Methods to assess on-farm biosecurity in Europe and beyond.

The aim of this study was to identify which biosecurity assessment methods (BAMs) are currently used in practice in animal farms. To address this, a structured questionnaire was developed to gather information such as the animal species, main objectives, type of enforcement, output generated and feedback of the result. In the context of the BETTER Cost Action project, country representatives identified in each of their countries which BAMs were used and completed an online survey.

N-doped graphene quantum dots combined with Ag nanoparticles for luminescence based analytical sensing of gentamycin after solid-phase extraction in a molecularly-imprinted polymer.

A luminescence-based method was developed to detect gentamicin using silver nanoparticles (AgNPs) associated with nitrogen-doped graphene quantum dots (N-GQDs). When gentamicin sulfate interacts with the AgNPs/N-GQDs system, the characteristic blue fluorescence of N-GQDs, which had been previously turned off by AgNPs, is restored. Under specific conditions (such as the amount of synthesis dispersion and pH), this AgNPs/N-GQDs probe enabled quantification of gentamicin ranging from 3.

Assessing the value of environmental DNA into conservation planning: A case study of freshwater bivalves in France.

Environmental DNA (eDNA) is emerging as a valuable tool for generating standardised biodiversity data. Whether used alone or alongside conventional surveys, it is expected that eDNA data can improve conservation planning, but this remains largely untested. Here, we assessed the value of eDNA data for making more robust conservation prioritisation decisions, by comparing errors made when identifying priority areas based on conventional data, eDNA or a combination of both.

Worldwide Innovative Network (WIN) Consortium in Personalized Cancer Medicine: Bringing next-generation precision oncology to patients.

The human genome project ushered in a genomic medicine era that was largely unimaginable three decades ago. Discoveries of druggable cancer drivers enabled biomarker-driven gene- and immune-targeted therapy and transformed cancer treatment. Minimizing treatment not expected to benefit, and toxicity-including financial and time-are important goals of modern oncology.

Time dependence of the pre-chromatographic oxidation method for bivalves contaminated with paralytic shellfish poisoning toxins.

The neurotoxins of the saxitoxin family can be the origin of the human neurological syndrome of paralytic shellfish poisoning via contaminated marine bivalve vectors. A pre-chromatographic oxidation method is the official testing method in the EU, also known as the 'Lawrence method'. It involves several steps, including toxin extraction, solid-phase clean-up, and oxidation to produce fluorescent derivatives.

Nursing activities and quality of care: French perspectives and leadership challenges.

Objectives: to assess nurses' perceptions of nursing activities that contribute to quality of care in France.

Methods: descriptive cross-sectional study, between February and August 2020 in France. Sociodemographic characteristics were recorded, and nurses' perceptions were assessed using F-EPAECQC.

Construction of a middle-range nursing theory for transpersonal home care.

Objectives: to describe the development of a middle-range nursing theory for transpersonal home care.

Methods: this is a theoretical study that used concept analysis, statement synthesis and derivation. It combined theoretical deduction strategies with induction, based on literature review and concept analysis.

Health gains for users of long-term home care services in Portugal.

Objectives: to evaluate health gains sensitive to nursing care in the context of long-term home care.

Methods: this was a quantitative, retrospective study carried out in the north of Portugal. The sample consisted of 151 users aged 18 or over.

Protective role of calcium-based agents in dental bleaching gels: insights from a systematic review and meta-analysis of clinical and laboratory evidence.

Objectives: This systematic review and meta-analysis (SRM) evaluated the effect of incorporating calcium-based bioactive agents in bleaching gels on dental structure preservation and whitening efficacy.

Methods: A comprehensive search was conducted across databases up to November 2024. Two independent reviewers screened and selected clinical trials and in vitro studies evaluating the effects of calcium-based bioactive agents in bleaching gels, following predefined PICO criteria.

Higher life's essential 8 score is associated with reduced risk of related surgery and all-cause mortality among 3,232 individuals with inflammatory bowel disease in a longitudinal cohort study.

Background: Previous studies indicated discrete lifestyle health metrics that benefit cardiovascular health are associated with better prognosis in inflammatory bowel disease (IBD), while evidence regarding the comprehensive impact of cardiovascular health remains limited. This study aimed to investigate the association between the overall cardiovascular health indicator, Life's Essential 8 (LE8), and the adverse outcomes of IBD.

Materials And Methods: We included 3,232 IBD participants recruited from the UK Biobank between 2006 and 2010.

Preserving the Biologically Coherent Generic Concept of , 'Plant Destroyer'.

is a long-established, well known and globally important genus of plant pathogens. Phylogenetic evidence has shown that the biologically distinct, obligate biotrophic downy mildews evolved from at least twice. Since, cladistically, this renders 'paraphyletic', it has been proposed that evolutionary clades be split into multiple genera (Runge et al.

Ferroelectric and Non-Linear Optical Nanofibers by Electrospinning: From Inorganics to Molecular Crystals.

In recent decades, substantial progress has been made in embedding molecules, nanocrystals, and nanograins into nanofibers, resulting in a new class of hybrid functional materials with exceptional physical properties. Among these materials, functional nanofibers exhibiting ferroelectric, piezoelectric, pyroelectric, multiferroic, and nonlinear optical characteristics have attracted considerable attention and undergone substantial improvements. This review critically examines these developments, focusing on strategies for incorporating diverse compounds into nanofibers and their impact on enhancing their physical properties, particularly ferroelectric behavior and nonlinear optical conversion.

