Health Care Professionals and Data Scientists' Perspectives on a Machine Learning System to Anticipate and Manage the Risk of Decompensation From Patients With Heart Failure: Qualitative Interview Study.

Background: Heart failure (HF) is a significant global health problem, affecting approximately 64.34 million people worldwide. The worsening of HF, also known as HF decompensation, is a major factor behind hospitalizations, contributing to substantial health care costs related to this condition.

Impact of Lower-Volume Training on Physical Fitness Adaptations in Team Sports Players: A Systematic Review and Meta-analysis.

Background: A small number of reviews have explored lower- versus higher-volume training in non-athletes, but the growing challenge of congested schedules in team sports highlights the need to synthesize evidence specific to team sport athletes. Thus, the objectives of this systematic review with meta-analysis are twofold: (i) to summarize the primary physiological and physical fitness outcomes of lower-volume versus higher-volume training interventions in team sports players; and (ii) to compare the effects of lower-volume training with higher, considering the training modalities used.

Methods: We conducted searches across key databases, including PubMed, Scopus, SPORTDiscus, and Web of Science.

Cellular dynamics of cervical remodelling: insights from preterm and term labour.

Introduction: Preterm birth remains a global health challenge with significant perinatal morbidity and mortality rates. Despite extensive research, the underlying mechanisms triggering preterm birth remain elusive, needing a deeper understanding of cervical cellular remodelling processes.

Purpose: This study aims to elucidate the cellular mechanisms underlying cervical remodelling in spontaneous preterm labour (PTL) compared to term labour (TL), focusing on the roles of inflammatory cells and fibroblasts.

In silico, in vitro and in vivo characterisation of thiamin binding proteins from plant seeds.

Thiamin, an essential micronutrient, is a cofactor for enzymes involved in the central carbon metabolism and amino acids pathways. Despite efforts to enhance thiamin content in rice by incorporating thiamin biosynthetic genes, increasing thiamin content in endosperm remains challenging, possibly due to a lack of thiamin stability and/or a local sink. The introduction of storage proteins has been successful in biofortification strategies and similar efforts targeting thiamin led to a 3-4-fold increase in white rice.

Acute pancreatitis with panniculitis: a rare and striking clinical presentation.

Pancreatic panniculitis is a rare dermatological manifestation of pancreatic disorders, characterized by painful, erythematous nodules. We present the case of an 84-year-old woman with acute pancreatitis who developed erythematous-violaceous nodular lesions on her lower limbs. Histopathological examination revealed lobular panniculitis with fat necrosis and ghost adipocytes, confirming the diagnosis.

adapted to steppe-desert climate extremes one million years ago.

Questions about when early members of the genus adapted to extreme environments like deserts and rainforests have traditionally focused on . Here, we present multidisciplinary evidence from Engaji Nanyori in Tanzania's Oldupai Gorge, revealing that thrived in hyperarid landscapes one million years ago. Using biogeochemical analyses, precise chronometric dating, palaeoclimate simulations, biome modeling, fire history reconstructions, palaeobotanical studies, faunal assemblages, and archeological evidence, we reconstruct an environment dominated by semidesert shrubland.

Impact of Red Cell Exchange Transfusion on Inflammatory Markers in Sickle Cell Disease.

Background: Red Blood Cell Exchange (RBCX) is a common treatment for pediatric sickle cell disease (SCD). Since inflammation with elevated proinflammatory cytokines plays a crucial role in SCD, this study hypothesized that RBCX might lower these cytokines and aimed to assess the impact of this technique on these markers.

Methods: Prospective and observational study of pediatric SCD patients (HbSS genotype) enrolled in a chronic RBCX program at a Portuguese Hospital from October 2022 to August 2024.

Fungal Planet description sheets: 1697-1780.

Novel species of fungi described in this study include those from various countries as follows: , from accumulated snow sediment sample. , on leaf spots of . , on submerged decaying wood in sea water, on , as endophyte from healthy leaves of .

Is provisioning rate of parents and helpers influenced by the simulated presence of novel individuals?

Abstract: Cooperative behaviour is widespread in animals and is likely to be the result of multiple selective pressures. A contentious hypothesis is that helping enhances the probability of obtaining a sexual partner (i.e.

Exploring the therapeutic potential of acorn extract in papillomavirus-induced lesions.

Background And Aim: Papillomaviruses (PVs) infections have been documented in numerous animal species across different regions worldwide. They often exert significant impacts on animal health and livestock production. Scientists have studied natural products for over half a century due to their diverse chemical composition, acknowledging their value in fighting cancer.

Neurodegeneration and choroidal vascular features on OCT in the progression to advanced age-related macular degeneration.

Aim: To quantify and compare longitudinal thickness changes of the ganglion cell complex (GCC) and the choroid in patients with different patterns of age-related macular degeneration (AMD) progression.

Methods: Retrospective cohort analysis of anonymized data from participants aged 50y or more and diagnosed with early/intermediate AMD in at least one eye (with no evidence of advanced AMD). A total of 64 participants were included from the Instituto de Retina de Lisboa (IRL) study (IPL/2022/MetAllAMD_ESTeSL) and divided into 4 groups according to the Rotterdam classification for AMD.

The Chemistry of Sporopollenin Ektexine and Endexine Layers Isolated from Sunflower Pollen through an Ionic Liquid-Mediated Process.

