171,432 results match your criteria: "Portugal; CEDOC - Chronic Diseases Research Center[Affiliation]"

Curcumin-Loaded Lipid Nanoparticles: A Promising Antimicrobial Strategy Against in Endodontic Infections.

Pharmaceutics

January 2025

Laboratório Associado para a Química Verde-Rede de Química e Tecnologia (LAQV, REQUIMTE), Instituto de Ciências Biomédicas de Abel Salazar, Universidade do Porto, Rua de Jorge Viterbo Ferreira 228, 4050-313 Porto, Portugal.

This study aims to evaluate the efficacy of curcumin (CUR), a natural polyphenol with potent antimicrobial and anti-inflammatory properties, when formulated as solid lipid nanoparticles (CUR-loaded SLN) against . Solid lipid nanoparticles (SLNs) were prepared as a carrier for CUR, which significantly improved its solubility. SLNs made with cetyl palmitate and Tween 80 were obtained via the hot ultrasonication method.

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Monogenic disorders are a group of human diseases caused by mutations in single genes. While some disease-altering treatments offer relief and slow the progression of certain conditions, the majority of monogenic disorders still lack effective therapies. In recent years, gene therapy has appeared as a promising approach for addressing genetic disorders.

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Cutting-Edge Advances in Anticancer Therapies: Insights from the Third Edition of the Special Issue "Novel Anticancer Strategies".

Pharmaceutics

January 2025

UNIPRO-Oral Pathology and Rehabilitation Research Unit, University Institute of Health Sciences (IUCS), Cooperativa de Ensino Superior Politécnico e Universitário (CESPU), Rua Central de Gandra, 1317, 4585-116 Gandra, Portugal.

Cancer incidence and mortality continue to rise at an alarming rate worldwide, underscoring the urgent need for more effective therapeutic interventions [...

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Background: Salbutamol, a short-acting β-agonist used in asthma treatment, is available in multiple formulations, including inhalers, nebulizers, oral tablets, and intravenous, intramuscular, and subcutaneous routes. Each formulation exhibits distinct pharmacokinetic (PK) and pharmacodynamic (PD) profiles, influencing therapeutic outcomes and adverse effects. Although asthma management predominantly relies on inhaled salbutamol, understanding how these formulations interact with patient-specific characteristics could improve personalized medicine approaches, potentially uncovering the therapeutic benefits of alternative formulations for an individual patient.

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Potato ( L.) is the world's third most popular vegetable in terms of consumption and the fourth most produced. Potatoes can be easily cultivated in different climates and locations around the globe and often in soils contaminated by heavy metals due to industrial activities.

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The Role of Meat Lipids in Nutrition and Health: Balancing Benefits and Risks.

Nutrients

January 2025

CIISA-Centro de Investigação Interdisciplinar em Sanidade Animal, Faculdade de Medicina Veterinária, Universidade de Lisboa, Av. da Universidade Técnica, 1300-477 Lisboa, Portugal.

Meat lipids are determinants of the nutritional, sensory and physiological qualities of meat, encompassing triglycerides, phospholipids, cholesterol and bioactive compounds. These lipids provide essential fatty acids, including omega-3 and omega-6 polyunsaturated fatty acids, critical for metabolic regulation, inflammation control and cognitive health. However, the dual role of meat lipids as essential nutrients and potential contributors to health risks, such as cardiovascular disease and oxidative stress, necessitates a nuanced understanding.

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Dietary Surveys and Nutritional Epidemiology.

Nutrients

January 2025

School of Life Sciences and Environment, University of Trás-os-Montes and Alto Douro (UTAD), 5000-801 Vila Real, Portugal.

As the prevalence of lifestyle-related diseases continues to increase globally [...

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Background: The dietary intake of hospitalised patients is often compromised during hospitalisation, which can be a causal factor for hospital malnutrition. This is considered a public health problem worldwide and is associated with an increased risk of other complications.

Objectives: Our objective was to determine the dietary intake of hospitalised individuals and if the prescribed diet influences it.

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Processed Food Consumption and Sleep Quality in School-Aged Children: Insights from a Cross-Sectional Study.

Nutrients

January 2025

Health Sciences Research Unit: Nursing (UICISA: E), Nursing School of Coimbra, Avenida Bissaya Barreto, Polo C, 3046-851 Coimbra, Portugal.

Objective: This cross-sectional study aimed to investigate the association between processed food consumption and sleep quality among school-aged children.

Methods: Our sample consisted of 137 children, with 52.6% being girls with a mean age of 7.

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The food packaging industry is one of the fastest growing sectors of our economy, with a large contribution to environmental concerns due to the extensive use of fossil-derived materials. Combining wood-based materials, such as particleboards, with bio-adhesives may offer a great opportunity to develop sustainable packaging solutions with active antioxidant properties. In the present work, a phenolic extract of poplar bark was produced and bio-adhesives were formulated using citric acid as a cross-linker.

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Smart textiles provide a significant technological advancement, but their development must balance traditional textile properties with electronic features. To address this challenge, this study introduces a flexible, electrically conductive composite material that can be fabricated using a continuous bi-component extrusion process, making it ideal for sensor electrodes. The primary aim was to create a composite for the filament's core, combining multi-walled carbon nanotubes (MWCNTs), polypropylene (PP), and thermoplastic elastomer (TPE), optimised for conductivity and flexibility.

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Acylase-Based Coatings on Sandblasted Polydimethylsiloxane-Based Materials for Antimicrobial Applications.

Polymers (Basel)

January 2025

Center for Micro-Electro Mechanical Systems (CMEMS), Campus Azurém, University of Minho, 4800-058 Guimarães, Portugal.

Indwelling medical devices, such as urinary catheters, often experience bacterial colonization, forming biofilms that resist antibiotics and the host's immune defenses through quorum sensing (QS), a chemical communication system. This study explores the development of antimicrobial coatings by immobilizing acylase, a quorum-quenching enzyme, on sandblasted polydimethylsiloxane (PDMS) surfaces. PDMS, commonly used in medical devices, was sandblasted to increase its surface roughness, enhancing acylase attachment.

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The idea supporting the investigation of the current manuscript was to develop customized filters for air conditioners with different pore percentages and geometry with the additional advantage of presenting antibacterial performance. This property was expected due to the reinforcement of Cu nanoparticles in the polymeric matrix of poly(lactic acid) (PLA) and polyurethane (TPU). The filaments were characterized by their chemical composition, thermal and mechanical properties, and antibacterial behavior before and after processing by fused filament fabrication.

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Bio-Microcapsules of Polybutylene Succinate (PBS) and Isocyanates: Towards Sustainable, Safer, and Efficient Adhesives.

Polymers (Basel)

January 2025

CERENA-Centro de Recursos Naturais e Ambiente, Department of Chemical Engineering (DEQ), Instituto Superior Técnico, Universidade de Lisboa, Avenida Rovisco Pais, 1049-001 Lisboa, Portugal.

This work describes the encapsulation of three different aliphatic isocyanates to reduce the risks associated with isocyanates' direct handling. The use of bio-based polybutylene succinate (bio-PBS) increases the sustainability factor as it allows for the use of microcapsules (MCs) from renewable sources with biodegradable features. The three different MCs (MCs-Monomer, MCs-Trimer, and MCs-Polymer) are spherical, crack-free, and matrix-type, containing an isocyanate payload between 67 wt% and 70 wt%.

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The present work constitutes the initial experimental effort to characterise the dynamic tensile performance of basalt fibre grids employed in TRM systems. The tensile behaviour of a bi-directional basalt fibre grid was explored using a high-speed servo-hydraulic testing machine with specialised grips. Deformation and failure modes were captured using a high-speed camera.

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Sustainable Skincare Innovation: Cork Powder Extracts as Active Ingredients for Skin Aging.

Pharmaceuticals (Basel)

January 2025

UCIBIO-Applied Molecular Biosciences Unit, Department of Drug Sciences, Faculty of Pharmacy, University of Porto, R. Jorge Viterbo Ferreira 228, 4050-313 Porto, Portugal.

: An emerging practice within the concept of circular beauty involves the upcycling of agro-industrial by-products. Cork processing, for instance, yields by-products like cork powder, which presents an opportunity to create value-added cosmetic ingredients. Building upon our previous research, demonstrating the antioxidant potential of hydroalcoholic extracts derived from two distinct cork powders (P0 and P1), in this work, aqueous extracts were prepared and analyzed.

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Synthesis and Evaluation of Cytotoxic Activity of RuCp(II) Complexes Bearing (Iso)nicotinic Acid Based Ligands.

Pharmaceuticals (Basel)

January 2025

Centro de Química Estrutural, Institute of Molecular Sciences, Faculdade de Ciências, Universidade de Lisboa, Campo Grande, 1749-016 Lisboa, Portugal.

Background/objectives: Cancer remains one of the major challenges of our century. Organometallic ruthenium complexes are gaining recognition as a highly promising group of compounds in the development of cancer treatments.

