Unraveling rosmarinic acid anticancer mechanisms in oral cancer malignant transformation.

Oral squamous cell carcinoma (OSCC) is expected to rise ca. 40 % by 2040. Rosmarinic acid (RA) has been recognized for its anticancer properties, although its role in OSCC has been neglected.

Enhancing phosphorus recovery from poultry litter ash through microwave-assisted thermochemical treatment for improving its solubility.

This study explores for the first time the P recovery from poultry litter ash (PLA) using microwave-assisted thermochemical treatment, aiming to improve its bioavailability for utilization as a fertilizer. PLA samples, originating from laying hens' manure incineration, were subjected to microwave treatment with the addition of sodium bicarbonate, and their physical-chemical characteristics were analyzed using X-ray fluorescence (XRF), X-ray diffraction (XRD), and scanning electron microscopy with energy dispersive spectroscopy (SEM-EDS). The results indicate that the microwave treatment led to the formation of NaCaPO crystals, with a significant increase in P solubility post-treatment, which is crucial for plant uptake.

Does music training improve emotion recognition and cognitive abilities? Longitudinal and correlational evidence from children.

Music training is widely claimed to enhance nonmusical abilities, yet causal evidence remains inconclusive. Moreover, research tends to focus on cognitive over socioemotional outcomes. In two studies, we investigated whether music training improves emotion recognition in voices and faces among school-aged children.

Challenges of Congenital HHV6 Infection Diagnosis and Treatment: Two Case Reports and Literature Review.

Introduction: Congenital human herpesvirus 6 (HHV6) infection occurs in 1% of the general population and may result from the transmission of an inherited chromosomally integrated HHV6 (iciHHV6) or transplacental infection. It is mostly asymptomatic.

Case Reports: Case 1: a 29th-week-old female preterm newborn, admitted to the neonatal intensive care unit, became clinically unstable and irritable on the 20th day of hospitalization.

Impact of Demographic and Clinical Subgroups in Google Trends Data: Infodemiology Case Study on Asthma Hospitalizations.

Background: Google Trends (GT) data have shown promising results as a complementary tool to classical surveillance approaches. However, GT data are not necessarily provided by a representative sample of patients and may be skewed toward demographic and clinical groups that are more likely to use the internet to search for their health.

Objective: In this study, we aimed to assess whether GT-based models perform differently in distinct population subgroups.

Clinical Outcomes of Chemo-Immunotherapy for Extensive Stage Small Cell Lung Cancer: A Real-World Single Centre Study in Portugal.

Small cell lung cancer (SCLC) is an aggressive type of lung cancer. Recent studies have provided a new hope by adding atezolizumab to the standard treatment of extensive disease SCLC (E-SCLC). The aim of our study was to evaluate the real-life performance of atezolizumab plus chemotherapy in extensive stage SCLC in a Portuguese setting.

Cancer nursing research priorities: findings from a cancer nurses' consultation in Europe.

Background: Nurses are well positioned to identify the most critical issues in patient care and to determine priorities for investigation. Involving nurses in developing research priorities may increase their engagement in research and enhance the development high-quality nursing practice.

Aim: This study aimed to scope the potential topics for future cancer nursing research in Europe from the perspective of cancer nurses.

Methodological optimization for ecotoxicological community tests with Enchytraeids-extraction procedures and sampling effort.

Enchytraeids play important roles in ecosystems, contributing to the decomposition of organic matter, given the feeding activity in the litter and the interaction with soil microorganisms, affecting the regulation, flow, and cycling of carbon and nutrients in ecosystems. Despite their ecological relevance, enchytraeids are commonly neglected in soil biodiversity assessments. To develop a methodology to assess the effects of pollutants on natural communities of enchytraeids, some methodologies require optimization.

Non-invasive derivation of instantaneous free-wave ratio from invasive coronary angiography using a new deep learning artificial intelligence model and comparison with human operators' performance.

Invasive coronary physiology is underused and carries risks/costs. Artificial Intelligence (AI) might enable non-invasive physiology from invasive coronary angiography (CAG), possibly outperforming humans, but has seldom been explored, especially for instantaneous wave-free Ratio (iFR). We aimed to develop binary iFR lesion classification AI models and compare them with human performance.

CCL2 expression predicts clinical outcomes, and regulates E-cadherin and angiogenesis in pituitary tumours.

The crosstalk between tumour cells and microenvironment components in pituitary neuroendocrine tumours (PitNETs), including chemokines, may impact tumour behaviour and clinical outcomes. CCL2 was previously identified as a key chemokine in PitNETs, but its role remains unknown. We aimed to study the role of CCL2 in defining the phenotype and clinical outcomes of PitNETs, and in regulating macrophage chemotaxis, epithelial-to-mesenchymal transition (EMT) and angiogenesis.

Current Perspectives on Additive Manufacturing and Titanium Surface Nanotopography in Bone Formation.

This study aimed to assess the impact of manufacturing methods (conventional and additive manufacturing) and surface treatments (polished and nanotopographic) on the physicochemical properties of Ti6Al4V alloy and their correlation with osteoblast cellular behavior. The evaluated groups were Machined Discs (MD), Machined Discs with Treatment (MD-WT), Additive-manufactured Discs (AD), and Additive-manufactured Discs with Treatment (AD-WT). Surface analyses included SEM, AFM, surface roughness, EDS, XRD, surface free energy, and zeta potential.