Sporopollenin is a plant polymer present in the exine of the pollen grains that comprises two layers: the endexine and the ektexine. It possesses remarkable mechanical, thermal, and chemical stability and is also highly recalcitrant to hydrolysis. The chemical backbone of sporopollenin mostly consists of a polyhydroxylated aliphatic component and polyketide-derived aliphatic α-pyrone elements.

Methods for data extraction and data transformation in convergent integrated mixed methods systematic reviews.

Objective: The objective of this guidance paper is to describe data transformation involving qualitization, including when and how to undertake this process, and to clarify how it aligns with data extraction in order to expand on the current guidance for JBI convergent integrated mixed methods systematic reviews (MMSRs).

Introduction: The convergent integrated approach to MMSRs involves combining extracted data from both quantitative studies (including the quantitative components of mixed methods studies) and qualitative studies (including the qualitative components of mixed methods studies). This process requires data transformation, which can occur either by converting qualitative data into quantitative data (ie, quantitizing) or converting quantitative data into qualitative data (ie, qualitizing).

Phenolic Compounds and Bacteriocins: Mechanisms, Interactions, and Applications in Food Preservation and Safety.

Beneficial properties of different natural antimicrobials are topics of scientific curiosity for improving safety and extending the shelf life of food commodities. In this regard, phenolic compounds, natural molecules known for their antioxidant, anti-inflammatory, and antimicrobial properties can be right choice. Moreover, bacteriocins, antimicrobial peptides produced by various microorganisms, capable of inhibiting the growth of other bacteria, particularly closely related species can be genuine alternative.

Enhanced Photocatalytic Efficiency Through Oxygen Vacancy-Driven Molecular Epitaxial Growth of Metal-Organic Frameworks on BiVO.

Efficient charge separation at the semiconductor/cocatalyst interface is crucial for high-performance photoelectrodes, as it directly influences the availability of surface charges for solar water oxidation. However, establishing strong molecular-level connections between these interfaces to achieve superior interfacial quality presents significant challenges. This study introduces an innovative electrochemical etching method that generates a high concentration of oxygen vacancy sites on BiVO surfaces (Ov-BiVO), enabling interactions with the oxygen-rich ligands of MIL-101.

Prenatal couple relationship satisfaction, romantic attachment, and childbirth-related posttraumatic stress symptoms.

Background: Traumatic childbirth can lead to childbirth-related posttraumatic stress symptoms (CB-PTSS). Although underexplored, prenatal couple relationship satisfaction and romantic attachment orientations are modifiable factors that may increase or mitigate the risk of CB-PTSS after a traumatic childbirth experience.

Objectives: This study examined (1) the associations between prenatal couple relationship satisfaction and romantic attachment, traumatic childbirth and CB-PTSS; (2) whether prenatal couple relationship satisfaction moderates the association between traumatic childbirth and CB-PTSS; and (3) whether the interaction between prenatal couple relationship satisfaction and romantic attachment moderates the association between traumatic childbirth and CB-PTSS.

Production of nondairy fermented products with chestnut puree as substrate and milk kefir grains or two lactic acid bacteria.

This work aimed to study the production, for the first time, of three fermented products of chestnut puree (CP) with milk kefir grains, a higher nisin-producing (Lactococcus (L.) lactis CECT 539) and a higher lactic acid-producing (Lactobacillus (Lb.) casei CECT 4043) lactic acid bacteria (LAB).

Miyazaki syndrome.

Miyazaki syndrome is a rare complication in patients with ventricular shunts, characterised by cervical myelopathy from cerebrospinal fluid overdrainage. Here we report a case of a young woman with a history of hydrocephalus who had a ventricular shunt placed in infancy, presenting to our department with signs and symptoms of myelopathy due to overshunting. This diagnosis is challenging because of the frequent absence of typical signs of intracranial hypotension, leading to delays in treatment, which carries the risk of potentially devastating consequences.

Anticancer efficacy of thiazole-naphthyl derivatives targeting DNA: Synthesis, crystal structure, density functional theory, molecular docking, and molecular dynamics studies.

Two newly synthesized ligands, 1-((2-(4-(4-methoxyphenyl)thiazol-2-yl)hydrazono)methyl)naphthalen-2-ol (HL1) and 1-((2-(4-(naphthalen-1-yl)thiazol-2-yl)hydrazono)methyl)naphthalen-2-ol (HL2) were characterized using spectroscopy and single X-ray crystallography. Both belong to triclinic systems with space groups P21/c (HL1) and P-1 (HL2), exhibiting planar structures. Biological assays revealed significant antitumor activity, with HL2 showing significant antitumor activity against HepG2 cells (IC: 3.

Temporal Trends and Outcomes of Rotational Atherectomy: A Single-Centre Experience.

Introduction And Objectives: Rotational atherectomy (RA) is widely used for the management of calcified coronary stenoses. However, there is limited data on its use, trends, and outcomes. We sought to report our twelve-year experience with RA and explore the trends and outcomes of percutaneous coronary intervention (PCI) with this device.

Understanding the determinants and outcomes of education in pulmonary rehabilitation: moving towards person-centered care.

Topic Importance: Education and psychosocial support are essential components of pulmonary rehabilitation (PR). However, the delivery of education often follows a one-size-fits-all approach, with individual factors that influence learning rarely considered. Moreover, education-related outcomes are frequently overlooked in PR assessments, and inconsistent use of these outcomes has limited our understanding of the impact of education on people with chronic respiratory diseases.