3,786 results match your criteria: "Postherpetic Neuralgia"
Article Synopsis
- A study involving 295 adults aged 50 and older found that a significant portion of participants had low knowledge about HZ (58%) and its vaccines (67.5%), with knowledge varying by factors such as age, education, and gender.
- The results indicate a strong need for targeted educational programs to improve awareness and understanding of HZ and its vaccines, particularly for older adults and women who may be at higher risk. *
Predictive Value of Current Perception Threshold for Prognosis of Pulsed Radiofrequency in Patients with Acute Herpetic Neuralgia.
J Pain Res
October 2024
Department of Anesthesiology and Pain Research Center, The Affiliated Hospital of Jiaxing University, Jiaxing City, Zhejiang Province, People's Republic of China.
Objective: This study aimed to evaluate the prognostic accuracy of the Current Perception Threshold (CPT) in Acute Herpetic Neuralgia (AHN) patients receiving Pulsed Radiofrequency (PRF) therapy and to develop a corresponding prognostic model.
Methods: We retrospectively analyzed data from 106 AHN patients treated with PRF between January 2022 and May 2023. The occurrence of Postherpetic Neuralgia (PHN) after treatment categorized patients into non-PHN and PHN groups.
8. Herpes zoster and post herpetic neuralgia.
Pain Pract
October 2024
Pain Clinic, Department of Anesthesiology, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands.
Article Synopsis
- Patients with postherpetic neuralgia (PHN) experience persistent pain following a herpes zoster infection, with a significant portion of those affected suffering from a reduced quality of life and challenging treatment options.
- The review highlights the effectiveness of antiviral therapy within 72 hours of symptom onset as crucial for managing acute herpes zoster pain, alongside analgesics and various medications.
- For patients who do not respond to conventional treatments, newer interventional techniques, particularly pulsed radiofrequency treatment of the dorsal root ganglion, show promise in alleviating pain associated with PHN.
Comment on "Short-Term Supraorbital Nerve Stimulation and Pain Relief for Acute and Subacute Ophthalmic Herpetic Neuralgia: A Randomized Controlled Crossover Trial".
Pain Physician
September 2024
Department of Pain Management, West China Hospital/West China Tianfu Hospital, Sichuan University, Chengdu, Sichuan Province, P. R. China.
Short-Term Trigeminal Ganglion Stimulation in Patients with Multi-Branch Trigeminal Herpetic Neuralgia: A Pilot Study.
Pain Physician
September 2024
Dept. of Pain Medicine, First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, China.
Article Synopsis
Efficacy Analysis of Temporary Spinal Cord Stimulation in the Treatment of Refractory Postherpetic Neuralgia.
Pain Physician
September 2024
Department of Pain, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China.
Background: Spinal cord stimulation can be considered in PHN patients if conservative treatment is not effective. However, the long-term pain outcomes of temporary (7-14 days) spinal cord stimulation (tSCS) in refractory PHN patients with a course of more than 3 months have not been documented.
Objectives: To investigate the efficacy of tSCS as a treatment for refractory PHN.
Antidepressant Medication Use for Treatment of Chronic Ocular Pain.
Cornea
November 2024
Surgical Services, Miami Veterans Administration Medical Center, Bascom Palmer Eye Institute, University of Miami, Miami, FL.
Chronic ocular pain (COP) is a leading cause of eye care visits in the US and has a substantial impact on quality of life and visual functioning. Although many conditions underlie COP, such as dry eye disease or post-herpetic neuralgia, some people experience pain without significant ocular signs on examination or known risk factors (eg, traumatic injury). Antidepressant medications that act primarily on the central nervous system, such as tricyclic antidepressants and serotonin and norepinephrine reuptake inhibitors, are often used to treat patients with COP, but a recent Cochrane review and network meta-analysis investigating 25 different antidepressants concluded that only two serotonin and norepinephrine reuptake inhibitors, have sufficient data to support their use in chronic pain.
