Dual EGFR and telomerase inhibitory potential of new triazole tethered Schiff bases endowed with apoptosis: design, synthesis, and biological assessments.

Many cancers have displayed resistance to chemotherapeutic drugs over the past few decades. EGFR has emerged as a leading target for cancer therapy inhibiting tumor angiogenesis. Besides, studies strongly suggest that blocking telomerase activity could be an effective way to control the growth of certain cancer cells.

Pioneering study of Egyptian Neem and Jojoba extracts with molecular docking combat hospital multidrug resistant bacteria.

Hospital surfaces are often contaminated with multidrug-resistant pathogenic bacteria that cause healthcare-associated infections and lead to increased mortality and morbidity. There is a need for new alternative antibacterial agents to overcome antibiotic resistance. Azadirachta indica and Simmondsia chinensis have been found to possess antibacterial activity and medicinal value.

Navigating the fear: assessing nursing students' concerns and preventive practices in response to Monkeypox in Egypt.

Background: Monkeypox has emerged as a global health concern, necessitating preventive measures and awareness among healthcare students. Understanding nursing students' fears, concerns, and preventive practices regarding Monkeypox can help improve preparedness and response strategies.

Aim: This study aimed to assess the levels of fear, concerns, and preventive practices related to monkeypox among nursing students at Beni Suef University, Egypt, during the 2024-2025 academic year.

Cloud computing practice activities and mental capacity on developing reproductive health and cognitive absorption.

The current study aims to determine how the interactions between practice (distributed/focused) and mental capacity (high/low) in the cloud-computing environment (CCE) affect the development of reproductive health skills and cognitive absorption. The study employed an experimental design, and it included a categorical variable for mental capacity (low/high) and an independent variable with two types of activities (distributed/focused). The research sample consisted of 240 students from the College of Science and College of Applied Medical Sciences at the University of Hail's.

Antimicrobial Stewardship Intervention for the Family Caregiver Attending Primary Health Care Setting: A Quasi-Experimental Study.

Antimicrobial resistance (AMR) has been identified as one of the top ten public health threats facing humanity. The purpose of this study was to assess the effect of an antimicrobial stewardship educational intervention on family caregivers' knowledge and practices in primary healthcare settings in Egypt. A quasi-experimental, one-group pretest-posttest design involving a sample of 300 family caregivers attending family health centers.

An intelligent hybrid approach combining fuzzy C-means and the sperm whale algorithm for cyber attack detection in IoT networks.

The Internet of Things (IoTs) has revolutionized cities, enabling them to become smarter. IoTs play an important role in monitoring the traffic cameras, roads, smart farming, connected vehicles, air quality, water level, humidity, and carbon dioxide pollution levels in city buildings. One of the major challenges of smart cities is the cyber threat to sensitive data.

DNA mismatch repair (MMR) genes expression in lung cancer and its correlation with different clinicopathologic parameters.

Lung cancer (LC) is a crucial rapidly developing disease. In Egypt, it is one of the five most frequent cancers. Little is known about the impact of deleted mismatch repair genes and its correlation to clinicopathological characteristics.

Interleukin-10 levels in azithromycin-induced cardiac damage and the protective role of combined selenium and vitamin E treatment.

Azithromycin is a broad-spectrum antibiotic commonly used to treat bacterial infections but is associated with adverse cardiac effects, including oxidative damage and myocardial inflammation. This study aims to explore the histopathological and biochemical changes, including serum interleukin-10 levels, induced by azithromycin in the hearts of male albino rats and to evaluate the protective role of combined selenium and vitamin E treatment. Forty rats were divided into four groups: a control group, an azithromycin treatment group, selenium and vitamin E treatment group, and a combined treatment group receiving both azithromycin, selenium, and vitamin E.

The potential of bone marrow derived mesenchymal stem cells in treating cisplatin induced sensorineural hearing loss in a guinea pig animal model.

Background: Sensorineural hearing loss (SNHL) is the most common sensory deficit worldwide. Current solutions for SNHL, including hearing aids, cochlear implants, and hearing assistive devices, do not provide consistent results and fail to address the underlying pathology of hair cell and ganglion cell damage. Stem cell therapy is a cornerstone in regenerative medicine.

Role of violence exposure on altruistic behavior and grit among emergency nurses in rural hospitals.

Aim: To explore the effect of violence exposure on altruistic behavior and grit among emergency nurses in 103-bed emergency departments in rural hospitals in Egypt.

Background: Workplace violence is a pervasive issue in emergency departments. Nurses in rural hospitals, facing limited resources and isolation, may be even more vulnerable to the adverse effects of workplace violence.

Nano-second pulsed laser ablation of inconel 718 and MMPCD for simultaneous optimal ablation rate and surface quality.

This study investigates the ablation performance of Inconel 718, a nickel-based superalloy, and metal matrix polycrystalline diamond (MMPCD), a super composite, using a nano-second (ns) pulsed laser across a range of ablation conditions. Single trenches varying in energy fluence and scanning speeds were created, analyzing the experimental responses in terms of ablation rate and surface roughness. Using regression techniques, models were developed to understand these relationships.

Possible relationship between pre-pregnancy maternal body mass index and offspring hippocampus: An experimental study in albino Wistar rat.

Background: Cognitive impairment and attention deficit disorder have been on the rise among generations in recent times. A significant portion of the brain involved in learning and cognition is the hippocampus. Its development begins in utero till weaning.

