Implementation of the ProMisE classifier and validation of its prognostic impact in Brazilian endometrial carcinomas.

Purpose: Molecular classification of endometrial cancer (EC) has emerged as a key approach to individualize therapy and define prognostic outcomes. This study aimed to implement the traditional ProMisE classification in a Brazilian population, compared with a molecular setting of ProMisE biomarkers, and evaluate its impact on patients' prognosis.

Patient And Methods: A prospective cohort of 114 patients with primary EC treated at Barretos Cancer Hospital (BCH) between October 2020 and December 2022 was conducted.

Prostaglandin pathways in equine myometrium regulations: endometrosis progression.

Introduction: Prostaglandins (PG) are important regulators of the myometrial contractility in mammals. Endometrosis, a condition characterized by morphological changes in the equine endometrium, also affects endometrial secretory function. However, it remains unclear whether and how endometrosis affects myometrial function.

Characterization of risk factors for early ambulation in paraplegic dogs with absent pain perception undergoing decompressive surgery for thoracolumbar intervertebral disk extrusions.

Background: Current literature warrants surgical decompression in paraplegic dogs with absent pain perception (APP), but the rate of ambulatory dogs with APP following thoracolumbar (TL) IVDE surgery in a clinical setting remains unknown. Furthermore, the outcome of paraplegic APP French Bulldogs (FBs) is anecdotally considered poor. The aims of this study were threefold within a large population of TL-IVDE paraplegic dogs with APP undergoing decompressive surgery: (1) to characterize early spontaneous pelvic limb movement and ambulation following surgery; (2) to identify risk factors for the recovery of ambulation; and (3) to compare the outcome of FBs and Dachshunds presenting with APP.

SeqLengthPlot v2.0: an all-in-one, easy-to-use tool for visualizing and retrieving sequence lengths from FASTA files.

Motivation: Accurate sequence length profiling is essential in bioinformatics, particularly in genomics and proteomics. Existing tools like SeqKit and the Trinity toolkit provide basic sequence statistics but often fall short in offering comprehensive analytics and plotting options. For instance, SeqKit is a very complete and fast tool for sequence analysis, delivering useful metrics (e.

Description of two new species ( sp. nov and sp. nov.) (Tanaidacea: Crustacea) from the Mediterranean and a biogeographic overview of the genus.

The Mediterranean Sea is recognized as one of the most threatened marine environments due to pollution, the unintentional spread of invasive species, and habitat destruction. Understanding the biodiversity patterns within this sea is crucial for effective resource management and conservation planning. During a research cruise aimed at assessing biodiversity near desalination plants in the vicinity of Larnaca, Cyprus, conducted as part of the WATER-MINING project (Horizon 2020), specimens of the tanaidacean genus were collected.

Persistent Knee Monoarthritis as a Lyme Disease Presentation: A Diagnostic Challenge - Case Report.

There are several differential diagnoses for knee monoarthritis. We report a patient with recurrent episodes of knee effusion, in which the non-specific clinical condition implied several diagnostic hypotheses, therapeutic inaccuracies, and a delay in implementing adequate treatment. For more than 2 years, the patient underwent different Orthopedics and Rheumatology visits.

Proximal Humerus Epiphysiolysis as a Rare Cause of Fracture in Childbirth - A Case Report.

Proximal humeral epiphysiolysis (PHE) are rare at 10.1/100,000 births and there are few cases described in the literature. We present the case of a newborn diagnosed with PHE submitted to conservative treatment.

Cavitary Pulmonary Tuberculosis in an Infant.

Tuberculosis (TB) continues to pose a significant health challenge globally and in Portugal. Diagnostic challenges persist, especially in infants, where TB often presents with atypical symptoms. A previously healthy three-month-old male infant from Vila Nova de Famalicão, Portugal, was admitted with cough, rhinorrhea, respiratory distress, and high-grade fever.

Anything goes for participant, patient and public involvement in youth mental health research.

Background: Participant and Public Involvement in youth mental health research aims at making research more responsive to the needs of youth struggling with mental health issues, their parents, and mental health professionals and other stakeholders. Do characteristics of Patient and Public Involvement (PPI) in youth mental health research align with transparency and replication prerequisites as necessary conditions for translation? Relatedly, the question is addressed whether co-authorship should be assigned to youth involved in the study.

Methods: Here we address these questions re-visiting 50 PPI studies included in two recent systematic reviews of PPI on characteristics that are pertinent to questions about transparency, replicability, translatability, and co-authorship in PPI research.

Effects of experimental nest treatment with herbs on ectoparasites and body condition of nestlings.

Nest fumigation behavior involves the incorporation of fresh green plant fragments that contain ectoparasite-repellent volatile compounds into birds' nests. This behavior is relatively rare among bird species, and there is ongoing debate about whether it benefits parental breeding success. In this study, we experimentally tested whether the inclusion of aromatic-herbal plant fragments in the nests of great tits affects the physiological condition of nestlings, as indicated by blood levels of hematocrit, hemoglobin, glucose, and body condition indices, such as weight and wing length.

Comparison of ELISA and IFAT for Leishmania infantum by European and Middle Eastern diagnostic laboratories.

Background: Visceral leishmaniosis (VL) is the most severe form of human leishmaniosis, with an estimated 95% case fatality if left untreated. Dogs act as peridomestic reservoir hosts for the protozoan parasite Leishmania infantum, a causative agent for human leishmaniosis, endemic throughout the Mediterranean basin. To assure consistent and accurate surveillance of canine infection and prevent transmission to people, consistent diagnosis of canine L.

New low-dose curcumin derivative with therapeutic potential in Alzheimer's disease: Results from an in vitro and in vivo study in mice.

Curcumin has been proposed as a potential treatment for Alzheimer's disease (AD) due to its ability to inhibit amyloid-β (Aβ) peptide aggregates and to destabilise pre-formed ones. Derivative 27 was synthesized to improve low-dose efficacy in the context of AD. Its anti-inflammatory, antioxidant and anti-amyloidogenic activities were evaluated in chemico, in vitro using AD and neuroinflammation cell models, and in vivo using the double-transgenic APP/PS1 mice.

The effect of genotype and sex on carcass characteristics and fatty acid profile of Pekin broiler ducks.

The aim of this study was to compare two different strains of Pekin duck and to answer one scientific hypothesis: 1) Strain and sex influence live body weight, hot and cold carcass weights and carcass portions weights and yields, fatty acid content, fatty acid total cholesterol and α-tocopherol contents of meat. The study used 50 individuals of each strain in comparison (Cherry Valley and Grimaud) equally divided between both sexes), raised in equal rearing and feeding conditions. The results show that, when raised in equal rearing and feeding conditions and slaughtered at matching age, the strain had no significant influence on live body weight at slaughter, warm and cold carcass weights.

Antarctic Expeditions: A Systematic Review of the Physiological, Nutritional, Body Composition and Psychological Responses to Treks Across the Continental Ice.

Background: Antarctic expeditions, although supported by scientific knowledge, face various challenges, with little research conducted to explore the physical demands that explorers experience.

Objective: To summarise physiological, psychological, body composition and nutritional changes faced during trek expeditions in the Antarctic's continental portion.

Design: Systematic review.

- a large-scale dataset of 3D medical shapes for computer vision.

Objectives: The shape is commonly used to describe the objects. State-of-the-art algorithms in medical imaging are predominantly diverging from computer vision, where voxel grids, meshes, point clouds, and implicit surface models are used. This is seen from the growing popularity of ShapeNet (51,300 models) and Princeton ModelNet (127,915 models).

How to determine hands' vibration perception thresholds - a systematic review.

The vibration perception threshold (VPT) is the minimum amplitude required for conscious vibration perception. VPT assessments are essential in medical diagnostics, safety, and human-machine interaction technologies. However, factors like age, health conditions, and external variables affect VPTs.

Potential backfiring effects of Marine Protected Areas on kelp herbivory.