Sunlight-Induced Photocatalytic Removal of Paracetamol Using Au-TiO Nanoparticles.

Using sunlight as the driving force for photocatalytic processes holds great promise for sustainability. As a starting point for developing a material capable of degrading aquatic pollutants using solar energy as a stimulus, this work focuses on synthesizing Au-TiO nanocomposites using the deposition-precipitation method. Characterization of Au-TiO nanoparticles was performed by X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FTIR), and Transmission Electron Microscopy (TEM).

Tetrahedrite Nanocomposites for High Performance Thermoelectrics.

Thermoelectric (TE) materials offer a promising solution to reduce green gas emissions, decrease energy consumption, and improve energy management due to their ability to directly convert heat into electricity and vice versa. Despite their potential, integrating new TE materials into bulk TE devices remains a challenge. To change this paradigm, the preparation of highly efficient tetrahedrite nanocomposites is proposed.

Thermal Properties and Features of Nanofluids.

Nanofluids have emerged as an advanced media in many applications, particularly thermal management and energy efficiency applications, with extensive research focusing on their thermophysical properties and thermal performances [...

Design Strategies of S Molecule Cathodes for Room-Temperature Na-S Batteries.

Sodium-sulfur batteries have been provided as a highly attractive solution for large-scale energy storage, benefiting from their substantial storage capacity, the abundance of raw materials, and cost-effectiveness. Nevertheless, conventional sodium-sulfur batteries have been the subject of critique due to their high operating temperature and costly maintenance. In contrast, room-temperature sodium-sulfur batteries exhibit significant advantages in these regards.

Exploring Metabolic Shifts in Kidney Cancer and Non-Cancer Cells Under Pro- and Anti-Apoptotic Treatments Using NMR Metabolomics.

This study investigates the metabolic responses of cancerous (RCC) and non-cancerous (HK2) kidney cells to treatment with Staurosporine (STAU), which has a pro-apoptotic effect, and Bongkrekic acid (BKA), which has an anti-apoptotic effect, individually and in combination, using H NMR metabolomics to identify metabolite markers linked to mitochondrial apoptotic pathways. BKA had minimal metabolic effects in RCC cells, suggesting its role in preserving mitochondrial function without significantly altering metabolic pathways. In contrast, STAU induced substantial metabolic reprogramming in RCC cells, disrupting energy production, redox balance, and biosynthesis, thereby triggering apoptotic pathways.

Statins as an Adjunctive Antithrombotic Agent in Thrombotic Antiphospholipid Syndrome: Mechanisms and Clinical Implications.

The thrombotic physiopathology of antiphospholipid syndrome (APS) is complex, heterogeneous, and dynamic. While venous thromboembolism (VTE) is the most common initial presentation, arterial thrombotic events (ATE) become more frequent in advanced stages and are associated with high morbidity and mortality. Despite the use of oral anticoagulants (OACs), thrombotic APS remains associated with a high risk of recurrent thrombosis.

Penile prosthesis for erectile dysfunction: recommendations from the 5th International Consultation on Sexual Medicine.

Introduction: Penile prosthesis (PP) is one of the main approved therapies for erectile dysfunction (ED). Greater than 50 years of clinical use has led to considerable innovation in PP surgery and patient care.

Objectives: To summarize the current literature and provide updated clinical evidence to inform healthcare providers on best practices with PP.

Enhancing cryopreservation of human induced pluripotent stem cells: Bottom-up versus conventional freezing geometry.

Induced pluripotent stem cells (iPSCs) hold large potential in regenerative medicine due to their pluripotency and unlimited self-renewal capacity without the ethical issues of embryonic stem cells. To provide quality-controlled iPSCs for clinical therapies, it is essential to develop safe cryopreservation protocols for long-term storage, preferably amenable to scale-up and automation. We have compared the impact of two different freezing geometries (bottom-up and conventional radial freezing) on the viability and differentiation potential of human iPSCs.

Age and Latent Cytomegalovirus Infection Do Not Affect the Magnitude of De Novo SARS-CoV-2-Specific CD8 T Cell Responses.

Immunosenescence, age-related immune dysregulation, reduces immunity upon vaccinations and infections. Cytomegalovirus (CMV) infection results in declining naïve (T) and increasing terminally differentiated (T) T cell populations, further aggravating immune aging. Both immunosenescence and CMV have been speculated to hamper the formation of protective T-cell immunity against novel or emerging pathogens.

HIV-2EU - Supporting Standardized HIV-2 Drug Resistance Interpretation: an Update.

Human immunodeficiency virus type 2 (HIV-2) is an attenuated retroviral infection characterized by specific natural susceptibility to antiretroviral drugs and acquired resistance profiles. Based on the latest knowledge of phenotypic data and clinical follow-up, HIV-2 resistance interpretation rules have been updated and implemented in a freely available resistance analysis tool.

Highlights from the breakout session: diagnosis and classification of vasculitis.

The session on 'Diagnosis and Classification of Vasculitis' featured six oral presentations covering various aspects of vasculitis diagnosis and classification. The application of the Ankara criteria for IgA vasculitis in adults was evaluated, finding that while the criteria showed good sensitivity, their specificity was insufficient, suggesting the need for refinement. A clustering approach to classifying ANCA-associated vasculitis (AAV) identified five distinct clusters, which improved prediction of disease outcomes.