traumatic epilepsy (PTE) and non-PTE groups according to whether or not they developed PTE. EEGs of frontal, central and parietal lobes were recorded at the time of their admission.
Neurol Int
August 2024
Department of Neurosurgery, Lewis Katz School of Medicine, Temple University, Philadelphia, PA 19140, USA.
Objective: This study aimed to measure NP students' knowledge and perception of medical marijuana (MM) and determine whether they need additional education on the topic.
Methods: A cross-sectional, descriptive study was implemented. NP students were asked to complete a survey that assessed their knowledge of MM, including adverse reactions and medical indications.
Front Neurol
August 2024
Neurology Neuroscience Postgraduation Program, Physiology Department, Escola Paulista de Medicina, Universidade Federal de São Paulo, São Paulo, Brazil.
There is currently no efficacious intervention for preventing post-traumatic epilepsy (PTE). Preclinical studies support the potential use of anticholinergics for this condition. The purpose of this study was to evaluate the effects of biperiden as an intervention for preventing PTE.
View Article and Find Full Text PDFBrain Stimul
August 2024
Toulouse University Hospital, Department of Neurology, Toulouse, France; Brain and Cognition Research Center (CerCo), Centre National de la Recherche Scientifique, UMR5549, Toulouse, France; University of Toulouse, Paul Sabatier University, Toulouse, France. Electronic address:
Neurobiol Dis
October 2024
Department of Biological Sciences, University of North Texas, Denton, TX 76205, USA. Electronic address:
Thrombospondins (TSPs) are astrocyte-secreted extracellular matrix proteins that play key roles as regulators of synaptogenesis in the central nervous system. We previously showed that TSP1/2 are upregulated in the partial neocortical isolation model ("undercut" or "UC" below) of posttraumatic epileptogenesis and may contribute to abnormal axonal sprouting, aberrant synaptogenesis and epileptiform discharges in the UC cortex. These results led to the hypothesis that posttraumatic epileptogeneis would be reduced in TSP1/2 knockout (TSP1/2 KO) mice.
View Article and Find Full Text PDFJ Craniofac Surg
August 2024
Department of Neurology, Guangxi Medical University First Affiliated Hospital, Nanning, China.
Posttraumatic epilepsy (PTE) is considered to be one of the most severe and enduring outcomes that can arise from traumatic brain injury (TBI). The authors' study aims to create and authenticate a prognostic model for forecasting the PTE occurrence after TBI. The clinical prognostic model was developed in 475 people who had a TBI history in Nanning using a multivariate logistic regression model.
View Article and Find Full Text PDFInflammation
July 2024
Department of Physiology and Pharmacology, Pasteur Institute of Iran, Pasteur Street, Tehran, 13169455, Iran.
Toll-like receptors (TLRs) are activated by endogenous molecules released from damaged cells and contribute to neuroinflammation following traumatic brain injury (TBI) and epilepsy. TLR1/2 agonist tri-palmitoyl-S-glyceryl-cysteine (Pam3cys) is a vaccine adjuvant with confirmed safety in humans. We assessed impact of TLR1/2 postconditioning by Pam3cys on epileptogenesis and neuroinflammation in male rats, 6, 24, and 48 h after mild-to-moderate TBI.
View Article and Find Full Text PDFNeurotrauma Rep
May 2024
Department of Epidemiology, Care and Public Health Research Institute, Maastricht University, Maastricht, the Netherlands.
A precise understanding of the latency to post-traumatic epilepsy (PTE) following a traumatic brain injury (TBI) is necessary for optimal patient care. This precision is currently lacking despite a surprising number of available data sources that could address this pressing need. Following guidance from the Cochrane Collaboration and Joanna Briggs Institute, we conduct a systematic review to address the research questions: What is the cumulative incidence of PTE following mild TBI (mTBI; concussion), and what is the distribution of the latency to onset? We designed a comprehensive search of medical databases and gray literature sources.
View Article and Find Full Text PDFAnn Afr Med
April 2024
Department of Neurosurgery, Faculty of Medicine, Jordan University of Science and Technology, Irbid, Jordan.
Background: Decompressive craniectomy (DC) is a surgical procedure to treat refractory increase in intracranial pressure. DC is frequently succeeded by cranioplasty (CP), a reconstructive procedure to protect the underlying brain and maintain cerebrospinal fluid flow dynamics. However, complications such as seizures, fluid collections, infections, and hydrocephalus can arise from CP.
View Article and Find Full Text PDFEpilepsy Res
September 2024
Laboratory of Neurobiology, Department of Physiology, Universidade Federal de São Paulo, São Paulo, Brazil; Instituto D'Or de Pesquisa e Ensino, São Paulo, São Paulo, Brazil.
Objective: This study aims to assess the clinical, inflammatory, and genetic profiles of traumatic brain injury (TBI) patients over a 2-year follow-up period, focusing on the development of posttraumatic epilepsy (PTE).
Methods: Fifty-nine patients with acute TBI were recruited in the emergency unit of a hospital in Brazil. Clinical data and blood samples were collected after 10 days of hospitalization for posterior genetic profile (Apolipoprotein E- ApoE and Glutamic Acid Descarboxylase-GAD sequencing) analyses.
J Neuroinflammation
July 2024
The Department of Neuroscience, School of Translational Medicine, Monash University, 99, Commercial Road, Melbourne, Australia.
Post-traumatic epilepsy (PTE) is one of the most debilitating consequences of traumatic brain injury (TBI) and is one of the most drug-resistant forms of epilepsy. Novel therapeutic treatment options are an urgent unmet clinical need. The current focus in healthcare has been shifting to disease prevention, rather than treatment, though, not much progress has been made due to a limited understanding of the disease pathogenesis.
View Article and Find Full Text PDFNeuroRehabilitation
November 2024
Virginia Commonwealth University, Richmond, VA, USA.
Background: Conducting mild traumatic brain injury (mTBI) longitudinal studies across multiple sites is a challenging endeavor which has been made more challenging because of COVID-19.
Objective: This article briefly describes several concerns that need to be addressed during the conduct of research to account for COVID-19's impact.
Methods: The recent actions and steps taken by the Long-term Impact of Military-relevant Brain Injury Consortium (LIMBIC)-Chronic Effects of Neurotrauma Consortium (CENC) researchers are reviewed.
Epilepsia Open
October 2024
National Epilepsy Center, NHO Shizuoka Institute of Epilepsy and Neurological Disorders, Shizuoka, Japan.
Objective: To examine the efficacy and safety of perampanel (PER) in patients with post-stroke epilepsy (PSE), brain tumor-related epilepsy (BTRE), and post-traumatic epilepsy (PTE) using Japanese real-world data.
Methods: The prospective post-marketing observational study included patients with focal seizures with or without focal to bilateral tonic-clonic seizures who received PER combination therapy. The observation period was 24 or 52 weeks after the initial PER administration.
Epilepsy Behav
September 2024
St George's University Hospitals NHS Foundation Trust, London, United Kingdom. Electronic address: