Inhibition of Semaphorin 3A in Hippocampus Alleviates Postpartum Depression-Like Behaviors in Mice.

Postpartum depression (PPD) is a widespread psychiatric condition affecting up to 20% of postpartum women. Although it is known to be associated with ovarian hormone withdrawal following delivery, current treatments remain limited due to a lack of underlying mechanism. Here, in mice, we identified that semaphorin 3A (sema3A) exhibited a notable increase in expression within the hippocampus of postpartum depression mice, whereas no such upregulation was observed in female mice experiencing depression induced by lipopolysaccharide or chronic restraint stress.

Translation and Validation of the Edinburgh Postnatal Depression Scale for Eritrea: A Screening Tool for Postpartum Depression in Primary Health Care Facilities.

Introduction: Postpartum depression (PPD) is a mood disorder characterized by symptoms such as changes in sleep and eating patterns, fatigue, sadness, crying, anxiety, and guilt. The Edinburgh Postnatal Depression Scale (EPDS) was developed to be used as a self-report questionnaire for English-speaking populations to screen for postnatal depression. This study aims to translate, validate, and adapt the EPDS into Eritrean settings.

Care bundles for women during pregnancy, labour/birth, and postpartum: a scoping review.

Background: Care bundles, introduced in 2001, are described as a set of at least three evidence-based healthcare interventions delivered together in a clinical care episode by all healthcare providers. Although widely implemented in some healthcare areas, care bundle use in maternity care appears relatively recent. To identify the types of care bundles that have been developed, evaluated, or implemented for women during the perinatal period, we undertook a scoping review.

Effect of Informative Cesarean Delivery Operative Steps Video on Maternal Anxiety Level: A Randomized Controlled Trial.

Background: Cesarean section is the most common obstetric procedure performed. This can lead to maternal anxiety, which is a significant contributor to postpartum depression. This can adversely affect pregnant women both mentally and emotionally, negatively impacting their well-being and family bonding.

Outcomes of the ROSE Sustainment (ROSES) Study, a sequential multiple assignment randomized implementation trial to determine the minimum necessary intervention to sustain a postpartum depression prevention program in agencies serving low-income pregnant people.

Background: This Sequential Multiple Assignment Randomized Trial (SMART) was conducted to determine minimum implementation support needed for agencies serving pregnant people on public assistance to adopt and sustain the ROSE (Reach Out, Stay Strong, Essentials for mothers of newborns) postpartum depression (PPD) prevention program.

Methods: Enrolled prenatal agencies (N=98) received thorough initial implementation support (initial training + written sustainment planning). Agencies were identified as at risk for non-sustainment within the first 15 months (N=56) were randomized to: (1) no additional implementation support (N=12), or (2) quarterly implementation support (coaching and feedback; N=44).

COVID-19 prevention strategies and compliance among postnatal adolescent mothers with postnatal depression and generalised anxiety in rural Malawi: a cross-sectional study.

Objectives: This study examines the relationship between adolescent mothers' mental health problems (postnatal depression and generalised anxiety) and adherence to COVID-19 public health prevention strategies in rural Malawi. It is part of a larger previously published study investigating the impact of social and cultural factors on the mental health in adolescent mothers.

Design: A cross-sectional study was conducted from September 2021 to March 2022.

Evaluation of the Effectiveness of WeChat-Based Continuing Care Services on Maternal Parenting Competence.

Purpose: To evaluate the effectiveness of WeChat-based continuing care services in enhancing maternal parenting competence.

Design: This study included 524 primiparas who underwent obstetrics department from June 2022 to June 2023. 286 women were assigned to the intervention group, receiving WeChatbased continuing care services, while 238 women were assigned to the control group, receiving traditional care services.

The Effect of Platelet-Rich Fibrin (PRF) in Accelerating Periodontal Regeneration: A Randomized Controlled Clinical Trial.

Background: Regeneration of periodontal tissues is an essential component in treating periodontal disease, and there is an increasing focus on biological agents that might improve the healing process.

Materials And Methods: The randomized controlled clinical study included a cohort of 60 individuals diagnosed with chronic periodontitis. Each participant was randomly allocated to one of two groups: the experimental group (n = 30), which underwent PRF in combination with traditional open flap debridement (OFD), and the control group (n = 30), which received OFD alone.

Electroconvulsive Therapy: A Scotland-Wide Naturalistic Study of 4826 Treatment Episodes.

