Evaluation of Fungitell (1,3)-β-D-glucan assay in tear samples for rapid diagnosis of fungal keratitis.

Fungal keratitis (FK) is a serious suppurative and ulcerative corneal infection leading to blindness and vision loss. Rapid diagnosis of FK can contribute to prompt clinical management with early recovery. The study aimed to standardize the detection of (1,3)-β-D-glucan (BDG) and establish the diagnostic cut-off concentration in tears of suspected FK patients along with non-infected controls.

Vestibular Schwannoma Koos Grade II International Study of Active Surveillance Versus Stereotactic Radiosurgery: The VISAS-K2 Study.

Background And Objectives: This study assessed the efficacy and safety of stereotactic radiosurgery (SRS) in comparison with watchful waiting for managing Koos grade II vestibular schwannomas (VS).

Methods: A retrospective, multicentric analysis was conducted, focusing on patients with Koos grade II VS who either received SRS (SRS group) or were observed (observation group). To ensure comparability between groups, propensity score matching was used, including factors such as demographic characteristics, tumor dimensions, and hearing assessments.

Vestibular Schwannoma Koos Grade I International Study of Active Surveillance Versus Stereotactic Radiosurgery: The VISAS-K1 Study.

Background And Objective: This investigation evaluates the safety and efficacy of stereotactic radiosurgery (SRS) vs observation for Koos grade I vestibular schwannomas (VS).

Methods: In a multicenter study, we retrospectively analyzed data of patients with Koos grade I VS who underwent SRS (SRS group) or were observed (observation group). Propensity score matching was used to equilibrate demographics, tumor size, and audiometric data across groups.

A systematic compilation of rating scales developed, translated, and adapted in India.

Background: There is a lack of comprehensive data sources on various rating instruments that have been developed, translated, and adapted in Indian context.

Aim: Accordinly, this review aimed to compile the available scales/questionnaires/instruments developed, adapted, and translated for use in India.

Methods: For this, the search engines like PUBMED, Google Scholar, MedKnow, and Science Direct were searched for scales that have been developed, translated, and adapted in Indian context or an Indian language.

Amend the Mental Health Care Act 2017: A Survey of Indian Psychiatrists (Paper 1).

Aim: This paper highlights the difficulties and lacunae in the Mental Health Care Act 2017 that hinder its implementation and use for the care and treatment of persons with mental illness in India.

Methods: An online nationwide survey, involving structured questions as well as open-ended questions, to elicit the level of implementation, experience in complying with the provisions of the Act, and level of satisfaction, of practicing psychiatrists was carried out. Responses were analyzed using appropriate statistics.

Systemic immune inflammatory response index (SIIRI) in acute myocardial infarction.

Background: Different treatment approaches exist for non-ST elevation acute coronary syndrome (ACS) patients. This study assessed the systemic immune inflammatory response index (SIIRI) for its prognostic value and incremental clinical utility in determining optimal timing for percutaneous coronary intervention (PCI) in non-ST elevation myocardial infarction (NSTEMI) patients, particularly when troponin levels are initially negative.

Methods: This study included 1270 ACS patients: 437 STEMI, 422 NSTEMI, and 411 unstable angina.

Morphological characterization of coronary plaques in young indian patients with acute coronary syndrome: A multicentric study.

Objectives: The prevalence of atherosclerosis and acute coronary syndrome (ACS) is increasing in young Indians (18-50 years of age). However, the characteristics of atherosclerotic plaques in such individuals are poorly understood, presenting distinct challenges for the management of ACS. This study aims to analyze plaque characteristics in young Indian patients with ACS who underwent percutaneous coronary intervention (PCI) using optical coherence tomography (OCT) imaging.

On being on the same page: Predictors of gastroenterologist-patient misalignment in inflammatory bowel disease.

Objectives: This study explored the prevalence and degree of misalignment between gastroenterologists and people with inflammatory bowel disease (IBD) and investigated communication features related to misalignment.

Methods: A mixed-methods approach incorporated qualitative and quantitative analyses of consultations and post-consultation patient and doctor interviews. Gastroenterologists at two Australian teaching hospitals and IBD patients participated in this study.

Investigation of a Questionnaire Used to Measure Self-Perception of Self-Regulated Learning in Veterinary Students.

In the United States, the veterinary medical curriculum is 4 years, and at most institutions, no more than one-third of that time is devoted to clinical training, meaning that graduates must continue learning post graduation. Additionally, practicing veterinarians must keep up with new discoveries and techniques in the veterinary medical field and may also choose to pursue specific interests or specialties post graduation. For these reasons, it is essential that veterinarians be competent, self-regulated, life-long learners.

Reliability of distal radius fracture classification systems: a CT based study.