Methods: Building on the auspicious results obtained for [Ru(η-CH)(PPh)(bipy)][CFSO] (TM34), our focus has shifted to examining the effects of incorporating bioactive ligands into the TM34 framework, particularly within the cyclopentadienyl ring.

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Chemical Characterization and Differential Lipid-Modulating Effects of Selected Plant Extracts from Côa Valley (Portugal) in a Cell Model for Liver Steatosis.

Pharmaceuticals (Basel)

January 2025

Clinic Academic Center of Coimbra (CACC), Faculty of Medicine, Coimbra Institute for Clinical and Biomedical Research (iCBR), University of Coimbra, 3000-548 Coimbra, Portugal.

Background/objectives: Côa Valley, located in the northeast of Portugal, harbors more than 500 medicinal plant species. Among them, four species stand out due to their traditional uses: Desf. (hemorrhages, urethritis, hepatitis), L.

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Leaves Extracts Inhibit the Development of Ascitic and Solid Ehrlich Tumors.

Pharmaceuticals (Basel)

December 2024

Post Graduate Program in Structural and Functional Biology, Paulista School of Medicine (UNIFESP-EPM), Federal University of São Paulo, São Paulo 04023-062, SP, Brazil.

is traditionally known for its medicinal properties. Objectives: Here, we investigated the effects of crude extract (CE) and ethyl acetate fraction (EAF) obtained from leaves on the ascitic (EA) and solid (ES) forms of Ehrlich tumors. : Induced and uninduced BALB/c mice were treated intramuscularly, for 7 or 14 days, with saline solution or CE and EAF, both at a 10% concentration, based on in vitro cytotoxicity assessment.

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Background: Chemoresistance is a major obstacle in high-grade serous carcinoma (HGSC) treatment. Although many patients initially respond to chemotherapy, the majority of them relapse due to Carboplatin and Paclitaxel resistance. Drug repurposing has surfaced as a potentially effective strategy that works synergically with standard chemotherapy to bypass chemoresistance.

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Globally, forests are constantly threatened by a plethora of disturbances of natural and anthropogenic origin, such as climate change, forest fires, urbanization, and pollution. Besides the most common stressors, during the last few years, Portuguese forests have been impacted by severe decline phenomena caused by invasive pathogens, many of which belong to the genus . The genus includes a large number of species that are invading forest ecosystems worldwide, chiefly as a consequence of global trade and human activities.

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One of the significant challenges facing modern medicine is the rising rate of antibiotic resistance, which impacts public health, animal health, and environmental preservation. Evaluating antibiotic resistance in wildlife and their environments is crucial, as it offers essential insights into the dynamics of resistance patterns and promotes strategies for monitoring, prevention, and intervention. and genera isolates were recovered from fecal samples of wild animals and environmental samples using media without antibiotic supplementation.

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Screening Wild Birds for Tick-Borne Zoonotic Pathogens in Portugal.

Pathogens

January 2025

Animal and Veterinary Research Centre (CECAV), Associate Laboratory for Animal and Veterinary Sciences (AL4AnimalS), University of Trás-os-Montes e Alto Douro (UTAD), 5000-801 Vila Real, Portugal.

Wild birds may be involved in the transmission of agents of infectious diseases, including zoonoses, a circumstance which raises a number of public and animal health issues. Migratory bird species play a significant role in the introduction of tick-borne pathogens to new geographic areas, contributing to the dissemination of various etiological agents. This preliminary study aimed to assess the occurrence of four potentially zoonotic pathogens ( spp.

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First Detection of in Bats from the World's Largest Wetland, the Pantanal, Brazil.

Pathogens

January 2025

Laboratório de Virologia e Rickettsioses, Faculdade de Medicina Veterinária, Universidade Federal de Mato Grosso, Fernando Correa da Costa, 2367, Cuiabá 78060-900, Brazil.

Coronaviruses (CoV) infect a wide variety of hosts, causing epidemics in humans, birds, and mammals over the years. Bats (order Chiroptera) are one of the natural hosts of the Coronaviridae family. They represent 40% of the total number of mammal species in the Pantanal, a biodiversity hotspot in South America.

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Unlabelled: In recent years, the EnodePro device has been one of the most frequently used velocity sensors to track the bar velocity in resistance training, with the aim of providing load-velocity profiles. However, recent articles highlight a lack of reliability and validity in the estimated maximal strength, which can cause a serious health risk due to the overestimation of the bar velocity. With this study, we aimed to investigate whether imprecision in the measurement could explain the variance in this measurement error.

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