22,968 results match your criteria: "Postgraduate T & R Base of Zhengzhou University[Affiliation]"

Endometriosis is a common chronic disorder characterized by the growth of endometrium-like tissue outside the uterine cavity. The disease is associated with chronic inflammation and pelvic pain and may have an impact on the patient's fertility. The causative factors and pathophysiology of the disease are still poorly recognized.

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OSU-T315 overcomes immunosuppression in triple-negative breast cancer by targeting the ILK/NF-κB signaling pathway to enhance immunotherapeutic efficacy.

Int Immunopharmacol

December 2024

Integrated Traditional Chinese and Western Medicine Breast Department, Longhua Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai 200030, China; Postgraduate School, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China. Electronic address:

Triple negative breast cancer (TNBC) is an aggressive and immunogenic subtype of breast cancer. The absence of biomarker has given immune checkpoint inhibitors (ICIs) a broad prospect in this type of breast cancer. The infiltration of regulatory T cells (Tregs) expressing transcription factor forkhead box P3 (Foxp3) in the tumor microenvironment (TME) is the key factor leading to ICIs resistance.

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Dementia not only affects the person living with the condition but also their family and wider social circle. For that reason, it is important to educate family members, the wider public and health professionals. How a child and young people's (CYP) nurse supports and responds to a CYP whose family member has dementia or acts as a carer is of interest to pre-licensure (pre-registration) CYP nursing programs.

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To develop, apply and evaluate the impact of cooking knowledge refresher classes (CKRC) on the cooking skills of university students. University students who participated in the first phase of the Nutrition and Culinary in the Kitchen (NCK) intervention A quasi-experimental cooking class intervention was conducted to reinforce cooking skills. Participants completed a validated online survey before and after the intervention.

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  • The study investigates the anti-ulcer effects of hydroalcoholic extract (HETp) and its active component parthenolide (PTL) against gastric ulcers induced by ethanol and piroxicam.
  • Results showed that both HETp and PTL significantly reduced ulcer formation, with additional histological support confirming their effectiveness.
  • The protective effects involve various mechanisms, including the influence of nitric oxide, adrenergic receptors, and prostaglandins, while also enhancing antioxidant levels and reducing harmful enzyme activity.
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Objective: This study was designed to investigate if artificial intelligence (AI) detection software can determine the use of AI in personal statements for residency applications.

Method: Previously written personal statements were collected from physicians who had already matched to residency through the Electronic Residency Application System. Physicians were recruited for the study through collegial relationships and were given study information via email.

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Background: Considering the global shortage of nurses, leaders in the field must understand the strengths and weaknesses of various nursing specialties in order to retain professionals within the field. Occupational prestige reflects the perceived contribution of an occupation 'to society', and measures its desirability, benefit and values. Understanding how experienced nurses view the prestige of nursing specialties may help to explain why some specialties are more desirable than others.

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  • Penile squamous cell carcinoma (PSCC), mainly affecting poorer regions, has risk factors such as low socioeconomic status, phimosis, and HPV infection, but its immune response and treatment options are still unclear.
  • The study collected data from 30 PSCC patients (mostly HPV-positive) and 19 healthy donors to analyze immune cell behavior and utilize a tumor-mimicking environment created from HPV-positive tumor cultures.
  • Results indicated that HPV-positive tumors had fewer T lymphocytes and that dendritic cells in these patients were less mature and had lower activation compared to healthy controls, potentially affecting the immune response and disease progression.
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Background and objectives The efficiency of healthcare systems and nursing care depends on appropriate leadership. The purpose of this study was to determine the association between leadership styles of nurse managers and the staff turnover intention in Saudi Arabia. The nurses' intention to quit their jobs was considered as indicative of staff turnover intention.

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Common Spatial Pattern (CSP) has been recognized as a standard and powerful method for the identification of Electroencephalography (EEG)-based Motor Imagery (MI) tasks when implementing brain-computer interface (BCI) systems towards the motor rehabilitation of lost movements. The combination of BCI systems with robotic systems, such as upper limb exoskeletons, has proven to be a reliable tool for neuromotor rehabilitation. Therefore, in this study, the effects of temporal and frequency segmentation combined with layer increase for spatial filtering were evaluated, using three variations of the CSP method for the identification of passive movement vs.