Objective: To assess the reliability and reproducibility of AO/OTA, Frykman and Fernandez classification systems for distal radius fractures on CT.

Materials And Methods: Four radiologists, including one radiology resident, two musculoskeletal radiology fellows and one radiology consultant independently evaluated CT scans of 115 patients with distal radius fractures and classified the fractures according to AO/OTA, Frykman and Fernandez classification system. To assess reproducibility, a second set of reading was done by two observers after an interval of six weeks.

Intracellular dynamics of ubiquitin-like 3 visualized using an inducible fluorescent timer expression system.

Exosomes are small extracellular vesicles (sEVs) secreted via multivesicular bodies (MVBs)/late endosomes and mediators of cell-cell communication. We previously reported a novel post-translational modification by ubiquitin-like 3 (UBL3). UBL3 is localized in MVBs and the plasma membrane and released outside as sEVs, including exosomes.

Turnover intention and continuing professional development of rural doctors from targeted admission medical education program in China: a cross-sectional study in the post-COVID-19 era.

Background: Turnover intention (TI) indicates an employee's intention to depart from their current role within a defined timeframe. In China, the Targeted Admission Medical Education (TAME) program, initiated in 2010, offers tuition-free education to cultivate rural doctors. Despite continuous professional development (CPD) being considered a viable retention strategy, TI of alumni doctors from the TAME program remains high in recent years.

Cautionary lessons from the COVID-19 pandemic: Healthcare systems grappled with the dual responsibility of delivering COVID-19 and non-COVID-19 care.

During the COVID-19 pandemic, hospitals were challenged to provide both COVID-19 and non-COVID treatment. A survey questionnaire was designed and distributed via email to hospitals empanelled under the Ayushman Bharat-Pradhan Mantri Jan Arogya Yojana(AB-PMJAY), the world's largest National Health Insurance Scheme. Telephonic follow-ups were used to ensure participation in places with inadequate internet.

Is infection protective against esophageal cancer?

() infection affects a substantial proportion of the global population and causes various gastric disorders, including gastric cancer. Recent studies have found an inverse relationship between infection and esophageal cancer (EC), suggesting a protective role against EC. This editorial focuses on the possible mechanisms underlying the role of infection in EC and explores the role of gut microbiota in esophageal carcinogenesis and the practicality of eradication.

Assessment of the Effectiveness of Educating Elderly Residents in an Urban Community in South India on Managing Post-COVID-19 Musculoskeletal Complications.

Objective This study aimed to enhance post-COVID-19 patients' understanding of musculoskeletal issues and their management through a structured educational program in the elderly population. Methodology The study included 60 participants. Each participant was assessed using sociodemographic tools and a structured knowledge questionnaire on post-COVID-19 musculoskeletal complications among elderly individuals.

A Prospective Study on the Spectrum of Liver Abscess With Special Reference to Ruptured Abscess in a Tertiary Care Hospital.

Introduction Liver abscesses are one of the most concerning healthcare issues in Western countries, with a prevalence rate of three per 100,000. Although with the improvement in the socio-economic status and the health care system, its incidence has decreased in developed nations, pyogenic and amoebic liver abscesses are still high in resource-poor countries. Low socioeconomic conditions, improper hygiene, lack of awareness, and often a delay in diagnosis can lead to fatal complications and high mortality.

Serum Uric Acid and Iron Status: Exploring a Complex Interaction in Metabolic Syndrome Patients of Eastern India.

Background: Metabolic syndrome, a cluster of illnesses including insulin resistance, hyperlipidemia, hypertension, and central obesity, is affecting roughly a quarter of the world population. Dysregulation of iron homeostasis may be associated with insulin resistance, leading to metabolic syndrome. Uric acid is an antioxidant currently studied in relation to several metabolic disorders.

Cognitive, behavioral, neuroimaging and inflammatory biomarkers after hospitalization for covid-19 in Brazil.

Post-COVID-19 Condition (PCC) refers to a multisystemic syndrome that persists for months after SARS-CoV-2 infection. Cognitive deficits, fatigue, depression, and anxiety are common manifestations of the condition, but the underlying mechanisms driving these long-lasting neuropsychiatric features are still unclear. We conducted a prospective multi-method investigation of post-hospitalization COVID-19 patients in Rio de Janeiro, Brazil.

Effect of pre-operative patient anxiety on post-spinal shivering during elective cesarean delivery: a prospective observational study.

Background: Shivering after spinal anesthesia is common during cesarean delivery (CD), and is thought to be primarily a thermoregulatory response. By inducing autonomic changes, pre-operative anxiety could alter the functioning of the thermoregulatory center, hence modifying the incidence and severity of obstetric post-spinal shivering. This prospective observational study was conducted to explore the relationship between pre-operative anxiety and obstetric post-spinal shivering.