13 results match your criteria: "Post Graduate Institute Medical Education and Research[Affiliation]"

Article Synopsis
  • Autism Spectrum Disorder (ASD) is a complex condition, and current animal models like Valproic Acid (VPA) and Propionic Acid (PPA) were found to be inadequate in mimicking the human disease fully.
  • The study tested several chemically induced animal models (including Poly I:C and Dioxin) to identify which best reflects the clinical features of ASD, with the Poly I:C model showing the closest resemblance.
  • Findings indicated significant behavioral and developmental changes, increased oxidative stress, and altered gene expression related to ASD in the model groups, highlighting the role of maternal immune activation in influencing embryonic development and contributing to ASD.
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() is the most common chronic bacterial infection, affecting approximately half of the world's population. is a Class I carcinogen according to the World Health Organization, and the International Agency for Research on Cancer (IARC) has linked it to 90% of stomach cancer cases worldwide. The overall pattern points to a yearly reduction in eradication rates of with the likelihood of success further decreasing after each unsuccessful therapeutic effort.

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Background: Nitrous oxide has been used during surgical anesthesia for many years. However, information about occupational exposure and related risks due to NO exposure to the health care personnel in India are still poorly understood. Here, we measured the residual NO levels during the working time of operation theatre room air in our tertiary care hospital.

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Purpose: To report clinical features and outcomes of nontuberculous mycobacteria (NTM) presenting as uveitis in HIV positive patients.

Materials And Methods: Retrospective study of HIV positive patients who were diagnosed as uveitis due to NTM.

Results: Six eyes of four HIV positive patients with NTM were studied.

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Background And Aims: The efficacy of preemptive multimodal analgesia in post-traumatic patients has not been elucidated. Our aim was to evaluate the efficacy of preemptive MMA regimen in reducing the epidural demand boluses in the first 48 hours following the traumatic shaft of femur fractures.

Methods: Patients scheduled for traumatic femur fracture surgery were randomised ( = 135) into two groups in this double blind, placebo controlled trial.

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Objectives: The association between the extent and degree of perfusion-metabolism mismatch and improvement in perfusion and left ventricular ejection fraction (LVEF) after revascularization was assessed. The secondary aim was to identify the best precoronary artery bypass graft surgery (pre-CABG) PET parameter, if any, to predict the improvement in the perfusion and LVEF after CABG.

Methods And Results: Overal, 31 patients (mean age: 58+8.

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Objective: To identify the predictors of pre-operative anxiety in school-going children in India.

Methods: A prospective observational study was done at a tertiary care teaching hospital. Children aged 7-12 y scheduled for elective surgery and their parents were enrolled.

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Chylous polyserositis and autoimmune myelofibrosis occurring concomitantly inn a case of SLE are a rare phenomenon. We here report a case of a 38-year-old woman who was admitted with a history of cough and shortness of breath for 1½ months along with fever and abdominal distension for 1 month. She also had arthralgias, weight loss and pancytopenia.

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Role of colostrum in gastrointestinal infections.

Indian J Pediatr

September 2008

Division of Pediatric Gastroenterology, Department of Gastroenterology, Post Graduate Institute Medical Education and Research, Chandigarh, India.

Colostrum is breast milk produced after the birth of the newborn and lasts for 2-4 days. Colostrum is very important part of breast milk and lays down the immune system and confers growth factors and other protective factors for the young ones in mammals. This is the source of passive immunity transferred to the baby from the mother.

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Molecular link between cholesterol, cytokines and atherosclerosis.

Mol Cell Biochem

March 2001

Department of Experimental Medicine and Biotechnology, Post Graduate Institute Medical Education and Research, Chandigarh, India.

Current investigation on the origin of atherosclerosis has initiated an intense debate over whether atherosclerosis results from hypercholesterolemia or an inappropriate immune response to vascular injury. Although the role of the immune system has been questioned, the overwhelming body of evidence clearly indicates that atherogenesis is initiated by the interplay between cholesterol and cellular secretion of cytokines (especially IL-6) and apolipoprotein 'E' within the arterial wall. Recent studies have revealed that cells possess two cholesterol-sensors: (a) Receptor-Ck which senses the extracellular cholesterol and initiates signalling pathway responsible for the regulation of genes involved in the cell cycle, cell death, cellular cholesterol homeostasis and cytokines including IL-6; (b) LxR alpha which senses intracellular oxysterols and controls genes involved in cell death, cellular cholesterol homeostasis and cytokine IL-8.

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