30 results match your criteria: "Portuguese Institute of Blood and Transplantation[Affiliation]"
Scheme for the selection of measurement uncertainty models in blood establishments' screening immunoassays.
Transfus Apher Sci
February 2015
Directive Board, Portuguese Institute of Blood and Transplantation, Lisbon, Portugal.
Blood establishments routinely perform screening immunoassays to assess safety of the blood components. As with any other screening test, results have an inherent uncertainty. In blood establishments the major concern is the chance of false negatives, due to its possible impact on patients' health.
View Article and Find Full Text PDFEvaluation of the measurement uncertainty in screening immunoassays in blood establishments: computation of diagnostic accuracy models.
Transfus Apher Sci
February 2015
International Consultancy in Blood Components Quality/Safety Improvement, Audit / Inspection and DDR Strategy, London, United Kingdom. Electronic address:
Article Synopsis
- The European Union regulation does not require blood establishments to evaluate measurement uncertainty in virology screening tests, unlike ISO 15189 guidelines which emphasize this evaluation.
- Researchers have debated GUM modular approaches in medical laboratories but haven't reached a consensus on how to apply them practically.
- The article reviews and proposes probability-based models for diagnostic accuracy in blood screening tests as alternatives to traditional measurement uncertainty concepts, demonstrating their effectiveness with a case study on anti-HCV testing.
Proteolytic systems and AMP-activated protein kinase are critical targets of acute myeloid leukemia therapeutic approaches.
Oncotarget
October 2015
Life and Health Sciences Research Institute (ICVS), School of Health Sciences, University of Minho, Braga, Portugal.
The therapeutic strategies against acute myeloid leukemia (AML) have hardly been modified over four decades. Although resulting in a favorable outcome in young patients, older individuals, the most affected population, do not respond adequately to therapy. Intriguingly, the mechanisms responsible for AML cells chemoresistance/susceptibility are still elusive.
View Article and Find Full Text PDFEndothelial progenitor cells in diabetic patients with myocardial infarction - can statins improve their function?
Eur J Pharmacol
October 2014
Laboratory of Pharmacology and Experimental Therapeutics, Institute for Biomedical Imaging and Life Sciences, Faculty of Medicine, University of Coimbra, Portugal.
The effect of statins on endothelial progenitor cells (EPCs) function derived from diabetic patients (DMpts) with acute myocardial infarction (AMI) is unknown. In this study we assess the response of early and late EPCs from diabetic versus non-diabetic patients (NDMpts) with AMI to statins. EPCs were obtained from 10 diabetic and 10 age-matched non-diabetic male patients with AMI.
View Article and Find Full Text PDFDifferent frequencies of Tc17/Tc1 and Th17/Th1 cells in chronic spontaneous urticaria.
Int Arch Allergy Immunol
October 2013
Blood and Transplantation Center of Coimbra, Portuguese Institute of Blood and Transplantation, Coimbra, Portugal.
Background: Chronic urticaria is associated with an immune dysregulation usually mediated by T lymphocytes. Recently, Th17 and Tc17 have been implicated in autoimmune diseases; however, their role in urticaria is not clear yet.
Methods: For the study we recruited 20 patients [10 of them had autoreactive chronic spontaneous urticaria (positive autologous intradermal serum test response, ASST+), and the other 10 were nonautoreactive chronic spontaneous urticaria patients (ASST-)] and 17 healthy age- and gender-matched controls (HG).