View Article and Find Full Text PDFEfficacy of Gasserian Ganglion High-Voltage, Long-Duration Pulsed Radiofrequency Combined With Block on Acute/Subacute Zoster-Related Trigeminal Neuralgia.
Pain Res Manag
September 2024
Department of Emergency Northern Jiangsu People's Hospital Affiliated to Yangzhou University, Yangzhou, Jiangsu, China.
Article Synopsis
- Trigeminal postherpetic neuralgia (TPHN) is a chronic pain condition resulting from herpes zoster that has significant socioeconomic impacts, prompting the need for effective treatment options.
- A study involving 83 patients used high-voltage, long-duration pulsed radiofrequency (HL-PRF) on the Gasserian ganglion and showed significant pain reduction, with lower Numerical Rating Scale (NRS) scores in the acute herpes phase compared to the subacute phase.
- The overall effectiveness of this treatment was 74.7%, with a lower incidence of TPHN in the acute group (12.77%) versus the subacute group (33.33%), and no serious adverse reactions were reported.
Assessment of ultrasound-guided intercostal nerve block for acute herpes zoster and its' possible prophylaxis for postherpetic neuralgia: a retrospective and case-controlled trial.
Korean J Pain
October 2024
Department of Anesthesiology, Beijing Chuiyangliu Hosptial Affiliated to Tsinghua University, Beijing, China.
Article Synopsis
- - The study compared two treatment methods, intercostal nerve block (ICNB) and thoracic paravertebral block (TPVB), for managing pain from herpes zoster and preventing long-term pain (post-herpetic neuralgia) in 128 patients.
- - Results showed that both treatment methods significantly reduced the burden of illness compared to standard antiviral treatment alone, with no notable difference in effectiveness between TPVB and ICNB.
- - ICNB was quicker to perform than TPVB and both methods were effective, suggesting ICNB as a practical alternative for managing herpes zoster pain with fewer side effects.
Peripheral Nerve Stimulation for Neuropathic Pain Management: A Narrative Review.
Pain Ther
December 2024
Department of Pain, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, No. 1277, Jiefang Avenue, Wuhan, 430022, China.
This narrative review examines the therapeutic efficacy of peripheral nerve stimulation (PNS) in the treatment of neuropathic pain (NP), a type of pain arising from lesions or diseases of the somatosensory system with a global prevalence ranging from 6.90% to 10.00%.
View Article and Find Full Text PDFGlycoprotein E-Displaying Nanoparticles Induce Robust Neutralizing Antibodies and T-Cell Response against Varicella Zoster Virus.
Int J Mol Sci
September 2024
State Key Laboratory of Vaccines for Infectious Diseases, Xiang An Biomedicine Laboratory, School of Public Health, School of Life Sciences, Xiamen University, Xiamen 361102, China.
Article Synopsis
- The Varicella zoster virus (VZV) causes chickenpox in children and can reactivate as shingles later in life, making vaccination crucial for prevention.
- Current vaccines based on attenuated strains can have side effects, and researchers explored a nanoparticle-based vaccine called FR-gE that shows promise in eliciting stronger immune responses.
- The FR-gE vaccine demonstrated significantly higher VZV-neutralizing antibody responses and a robust immune profile in mouse models compared to existing vaccines, indicating its potential as an effective alternative for preventing varicella and herpes zoster.
Herpes zoster is an acute cutaneous viral disease resulting from reactivation of dormant varicella-zoster virus. The maxillary nerve is the least frequently affected branch of the trigeminal nerve. Rarely, cutaneous lesions can be secondarily infected with species.
View Article and Find Full Text PDFEfficacy and Safety of Crisugabalin (HSK16149) in Adults with Postherpetic Neuralgia: A Phase 3 Randomized Clinical Trial.
JAMA Dermatol
November 2024
Hospital for Skin Diseases (Institute of Dermatology), Chinese Academy of Medical Sciences and Peking Union Medical College, Nanjing, Jiangsu, China.