Background: Electroconvulsive therapy (ECT) is an effective treatment option for several psychiatric disorders, including treatment-resistant depression, but there are concerns about potential adverse effects, particularly on cognition. This study describes ECT response and side effects in the Scottish ECT Audit Network.

Methods: Data collected from 4826 treatment episodes includes pre-ECT and post-ECT illness severity scores (Clinical Global Impression-Severity [CGI-S] and Montgomery-Åsberg Depression Rating Scale [MADRS]), diagnosis, age, sex, consent status, treatment year, treatment frequency, dose, and reported side effects.

Prenatal Psychosocial Stressors and Blood Pressure Across 4 Years Postpartum.

Background: Psychosocial stress is a cardiovascular risk factor; however, little is known about whether prenatal psychosocial stressors influence postpartum cardiovascular health. We aimed to examine the associations of multiple measures of prenatal psychosocial stress on maternal blood pressure (BP) in the first 4 years after birth.

Methods: Among 225 MADRES cohort (Maternal and Developmental Risks From Environmental and Social Stressors) participants, we examined associations of average prenatal Perceived Stress Scale (PSS), Center for Epidemiological Studies Depression (CES-D) scores, and second-trimester neighborhood social cohesion scores on systolic and diastolic BP collected at annual postpartum study visits (1-4 years) using linear mixed-effects models, adjusted for covariates.

Interventions to address postpartum depression in South Asian countries: a scoping review.

Background: Postpartum depression (PPD) can result in poor health outcomes in mothers, affect maternal-child bonding and have long-term effects on child development.

Aims: The aim of this review was to identify existing studies on PPD and characterise any gaps in literature.

Methods: We conducted a scoping review of 14 databases using a combination of search terms and phrases related to PPD and the respective Southern Asian countries.

Supportive Nursing Care Intervention for Handling Depression and Anxiety Among Mothers of Neonates Admitted in Neonatal Intensive Care Unit (NICU): A Meta-Analysis.

Aim: This study aims to evaluate the effectiveness of supportive nursing care interventions in reducing depression and anxiety among mothers with infants in the neonatal intensive care unit.

Design: Systematic review and meta-analysis.

Methods: Randomised controlled trials conducted in mothers with infants admitted to the neonatal intensive care unit with any form of supportive nursing interventions compared to no intervention or usual care in terms of either reduction in depression or reduction in anxiety level of the mothers reported in both groups were included.

The essential role of sphingolipids in TRPC5 ion channel localization and functionality within lipid rafts.

Sphingolipids are critical components of cellular membranes that play a pivotal role in modulating ion channel function by forming lipid rafts that stabilize and localize these channels. These lipids regulate membrane fluidity and protein-lipid interactions, directly influencing ion channel activity, trafficking, and signaling pathways essential for maintaining cellular homeostasis. Despite their fundamental role, the impact of sphingolipids on ion channel functionality, particularly within the nervous system, remains insufficiently understood.

Birthing parents' perceptions of an online peer-delivered 1-day cognitive-behavioural therapy-based workshop for postpartum depression added to usual care.

Problem: Postpartum depression affects as many as 20 % of birthing parents, with most preferring to be treated with psychotherapy.

Background: An increasing number of these individuals would like to receive support from those with lived experience of postpartum depression. Emerging evidence suggests that peer-administered interventions can reduce symptoms of depression in the postpartum period.

Struggles of Fatherhood: A Prospective Study on the Incidence of Paternal Postpartum Depression and Associated Factors.

Aim: To investigate the incidence and the factors associated with paternal postpartum depression amongst new fathers in Singapore.

Design: A prospective repeated measures study was conducted from September 2023 to March 2024.

Methods: A total of 200 fathers aged 21 years and above who had a neonate born at full term and no serious health events for both mother and neonate were recruited from a local hospital via convenience sampling.

Voice analysis and deep learning for detecting mental disorders in pregnant women: a cross-sectional study.

Introduction: Perinatal mental disorders are prevalent, affecting 10-20% of pregnant women, and can negatively impact both maternal and neonatal outcomes. Traditional screening tools, such as the Edinburgh Postnatal Depression Scale (EPDS), present limitations due to subjectivity and time constraints in clinical settings. Recent advances in voice analysis and machine learning have shown potential for providing more objective screening methods.

Perceived Stress and Early Postpartum Depressive Symptoms in Women with Recent GDM: Implications for Postpartum Lifestyle Programs.