The management and creation of Marine Protected Areas (MPAs) is currently under great focus, with international organisations aiming to protect 30% of our oceans by 2030. The success of MPAs depends on a nuanced understanding of local ecological dynamics and threats, which can significantly influence ecosystem balance. Herbivory can be a stressor for foundation species, namely kelp forests, contributing to their decline in several regions of the globe.

Perivascular adipose tissue: a central player in the triad of diabetes, obesity, and cardiovascular health.

Perivascular adipose tissue (PVAT) is a dynamic tissue that affects vascular function and cardiovascular health. The connection between PVAT, the immune system, obesity, and vascular disease is complex and plays a pivotal role in the pathogenesis of vascular diseases such as atherosclerosis, hypertension, and vascular inflammation. In cardiometabolic diseases, PVAT becomes a significant source of proflammatory adipokines, leading to increased infiltration of immune cells, in cardiometabolic diseases, PVAT becomes a significant source of proinflammatory adipokines, leading to increased infiltration of immune cells, promoting vascular smooth muscle cell proliferation and migrationpromoting vascular smooth muscle cell proliferation and migration.

Chronic spontaneous urticaria remission definition and therapy stepping-down. WAO Position Paper.

Background: There is no global agreement on the definition of Chronic Spontaneous Urticaria (CSU) remission.

Objective: To generate a consensus for clinical definitions in CSU focused on remission.

Methods: The World Allergy Organization (WAO) Urticaria Committee systematically reviewed current available longitudinal articles.

Trends in the epidemiology of anxiety disorders from 1990 to 2021: A global, regional, and national analysis with a focus on the sociodemographic index.

Background: Anxiety disorders are widespread across the world. Understanding the global burden of anxiety disorders in the past and future can provide important references for optimizing prevention and control strategies in healthcare systems.

Methods: The estimation of anxiety disorders in the Global Burden of Disease Study 2021 using systematic review was conducted to describe incidence, prevalence and disability adjusted life years (DALYs) in 204 countries and regions from 1990 to 2021.

Nano versus bulk: Evaluating the toxicity of lanthanum, yttrium, and cerium oxides on Enchytraeus crypticus.

Considering the increase in demand for rare earth elements (REEs) and their accumulation in soil ecosystems, it is crucial to understand their toxicity. However, the impact of lanthanum, yttrium and cerium oxides (LaO, YO and CeO, respectively) on soil organisms remains insufficiently studied. This study aims to unravel the effects of LaO, YO and CeO nanoparticles (NPs) and their corresponding bulk forms (0, 156, 313, 625, 1250 and 2500 mg/kg) on the terrestrial species Enchytraeus crypticus.

Looking at the albumin-drug binding via partitioning in aqueous two-phase system.

The partition coefficient of human serum albumin (HSA) was analyzed in the PEG600-Dex70, 0.15 M NaCl/KCl in 0.01 M Na/K phosphate buffer, pH 7.

Untargeted metabolomics to relate changes produced by biocontrol agents against Aspergillus westerdijkiae and Penicillium nordicum in vitro on dry-cured ham.

Dry-cured ham is a highly appreciated meat product. During the ripening, moulds grow on its surface such as Penicillium nordicum and Aspergillus westerdijkiae producers of ochratoxin A (OTA). This mycotoxin poses a risk to consumers that must be controlled.

Safety of baricitinib in vaccinated patients with severe and critical COVID-19 sub study of the randomised Bari-SolidAct trial.

Background: The Bari-SolidAct randomized controlled trial compared baricitinib with placebo in patients with severe COVID-19. A post hoc analysis revealed a higher incidence of serious adverse events (SAEs) among SARS-CoV-2-vaccinated participants who had received baricitinib. This sub-study aimed to investigate whether vaccination influences the safety profile of baricitinib in patients with severe COVID-19.

Dual-compartment-gate organic transistors for monitoring biogenic amines from food.

According to the Food and Agriculture Organization of the United Nations (FAO) more than 14% of the world's food production is lost every year before reaching retail, and another 17% is lost during the retail stage. The use of the expiration date as the main estimator of the life-end of food products creates unjustified food waste. Sensors capable of quantifying the effective food freshness and quality could substantially reduce food waste and enable more effective management of the food chain.