Comparison of opportunities and perceptions towards neurosurgery between the public and private sector in Pakistan: a national survey of medical students and recent graduates.

Public and private medical institutes must adhere to the same standards of quality set by the Pakistan Medical & Dental Council (PMDC). However, studies have noted varied learning environments. The current study aims to assess opportunities and compare the differences in perceptions between the two sectors.

HIF1α Plays a Crucial Role in the Development of TFE3-Rearranged Renal Cell Carcinoma by Orchestrating a Metabolic Shift Toward Fatty Acid Synthesis.

Tumor development often requires cellular adaptation to a unique, high metabolic state; however, the molecular mechanisms that drive such metabolic changes in TFE3-rearranged renal cell carcinoma (TFE3-RCC) remain poorly understood. TFE3-RCC, a rare subtype of RCC, is defined by the formation of chimeric proteins involving the transcription factor TFE3. In this study, we analyzed cell lines and genetically engineered mice, demonstrating that the expression of the chimeric protein PRCC-TFE3 induced a hypoxia-related signature by transcriptionally upregulating HIF1α and HIF2α.

A nationwide study of the influence of training institutions in the postgraduate year training program for dentists on the future dental practice choices in Taiwan.

Background/purpose: The postgraduate year training program for dentists (PGYD) provides the comprehensive clinical training to bridge the gap between the academic education and the hands-on clinical practice. This study mainly explored the influence of training institutions on the future dental practice choices (in clinics or hospitals) after the completion of the PGYD program in Taiwan.

Materials And Methods: A nationwide, register-based cohort analysis was conducted on all 3,966 PGYD trainees from July 2010 to April 2023.

Developing competency-based medical education for dental education in Taiwan: A pilot study of tooth extraction entrustable professional activities.

Background/purpose: This study aimed to evaluate the initial implementation of competency-based medical education (CBME) through entrustable professional activities (EPAs) in Taiwan dental education, focusing on tooth extraction EPAs across undergraduate year (UGY), postgraduate year (PGY), and oral and maxillofacial surgery-residency (OS-R) levels.

Materials And Methods: Using the Delphi method, an advisory team developed and validated three levels of trial EPAs, which were implemented through the Emyway platform. A structured questionnaire was used to evaluate teachers' and students' experiences and satisfaction with Emyway and the EPAs.

Incremental cost of treating antimicrobial-resistant infections among hospitalised patients in India: a cohort study.

Background: Accurate estimates of incremental cost (IC) attributable to antimicrobial resistance (AMR) provide information of immense public health importance to the policy makers. Here, we present the IC from patient perspective for treating antimicrobial-resistant pathogens in India.

Methods: This cohort study was conducted in eight hospitals including government (GH), private (PH) and trust hospitals (TH), considering their ownership, geographical location and categories of cities.

Chikungunya infection in children: clinical profile and outcome.

The clinical profile and outcomes of children with chikungunya infection differ from those observed in adults. As there is a paucity of data on chikungunya infection in children, this study aimed to find the clinical course, complications, and mortality rates of chikungunya infection in children. This was a combined retrospective and prospective observational study.

Dysregulated autoantibodies targeting AGTR1 are associated with the accumulation of COVID-19 symptoms.

Coronavirus disease 2019 (COVID-19) presents a wide spectrum of symptoms, the causes of which remain poorly understood. This study explored the associations between autoantibodies (AABs), particularly those targeting G protein-coupled receptors (GPCRs) and renin‒angiotensin system (RAS) molecules, and the clinical manifestations of COVID-19. Using a cross-sectional analysis of 244 individuals, we applied multivariate analysis of variance, principal component analysis, and multinomial regression to examine the relationships between AAB levels and key symptoms.

Tissue fibrosis in cardiorenal syndrome: crosstalk between heart and kidneys.

Cardiorenal syndrome (CRS) is represented as an intricate dysfunctional interplay between the heart and kidneys, marked by cardiorenal inflammation and fibrosis. Unlike other organs, the repair process in cardiorenal injury involves a regenerative phase characterized by proliferation and polyploidization, followed by a subsequent pathogenic phase of fibrosis. In CRS, acute or chronic cardiorenal injury leads to hyperactive inflammation and fibrotic remodeling, associated with injury-mediated immune cell (Macrophages, Monocytes, and T-cells) infiltration and myofibroblast activation.

Access to pharmacy supplied emergency hormonal contraception vs the conscience clause of pharmacist.

Introduction: In light of the current state of the law, it is not possible to invoke the conscience clause when providing pharmaceutical services, which includes the procedure for dispensing emergency contraception to a patient. Introduction of emergency contraception available withut prescription is associated with a necessity of creating safe procedures both for patients and pharmacists.

Aim Of The Study: The purpose of the study was to analyze the Polish and international legal regulation of the conscience clause issue and how to optimize the process of making emergency contraception available without a prescription.

An Albumin-Photosensitizer Supramolecular Assembly with Type I ROS-Induced Multifaceted Tumor Cell Deaths for Photodynamic Immunotherapy.

Photodynamic therapy holds great potentials in cancer treatment, yet its effectiveness in hypoxic solid tumor is limited by the oxygen-dependence and insufficient oxidative potential of conventional type II reactive oxygen species (ROS). Herein, the study reports a supramolecular photosensitizer, BSA@TPE-BT-SCT NPs, through encapsulating aggregation-enhanced emission photosensitizer by bovine serum albumin (BSA) to significantly enhance ROS, particularly less oxygen-dependent type I ROS for photodynamic immunotherapy. The abundant type I ROS generated by BSA@TPE-BT-SCT NPs induce multiple forms of programmed cell death, including apoptosis, pyroptosis, and ferroptosis.