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  • Resilience is essential for students' mental health and helps them adapt to academic challenges, but there's limited understanding of how it varies among students in different fields of study in Brazil.
  • A multi-center study surveyed 8,650 undergraduate students across eight institutions, using the Connor-Davidson Resilience Scale to measure resilience and various demographic, economic, and academic factors as independent variables.
  • Findings indicated that lower resilience was linked to factors like being female, having low family income, and being from specific academic backgrounds, with an average resilience score of 19.86 out of a possible higher score.
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ATF4/NUPR1 axis promotes cancer cell survival and mediates immunosuppression in clear cell renal cell carcinoma.

Discov Oncol

October 2024

State Key Laboratory of Kidney Diseases, Senior Department of Urology, The Third Medical Center of Chinese PLA General Hospital, Yongding Road 69, Haidian District, Beijing, 100039, China.

Article Synopsis
  • Cancer cells experience stress during growth, and the transcription factor ATF4 helps them adapt by upregulating genes related to stress relief; however, its role in clear cell renal cell carcinoma (ccRCC) was previously unknown.
  • In this study, elevated ATF4 levels in ccRCC tumors correlated with poor patient outcomes, and reducing ATF4 hindered cancer cell growth and invasion by affecting key signaling pathways.
  • The research identified NUPR1 as a crucial target of ATF4 that helps ccRCC cells survive, while targeting ATF4 or using NUPR1 inhibitors enhanced anti-tumor immunity, suggesting new treatment strategies for ccRCC patients.
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The redox homeostasis and photosynthetic pigments changes vary with Tetranychus ludeni infestation, with longer-cycle genotypes showing greater tolerance and efficiency in antioxidant defense. Infestations of Tetranychus ludeni Zacher (Tetranychidae) have been frequently observed in soybean plants. In this context, understanding the oscillation of redox homeostasis is crucial for detecting and assessing the stress levels caused in the plants by these organisms.

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  • The study evaluates Chloramine T as a treatment for gingivitis in hospitalized patients, comparing its effectiveness to Chlorhexidine and a placebo.
  • After five and ten days, both chloramine T and chlorhexidine groups showed significant improvements in gingival health, while the control group showed no changes.
  • Chloramine T proved to be as effective as chlorhexidine in reducing gingivitis without the negative side effects associated with long-term chlorhexidine use, suggesting its potential as a safer alternative for hospital patients.
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  • Social media addiction is increasingly problematic among medical students, impacting their mental health, academic performance, and relationships, necessitating research into the associated factors.
  • A study involving 292 medical students used various scales to assess social media addiction, social interaction, well-being, and personality traits, finding similar addiction levels in both male and female students.
  • Key findings indicate that time spent on social media and the personality trait of agreeableness significantly predict social media addiction, suggesting that psychological profiles do not differ substantially between genders in this context.
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Electrochemically-Switched Microwave Response of MXene in Organic Electrolyte.

Adv Mater

December 2024

State Key Laboratory of Organic Electronics and Information Displays & Jiangsu Key Laboratory for Biosensors, Institute of Advanced Materials (IAM), Nanjing University of Posts & Telecommunications, Nanjing, 210023, China.

The increasingly complex electromagnetic (EM) environment necessitates advanced electrically controllable electromagnetic interference (EMI) shielding materials that can adapt to varying EM conditions. This study develops a flexible electrochemically tunable EMI shielding device based on ultrathin TiCT MXene films, exhibiting reversible shielding effectiveness (SE) modulation from 18.9 to 26.

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Background: Virtual journal clubs (VJCs) are innovative technologies with the potential to foster collaboration, facilitate multilingual communication, improve cultural competencies, and expand global professional networks. This allowed participants to be exposed to critical appraisal of the articles. However, its long-term impact on competency development has been debated.

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  • Clinical studies on repetitive transcranial magnetic stimulation (rTMS) show inconsistent results, possibly due to differences in study methods, prompting a review of preclinical rTMS protocols in mice for epilepsy research.
  • A comprehensive search identified 23 relevant studies that used various epilepsy induction methods and defined motor thresholds, exploring the effects of different rTMS frequencies on seizure activity.
  • Findings indicate that low-frequency rTMS (≤5 Hz) generally suppresses seizures and improves behavioral outcomes, while high-frequency rTMS (≥5 Hz) had mixed effects, highlighting the importance of stimulation frequency in optimizing clinical applications for epilepsy treatment.
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Background And Aims: Cancer therapy is one of the most researched upon medical field in the world. Non invasive technologies such as liquid biopsy are gaining more importance in cancer therapy because of their manifold advantages over traditional invasive biopsy methods. Liquid biopsy is used to analyze nucleic acids such as ctDNA, cfDNA and RNA, cellular and subcellular components such as proteins, extracellular vesicles and circulating tumor cells in various biological fluids such as blood, urine, cerebrospinal fluid, pleural fluid and ascites fluid for diagnosis of cancer.