Diplopstomiasis and acanthamoebiasis syndromes in the different organs of Oreochromis aureus collected from Lake Manzala.

Background: is a member of the tilapia family that is considered one of the main food sources in different countries all over the world.

Aim: Thus, studying the different pathogens infecting tilapia species is still one of the interesting search points.

Methods: One hundred and eighty specimens of were collected from Lake Manzala and transported directly in iceboxes to the laboratory of the faculty of Science at Port Said University.

Approach to death and dying patients and its relation with death anxiety among medical interns: a multicenter cross-sectional study.

Background: Dealing with death and dying patients is one of the most challenging aspects of medical practice. The purpose of this study was to assess the attitude of medical interns toward death and dying patients as well as their level of death anxiety.

Methods: This cross-sectional study was conducted on medical interns across three countries-Egypt, Jordan, and Palestine-using an online survey created with Google Forms.

Leveraging Green Chromatography in Quality-by-Design-Driven Study for the Simultaneous Analysis of Essential Single-Pill Antidiabetic Drug Combinations.

Micellar liquid chromatography (MLC) has proven beneficial efficiency and ecological impact for routine quality control activities. In the proposed study, cyrene was investigated for the first time, together with other green additives, as a novel safe organic solvent in reversed-phase MLC. Quality-by-design (QbD) approach screened their effect on the separation performance.

Examining patient safety protocols amidst the rise of digital health and telemedicine: nurses' perspectives.

Background: Integrating digital health and telemedicine technologies is transforming healthcare delivery. In light of this transition, it is critical to ascertain the efficacy of patient safety protocols and evaluate the awareness of healthcare professionals, particularly nurses, regarding the integration of digital health technologies.

Aim: This study examines the factors influencing the successful adoption of digital health and telemedicine technologies from the nurses' perspective, focusing on ensuring patient safety and enhancing organizational readiness for digital health integration.

Tailoring nursing interventions to empower patients: personal coping strategies and self-management in type 2 diabetes care.

Background: Diabetes is one of the most common chronic diseases that severely reduce a patient's quality of life. Effective self-care and management are critical for maintaining blood glucose levels and preventing complications.

Aim: This study evaluates the effectiveness of a structured diabetes self-management education program on patients' self-management behaviors, empowerment, and activation levels.

Facilitators and barriers to AI adoption in nursing practice: a qualitative study of registered nurses' perspectives.

Background: Integrating Artificial Intelligence (AI) in nursing practice is revolutionising healthcare by enhancing clinical decision-making and patient care. However, the adoption of AI by registered nurses, especially in varied healthcare settings such as Saudi Arabia, remains underexplored. Understanding the facilitators and barriers from the perspective of frontline nurses is crucial for successful AI implementation.

The psychological impact of COVID-19 on front-line healthcare providers in the United Arab Emirates: A cross-sectional study.

Background: The COVID-19 pandemic has significantly impacted the psychological well-being of healthcare providers (HCPs) worldwide. Understanding the prevalence and associated factors of depression, generalized anxiety disorder (GAD), and posttraumatic stress disorder (PTSD) among these providers is crucial. Assess the prevalence of major depression, GAD, and PTSD symptoms among HCPs in the United Arab Emirates (UAE) during the COVID-19 pandemic.

Transcutaneous Lower Blepharoplasty with Midface Lift by Malar Fat Suspension to Lateral Part of Infraorbital Wall.

Background: The anatomy of the eyelid changes with age. Multiple changes were observed in the eyelids and the surrounding structures including the malar region. Aging affects the appearance of eyelids and midface by the formation of tear trough deformity and malar flattening and ptosis.

The effect of vildagliptin versus metformin on hepatic steatosis in type 2 diabetic patients: a randomized controlled trial.

Background: The risk of hepatic steatosis (HS) is elevated in patients with type 2 diabetes mellitus (T2D). Antidiabetic medications may contribute to the prevention or treatment of HS. This study aimed to compare the effects of vildagliptin and metformin on hepatic steatosis in newly diagnosed T2D patients, using the Hepatic Steatosis Index (HSI) and ultrasound grading.

Synergistic enhancing of micellization and thermodynamic properties of some Gemini cationic surfactants related to benzo[d]thiazol-3-ium bromide.

Herrin, three Gemini cationic surfactants related to benzo[d]thiazol-3-ium bromide with variable hydrocarbon chain lengths (TBC n = 6, 12, and 18) were synthesized successfully and confirmed by using IR and HNMR spectroscopies. Critical micelle concentration and different thermodynamic properties of all surfactants under study were measured using conductivity, density, molal volume, and refractive index techniques. The Critical micelle concentration of TBC 6, TBC 12, and TBC 18 surfactants measured from the different techniques shows an acceptable agreement.

Reducing sedentary behavior improves depressive symptoms among patients with heart failure enrolled in a home-based mobile health app cardiac rehabilitation.

Background: Depressive symptoms are common, worsening heart failure (HF) progression and reducing quality of life. While supervised structured exercise training is effective for managing depressive symptoms, it often demands a substantial time commitment or intensive activity that may discourage participation.

Objective: Evaluate the impacts of reducing sedentary time with short bouts of light physical activities or greater intensity levels on depressive symptoms after HF patients' enrollment in a home-based intervention.