Unilateral progressive proptosis in neonate.

Orbital teratomas are congenital germ cell tumors that present at birth or within the first few months of life with unilateral proptosis. Primary orbital teratomas produce diffuse enlargement of the orbit. Orbital teratoma contains a wide diversity of tissues ranging from undifferentiated mass of tissue to a fully differentiated fetus in fetus.

Fluconazole.

Incidence of systemic candidiasis is increasing with improvement in the survival of high risk neonates who undergo multiple interventions. Therapies available to treat systemic fungal infection are few and have several drawbacks. Fluconazole, a new triazole derivative may be a useful anti-fungal agent in view of its excellent oral absorption, easy administration, low plasma protein affinity, long half-life, high concentrations in urine and CSF, minimal adverse reactions, wide spectrum of anti-fungal activity and high specificity for fungal cytochrome P450 system.

Effect of clofazimine on eye in multibacillary leprosy.

Seventy-six patients of multibacillary leprosy received clofazimine as part of multidrug therapy (MDT) for periods ranging between 6 and 24 months. Complete ocular examination including slit lamp microscopy and examination of tears was carried out in all these patients. Reddish brown conjunctival and corneal pigmentation was seen in 46% and 53% of the patients respectively.