Objectives: To inform the development and adaptation of lifestyle programs to prevent type 2 diabetes, we sought to identify factors associated with depressive symptoms in the early postpartum period among women with recent gestational diabetes (GDM).

Methods: Participants are from the Balance after Baby Intervention (BABI) study, a two-year randomized clinical trial of a lifestyle program for women with recent GDM conducted in Boston, MA, and Denver, CO between 2016 and 2019. The Edinburgh Postpartum Depression Scale (EPDS) and Perceived Stress Scale (PSS-10) were administered at an average of 8-weeks postpartum.

Poor sleep quality and associated factors among HIV-positive and negative postpartum women in Addis Ababa, Ethiopia: a comparative cross-sectional study.

Background: Poor sleep quality is common during the postpartum period due to nighttime feeding and frequent nocturnal awakenings of infants. In addition, the condition may worsen among postpartum women living with human immunodeficiency virus (HIV), affecting their capacity to care for their child. Therefore, this study will provide baseline information by assessing the burden of poor sleep quality and associated factors among HIV-positive and negative postpartum women in Addis Ababa, Ethiopia.

Socioeconomic factors and sex effects of postpartum maternal depression on offspring internalizing symptoms: a systematic review and meta-analysis.

Background: Postpartum maternal depression and socioeconomic factors are established risk factors for the mental health of offspring. It has been consistently unclear as to whether female or male offspring are more vulnerable to the effects of postpartum maternal depression at different stages of the child's life course. To determine whether the characteristics of postpartum maternal depression with a history of prenatal depression influence sex differences in offspring internalizing symptoms across childhood and adolescence, socioeconomic factors should be considered.

Efficacy and safety of ketamine and esketamine in reducing the incidence of postpartum depression: an updated systematic review and meta-analysis.

Background: Postpartum depression (PPD) is categorized by the Disorders-Fifth Edition as depression that begins during pregnancy or within the first month after giving birth. Ketamine and esketamine have shown promising results in the treatment of several depressive disorders, which suggests that they may have a role in the prevention of PPD. This systematic review and meta-analysis aim to update evidence about the efficacy and safety of using ketamine and esketamine to reduce PPD incidence.

The efficacy of antenatal Cognitive Behavioural Therapy for antenatal and postnatal depression: A PRISMA based systematic review and meta-analysis.

Background: Considerable research has assessed the effectiveness of Cognitive Behavioural Therapy (CBT) for perinatal depression, however limited attention has been paid to its effectiveness when delivered during pregnancy. The primary aim of this review was to review evidence of the efficacy of CBT interventions delivered antenatally to treat symptoms of depression in women during the antenatal and postnatal periods. The review's secondary aim was to evaluate potential moderators of treatment outcome.

Antidepressant adherence using group-based trajectory modeling among postpartum women with Texas Medicaid.

Background: Mental health conditions are among the most frequent underlying causes of pregnancy-related death, and antidepressants may have a positive impact. However, adherence is suboptimal, and little is known regarding antidepressant adherence trajectories among postpartum women in the United States.

Objective: To describe antidepressant use among postpartum women with Texas Medicaid and determine factors associated with adherence trajectories.

"Psychiatric oblivion": considerations on the hypothesis of a law.

The introduction of a law on psychiatric oblivion, similar to the recent one for oncological oblivion, presents numerous complexities due to the differences between the two areas of illness, especially in terms of recovery and clinical stability. While a definitive cure is often achievable in oncological diseases, in severe mental disorders, such as schizophrenia or bipolar disorder, complete remission in the absence of therapies is rare. Even in cases of effective treatment response, patients may exhibit subclinical symptoms or cognitive and functional deficits, making the concept of psychiatric oblivion particularly problematic.

A multi-level meta-analysis of the relationship between decision-making during birth and postpartum mental health.

Introduction: There is accumulating evidence of ineffective decision-making between birthing individuals and healthcare providers during childbirth. While research syntheses have demonstrated that negative birth experiences are associated with postpartum mental health, primary quantitative studies linking specific decision-making measures and mental health outcomes have not been synthesised. The present study aims to fill this gap in order to provide hands-on evidence on how to further improve perinatal care.

The effect of on the prevention of postpartum depression symptoms and sleep quality: A triple-blind randomized controlled clinical trial.

Background: Postpartum depression is a multifactorial and complex disorder. Various approaches for preventing and treating this condition have been suggested. Nevertheless, there is no definitive proof confirming their efficacy.