Article Synopsis
- China faces a significant challenge with postherpetic neuralgia, necessitating effective new treatment options that minimize neurotoxic effects compared to current calcium channel ligands.
- The study aimed to evaluate the efficacy and safety of crisugabalin, a new oral medication, involving a randomized clinical trial across 48 care centers in China, which included a 12-week treatment phase and a subsequent 14-week extension phase.
- Results showed improvement in pain relief for patients taking crisugabalin, particularly at the 40 mg and 80 mg doses, highlighting its potential as a more effective treatment for managing postherpetic neuralgia compared to a placebo.
Herpes zoster (HZ) is typically characterized by a burning, stabbing pain, hyperalgesia, and allodynia. In some patients, despite the lesions resolving, the pain persists and becomes chronic. If the pain continues for more than 6 months after the onset of the pain phase, this condition is called postherpetic neuralgia (PHN).
View Article and Find Full Text PDFComparison of the efficacy of pulsed radiofrequency in treating acute herpetic neuralgia and postherpetic neuralgia in the thoracic segment.
Front Neurol
August 2024
Department of Pain Management, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'An, China.
Article Synopsis
- This study evaluated the effectiveness of pulsed radiofrequency (PRF) treatment for acute herpetic neuralgia (AHN) and postherpetic neuralgia (PHN) in patients with thoracic herpes zoster-related pain.
- Researchers analyzed data from 243 patients and measured various health scores before and after PRF treatment, finding significant improvements in the AHN group compared to the PHN group.
- The results suggest that PRF is a valuable treatment option, especially for AHN, as it leads to better pain management and improved sleep and mental health outcomes over time.
Natural Language Processing Versus Diagnosis Code-Based Methods for Postherpetic Neuralgia Identification: Algorithm Development and Validation.
JMIR Med Inform
September 2024
Department of Research & Evaluation, Kaiser Permanente Southern California, 100 S Los Robles Ave, 2nd Floor, Pasadena, CA, 91101, United States, 1 626-986-8665, 1 626-564-7872.
Article Synopsis
- A study developed and validated a natural language processing (NLP) algorithm to identify postherpetic neuralgia (PHN) from unstructured electronic health records (EHRs), aiming to improve accuracy compared to traditional diagnosis codes and prescription data.
- The research involved reviewing EHRs from a large health care system and comparing the NLP's performance with code-based methods by analyzing sensitivity, specificity, and other statistical measures.
- Results showed the NLP algorithm had high sensitivity (90.9%) and specificity (98.5%), with notable advantages in identifying PHN cases compared to code-based methods, which exhibited much lower sensitivity (52.7%-61.8%).
Letter to the Editor Regarding "Efficacy of Paravertebral Injection of Interferon-α2b Combined with High-Voltage, Long-Term Pulsed Radiofrequency in DRG in Mitigation of Postherpetic Neuralgia: A Retrospective Study".
World Neurosurg
September 2024
Department of Neurosurgery, Dell Medical School, University of Texas, Austin, Texas, USA.
Patient Experience of Herpes Zoster Disease in Argentina: Validation of a Health-Related Quality of Life Conceptual Model.
Value Health Reg Issues
November 2024
Value Evidence Outcome Department, GlaxoSmithKline, Wavre, Belgium.
Objectives: Herpes zoster (HZ) substantially affects patients' health-related quality of life (HRQoL), both in the acute phase and also in those developing postherpetic neuralgia (PHN). Building upon a previous qualitative concept elicitation study in Canada, we adopted a similar approach to further understand the patient experience of HZ/PHN in Argentina and impact on quality of life and qualitatively validate the previously published conceptual model for Argentina.
Methods: (1) Comprehensive literature review of HZ impact on HRQoL in Latin America.
Impact of Herpes Zoster and Postherpetic Neuralgia on the Quality of Life in China: A Prospective Study.
Clin Cosmet Investig Dermatol
August 2024
Department of Tuberculosis, Tianjin Haihe Hospital, Tianjin, People's Republic of China.