How to Design a Study and Write a Grant in Radiology?

Radiology as a specialty has grown immensely over the last few decades. The advancements in diagnostic radiology are facilitated by state-of-the-art equipment and a revolution in computation. Parallelly, interventional radiology has benefited and interventional radiologists are at the forefront of several therapeutic procedures.

Ethics: The Elixir of Publications.

Scientific papers are the driving force for research, information dissemination, and policymaking that directly impacts society. Thus, ethical practices are the elixir of publications. Adherence to ethical practices promotes integrity in research and publication.

Building Credibility with Comprehensive Citation Practices.

Honoring those who paved the way and paving the way for others is an old saying and practice that emphasizes the importance of acknowledging the contributions of others while also guiding and mentoring those who follow in your footsteps. In academic and scientific writings, citations are very important for maintaining the integrity, credibility, and progression of scientific knowledge. This article examines the significance of citations, their various types and methods, and the different styles used.

Historiography of Scientific Publishing across Cultures and Disciplines.

Historiography is a vital perspective of our scientific literature that charts the evolution of scientific publishing, from its early origins to the present status. The key transformations including the shift from a limited self-published legacy to specialized and professional peer-reviewed journals, the impact of technological advancements, and the emergence of new profitable business models are learning points for the future course and couture. Science is pursued and persevered by real humans in social and cultural contexts and not in isolation of laboratories or clinics.

Transitioning from Teaching to Mentoring in Medical Sciences.

The transition from traditional teaching to mentoring in medical education is urgently required to create future-ready physicians, researchers, and medical teachers in India. A roadmap was drawn by the pioneers of modern medicine more than 100 years ago, who mentored and prepared the next generation of subspecialists and teachers. We need mentors rather than conventional teachers to inspire students to dream, learn, and grow.

Navigating the Editorial Gauntlet for Excellence in Radiology Publishing.

Any scientific journal of repute constantly strives to ensure the highest possible quality, integrity, and ethical standards of published research. This article attempts to the highlight multifaceted responsibilities of an Editor in Chief (EiC) and editors such as managing the peer review process, detecting plagiarism, and ensuring quality of selected manuscript before publication. The EiC also has to tackle issues of salami slicing, duplicate submissions, secondary publications, and guest and ghost authorship while adhering to constantly evolving guidelines of the International Committee of Medical Journal Editors (ICMJE) and the Committee on Publication Ethics (COPE).

The interplay of heart rate variability and ventricular repolarization parameters in the obese state: a review.

The impact of obesity on heart rate variability (HRV) and ventricular repolarization, both vital indicators of cardiovascular health, is the focus of this review. Obesity, measured by BMI, waist circumference, and waist-to-hip ratio, significantly increases cardiovascular disease (CVD) risk due to structural and autonomic heart changes. Findings show that obese individuals exhibit prolonged QT and Tpeak-to-Tend (Tpe) intervals, suggesting delayed ventricular recovery and greater arrhythmia risk.

Clinical features and outcomes of total pancreatic lipomatosis with chronic pancreatitis: a case series.

Background: Fatty changes in the pancreas are common, whereas total pancreatic lipomatosis (PL) is rare. Commonly associated with various components of metabolic syndrome and metabolic-associated steatotic liver disease, total PL can have various etiologies and can manifest with severe pancreatic exocrine insufficiency.

Method: We retrospectively analysed the clinical profile and management outcomes of 8 patients (mean age: 37.

Prevention of Delirium in the Intensive Care Unit through Nonpharmacological Interventions: An Umbrella Review.

Introduction: Delirium is a syndrome commonly seen in intensive care unit (ICU) patients. It is characterized by acute changes in mental status, inattention, disorganized thinking, and altered level of consciousness. Due to its higher prevalence in mechanically ventilated ICU patients, it is crucial to recognize it early and implement standardized evidence-based protocols for preventing it in regular practice.

Successful Treatment of Chronic Wound in a Patient with Longstanding Shell Injury on Heel using, a Novel Product Formulation: A Case Report.

Introduction: Chronic wounds pose a significant burden on patients' physical and mental well-being and significantly raise health-care costs.

Case Report: We report healing with VG111 application alone in a case of chronic wound in a patient who sustained a shell injury to the heel 35 years prior in 1988. Despite conventional wound care and multiple surgeries, the wound persisted.

Burden of diabetes in correctional facilities: A global systematic review and meta-analysis.

Background: Diabetes mellitus presents significant public health challenges worldwide. While its prevalence and management in the general population have been extensively studied, comprehensive research on diabetes among incarcerated individuals is lacking. This study aims to conduct a systematic review and -analysis to determine the prevalence of diabetes within the prison population.

Up-front dissection of the uterovesical space or "bladder-first approach" reduces hemorrhage and bladder injury during hysterectomy for placenta accreta spectrum: reconfirmed in 78 more cases in a prospective single-center study.

Background: Cesarean hysterectomy for placenta accreta spectrum disorder may be associated with severe hemorrhage because of placental invasion of the myometrium and the uterovesical space or parametrium. It leads to serious complications, such as massive hemorrhage requiring massive transfusion, coagulopathy, bladder and ureteric injuries, need for intensive care unit admission and prolonged hospital stay. To reduce the complications of cesarean hysterectomy for placenta accreta spectrum disorder, ongoing efforts are being made to develop different surgical approaches.