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Revised International Prognostic (R-IPI) score is used widely for risk stratification of DLBCL cases, yet some patients belonging to same risk category tend to exhibit different outcomes. The role of T-cells and macrophages in prognostication of lymphomas has been a point of interest of late. We aimed to study the association of FOXP3 positive T-regulatory cells, cytotoxic T-cells and macrophages with the immunophenotypic subtypes, clinicopathological characteristics, treatment response and survival in nodal diffuse large B-cell lymphoma (DLBCL) patients.

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Prognostic Significance of Regulatory T-Cells and PD-1 + CD8 T-Cells in Chronic Myeloid Leukemia Patients Treated with Generic Imatinib.

Indian J Hematol Blood Transfus

October 2024

Department of Clinical Hematology and Medical Oncology, Postgraduate Institute of Medical Education and Research (PGIMER), Nehru Hospital, Room No 18, 4th Level, F Block, Chandigarh, India.

The impact of T-regulatory cells (Tregs), PD-1 + CD8 T-cells, and their dynamics during treatment with imatinib mesylate remains poorly understood in patients with chronic myeloid leukemia (CML). We conducted a prospective study on newly diagnosed, treatment-naïve adult (> 18 years old) patients with CML in the chronic phase (CP) and age- and sex-matched controls. Peripheral blood samples were collected at diagnosis and after three months of imatinib therapy to assess Tregs and PD-1 + CD8 T-cell levels using flow cytometry.

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Dual metal-organic-frameworks mediated resonance energy transfer for ultrasensitive electrochemiluminescence immunosensing.

Mikrochim Acta

October 2024

State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, Key Laboratory for Bio-Nanotechnology and Molecular Engineering of Hunan Province, Hunan University, Changsha, 410082, Hunan, P. R. China.

Article Synopsis
  • A new electrochemiluminescence (ECL) biosensor was created to detect carcinoembryonic antigen (CEA) using a resonance energy transfer (RET) technique that involves a ruthenium complex and a modified metal-organic framework (MOF).
  • The biosensor features a sandwich structure composed of AuCoFe MOF, the target CEA antigen, and a zinc oxalate MOF that houses the ruthenium complex, which enhances detection through signal quenching.
  • The sensor demonstrates impressive analytical capabilities, with a detection range between 1.0×10 to 1.0×10 mg/mL, a minimum limit of detection at 1.4×10 mg/mL, and high recovery
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Background: A-mode ultrasound (US) is a potential method for directly measuring muscle thickness in patients with cancer, but its utility remains underexplored. We aimed to evaluate the feasibility of using A-mode US to assess muscle thickness, compare it with computed tomography (CT)-derived results, and assess its ability to diagnose sarcopenia.

Methods: A cross-sectional analysis was conducted with hospitalized patients with cancer.

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The Educational Benefits of Plastic Surgery Rotations for Off-Service Residents.

Adv Med Educ Pract

October 2024

Michigan State University, College of Human Medicine, Henry Ford Hospital, Detroit, MI, USA.

Purpose: With increasing specialization among surgical divisions, a well-rounded education during a surgical residency is often accomplished by rotating among different subspecialties. Inclusion of specific rotations in the resident curriculum can be considered as a cost-benefit calculation balancing the value of exposure to a subspecialty versus the opportunity cost of potential learning from another rotation. We find that often these decisions are based on anecdotal feedback.

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Cardiac electrical and functional activity following an outdoor cold-water swimming event.

J Therm Biol

October 2024

Normandie Univ, UNICAEN, Inserm Comete, GIP Cyceron, 14000, Caen, France; Normandie Univ, UNICAEN, CHU de Caen Normandie, Department of Cardiology, 14000, Caen, France; Normandie Univ, UNICAEN, CHU Caen Normandie, Department of Sports Medicine, 14000, Caen, France. Electronic address:

Aims: Participation in outdoor cold-water swimming (OCWS) events combines endurance exercise and cold exposure. Concerns have emerged about the potential risk of acute adverse cardiac events during OCWS, particularly during endurance events. We analysed the effect of prolonged OCWS on cardiac function in trained athletes.

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