Failure to rescue in acute liver failure: A multicenter cohort study.

Introduction: The concept of failure to rescue has been used to measure the quality of care for complications developed following surgery. The concept of failure to rescue has been poorly studied in patients with primary medical diseases, such as sepsis or acute liver failure (ALF).

Methods: Retrospective multicenter cohort including consecutive patients with ALF within the United States ALF Study Group (USALFSG) prospective registry from 2010 to 2016.

Conditional Activation of Protein Therapeutics by Templated Removal of Peptide Nucleic Acid Masking Groups.

Interleukin-2 (IL-2)-based therapeutics are emerging as treatments for immunotherapy; however, systemic activation of immune cells hampers their success. Chemically controlling the activity of potent cytokines could mitigate unwanted T cell stimulation and widen their therapeutic window. In this study, we developed a strategy for the conditional activation of proteins utilizing removable peptide nucleic acid (PNA) masking groups.

Kidney-Derived ECM Hydrogels as Cell Delivery Devices.

Chronic kidney disease (CKD) represents a significant global health challenge, as emphasized by its increasing prevalence and limited treatment options. Stem cell-based therapies are promising alternatives for CKD treatment. In particular, adipose-derived mesenchymal stem cells (ASCs) have emerged as an attractive candidate cell source.

On the development of diagnostic support algorithms based on CPET biosignals data machine learning and wavelets.

For preventing health complications and reducing the strain on healthcare systems, early identification of diseases is imperative. In this context, artificial intelligence has become increasingly prominent in the field of medicine, offering essential support for disease diagnosis. This article introduces an algorithm that builds upon an earlier methodology to assess biosignals acquired through cardiopulmonary exercise testing (CPET) for identifying metabolic syndrome (MS), heart failure (HF), and healthy individuals (H).

Pediatric Non-cystic Fibrosis Bronchiectasis in a Portuguese Tertiary Care Center: A Cross-Sectional Observational Study.

Introduction Non-cystic fibrosis bronchiectasis (bronchiectasis) is an increasingly recognized but understudied disease in children. National data on this disease are scarce. This study aimed to describe the clinical, radiological, and microbiological characteristics of Portuguese children with bronchiectasis.

Atlantic oceanic islands and archipelagos: Physical structures, plant diversity, and affinities of the bryofloras.

We investigated the species richness, endemism, and similarities of the bryofloras on ten islands and archipelagos in the Atlantic Ocean. We address the following questions: 1) How many bryophyte taxa are there on each island and archipelago? 2) Do mosses and liverworts share similar patterns of diversity? 3) What are their taxonomic distribution patterns? 4) How many endemic taxa are found on the islands? 5) Is there a high degree of similarity amost these bryofloras? We encountered 1,498 taxa, 408 genera, and 204 families, with the seven families representing 35% of all species. Over 14% of the bryophytes are African elements, 8% have global distributions, ca.

Pulmonary Hypertension and Acute Heart Failure Following Lumbar Disc Surgery.

A 70-year-old woman was admitted with heart failure and signs of pulmonary hypertension on echocardiogram. Cardiac catheterization demonstrated postcapillary pulmonary hypertension, elevated cardiac output, and O saturation enrichment. Computed tomography revealed a large arteriovenous fistula between the common iliac artery and vein, which was due to a lumbar disc surgery performed several years prior.

The Sustainability Spillover: Uncovering the Link Between Informal Elder Care and Eco-Conscious Behaviors Across the European Union.

Background And Objectives: This study explores the association between informal caregiving for older adults and environmentally sustainable behaviors across the 27 European Union countries, aiming to identify how the gendered and domestic nature of environmentalism relates to senior care.

Research Design And Methods: Data from 41,742 respondents aged 16-74 were analyzed from the Survey of Gender Gaps in Unpaid Care, Individual and Social Activities, and conducted by a scientific consortium in 2022. Frequency of sustainable behaviors was measured across 10 indicators.

Induced pluripotent stem cell-derived mesenchymal stem cells for modeling and treating metabolic associated fatty liver disease and metabolic associated steatohepatitis: Challenges and opportunities.

The potential of induced pluripotent stem cells (iPSCs) for modeling and treating metabolic associated fatty liver disease (MAFLD) and metabolic associated steatohepatitis (MASH) is emerging. MAFLD is a growing global health concern, currently with limited treatment options. While primary mesenchymal stem cells hold promise, iPSCs offer a versatile alternative due to their ability to differentiate into various cell types, including iPSC-derived mesenchymal stem cells.

A perspective from the European Network for Bipolar and Emotion Regulation on research and intervention for emotion dysregulation in bipolar disorder: challenges and lessons learned.

Bipolar disorder (BD) and emotion dysregulation present substantial challenges for individuals and healthcare providers. Although pharmacological treatments remain the primary approach, psychosocial interventions show promise in addressing sub-threshold symptoms and deepening understanding of mood and emotion dysregulation mechanisms. The European Network for Bipolar Emotion Regulation (ENBER) aims to close the gap between research and clinical practice by offering practical insights for clinicians while contributing to scientific discourse on BD and emotion regulation (ER).