170,054 results match your criteria: "Portugal; Clinical Academic Center-Braga 2CA-Braga[Affiliation]"
Front Public Health
December 2024
CIEC, University of Minho, Braga, Portugal.
Brain Spine
November 2024
Neurosurgery Department, King's College Hospital Foundation Trust, London, United Kingdom.
FEBS J
December 2024
UMIB - Unit for Multidisciplinary Research in Biomedicine, ICBAS - School of Medicine and Biomedical Sciences, University of Porto, Portugal.
Male fertility results from a complex interplay of physiological, environmental, and genetic factors. It is conditioned by the properly developed anatomy of the reproductive system, hormonal regulation balance, and the interplay between different cell populations that sustain an appropriate and functional environment in the testes. Unfortunately, the mechanisms sustaining male fertility are not flawless and their perturbation can lead to infertility.
View Article and Find Full Text PDFEur Spine J
December 2024
Department of Neuroradiology, Centro Hospitalar Universitário de Santo António, Unidade Local de Saúde de Santo António, Porto, Portugal.
Background: The evaluation of lumbar spine degeneration on magnetic resonance imaging (MRI) is prone to inter-reader variability, including when assessing foraminal changes. This variability, often due to subjective criteria and inconsistent terminology, may affect clinical correlations. Standardized criteria could help improve agreement among readers.
View Article and Find Full Text PDFJ Fish Biol
December 2024
Laboratorio de Paleobiología, Centro de Estudios Avanzados en Zonas Áridas, Coquimbo, Chile.
The diamond stingray (Hypanus dipterurus) is a species of cartilaginous fish that, according to the IUCN, is globally in a vulnerable state of conservation and its populations show a decline. New records of this ray species in southern Peru and northern Chile have expanded their known range. The species is distributed in the Eastern Central Pacific, from southern California to San Andres, on the central coast of Peru, but is poorly known in Chile.
View Article and Find Full Text PDFBMC Res Notes
December 2024
Faculty of Sport and Physical Education, University of Belgrade, Belgrade, Serbia.
Objective: Ultra-marathon running races are held as distance-limited or time-limited events, ranging from 6 h to 10 days. Only a few runners compete in 10-day events, and so far, we have little knowledge about the athletes' origins, performance, and event characteristics. The aim of the present study was to investigate the origin and performance of these runners and the fastest race locations.
View Article and Find Full Text PDFBMC Nurs
December 2024
Nursing School of Porto, Porto, Portugal.
Introduction: Generational diversity in nursing has introduced new challenges, for nurse managers and practice environments, in addressing both the nurses' and clients' needs and organizations' social and health policies. The organizational climate encourages professionals to preserve positive practice environments, which promotes a healthy coexistence between generations, respecting their distinctive characteristics and values, with the essential purpose of ensuring the team's effectiveness and the organization's success.
Objective: To map the available scientific evidence on the generational diversity of nurses in professional practice environments.
BMC Med Educ
December 2024
School of Nursing, Alborz University of Medical Sciences, Karaj, Iran.
Background: This study aimed to evaluate the psychometric properties of the Persian version of The Bullying Behaviors in Nursing Education (BBNE) scale among Iranian nursing students.
Method: In this cross-sectional study, 366 undergraduate nursing students from two public universities in Iran were selected through convenience sampling from April to June 2023. The BBNE scale was translated into Persian, and its content and construct validity, internal consistency and reliability were evaluated.
Harm Reduct J
December 2024
EUDA, Praça Europa 1, Cais do Sodré, 1249-289, Lisbon, Portugal.
Background: Harm Reduction, conceptualized by Russell Newcombe in the late 1980s, has revolutionized how drug use, individuals who use drugs, and drug policies are understood globally. Emerging from the HIV/AIDS crisis, Harm Reduction sought to address the dire rates of drug-related infections and the overwhelming burden on healthcare providers. Early initiatives, such as Opioid Substitution Treatment (OST) and needle exchange programs, were met with resistance but gradually established new standards of care, transforming attitudes toward people who use drugs and prioritizing human-centered, rather than solely medical, approaches.
View Article and Find Full Text PDFBMC Oral Health
December 2024
Universidade Católica Portuguesa, Faculty of Dental Medicine, Center for Interdisciplinary Research in Health, Viseu, 3504-505, Portugal.
Background: Oral health represents a public health problem due to its remarkable social impact and medical costs. Crenotherapy with sulfur water is shown to be a complementary, less toxic, and traumatizing therapy, but the number of studies that evaluate the effect of natural mineral waters effect on oral health are scarce. The aim of this pilot study is to evaluate the impact of thermal water therapy on the oral health of the participants, assessing parameters such as plaque index, gingival bleeding index and periodontal probing depth as well on the perception of symptoms of oral mucosa diseases (OMD).
View Article and Find Full Text PDFBMC Musculoskelet Disord
December 2024
Public Health Research Centre, Comprehensive Health Research Center, NOVA National School of Public Health, CHRC, NOVA University Lisbon, Lisbon, Portugal.
Background: Injury to the knee joint is associated with physical disability, stiffness, pain, restriction of movement and impairment of the person's quality of life, with a few treatment options, including surgery and rehabilitation. This study aims to evaluate the impact of a rehabilitation program on the quality of life reported by patients living in rural and urban areas after knee surgery, using patient-reported outcome measures (PROMs).
Methods: This quasi-experimental study with two groups of participants undergoing primary knee surgery was carried out in two rehabilitation centers, one in an urban area and another in a rural one.
Inorg Chem
December 2024
Department of Chemistry, University of Patras, Patras 26504, Greece.
Trivalent lanthanide ions have emerged as promising candidates for precise and remote temperature sensing. Among them, Pr-based luminescent thermometers remain underexplored, particularly those operating in the near-infrared (NIR) spectral region. This work presents the synthesis and thorough characterization of a novel Pr-based coordination polymer, {[PrPt(CN)(4,4'-bpyO)(HO)]·4HO} (), as a rare example of Pr luminescent thermometry.
View Article and Find Full Text PDFJ Headache Pain
December 2024
Department of Neurology, Headache Medical Center, Linz, Austria.
The association between migraine and cognitive function has been studied during the last decade, however, this relationship is not well established. As migraine prevalence is highest between the ages of 30-40, aligning with some of our most productive years, we must understand cognitive changes within this disorder. Cognitive impairment potentially limits social and professional interactions, thus negatively impacting quality of life.
View Article and Find Full Text PDFLancet Digit Health
December 2024
University Hospitals Birmingham NHS Foundation Trust, Birmingham, UK; National Institute for Health and Care Research (NIHR) Birmingham Biomedical Research Centre, Birmingham, UK; Centre for Patient Reported Outcomes Research, School of Health Sciences, College of Medical and Dental Sciences, Birmingham, UK; University of Birmingham, Birmingham, UK. Electronic address:
Without careful dissection of the ways in which biases can be encoded into artificial intelligence (AI) health technologies, there is a risk of perpetuating existing health inequalities at scale. One major source of bias is the data that underpins such technologies. The STANDING Together recommendations aim to encourage transparency regarding limitations of health datasets and proactive evaluation of their effect across population groups.
View Article and Find Full Text PDFTrends Plant Sci
December 2024
GIMM - Gulbenkian Institute for Molecular Medicine, Lisbon, Portugal. Electronic address:
Plant immunity involves a complex and finely tuned response to a wide variety of pathogens. Alternative splicing, a post-transcriptional mechanism that generates multiple transcripts from a single gene, enhances both the versatility and effectiveness of the plant immune system. Pathogen infection induces alternative splicing in numerous plant genes involved in the two primary layers of pathogen recognition: pattern-triggered immunity (PTI) and effector-triggered immunity (ETI).
View Article and Find Full Text PDFVet Comp Oncol
December 2024
Department of Veterinary Clinics, Institute of Biomedical Sciences Abel Salazar (ICBAS), University of Porto, Porto, Portugal.
Mast cell tumours (MCTs) are the most frequent cutaneous neoplasia of the dog, and they have very variable biological behaviour and survival times. Surgery is still the best treatment, and despite the several adjuvant therapies described, many cases are very aggressive and resistant to these treatments making it urgent to find new therapeutic targets. Nowadays, immunotherapy targeting immune checkpoints has been described as a complementary treatment for several human cancers, but it is still very scarcely studied in veterinary medicine.
View Article and Find Full Text PDFEur J Pharm Sci
December 2024
Laboratory of Pharmacology, Department of Pharmacy, University of Coimbra, Coimbra, Portugal; CIBIT/ICNAS - Coimbra Institute for Biomedical Imaging and Translational Research, University of Coimbra, Coimbra, Portugal. Electronic address:
Neuroinflammation is an undoubted hallmark of neurodegenerative processes characterized by memory impairment, loss of coordination and muscle strength in diseases such as Alzheimer's disease, Parkinson's disease and multiple sclerosis as well as depressive disorders. Cyclosporine A (CSA) has already been identified as a promising neuroprotective peptide, due to its well-known anti-inflammatory properties. Herein, CSA was encapsulated into α-tocopherol polyethylene glycol 1000 succinate (TPGS) micelles and intranasally administered to a lipopolysaccharide (LPS) induced mouse model of neuroinflammation.
View Article and Find Full Text PDFEnviron Pollut
December 2024
REQUIMTE/LAQV, Instituto Superior de Engenharia do Porto, Instituto Politécnico do Porto, Rua Dr. António Bernandino de Almeida 431, 4249-015 Porto, Portugal; Ciências Químicas e das Biomoléculas, Escola Superior de Saúde, Instituto Politécnico do Porto, Rua Dr. António Bernardino de Almeida 400, 4200-072 Porto, Portugal. Electronic address:
In recent years, microplastic (MP) pollution has garnered significant attention owing to its ability to permeate various ecosystems, including soil. These particles can infiltrate the environment, either directly or through the degradation of larger plastic items. Despite growing concerns, standardized methods for quantification are still lacking.
View Article and Find Full Text PDFInt J Biol Macromol
December 2024
Department of Chemistry, Faculty of Science, University of Zagreb, Horvatovac 102a, 10000 Zagreb, Croatia. Electronic address:
Streptococcus mutans, a bacterium commonly found in the human oral cavity, is considered the primary causative agent of dental caries. A key player in the pathophysiology of S. mutans is SloR, a 25-kDa metalloregulatory protein.
View Article and Find Full Text PDFLancet Public Health
December 2024
Department of Epidemiology of Microbial Diseases, Yale School of Public Health, Yale University, New Haven, CT, USA; Department of Medicine, Section of Infectious Diseases, Yale School of Medicine, Yale University, New Haven, CT, USA.
The 1990 resolution by the UN General Assembly committed member states to provide health-care equity for people in prison, who are included in the global goals to control HIV and eliminate hepatitis C virus (HCV) by 2030. WHO has set ambitious HCV elimination targets by including people who inject drugs (PWID), yet has not prioritised PWID who are incarcerated, a substantial population who have or are at risk for HCV infection. Human rights principles of health-care equity stipulate that "prisoners should enjoy the same standards of health care that are available in the community, without discrimination on the grounds of their legal status".
View Article and Find Full Text PDFJ Fr Ophtalmol
December 2024
Service d'ophtalmologie, Nouvel Hôpital Civil, hôpitaux universitaires de Strasbourg, BP 426, 67091 Strasbourg, France.
Objective: This study aims to present and analyze the results of the French cohort in a European Board of Ophthalmology (EBO) survey on cataract surgical training in Europe, highlighting the particularities of French training.
Materials And Methods: A 23-question electronic questionnaire was sent to interns applying for the EBO examination from 2018 to 2022. Responses from French participants were specifically collected and analyzed.
Eur J Med Chem
December 2024
LEPABE-Laboratory for Process Engineering, Environment, Biotechnology and Energy, Faculty of Engineering, University of Porto, Rua Dr. Roberto Frias, s/n, 4200-465, Porto, Portugal; ALICE-Associate Laboratory for Innovation in Chemical Engineering, Faculty of Engineering, University of Porto, Rua Dr. Roberto Frias, s/n, 4200-465, Porto, Portugal; DEQ-Department of Chemical Engineering, Faculty of Engineering, University of Porto, Rua Dr. Roberto Frias, s/n, 4200-465, Porto, Portugal. Electronic address:
Iron is essential for the formation, maturation and dispersal of bacterial biofilms, playing a crucial role in the physiological and metabolic functions of bacteria as well as in the regulation of virulence. Limited availability of iron can impair the formation of robust biofilms by altering cellular motility, hydrophobicity and protein composition of the bacterial surface. In this study, the antibiofilm activity of two natural iron chelating agents, kojic acid (5-hydroxy-2-hydroxymethyl-4H-pyran-4-one) and maltol (3-hydroxy-2-methyl-4-pyrone), were investigated against Staphylococcus aureus and Pseudomonas aeruginosa.
View Article and Find Full Text PDFEnzyme Microb Technol
December 2024
VBlab - Laboratory of Bacterial Viruses, University of Sorocaba, Sorocaba, SP 18023-000, Brazil; Department of Biology and CESAM, University of Aveiro, Campus Universitário de Santiago, Aveiro P-3810-193, Portugal. Electronic address:
Traditionally, control of coffee plant bacterial halo blight (BHB) caused by the phytopathogen Pseudomonas coronafaciens pv. garcae (Pcg) involves frequent spraying of coffee plantations with non-environmentally friendly and potentially bacterial resistance-promoting copper products or with kasugamycin hydrochloride. In this study we report a leap forward in the quest for a new ecofriendly approach, characterizing (both physicochemically and biologically) and testing both in vitro and ex vivo a new lytic phage for Pcg.
View Article and Find Full Text PDFEur J Cancer
November 2024
University of Perugia, Unit of Medical Oncology, Santa Maria della Misericordia Hospital, Perugia, Italy.
This guideline was developed in close collaboration with multidisciplinary experts from the European Association of Dermato-Oncology (EADO), the European Dermatology Forum (EDF) and the European Organization for Research and Treatment of Cancer (EORTC). Recommendations for the diagnosis and treatment of melanoma were developed on the basis of systematic literature research and consensus conferences. Cutaneous melanoma (CM) is the most dangerous form of skin tumor and accounts for 90 % of skin cancer mortality.
View Article and Find Full Text PDFJ Chromatogr A
December 2024
iBET, Instituto de Biologia Experimental e Tecnológica, Apartado 12 2780-901, Oeiras, Portugal; ITQB-NOVA, Instituto de Tecnologia Química e Biológica António Xavier, Universidade Nova de Lisboa, Oeiras, Portugal. Electronic address:
Adeno-associated viruses (AAV) are becoming increasingly popular as a powerful tool for gene delivery therapy applications. Although processes to produce AAV are established, future demand for this type of viral vector requires further development of manufacturing processes to make them more robust, scalable, and flexible to accommodate the rise of engineered capsids. This study focuses on designing and evaluating a two-step chromatography process for capturing and polishing AAV8 using monolith chromatography media.
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