Background: Herpes zoster (HZ) and postherpetic neuralgia (PHN) significantly affect patients' quality of life (QoL). Cultural differences may lead to different patient-reported outcomes across countries. The current study aims to evaluate the detrimental impact of HZ and PHN on QoL in China.
View Article and Find Full Text PDFExploring blood transcriptomic signatures in patients with herpes zoster and postherpetic neuralgia.
Front Cell Infect Microbiol
August 2024
School of Basic Medicine, Hebei University, Baoding, Hebei, China.
Postherpetic neuralgia (PHN) is a common, severe, and hard-to-treat chronic pain condition in clinics. Although PHN is developed from herpes zoster (HZ), the developing mechanism is unknown. A previous study investigated blood metabolomic and proteomic profiling in patients with PHN and HZ.
View Article and Find Full Text PDFAltered Effective Connectivity of the Pain Matrix in Herpes Zoster and Postherpetic Neuralgia Patients: Granger Causality Analysis of Resting-State fMRI.
J Integr Neurosci
August 2024
Department of Radiology, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, 330006 Nanchang, Jiangxi, China.
Background: Shingles can cause long-term pain and negative emotions, along with changes in brain function. In this study, Granger Causality Analysis (GCA) was used to compare herpes zoster (HZ) and postherpetic neuralgia (PHN) differences in effective connections within the "pain matrix" between patients and healthy controls to further understand patterns of interaction between brain regions and explore the relationship between changes in effective connections and clinical features.
Methods: Resting-state functional magnetic resonance imaging (fMRI) scans were performed on 55 HZ; 55 PHN; and 50 age-, sex- matched healthy controls (HCs).
Disrupted Balance of Short- and Long-Range Functional Connectivity Density in Patients with Herpes Zoster or Postherpetic Neuralgia: A Resting-State fMRI Study.
J Pain Res
August 2024
Department of Radiology, The First Affiliated Hospital, Nanchang University, Nanchang, People's Republic of China.
Purpose: This study aimed to explore the abnormal changes in short- and long-range functional connectivity density (FCD) in patients with herpes zoster (HZ) and postherpetic neuralgia (PHN).
Patients And Methods: Twenty HZ patients, 22 PHN patients, and 19 well-matched healthy controls (HCs) underwent resting-state functional magnetic resonance imaging scans. We used FCD mapping, a data-driven graph theory method, to investigate local and global functional connectivity patterns.
Efficacy of Botulinum Type A Injection for the Treatment of Postherpetic Neuralgia and Pruritus Persisting for More Than Four Years-A Case Report.
Medicina (Kaunas)
August 2024
Department of Anesthesiology and Pain Medicine, Korea University Medical Center, Guro Hospital, 148 Gurodong Road, Guro-gu, Seoul 08308, Republic of Korea.
: Postherpetic neuralgia (PHN) and postherpetic pruritus (PHP) are common complications of shingles that affect patients' quality of life. PHN and PHP can be managed using various medications and interventional procedures; however, complications persisting for at least six months may hamper recovery. Subcutaneous injections of botulinum toxin type A (BTX-A) can control persistent PHN and PHP.
View Article and Find Full Text PDF[Zoster vaccination].
Inn Med (Heidelb)
November 2024
Bereich Infektiologie und Tropenmedizin, Medizinische Klinik I (Hämatologie, Zelltherapie, Hämostaseologie und Infektiologie), Universitätsklinikum Leipzig, Liebigstr. 20, 04103, Leipzig, Deutschland.
Herpes zoster (HZ) is a sequela of the reactivation of a latent varicella zoster virus (VZV) infection of the sensory dorsal root ganglia and cranial nerves due to a decrease in specific T cell-mediated immunity as a result of immunosenescence, immunodeficiency diseases, e.g., human immunodeficiency virus (HIV) infection or immunosuppressive therapy.
View Article and Find Full Text PDF